Electron transfer flavoprotein-ubiquinone oxidoreductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

electron transfer flavoprotein-ubiquinone oxidoreductase, putative

Species:

Leishmania mexicana

UniProt:

E9AL72_LEIMU

TriTrypDb:

LmxM.07.0600

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AL72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL72

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0022900	electron transport chain	4	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	4	12
GO:0005488	binding	1	12
GO:0009055	electron transfer activity	3	12
GO:0016491	oxidoreductase activity	2	12
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	12
GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051539	4 iron, 4 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.504
CLV_C14_Caspase3-7	52	56	PF00656	0.410
CLV_MEL_PAP_1	219	225	PF00089	0.488
CLV_NRD_NRD_1	188	190	PF00675	0.464
CLV_PCSK_KEX2_1	221	223	PF00082	0.512
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.448
CLV_PCSK_SKI1_1	117	121	PF00082	0.407
CLV_PCSK_SKI1_1	322	326	PF00082	0.376
CLV_PCSK_SKI1_1	425	429	PF00082	0.416
CLV_PCSK_SKI1_1	460	464	PF00082	0.429
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DEG_SCF_FBW7_1	101	106	PF00400	0.487
DOC_ANK_TNKS_1	328	335	PF00023	0.308
DOC_CDC14_PxL_1	336	344	PF14671	0.312
DOC_MAPK_gen_1	460	468	PF00069	0.488
DOC_MAPK_gen_1	503	513	PF00069	0.393
DOC_PP1_RVXF_1	339	345	PF00149	0.348
DOC_PP2B_LxvP_1	357	360	PF13499	0.320
DOC_USP7_MATH_1	103	107	PF00917	0.479
DOC_USP7_MATH_1	115	119	PF00917	0.504
DOC_USP7_MATH_1	16	20	PF00917	0.620
DOC_USP7_MATH_1	368	372	PF00917	0.311
DOC_USP7_UBL2_3	186	190	PF12436	0.323
DOC_USP7_UBL2_3	217	221	PF12436	0.357
DOC_WW_Pin1_4	450	455	PF00397	0.500
DOC_WW_Pin1_4	99	104	PF00397	0.503
LIG_14-3-3_CanoR_1	189	196	PF00244	0.572
LIG_14-3-3_CanoR_1	3	9	PF00244	0.554
LIG_14-3-3_CanoR_1	405	409	PF00244	0.368
LIG_14-3-3_CanoR_1	420	424	PF00244	0.408
LIG_APCC_ABBAyCdc20_2	203	209	PF00400	0.310
LIG_BRCT_BRCA1_1	105	109	PF00533	0.365
LIG_CSL_BTD_1	122	125	PF09270	0.548
LIG_eIF4E_1	326	332	PF01652	0.308
LIG_FHA_1	169	175	PF00498	0.492
LIG_FHA_1	214	220	PF00498	0.333
LIG_FHA_1	231	237	PF00498	0.324
LIG_FHA_1	308	314	PF00498	0.348
LIG_FHA_1	435	441	PF00498	0.422
LIG_FHA_1	476	482	PF00498	0.275
LIG_FHA_1	553	559	PF00498	0.318
LIG_FHA_2	328	334	PF00498	0.341
LIG_FHA_2	450	456	PF00498	0.530
LIG_FHA_2	559	565	PF00498	0.335
LIG_IBAR_NPY_1	296	298	PF08397	0.334
LIG_Integrin_isoDGR_2	187	189	PF01839	0.398
LIG_LIR_Apic_2	240	245	PF02991	0.345
LIG_LIR_Apic_2	293	297	PF02991	0.297
LIG_LIR_Apic_2	467	473	PF02991	0.400
LIG_LIR_Apic_2	515	519	PF02991	0.247
LIG_LIR_Gen_1	106	115	PF02991	0.512
LIG_LIR_Gen_1	26	33	PF02991	0.328
LIG_LIR_Gen_1	333	344	PF02991	0.346
LIG_LIR_Gen_1	407	416	PF02991	0.256
LIG_LIR_Nem_3	106	112	PF02991	0.398
LIG_LIR_Nem_3	155	160	PF02991	0.336
LIG_LIR_Nem_3	26	31	PF02991	0.335
LIG_LIR_Nem_3	333	339	PF02991	0.329
LIG_LIR_Nem_3	399	403	PF02991	0.387
LIG_LIR_Nem_3	407	413	PF02991	0.371
LIG_LIR_Nem_3	426	432	PF02991	0.505
LIG_LIR_Nem_3	476	482	PF02991	0.296
LIG_LYPXL_S_1	156	160	PF13949	0.370
LIG_Pex14_1	4	8	PF04695	0.642
LIG_Pex14_1	429	433	PF04695	0.472
LIG_Pex14_2	404	408	PF04695	0.325
LIG_Pex14_2	423	427	PF04695	0.349
LIG_PTB_Apo_2	408	415	PF02174	0.202
LIG_PTB_Phospho_1	408	414	PF10480	0.198
LIG_SH2_CRK	294	298	PF00017	0.297
LIG_SH2_CRK	433	437	PF00017	0.368
LIG_SH2_GRB2like	294	297	PF00017	0.309
LIG_SH2_NCK_1	294	298	PF00017	0.333
LIG_SH2_NCK_1	380	384	PF00017	0.358
LIG_SH2_SRC	194	197	PF00017	0.383
LIG_SH2_SRC	380	383	PF00017	0.378
LIG_SH2_STAP1	380	384	PF00017	0.358
LIG_SH2_STAP1	400	404	PF00017	0.169
LIG_SH2_STAT3	571	574	PF00017	0.498
