Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL73_LEIMU

TriTrypDb:

LmxM.07.0610

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DEG_SPOP_SBC_1	114	118	PF00917	0.745
DOC_MAPK_HePTP_8	54	66	PF00069	0.516
DOC_MAPK_MEF2A_6	11	19	PF00069	0.514
DOC_MAPK_MEF2A_6	57	66	PF00069	0.491
DOC_PP1_RVXF_1	95	102	PF00149	0.382
DOC_PP4_FxxP_1	19	22	PF00568	0.526
DOC_PP4_FxxP_1	95	98	PF00568	0.473
DOC_SPAK_OSR1_1	74	78	PF12202	0.480
DOC_USP7_MATH_1	113	117	PF00917	0.714
DOC_USP7_MATH_1	33	37	PF00917	0.480
DOC_USP7_MATH_1	40	44	PF00917	0.655
DOC_USP7_MATH_1	46	50	PF00917	0.716
DOC_USP7_MATH_1	76	80	PF00917	0.476
DOC_WW_Pin1_4	115	120	PF00397	0.733
DOC_WW_Pin1_4	57	62	PF00397	0.504
DOC_WW_Pin1_4	78	83	PF00397	0.419
LIG_eIF4E_1	88	94	PF01652	0.414
LIG_FHA_1	153	159	PF00498	0.438
LIG_FHA_1	23	29	PF00498	0.417
LIG_FHA_1	33	39	PF00498	0.424
LIG_FHA_1	61	67	PF00498	0.409
LIG_FHA_2	180	186	PF00498	0.705
LIG_LIR_Apic_2	18	22	PF02991	0.537
LIG_LIR_Gen_1	100	105	PF02991	0.375
LIG_LIR_Nem_3	100	104	PF02991	0.368
LIG_LIR_Nem_3	150	156	PF02991	0.542
LIG_LIR_Nem_3	49	54	PF02991	0.413
LIG_LIR_Nem_3	87	91	PF02991	0.422
LIG_LYPXL_yS_3	153	156	PF13949	0.467
LIG_SH2_CRK	59	63	PF00017	0.487
LIG_SH2_CRK	88	92	PF00017	0.444
LIG_SH2_NCK_1	162	166	PF00017	0.595
LIG_SH2_NCK_1	59	63	PF00017	0.487
LIG_SH2_STAP1	162	166	PF00017	0.581
LIG_SH2_STAT5	88	91	PF00017	0.412
LIG_SH3_3	34	40	PF00018	0.587
LIG_SH3_3	99	105	PF00018	0.493
LIG_SUMO_SIM_par_1	25	30	PF11976	0.463
LIG_TRAF2_2	40	45	PF00917	0.623
LIG_TRFH_1	101	105	PF08558	0.452
LIG_TYR_ITIM	86	91	PF00017	0.397
MOD_CK1_1	117	123	PF00069	0.755
MOD_CK1_1	60	66	PF00069	0.509
MOD_CK2_1	189	195	PF00069	0.666
MOD_Cter_Amidation	125	128	PF01082	0.699
MOD_GSK3_1	113	120	PF00069	0.438
MOD_GSK3_1	152	159	PF00069	0.446
MOD_GSK3_1	23	30	PF00069	0.371
MOD_GSK3_1	93	100	PF00069	0.378
MOD_N-GLC_1	135	140	PF02516	0.633
MOD_NEK2_1	27	32	PF00069	0.346
MOD_NEK2_1	93	98	PF00069	0.409
MOD_NEK2_2	46	51	PF00069	0.560
MOD_PIKK_1	27	33	PF00454	0.440
MOD_Plk_2-3	189	195	PF00069	0.672
MOD_Plk_4	23	29	PF00069	0.358
MOD_Plk_4	33	39	PF00069	0.441
MOD_Plk_4	46	52	PF00069	0.512
MOD_Plk_4	97	103	PF00069	0.448
MOD_ProDKin_1	115	121	PF00069	0.730
MOD_ProDKin_1	57	63	PF00069	0.500
MOD_ProDKin_1	78	84	PF00069	0.426
TRG_ENDOCYTIC_2	153	156	PF00928	0.467
TRG_ENDOCYTIC_2	59	62	PF00928	0.491
TRG_ENDOCYTIC_2	88	91	PF00928	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E4	Leptomonas seymouri	63%	98%
A0A0S4JAK6	Bodo saltans	35%	100%
A0A1X0NPD6	Trypanosomatidae	34%	100%
A0A3S7WPW4	Leishmania donovani	93%	100%
A0A422N682	Trypanosoma rangeli	39%	93%
A4H511	Leishmania braziliensis	78%	100%
A4HT85	Leishmania infantum	93%	100%
C9ZUN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QIN1	Leishmania major	91%	100%
V5B8I1	Trypanosoma cruzi	38%	71%