Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL66_LEIMU

TriTrypDb:

LmxM.07.0540

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.808
CLV_C14_Caspase3-7	76	80	PF00656	0.663
CLV_NRD_NRD_1	108	110	PF00675	0.737
CLV_NRD_NRD_1	130	132	PF00675	0.680
CLV_NRD_NRD_1	21	23	PF00675	0.738
CLV_NRD_NRD_1	226	228	PF00675	0.575
CLV_NRD_NRD_1	573	575	PF00675	0.506
CLV_NRD_NRD_1	617	619	PF00675	0.562
CLV_NRD_NRD_1	667	669	PF00675	0.507
CLV_PCSK_KEX2_1	108	110	PF00082	0.737
CLV_PCSK_KEX2_1	130	132	PF00082	0.710
CLV_PCSK_KEX2_1	21	23	PF00082	0.738
CLV_PCSK_KEX2_1	226	228	PF00082	0.575
CLV_PCSK_KEX2_1	548	550	PF00082	0.595
CLV_PCSK_KEX2_1	573	575	PF00082	0.505
CLV_PCSK_KEX2_1	617	619	PF00082	0.711
CLV_PCSK_KEX2_1	667	669	PF00082	0.507
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.578
CLV_PCSK_PC7_1	126	132	PF00082	0.686
CLV_PCSK_SKI1_1	536	540	PF00082	0.754
CLV_PCSK_SKI1_1	549	553	PF00082	0.549
CLV_PCSK_SKI1_1	667	671	PF00082	0.630
CLV_PCSK_SKI1_1	736	740	PF00082	0.667
DEG_Kelch_Keap1_1	506	511	PF01344	0.821
DEG_SPOP_SBC_1	141	145	PF00917	0.816
DEG_SPOP_SBC_1	24	28	PF00917	0.537
DEG_SPOP_SBC_1	502	506	PF00917	0.701
DOC_CKS1_1	1	6	PF01111	0.664
DOC_CKS1_1	601	606	PF01111	0.645
DOC_MAPK_DCC_7	154	164	PF00069	0.786
DOC_MAPK_gen_1	548	557	PF00069	0.546
DOC_MAPK_gen_1	559	566	PF00069	0.528
DOC_MAPK_gen_1	573	579	PF00069	0.423
DOC_PP2B_LxvP_1	102	105	PF13499	0.624
DOC_PP4_FxxP_1	446	449	PF00568	0.806
DOC_USP7_MATH_1	17	21	PF00917	0.738
DOC_USP7_MATH_1	24	28	PF00917	0.795
DOC_USP7_MATH_1	272	276	PF00917	0.713
DOC_USP7_MATH_1	342	346	PF00917	0.756
DOC_USP7_MATH_1	348	352	PF00917	0.816
DOC_USP7_MATH_1	354	358	PF00917	0.717
DOC_USP7_MATH_1	374	378	PF00917	0.501
DOC_USP7_MATH_1	417	421	PF00917	0.666
DOC_USP7_MATH_1	426	430	PF00917	0.627
DOC_USP7_MATH_1	457	461	PF00917	0.746
DOC_USP7_MATH_1	46	50	PF00917	0.816
DOC_USP7_MATH_1	616	620	PF00917	0.681
DOC_USP7_MATH_1	77	81	PF00917	0.779
DOC_USP7_MATH_1	85	89	PF00917	0.715
DOC_USP7_MATH_1	90	94	PF00917	0.659
DOC_USP7_MATH_2	161	167	PF00917	0.777
DOC_USP7_UBL2_3	548	552	PF12436	0.567
DOC_WW_Pin1_4	135	140	PF00397	0.804
DOC_WW_Pin1_4	143	148	PF00397	0.662
DOC_WW_Pin1_4	260	265	PF00397	0.776
DOC_WW_Pin1_4	344	349	PF00397	0.731
DOC_WW_Pin1_4	365	370	PF00397	0.808
