Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL79_LEIMU

TriTrypDb:

LmxM.07.0660

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AL79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.454
CLV_C14_Caspase3-7	505	509	PF00656	0.598
CLV_C14_Caspase3-7	52	56	PF00656	0.631
CLV_PCSK_KEX2_1	97	99	PF00082	0.448
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.448
CLV_PCSK_SKI1_1	469	473	PF00082	0.455
CLV_PCSK_SKI1_1	75	79	PF00082	0.426
DEG_APCC_DBOX_1	464	472	PF00400	0.536
DEG_APCC_DBOX_1	74	82	PF00400	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.548
DEG_SPOP_SBC_1	248	252	PF00917	0.457
DEG_SPOP_SBC_1	323	327	PF00917	0.405
DEG_SPOP_SBC_1	56	60	PF00917	0.534
DOC_CDC14_PxL_1	148	156	PF14671	0.484
DOC_CYCLIN_RxL_1	465	476	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.467
DOC_MAPK_DCC_7	75	83	PF00069	0.518
DOC_MAPK_gen_1	485	492	PF00069	0.580
DOC_MAPK_HePTP_8	368	380	PF00069	0.438
DOC_MAPK_MEF2A_6	362	370	PF00069	0.397
DOC_MAPK_MEF2A_6	371	380	PF00069	0.418
DOC_MAPK_MEF2A_6	406	414	PF00069	0.418
DOC_PP1_RVXF_1	487	493	PF00149	0.578
DOC_PP2B_LxvP_1	41	44	PF13499	0.439
DOC_USP7_MATH_1	106	110	PF00917	0.573
DOC_USP7_MATH_1	12	16	PF00917	0.470
DOC_USP7_MATH_1	178	182	PF00917	0.349
DOC_USP7_MATH_1	191	195	PF00917	0.458
DOC_USP7_MATH_1	230	234	PF00917	0.594
DOC_USP7_MATH_1	242	246	PF00917	0.650
DOC_USP7_MATH_1	290	294	PF00917	0.414
DOC_USP7_MATH_1	308	312	PF00917	0.507
DOC_USP7_MATH_1	33	37	PF00917	0.414
DOC_USP7_MATH_1	424	428	PF00917	0.576
DOC_USP7_MATH_1	56	60	PF00917	0.588
DOC_WW_Pin1_4	120	125	PF00397	0.585
DOC_WW_Pin1_4	217	222	PF00397	0.650
DOC_WW_Pin1_4	250	255	PF00397	0.602
DOC_WW_Pin1_4	27	32	PF00397	0.700
DOC_WW_Pin1_4	362	367	PF00397	0.472
DOC_WW_Pin1_4	380	385	PF00397	0.223
DOC_WW_Pin1_4	398	403	PF00397	0.577
DOC_WW_Pin1_4	96	101	PF00397	0.529
LIG_14-3-3_CanoR_1	26	33	PF00244	0.625
LIG_14-3-3_CanoR_1	306	315	PF00244	0.377
LIG_14-3-3_CanoR_1	362	366	PF00244	0.302
LIG_Actin_WH2_2	346	364	PF00022	0.249
LIG_APCC_ABBA_1	413	418	PF00400	0.392
LIG_eIF4E_1	148	154	PF01652	0.376
LIG_eIF4E_1	37	43	PF01652	0.390
LIG_FHA_1	114	120	PF00498	0.488
LIG_FHA_1	138	144	PF00498	0.511
LIG_FHA_1	241	247	PF00498	0.654
LIG_FHA_1	250	256	PF00498	0.614
LIG_FHA_1	461	467	PF00498	0.481
LIG_FHA_1	58	64	PF00498	0.721
LIG_FHA_2	157	163	PF00498	0.515
