MPN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit h

Species:

Leishmania mexicana

UniProt:

E9AL77_LEIMU

TriTrypDb:

LmxM.07.0640

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005852	eukaryotic translation initiation factor 3 complex	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AL77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL77

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016579	protein deubiquitination	6	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.553
CLV_NRD_NRD_1	105	107	PF00675	0.602
CLV_NRD_NRD_1	108	110	PF00675	0.573
CLV_NRD_NRD_1	151	153	PF00675	0.531
CLV_NRD_NRD_1	207	209	PF00675	0.642
CLV_PCSK_KEX2_1	206	208	PF00082	0.573
CLV_PCSK_PC7_1	202	208	PF00082	0.607
CLV_PCSK_SKI1_1	109	113	PF00082	0.523
CLV_PCSK_SKI1_1	116	120	PF00082	0.490
CLV_PCSK_SKI1_1	56	60	PF00082	0.535
CLV_PCSK_SKI1_1	62	66	PF00082	0.507
DEG_APCC_DBOX_1	158	166	PF00400	0.508
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DOC_CYCLIN_RxL_1	104	115	PF00134	0.614
DOC_MAPK_DCC_7	159	167	PF00069	0.498
DOC_MAPK_MEF2A_6	159	167	PF00069	0.498
DOC_MAPK_MEF2A_6	83	90	PF00069	0.640
DOC_PP2B_PxIxI_1	85	91	PF00149	0.673
DOC_PP4_FxxP_1	35	38	PF00568	0.558
DOC_USP7_MATH_1	214	218	PF00917	0.587
DOC_USP7_MATH_1	256	260	PF00917	0.524
DOC_USP7_MATH_1	58	62	PF00917	0.578
DOC_USP7_UBL2_3	27	31	PF12436	0.677
DOC_WW_Pin1_4	183	188	PF00397	0.467
LIG_14-3-3_CanoR_1	173	177	PF00244	0.405
LIG_14-3-3_CanoR_1	206	211	PF00244	0.642
LIG_14-3-3_CanoR_1	56	65	PF00244	0.549
LIG_14-3-3_CanoR_1	7	17	PF00244	0.608
LIG_14-3-3_CanoR_1	95	102	PF00244	0.688
LIG_AP2alpha_2	170	172	PF02296	0.418
LIG_BRCT_BRCA1_1	139	143	PF00533	0.555
LIG_EH_1	143	147	PF12763	0.498
LIG_eIF4E_1	192	198	PF01652	0.558
LIG_FHA_1	128	134	PF00498	0.553
LIG_FHA_1	172	178	PF00498	0.566
LIG_FHA_1	275	281	PF00498	0.504
LIG_FHA_1	302	308	PF00498	0.467
LIG_FHA_1	313	319	PF00498	0.379
LIG_FHA_1	74	80	PF00498	0.469
LIG_FHA_2	95	101	PF00498	0.636
LIG_LIR_Apic_2	33	38	PF02991	0.590
LIG_LIR_Gen_1	235	245	PF02991	0.476
LIG_LIR_Gen_1	44	53	PF02991	0.307
LIG_LIR_Nem_3	140	146	PF02991	0.541
LIG_LIR_Nem_3	168	172	PF02991	0.521
LIG_LIR_Nem_3	188	194	PF02991	0.422
LIG_LIR_Nem_3	235	240	PF02991	0.468
LIG_LIR_Nem_3	252	257	PF02991	0.551
LIG_LIR_Nem_3	44	48	PF02991	0.418
LIG_NRBOX	47	53	PF00104	0.284
LIG_PTB_Apo_2	39	46	PF02174	0.469
LIG_SH2_CRK	194	198	PF00017	0.447
LIG_SH2_CRK	328	332	PF00017	0.558
LIG_SH2_SRC	265	268	PF00017	0.528
LIG_SH2_STAP1	194	198	PF00017	0.506
LIG_SH2_STAP1	328	332	PF00017	0.576
LIG_SH2_STAT5	185	188	PF00017	0.398
LIG_SH2_STAT5	265	268	PF00017	0.412
LIG_SUMO_SIM_par_1	75	81	PF11976	0.491
LIG_TRAF2_1	97	100	PF00917	0.668
LIG_TYR_ITIM	326	331	PF00017	0.555
LIG_UBA3_1	305	309	PF00899	0.510
MOD_CK1_1	147	153	PF00069	0.492
MOD_CK1_1	196	202	PF00069	0.593
MOD_CK1_1	217	223	PF00069	0.609
MOD_CK2_1	94	100	PF00069	0.708
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.510
MOD_GlcNHglycan	139	142	PF01048	0.460
MOD_GlcNHglycan	216	219	PF01048	0.532
MOD_GlcNHglycan	323	326	PF01048	0.548
MOD_GlcNHglycan	45	48	PF01048	0.349
MOD_GSK3_1	193	200	PF00069	0.609
MOD_GSK3_1	256	263	PF00069	0.560
MOD_GSK3_1	54	61	PF00069	0.526
MOD_GSK3_1	73	80	PF00069	0.343
MOD_LATS_1	310	316	PF00433	0.554
MOD_N-GLC_1	274	279	PF02516	0.529
MOD_N-GLC_1	41	46	PF02516	0.534
MOD_N-GLC_1	8	13	PF02516	0.591
MOD_NEK2_1	136	141	PF00069	0.544
MOD_NEK2_1	172	177	PF00069	0.381
MOD_NEK2_1	260	265	PF00069	0.558
MOD_NEK2_1	269	274	PF00069	0.339
MOD_NEK2_1	321	326	PF00069	0.445
MOD_NEK2_1	327	332	PF00069	0.429
MOD_NEK2_1	43	48	PF00069	0.302
MOD_PKA_1	206	212	PF00069	0.641
MOD_PKA_2	158	164	PF00069	0.614
MOD_PKA_2	172	178	PF00069	0.352
MOD_PKA_2	206	212	PF00069	0.641
MOD_PKA_2	94	100	PF00069	0.667
MOD_Plk_1	41	47	PF00069	0.462
MOD_Plk_2-3	94	100	PF00069	0.772
MOD_Plk_4	172	178	PF00069	0.454
MOD_Plk_4	193	199	PF00069	0.521
MOD_Plk_4	301	307	PF00069	0.446
MOD_Plk_4	327	333	PF00069	0.470
MOD_Plk_4	64	70	PF00069	0.580
MOD_ProDKin_1	183	189	PF00069	0.478
MOD_SUMO_for_1	230	233	PF00179	0.481
MOD_SUMO_rev_2	103	112	PF00179	0.576
MOD_SUMO_rev_2	75	84	PF00179	0.505
TRG_DiLeu_BaEn_1	303	308	PF01217	0.564
TRG_ENDOCYTIC_2	169	172	PF00928	0.394
TRG_ENDOCYTIC_2	194	197	PF00928	0.459
TRG_ENDOCYTIC_2	2	5	PF00928	0.571
TRG_ENDOCYTIC_2	328	331	PF00928	0.571
TRG_ER_diArg_1	206	208	PF00400	0.666
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B4	Leptomonas seymouri	73%	100%
A0A0S4KFQ8	Bodo saltans	28%	99%
A0A1X0NPP9	Trypanosomatidae	36%	100%
A0A3S7WPX1	Leishmania donovani	99%	100%
A0A422MVQ1	Trypanosoma rangeli	33%	100%
A4H515	Leishmania braziliensis	93%	100%
A4HTE9	Leishmania infantum	99%	100%
Q4QIM7	Leishmania major	98%	100%
V5BNS6	Trypanosoma cruzi	33%	100%