DOC_WW_Pin1_4	397	402	PF00397	0.737
DOC_WW_Pin1_4	54	59	PF00397	0.734
DOC_WW_Pin1_4	600	605	PF00397	0.628
DOC_WW_Pin1_4	677	682	PF00397	0.478
DOC_WW_Pin1_4	97	102	PF00397	0.815
LIG_14-3-3_CanoR_1	10	15	PF00244	0.823
LIG_14-3-3_CanoR_1	22	31	PF00244	0.710
LIG_14-3-3_CanoR_1	285	294	PF00244	0.552
LIG_14-3-3_CanoR_1	410	419	PF00244	0.592
LIG_14-3-3_CanoR_1	444	449	PF00244	0.650
LIG_14-3-3_CanoR_1	734	739	PF00244	0.530
LIG_14-3-3_CterR_2	736	740	PF00244	0.570
LIG_BRCT_BRCA1_1	428	432	PF00533	0.688
LIG_Clathr_ClatBox_1	644	648	PF01394	0.565
LIG_FHA_1	143	149	PF00498	0.531
LIG_FHA_1	306	312	PF00498	0.788
LIG_FHA_1	313	319	PF00498	0.711
LIG_FHA_1	387	393	PF00498	0.667
LIG_FHA_1	561	567	PF00498	0.527
LIG_FHA_2	109	115	PF00498	0.550
LIG_FHA_2	325	331	PF00498	0.824
LIG_FHA_2	601	607	PF00498	0.593
LIG_LIR_Apic_2	122	128	PF02991	0.823
LIG_LIR_Apic_2	293	297	PF02991	0.797
LIG_LIR_Apic_2	600	604	PF02991	0.613
LIG_LIR_Gen_1	110	119	PF02991	0.726
LIG_LIR_Gen_1	402	412	PF02991	0.551
LIG_LIR_Gen_1	660	669	PF02991	0.318
LIG_LIR_Nem_3	110	116	PF02991	0.729
LIG_LIR_Nem_3	217	222	PF02991	0.548
LIG_LIR_Nem_3	402	408	PF02991	0.821
LIG_LIR_Nem_3	660	665	PF02991	0.321
LIG_MYND_1	132	136	PF01753	0.715
LIG_PDZ_Class_2	735	740	PF00595	0.552
LIG_PTB_Apo_2	80	87	PF02174	0.670
LIG_PTB_Phospho_1	80	86	PF10480	0.671
LIG_SH2_CRK	219	223	PF00017	0.544
LIG_SH2_CRK	294	298	PF00017	0.829
LIG_SH2_CRK	662	666	PF00017	0.294
LIG_SH2_GRB2like	81	84	PF00017	0.793
LIG_SH2_PTP2	215	218	PF00017	0.534
LIG_SH2_SRC	113	116	PF00017	0.730
LIG_SH2_SRC	501	504	PF00017	0.698
LIG_SH2_SRC	81	84	PF00017	0.793
LIG_SH2_STAP1	188	192	PF00017	0.620
LIG_SH2_STAP1	638	642	PF00017	0.618
LIG_SH2_STAT5	183	186	PF00017	0.577
LIG_SH2_STAT5	215	218	PF00017	0.534
LIG_SH2_STAT5	501	504	PF00017	0.698
LIG_SH2_STAT5	589	592	PF00017	0.509
LIG_SH2_STAT5	651	654	PF00017	0.474
LIG_SH2_STAT5	81	84	PF00017	0.793
LIG_SH3_1	130	136	PF00018	0.678
LIG_SH3_1	366	372	PF00018	0.809
LIG_SH3_2	251	256	PF14604	0.727
LIG_SH3_3	130	136	PF00018	0.718
LIG_SH3_3	235	241	PF00018	0.674
LIG_SH3_3	248	254	PF00018	0.637
LIG_SH3_3	366	372	PF00018	0.809
LIG_SH3_3	398	404	PF00018	0.715
LIG_SH3_3	450	456	PF00018	0.676
LIG_SH3_3	544	550	PF00018	0.561
LIG_SH3_3	57	63	PF00018	0.681