LIG_FHA_2	332	338	PF00498	0.470
LIG_FHA_2	362	368	PF00498	0.548
LIG_FHA_2	428	434	PF00498	0.519
LIG_FHA_2	481	487	PF00498	0.462
LIG_FHA_2	56	62	PF00498	0.705
LIG_HP1_1	260	264	PF01393	0.378
LIG_LIR_Gen_1	145	155	PF02991	0.363
LIG_LIR_Gen_1	286	296	PF02991	0.432
LIG_LIR_Gen_1	35	45	PF02991	0.525
LIG_LIR_Gen_1	460	468	PF02991	0.421
LIG_LIR_Nem_3	139	144	PF02991	0.398
LIG_LIR_Nem_3	145	151	PF02991	0.457
LIG_LIR_Nem_3	233	237	PF02991	0.557
LIG_LIR_Nem_3	286	291	PF02991	0.386
LIG_LIR_Nem_3	34	40	PF02991	0.540
LIG_LIR_Nem_3	460	464	PF02991	0.393
LIG_LIR_Nem_3	476	482	PF02991	0.561
LIG_MYND_1	120	124	PF01753	0.564
LIG_Pex14_1	284	288	PF04695	0.315
LIG_SH2_CRK	144	148	PF00017	0.383
LIG_SH2_CRK	309	313	PF00017	0.399
LIG_SH2_CRK	38	42	PF00017	0.494
LIG_SH2_CRK	448	452	PF00017	0.492
LIG_SH2_NCK_1	148	152	PF00017	0.385
LIG_SH2_NCK_1	309	313	PF00017	0.385
LIG_SH2_NCK_1	434	438	PF00017	0.514
LIG_SH2_SRC	148	151	PF00017	0.393
LIG_SH2_STAP1	144	148	PF00017	0.364
LIG_SH2_STAP1	224	228	PF00017	0.667
LIG_SH2_STAP1	285	289	PF00017	0.428
LIG_SH2_STAP1	38	42	PF00017	0.422
LIG_SH2_STAT5	285	288	PF00017	0.438
LIG_SH2_STAT5	309	312	PF00017	0.481
LIG_SH2_STAT5	315	318	PF00017	0.502
LIG_SH2_STAT5	482	485	PF00017	0.597
LIG_SH3_3	118	124	PF00018	0.544
LIG_SH3_3	149	155	PF00018	0.486
LIG_SH3_3	215	221	PF00018	0.566
LIG_SH3_3	302	308	PF00018	0.290
LIG_SH3_3	378	384	PF00018	0.313
LIG_SH3_3	461	467	PF00018	0.488
LIG_SH3_3	67	73	PF00018	0.463
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.432
LIG_SUMO_SIM_par_1	258	265	PF11976	0.347
LIG_TRFH_1	76	80	PF08558	0.539
LIG_TYR_ITIM	146	151	PF00017	0.378
LIG_TYR_ITIM	307	312	PF00017	0.393
LIG_UBA3_1	1	8	PF00899	0.657
MOD_CK1_1	194	200	PF00069	0.416
MOD_CK1_1	250	256	PF00069	0.703
MOD_CK1_1	311	317	PF00069	0.393
MOD_CK1_1	324	330	PF00069	0.425
MOD_CK1_1	36	42	PF00069	0.459
MOD_CK1_1	427	433	PF00069	0.519
MOD_CK1_1	46	52	PF00069	0.588
MOD_CK1_1	59	65	PF00069	0.708
MOD_CK1_1	99	105	PF00069	0.577
MOD_CK2_1	120	126	PF00069	0.498
MOD_CK2_1	361	367	PF00069	0.476
MOD_CK2_1	427	433	PF00069	0.552
MOD_CK2_1	447	453	PF00069	0.281
MOD_CK2_1	480	486	PF00069	0.472
MOD_CK2_1	55	61	PF00069	0.687
MOD_DYRK1A_RPxSP_1	362	366	PF00069	0.302
MOD_GlcNHglycan	104	107	PF01048	0.777
MOD_GlcNHglycan	108	111	PF01048	0.766
MOD_GlcNHglycan	208	211	PF01048	0.531
MOD_GlcNHglycan	327	330	PF01048	0.545
