Protein kintoun

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kintoun

Gene product:

Nucleolar protein 54, putative

Species:

Leishmania mexicana

UniProt:

E9AL69_LEIMU

TriTrypDb:

LmxM.07.0570

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AL69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.703
CLV_NRD_NRD_1	104	106	PF00675	0.684
CLV_NRD_NRD_1	23	25	PF00675	0.377
CLV_NRD_NRD_1	31	33	PF00675	0.555
CLV_NRD_NRD_1	313	315	PF00675	0.685
CLV_NRD_NRD_1	39	41	PF00675	0.474
CLV_NRD_NRD_1	415	417	PF00675	0.472
CLV_NRD_NRD_1	418	420	PF00675	0.462
CLV_NRD_NRD_1	6	8	PF00675	0.537
CLV_NRD_NRD_1	61	63	PF00675	0.657
CLV_NRD_NRD_1	96	98	PF00675	0.742
CLV_PCSK_FUR_1	37	41	PF00082	0.639
CLV_PCSK_KEX2_1	315	317	PF00082	0.664
CLV_PCSK_KEX2_1	39	41	PF00082	0.531
CLV_PCSK_KEX2_1	436	438	PF00082	0.545
CLV_PCSK_KEX2_1	63	65	PF00082	0.564
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.664
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.463
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.531
CLV_PCSK_PC7_1	35	41	PF00082	0.601
CLV_PCSK_SKI1_1	148	152	PF00082	0.397
CLV_PCSK_SKI1_1	187	191	PF00082	0.429
CLV_PCSK_SKI1_1	259	263	PF00082	0.483
CLV_PCSK_SKI1_1	300	304	PF00082	0.728
CLV_PCSK_SKI1_1	338	342	PF00082	0.620
CLV_PCSK_SKI1_1	363	367	PF00082	0.522
CLV_PCSK_SKI1_1	397	401	PF00082	0.530
CLV_PCSK_SKI1_1	437	441	PF00082	0.487
DEG_COP1_1	130	140	PF00400	0.566
DEG_SPOP_SBC_1	129	133	PF00917	0.662
DEG_SPOP_SBC_1	56	60	PF00917	0.450
DOC_CKS1_1	264	269	PF01111	0.370
DOC_CYCLIN_RxL_1	237	249	PF00134	0.472
DOC_CYCLIN_RxL_1	434	444	PF00134	0.530
DOC_MAPK_gen_1	147	155	PF00069	0.348
DOC_MAPK_gen_1	184	190	PF00069	0.356
DOC_MAPK_gen_1	237	246	PF00069	0.444
DOC_MAPK_gen_1	255	264	PF00069	0.439
DOC_MAPK_gen_1	62	69	PF00069	0.575
DOC_MAPK_MEF2A_6	148	157	PF00069	0.338
DOC_MAPK_RevD_3	262	278	PF00069	0.364
DOC_PP1_RVXF_1	240	247	PF00149	0.453
DOC_PP1_RVXF_1	459	466	PF00149	0.547
DOC_PP2B_LxvP_1	188	191	PF13499	0.366
DOC_SPAK_OSR1_1	245	249	PF12202	0.507
DOC_USP7_MATH_1	112	116	PF00917	0.703
DOC_USP7_MATH_1	119	123	PF00917	0.661
DOC_USP7_MATH_1	127	131	PF00917	0.560
DOC_USP7_MATH_1	287	291	PF00917	0.753
DOC_USP7_MATH_1	355	359	PF00917	0.644
DOC_USP7_MATH_1	441	445	PF00917	0.483
DOC_USP7_MATH_1	56	60	PF00917	0.671
DOC_USP7_MATH_1	85	89	PF00917	0.689
DOC_USP7_UBL2_3	233	237	PF12436	0.484
DOC_USP7_UBL2_3	303	307	PF12436	0.688
DOC_USP7_UBL2_3	359	363	PF12436	0.697
DOC_USP7_UBL2_3	420	424	PF12436	0.461
DOC_WW_Pin1_4	107	112	PF00397	0.614
DOC_WW_Pin1_4	263	268	PF00397	0.584
DOC_WW_Pin1_4	307	312	PF00397	0.771
DOC_WW_Pin1_4	325	330	PF00397	0.517
DOC_WW_Pin1_4	347	352	PF00397	0.548
DOC_WW_Pin1_4	91	96	PF00397	0.602
LIG_14-3-3_CanoR_1	245	254	PF00244	0.446
LIG_14-3-3_CanoR_1	442	446	PF00244	0.688
LIG_FHA_1	410	416	PF00498	0.521
LIG_FHA_2	286	292	PF00498	0.708