LIG_SH3_3	591	597	PF00018	0.518
LIG_SUMO_SIM_anti_2	160	166	PF11976	0.505
LIG_SUMO_SIM_par_1	143	151	PF11976	0.531
LIG_SUMO_SIM_par_1	160	166	PF11976	0.463
LIG_SUMO_SIM_par_1	708	714	PF11976	0.551
LIG_TRAF2_1	112	115	PF00917	0.731
LIG_TRAF2_1	359	362	PF00917	0.812
LIG_TRAF2_1	632	635	PF00917	0.591
LIG_TYR_ITSM	109	116	PF00017	0.550
MOD_CDK_SPK_2	260	265	PF00069	0.572
MOD_CK1_1	121	127	PF00069	0.822
MOD_CK1_1	143	149	PF00069	0.677
MOD_CK1_1	25	31	PF00069	0.785
MOD_CK1_1	284	290	PF00069	0.831
MOD_CK1_1	341	347	PF00069	0.718
MOD_CK1_1	352	358	PF00069	0.693
MOD_CK1_1	411	417	PF00069	0.718
MOD_CK1_1	487	493	PF00069	0.802
MOD_CK1_1	504	510	PF00069	0.583
MOD_CK1_1	540	546	PF00069	0.675
MOD_CK1_1	560	566	PF00069	0.302
MOD_CK1_1	675	681	PF00069	0.751
MOD_CK1_1	93	99	PF00069	0.808
MOD_CK2_1	108	114	PF00069	0.702
MOD_CK2_1	33	39	PF00069	0.811
MOD_CK2_1	505	511	PF00069	0.820
MOD_CK2_1	56	62	PF00069	0.814
MOD_CK2_1	600	606	PF00069	0.537
MOD_CK2_1	629	635	PF00069	0.596
MOD_GlcNHglycan	12	15	PF01048	0.839
MOD_GlcNHglycan	150	153	PF01048	0.764
MOD_GlcNHglycan	202	205	PF01048	0.634
MOD_GlcNHglycan	274	277	PF01048	0.668
MOD_GlcNHglycan	303	306	PF01048	0.807
MOD_GlcNHglycan	332	335	PF01048	0.729
MOD_GlcNHglycan	340	343	PF01048	0.689
MOD_GlcNHglycan	35	39	PF01048	0.809
MOD_GlcNHglycan	354	357	PF01048	0.710
MOD_GlcNHglycan	376	379	PF01048	0.705
MOD_GlcNHglycan	394	397	PF01048	0.660
MOD_GlcNHglycan	446	449	PF01048	0.741
MOD_GlcNHglycan	508	511	PF01048	0.737
MOD_GlcNHglycan	543	546	PF01048	0.572
MOD_GlcNHglycan	75	78	PF01048	0.740
MOD_GlcNHglycan	83	86	PF01048	0.730
MOD_GlcNHglycan	95	98	PF01048	0.644
MOD_GSK3_1	142	149	PF00069	0.721
MOD_GSK3_1	280	287	PF00069	0.774
MOD_GSK3_1	301	308	PF00069	0.802
MOD_GSK3_1	338	345	PF00069	0.740
MOD_GSK3_1	34	41	PF00069	0.827
MOD_GSK3_1	348	355	PF00069	0.658
MOD_GSK3_1	388	395	PF00069	0.673
MOD_GSK3_1	465	472	PF00069	0.692
MOD_GSK3_1	47	54	PF00069	0.682
MOD_GSK3_1	501	508	PF00069	0.733
MOD_GSK3_1	536	543	PF00069	0.712
MOD_GSK3_1	585	592	PF00069	0.613
MOD_GSK3_1	73	80	PF00069	0.792
MOD_GSK3_1	81	88	PF00069	0.705
MOD_GSK3_1	93	100	PF00069	0.485
MOD_N-GLC_1	465	470	PF02516	0.668
MOD_N-GLC_1	734	739	PF02516	0.530
MOD_N-GLC_2	674	676	PF02516	0.593
MOD_NEK2_1	218	223	PF00069	0.530