LIG_SH2_STAT5	134	137	PF00017	0.367
LIG_SH2_STAT5	288	291	PF00017	0.363
LIG_SH2_STAT5	298	301	PF00017	0.303
LIG_SH2_STAT5	403	406	PF00017	0.277
LIG_SH2_STAT5	414	417	PF00017	0.491
LIG_SH2_STAT5	433	436	PF00017	0.203
LIG_SH2_STAT5	8	11	PF00017	0.672
LIG_SH3_3	116	122	PF00018	0.457
LIG_SH3_3	255	261	PF00018	0.471
MOD_CK1_1	38	44	PF00069	0.418
MOD_CK2_1	327	333	PF00069	0.323
MOD_CK2_1	390	396	PF00069	0.487
MOD_CK2_1	558	564	PF00069	0.335
MOD_Cter_Amidation	187	190	PF01082	0.474
MOD_GlcNHglycan	11	14	PF01048	0.632
MOD_GlcNHglycan	336	339	PF01048	0.434
MOD_GlcNHglycan	37	40	PF01048	0.314
MOD_GlcNHglycan	370	373	PF01048	0.309
MOD_GlcNHglycan	392	395	PF01048	0.474
MOD_GlcNHglycan	487	490	PF01048	0.291
MOD_GlcNHglycan	492	495	PF01048	0.291
MOD_GlcNHglycan	73	76	PF01048	0.275
MOD_GSK3_1	168	175	PF00069	0.523
MOD_GSK3_1	250	257	PF00069	0.394
MOD_GSK3_1	267	274	PF00069	0.274
MOD_GSK3_1	364	371	PF00069	0.329
MOD_GSK3_1	419	426	PF00069	0.399
MOD_GSK3_1	431	438	PF00069	0.292
MOD_GSK3_1	445	452	PF00069	0.472
MOD_GSK3_1	483	490	PF00069	0.301
MOD_GSK3_1	93	100	PF00069	0.438
MOD_LATS_1	485	491	PF00433	0.310
MOD_N-GLC_1	455	460	PF02516	0.473
MOD_N-GLC_1	483	488	PF02516	0.292
MOD_N-GLC_1	558	563	PF02516	0.351
MOD_NEK2_1	2	7	PF00069	0.539
MOD_NEK2_1	292	297	PF00069	0.319
MOD_NEK2_1	404	409	PF00069	0.318
MOD_NEK2_1	423	428	PF00069	0.444
MOD_NEK2_1	431	436	PF00069	0.379
MOD_NEK2_1	449	454	PF00069	0.542
MOD_NEK2_1	502	507	PF00069	0.458
MOD_NEK2_1	9	14	PF00069	0.541
MOD_NEK2_1	97	102	PF00069	0.252
MOD_NEK2_2	115	120	PF00069	0.507
MOD_NEK2_2	202	207	PF00069	0.308
MOD_PIKK_1	552	558	PF00454	0.310
MOD_PKA_2	188	194	PF00069	0.527
MOD_PKA_2	2	8	PF00069	0.540
MOD_PKA_2	211	217	PF00069	0.321
MOD_PKA_2	404	410	PF00069	0.353
MOD_PKA_2	419	425	PF00069	0.400
MOD_PKA_2	53	59	PF00069	0.395
MOD_Plk_1	267	273	PF00069	0.386
MOD_Plk_1	455	461	PF00069	0.473
MOD_Plk_1	473	479	PF00069	0.241
MOD_Plk_1	558	564	PF00069	0.367
MOD_Plk_2-3	396	402	PF00069	0.351
MOD_Plk_2-3	475	481	PF00069	0.154
MOD_Plk_4	202	208	PF00069	0.308
MOD_Plk_4	250	256	PF00069	0.417
MOD_Plk_4	271	277	PF00069	0.237
MOD_Plk_4	404	410	PF00069	0.318
MOD_Plk_4	435	441	PF00069	0.396
MOD_Plk_4	93	99	PF00069	0.502
MOD_ProDKin_1	450	456	PF00069	0.494
MOD_ProDKin_1	99	105	PF00069	0.506
MOD_SUMO_rev_2	390	399	PF00179	0.440
TRG_ENDOCYTIC_2	157	160	PF00928	0.355
TRG_ENDOCYTIC_2	302	305	PF00928	0.305
TRG_ENDOCYTIC_2	410	413	PF00928	0.420
TRG_ENDOCYTIC_2	433	436	PF00928	0.347
TRG_ENDOCYTIC_2	529	532	PF00928	0.291
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU17	Leptomonas seymouri	79%	98%
A0A0S4J6T4	Bodo saltans	67%	100%
A0A1X0NPE8	Trypanosomatidae	71%	100%
A0A3S5H5Y7	Leishmania donovani	97%	100%
A0A422N647	Trypanosoma rangeli	72%	100%
A4H510	Leishmania braziliensis	92%	100%
A4HT84	Leishmania infantum	97%	100%
C9ZUP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
O22854	Arabidopsis thaliana	50%	91%
P09820	Rhizobium meliloti (strain 1021)	24%	100%
P26484	Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571)	25%	100%
P53572	Azotobacter vinelandii	23%	100%
P55931	Sus scrofa	53%	93%
P87111	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	91%
P94132	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	46%	100%
Q08822	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	91%
Q11190	Caenorhabditis elegans	52%	96%
Q16134	Homo sapiens	54%	93%
Q2KIG0	Bos taurus	53%	93%
Q337B8	Oryza sativa subsp. japonica	50%	100%
Q4QIN2	Leishmania major	97%	100%
Q54XM6	Dictyostelium discoideum	51%	95%
Q5RDD3	Pongo abelii	53%	93%
Q6UPE1	Rattus norvegicus	54%	93%
Q921G7	Mus musculus	53%	93%
Q9HZP5	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	50%	100%
V5BTC8	Trypanosoma cruzi	71%	100%