MOD_GlcNHglycan	388	391	PF01048	0.410
MOD_GlcNHglycan	398	401	PF01048	0.447
MOD_GlcNHglycan	430	433	PF01048	0.544
MOD_GlcNHglycan	440	443	PF01048	0.543
MOD_GlcNHglycan	48	51	PF01048	0.635
MOD_GSK3_1	102	109	PF00069	0.671
MOD_GSK3_1	120	127	PF00069	0.518
MOD_GSK3_1	178	185	PF00069	0.452
MOD_GSK3_1	187	194	PF00069	0.460
MOD_GSK3_1	249	256	PF00069	0.739
MOD_GSK3_1	27	34	PF00069	0.651
MOD_GSK3_1	307	314	PF00069	0.461
MOD_GSK3_1	317	324	PF00069	0.432
MOD_GSK3_1	424	431	PF00069	0.580
MOD_GSK3_1	44	51	PF00069	0.500
MOD_GSK3_1	55	62	PF00069	0.717
MOD_GSK3_1	92	99	PF00069	0.636
MOD_N-GLC_1	102	107	PF02516	0.510
MOD_N-GLC_2	491	493	PF02516	0.436
MOD_N-GLC_2	518	520	PF02516	0.438
MOD_NEK2_1	25	30	PF00069	0.505
MOD_NEK2_1	361	366	PF00069	0.421
MOD_NEK2_1	396	401	PF00069	0.478
MOD_NEK2_2	391	396	PF00069	0.275
MOD_PIKK_1	12	18	PF00454	0.462
MOD_PIKK_1	313	319	PF00454	0.277
MOD_PKA_2	137	143	PF00069	0.391
MOD_PKA_2	25	31	PF00069	0.523
MOD_PKA_2	361	367	PF00069	0.302
MOD_PKA_2	65	71	PF00069	0.431
MOD_Plk_1	480	486	PF00069	0.517
MOD_Plk_2-3	480	486	PF00069	0.595
MOD_Plk_4	292	298	PF00069	0.277
MOD_Plk_4	33	39	PF00069	0.616
MOD_Plk_4	391	397	PF00069	0.447
MOD_ProDKin_1	120	126	PF00069	0.584
MOD_ProDKin_1	217	223	PF00069	0.654
MOD_ProDKin_1	250	256	PF00069	0.596
MOD_ProDKin_1	27	33	PF00069	0.692
MOD_ProDKin_1	362	368	PF00069	0.474
MOD_ProDKin_1	380	386	PF00069	0.229
MOD_ProDKin_1	398	404	PF00069	0.577
MOD_ProDKin_1	96	102	PF00069	0.532
MOD_SUMO_rev_2	200	208	PF00179	0.291
TRG_DiLeu_BaEn_2	340	346	PF01217	0.320
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.491
TRG_ENDOCYTIC_2	144	147	PF00928	0.372
TRG_ENDOCYTIC_2	148	151	PF00928	0.375
TRG_ENDOCYTIC_2	285	288	PF00928	0.340
TRG_ENDOCYTIC_2	309	312	PF00928	0.404
TRG_ENDOCYTIC_2	354	357	PF00928	0.407
TRG_ENDOCYTIC_2	37	40	PF00928	0.451
TRG_ENDOCYTIC_2	448	451	PF00928	0.495
TRG_ER_diArg_1	3	6	PF00400	0.509
TRG_ER_diArg_1	487	490	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX1	Leptomonas seymouri	53%	100%
A0A1X0NPG1	Trypanosomatidae	28%	100%
A0A3S5H5Z0	Leishmania donovani	84%	100%
A0A422N3S3	Trypanosoma rangeli	29%	100%
A4H517	Leishmania braziliensis	64%	99%
A4HT90	Leishmania infantum	84%	100%
C9ZUN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4QIM5	Leishmania major	85%	100%
V5BTD2	Trypanosoma cruzi	28%	100%