MOD_NEK2_1	231	236	PF00069	0.637
MOD_NEK2_1	281	286	PF00069	0.770
MOD_NEK2_1	301	306	PF00069	0.809
MOD_NEK2_1	408	413	PF00069	0.558
MOD_NEK2_1	438	443	PF00069	0.815
MOD_NEK2_1	465	470	PF00069	0.572
MOD_NEK2_1	537	542	PF00069	0.812
MOD_NEK2_1	557	562	PF00069	0.313
MOD_NEK2_1	95	100	PF00069	0.713
MOD_OFUCOSY	671	676	PF10250	0.573
MOD_PIKK_1	119	125	PF00454	0.726
MOD_PIKK_1	438	444	PF00454	0.816
MOD_PIKK_1	465	471	PF00454	0.649
MOD_PIKK_1	537	543	PF00454	0.805
MOD_PIKK_1	629	635	PF00454	0.596
MOD_PKA_1	108	114	PF00069	0.702
MOD_PKA_2	108	114	PF00069	0.745
MOD_PKA_2	270	276	PF00069	0.857
MOD_PKA_2	284	290	PF00069	0.556
MOD_PKA_2	338	344	PF00069	0.809
MOD_PKA_2	560	566	PF00069	0.537
MOD_PKA_2	616	622	PF00069	0.528
MOD_PKA_2	66	72	PF00069	0.659
MOD_PKA_2	77	83	PF00069	0.743
MOD_PKA_2	9	15	PF00069	0.806
MOD_PKB_1	256	264	PF00069	0.847
MOD_Plk_1	231	237	PF00069	0.637
MOD_Plk_1	484	490	PF00069	0.843
MOD_Plk_1	734	740	PF00069	0.547
MOD_Plk_4	232	238	PF00069	0.742
MOD_Plk_4	25	31	PF00069	0.718
MOD_Plk_4	388	394	PF00069	0.651
MOD_Plk_4	658	664	PF00069	0.464
MOD_Plk_4	711	717	PF00069	0.416
MOD_Plk_4	77	83	PF00069	0.761
MOD_Plk_4	90	96	PF00069	0.605
MOD_ProDKin_1	135	141	PF00069	0.805
MOD_ProDKin_1	143	149	PF00069	0.659
MOD_ProDKin_1	260	266	PF00069	0.774
MOD_ProDKin_1	344	350	PF00069	0.732
MOD_ProDKin_1	365	371	PF00069	0.808
MOD_ProDKin_1	397	403	PF00069	0.729
MOD_ProDKin_1	54	60	PF00069	0.725
MOD_ProDKin_1	600	606	PF00069	0.636
MOD_ProDKin_1	677	683	PF00069	0.479
MOD_ProDKin_1	97	103	PF00069	0.815
TRG_DiLeu_BaEn_2	231	237	PF01217	0.734
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.490
TRG_ENDOCYTIC_2	113	116	PF00928	0.730
TRG_ENDOCYTIC_2	215	218	PF00928	0.534
TRG_ENDOCYTIC_2	219	222	PF00928	0.546
TRG_ENDOCYTIC_2	405	408	PF00928	0.742
TRG_ENDOCYTIC_2	662	665	PF00928	0.301
TRG_ER_diArg_1	107	109	PF00400	0.568
TRG_ER_diArg_1	129	131	PF00400	0.693
TRG_ER_diArg_1	337	340	PF00400	0.538
TRG_ER_diArg_1	364	367	PF00400	0.828
TRG_ER_diArg_1	558	561	PF00400	0.624
TRG_ER_diArg_1	573	575	PF00400	0.412
TRG_ER_diArg_1	666	668	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F0	Leptomonas seymouri	44%	71%
A0A3S5H5Y4	Leishmania donovani	87%	67%
A4HT74	Leishmania infantum	87%	67%
Q4QIN8	Leishmania major	83%	100%