LIG_Integrin_RGD_1	284	286	PF01839	0.577
LIG_LIR_Gen_1	427	432	PF02991	0.454
LIG_LIR_Nem_3	183	189	PF02991	0.436
LIG_LIR_Nem_3	427	431	PF02991	0.458
LIG_SH2_CRK	186	190	PF00017	0.415
LIG_SH2_STAP1	182	186	PF00017	0.262
LIG_SH2_STAT5	182	185	PF00017	0.353
LIG_SH3_3	261	267	PF00018	0.545
LIG_SH3_4	359	366	PF00018	0.614
LIG_Sin3_3	269	276	PF02671	0.352
LIG_TRAF2_1	405	408	PF00917	0.544
LIG_TRAF2_2	161	166	PF00917	0.473
LIG_UBA3_1	234	242	PF00899	0.412
MOD_CDC14_SPxK_1	110	113	PF00782	0.457
MOD_CDC14_SPxK_1	94	97	PF00782	0.592
MOD_CDK_SPK_2	307	312	PF00069	0.765
MOD_CDK_SPK_2	347	352	PF00069	0.548
MOD_CDK_SPxK_1	107	113	PF00069	0.468
MOD_CDK_SPxK_1	91	97	PF00069	0.600
MOD_CDK_SPxxK_3	107	114	PF00069	0.480
MOD_CDK_SPxxK_3	307	314	PF00069	0.659
MOD_CDK_SPxxK_3	91	98	PF00069	0.601
MOD_CK1_1	122	128	PF00069	0.595
MOD_CK1_1	130	136	PF00069	0.599
MOD_CK1_1	310	316	PF00069	0.656
MOD_CK1_1	325	331	PF00069	0.516
MOD_CK1_1	87	93	PF00069	0.680
MOD_CK2_1	287	293	PF00069	0.707
MOD_CK2_1	347	353	PF00069	0.797
MOD_CK2_1	388	394	PF00069	0.489
MOD_CK2_1	402	408	PF00069	0.453
MOD_Cter_Amidation	336	339	PF01082	0.501
MOD_GlcNHglycan	114	117	PF01048	0.684
MOD_GlcNHglycan	124	127	PF01048	0.601
MOD_GlcNHglycan	335	338	PF01048	0.821
MOD_GlcNHglycan	87	90	PF01048	0.638
MOD_GSK3_1	125	132	PF00069	0.584
MOD_GSK3_1	176	183	PF00069	0.326
MOD_GSK3_1	310	317	PF00069	0.723
MOD_GSK3_1	325	332	PF00069	0.726
MOD_GSK3_1	52	59	PF00069	0.633
MOD_GSK3_1	87	94	PF00069	0.717
MOD_N-GLC_1	122	127	PF02516	0.665
MOD_N-GLC_1	347	352	PF02516	0.548
MOD_NEK2_2	57	62	PF00069	0.590
MOD_PIKK_1	246	252	PF00454	0.559
MOD_PKA_1	314	320	PF00069	0.727
MOD_PKA_2	246	252	PF00069	0.497
MOD_PKA_2	441	447	PF00069	0.679
MOD_PKA_2	450	456	PF00069	0.715
MOD_PKA_2	96	102	PF00069	0.646
MOD_Plk_4	132	138	PF00069	0.587
MOD_ProDKin_1	107	113	PF00069	0.615
MOD_ProDKin_1	263	269	PF00069	0.579
MOD_ProDKin_1	307	313	PF00069	0.770
MOD_ProDKin_1	325	331	PF00069	0.518
MOD_ProDKin_1	347	353	PF00069	0.548
MOD_ProDKin_1	91	97	PF00069	0.602
MOD_SUMO_rev_2	251	256	PF00179	0.393
MOD_SUMO_rev_2	319	328	PF00179	0.798
MOD_SUMO_rev_2	90	99	PF00179	0.544
TRG_ENDOCYTIC_2	186	189	PF00928	0.385
TRG_ER_diArg_1	256	259	PF00400	0.493
TRG_ER_diArg_1	61	64	PF00400	0.649
TRG_ER_diArg_1	76	79	PF00400	0.429
TRG_NLS_Bipartite_1	7	22	PF00514	0.524
TRG_NLS_MonoExtC_3	313	318	PF00514	0.762
TRG_NLS_MonoExtC_3	362	367	PF00514	0.685
TRG_NLS_MonoExtN_4	311	318	PF00514	0.722
TRG_NLS_MonoExtN_4	360	367	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB51	Leptomonas seymouri	61%	100%
A0A0S4IW25	Bodo saltans	30%	100%
A0A3R7ME95	Trypanosoma rangeli	40%	100%
A0A3S7WPV8	Leishmania donovani	88%	100%
A4H507	Leishmania braziliensis	72%	99%
A4HT71	Leishmania infantum	90%	100%
C9ZUP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	83%
Q4QIN5	Leishmania major	89%	99%
V5BY30	Trypanosoma cruzi	41%	98%