Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL74_LEIMU

TriTrypDb:

LmxM.07.0615

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.572
CLV_NRD_NRD_1	73	75	PF00675	0.534
CLV_PCSK_KEX2_1	220	222	PF00082	0.787
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.775
CLV_PCSK_SKI1_1	207	211	PF00082	0.489
DOC_CKS1_1	145	150	PF01111	0.703
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.539
DOC_MAPK_JIP1_4	2	8	PF00069	0.594
DOC_PP1_RVXF_1	185	191	PF00149	0.445
DOC_PP2B_LxvP_1	26	29	PF13499	0.595
DOC_PP4_FxxP_1	8	11	PF00568	0.503
DOC_USP7_MATH_1	123	127	PF00917	0.757
DOC_USP7_MATH_1	129	133	PF00917	0.755
DOC_USP7_MATH_1	139	143	PF00917	0.749
DOC_USP7_MATH_1	230	234	PF00917	0.695
DOC_USP7_MATH_1	51	55	PF00917	0.720
DOC_WW_Pin1_4	144	149	PF00397	0.715
DOC_WW_Pin1_4	249	254	PF00397	0.422
LIG_14-3-3_CanoR_1	185	191	PF00244	0.477
LIG_BRCT_BRCA1_1	234	238	PF00533	0.427
LIG_FHA_1	23	29	PF00498	0.467
LIG_FHA_1	240	246	PF00498	0.443
LIG_FHA_1	34	40	PF00498	0.387
LIG_FHA_2	145	151	PF00498	0.701
LIG_FHA_2	179	185	PF00498	0.549
LIG_LIR_Gen_1	172	179	PF02991	0.448
LIG_LIR_Gen_1	189	194	PF02991	0.407
LIG_LIR_Nem_3	172	177	PF02991	0.438
LIG_LIR_Nem_3	189	193	PF02991	0.423
LIG_Pex14_2	170	174	PF04695	0.544
LIG_SH2_STAT5	108	111	PF00017	0.526
LIG_SH3_1	45	51	PF00018	0.352
LIG_SH3_3	122	128	PF00018	0.623
LIG_SH3_3	142	148	PF00018	0.765
LIG_SH3_3	25	31	PF00018	0.474
LIG_SH3_3	45	51	PF00018	0.314
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.446
LIG_SUMO_SIM_par_1	240	246	PF11976	0.463
MOD_CDK_SPK_2	144	149	PF00069	0.491
MOD_CK1_1	132	138	PF00069	0.672
MOD_CK2_1	178	184	PF00069	0.545
MOD_CK2_1	230	236	PF00069	0.458
MOD_Cter_Amidation	218	221	PF01082	0.714
MOD_GlcNHglycan	102	105	PF01048	0.575
MOD_GlcNHglycan	125	128	PF01048	0.689
MOD_GlcNHglycan	132	135	PF01048	0.671
MOD_GlcNHglycan	154	157	PF01048	0.776
MOD_GlcNHglycan	171	174	PF01048	0.543
MOD_GlcNHglycan	39	42	PF01048	0.462
MOD_GSK3_1	100	107	PF00069	0.485
MOD_GSK3_1	139	146	PF00069	0.658
MOD_GSK3_1	18	25	PF00069	0.527
MOD_GSK3_1	239	246	PF00069	0.411
MOD_GSK3_1	33	40	PF00069	0.432
MOD_GSK3_1	49	56	PF00069	0.579
MOD_N-GLC_1	205	210	PF02516	0.784
MOD_NEK2_1	130	135	PF00069	0.554
MOD_NEK2_1	188	193	PF00069	0.479
MOD_NEK2_1	37	42	PF00069	0.400
MOD_PIKK_1	178	184	PF00454	0.545
MOD_PKA_2	186	192	PF00069	0.470
MOD_Plk_1	205	211	PF00069	0.699
MOD_Plk_1	239	245	PF00069	0.436
MOD_Plk_4	243	249	PF00069	0.423
MOD_ProDKin_1	144	150	PF00069	0.715
MOD_ProDKin_1	249	255	PF00069	0.440
TRG_DiLeu_BaEn_2	233	239	PF01217	0.419
TRG_ER_diArg_1	185	188	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.786

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P403	Leptomonas seymouri	45%	98%
A0A1X0NPF9	Trypanosomatidae	28%	100%
A0A3S5H5Y8	Leishmania donovani	80%	100%
A4H512	Leishmania braziliensis	61%	96%
A4HT86	Leishmania infantum	82%	100%
C9ZUN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4QIN0	Leishmania major	75%	98%