60S ribosomal protein L7a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L7a, putative

Species:

Leishmania mexicana

UniProt:

E9AL63_LEIMU

TriTrypDb:

LmxM.07.0510

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	14
GO:0022625	cytosolic large ribosomal subunit	5	14
GO:0032991	protein-containing complex	1	14
GO:0044391	ribosomal subunit	3	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AL63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL63

Function

Biological processes
Term	Name	Level	Count
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003723	RNA binding	4	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.459
CLV_NRD_NRD_1	137	139	PF00675	0.480
CLV_NRD_NRD_1	141	143	PF00675	0.487
CLV_NRD_NRD_1	227	229	PF00675	0.373
CLV_NRD_NRD_1	24	26	PF00675	0.478
CLV_NRD_NRD_1	266	268	PF00675	0.427
CLV_NRD_NRD_1	282	284	PF00675	0.454
CLV_NRD_NRD_1	6	8	PF00675	0.450
CLV_NRD_NRD_1	95	97	PF00675	0.451
CLV_PCSK_FUR_1	96	100	PF00082	0.457
CLV_PCSK_KEX2_1	103	105	PF00082	0.459
CLV_PCSK_KEX2_1	141	143	PF00082	0.550
CLV_PCSK_KEX2_1	266	268	PF00082	0.427
CLV_PCSK_KEX2_1	6	8	PF00082	0.450
CLV_PCSK_KEX2_1	98	100	PF00082	0.459
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.459
CLV_PCSK_PC7_1	99	105	PF00082	0.460
CLV_PCSK_SKI1_1	103	107	PF00082	0.449
CLV_PCSK_SKI1_1	128	132	PF00082	0.440
CLV_PCSK_SKI1_1	229	233	PF00082	0.324
CLV_PCSK_SKI1_1	39	43	PF00082	0.603
CLV_PCSK_SKI1_1	98	102	PF00082	0.460
DEG_APCC_DBOX_1	141	149	PF00400	0.639
DEG_APCC_KENBOX_2	152	156	PF00400	0.395
DOC_CKS1_1	54	59	PF01111	0.434
DOC_MAPK_gen_1	120	129	PF00069	0.422
DOC_MAPK_gen_1	181	189	PF00069	0.492
DOC_MAPK_gen_1	228	236	PF00069	0.573
DOC_MAPK_gen_1	25	33	PF00069	0.459
DOC_MAPK_gen_1	266	274	PF00069	0.436
DOC_MAPK_HePTP_8	264	276	PF00069	0.433
DOC_MAPK_MEF2A_6	26	35	PF00069	0.456
DOC_MAPK_MEF2A_6	267	276	PF00069	0.437
DOC_PP2B_LxvP_1	105	108	PF13499	0.442
DOC_PP2B_LxvP_1	200	203	PF13499	0.482
DOC_USP7_MATH_1	58	62	PF00917	0.628
DOC_USP7_UBL2_3	128	132	PF12436	0.420
DOC_USP7_UBL2_3	153	157	PF12436	0.564
DOC_USP7_UBL2_3	39	43	PF12436	0.582
DOC_WW_Pin1_4	49	54	PF00397	0.728
DOC_WW_Pin1_4	8	13	PF00397	0.465
LIG_14-3-3_CanoR_1	228	236	PF00244	0.573
LIG_14-3-3_CanoR_1	25	33	PF00244	0.478
LIG_BIR_II_1	1	5	PF00653	0.438
LIG_BIR_III_4	224	228	PF00653	0.507
LIG_CaM_IQ_9	169	185	PF13499	0.482
LIG_CSL_BTD_1	200	203	PF09270	0.482
LIG_CtBP_PxDLS_1	195	199	PF00389	0.482
LIG_EVH1_1	13	17	PF00568	0.471
LIG_FHA_1	113	119	PF00498	0.423
LIG_FHA_1	124	130	PF00498	0.416
LIG_FHA_1	174	180	PF00498	0.482
LIG_FHA_1	26	32	PF00498	0.483
LIG_FHA_1	43	49	PF00498	0.524
LIG_FHA_1	54	60	PF00498	0.430
LIG_LIR_Apic_2	52	57	PF02991	0.717
LIG_SH2_CRK	213	217	PF00017	0.482
LIG_SH2_CRK	54	58	PF00017	0.688
LIG_SH2_SRC	213	216	PF00017	0.482
LIG_SH2_STAP1	78	82	PF00017	0.469
LIG_SH3_1	6	12	PF00018	0.454
LIG_SH3_2	14	19	PF14604	0.485
LIG_SH3_3	6	12	PF00018	0.454
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.482
LIG_SUMO_SIM_par_1	164	170	PF11976	0.493
LIG_TYR_ITIM	211	216	PF00017	0.482
LIG_WRC_WIRS_1	1	6	PF05994	0.441
MOD_CDC14_SPxK_1	52	55	PF00782	0.719
MOD_CDK_SPxK_1	49	55	PF00069	0.728
MOD_CK1_1	275	281	PF00069	0.436
MOD_CK2_1	119	125	PF00069	0.430
MOD_CK2_1	275	281	PF00069	0.452
MOD_Cter_Amidation	226	229	PF01082	0.373
MOD_GSK3_1	119	126	PF00069	0.301
MOD_GSK3_1	21	28	PF00069	0.504
MOD_GSK3_1	49	56	PF00069	0.447
MOD_N-GLC_1	123	128	PF02516	0.295
MOD_N-GLC_2	204	206	PF02516	0.373
MOD_NEK2_1	250	255	PF00069	0.410
MOD_NEK2_1	272	277	PF00069	0.452
MOD_PIKK_1	25	31	PF00454	0.516
MOD_PIKK_1	42	48	PF00454	0.721
MOD_PKA_1	25	31	PF00069	0.691
MOD_PKA_1	42	48	PF00069	0.647
MOD_PKA_2	119	125	PF00069	0.430
MOD_PKA_2	18	24	PF00069	0.504
MOD_PKA_2	227	233	PF00069	0.573
MOD_Plk_1	123	129	PF00069	0.293
MOD_Plk_1	243	249	PF00069	0.528
MOD_Plk_1	80	86	PF00069	0.461
MOD_Plk_4	87	93	PF00069	0.437
MOD_ProDKin_1	49	55	PF00069	0.728
MOD_ProDKin_1	8	14	PF00069	0.468
MOD_SUMO_rev_2	174	184	PF00179	0.482
TRG_DiLeu_BaEn_1	125	130	PF01217	0.414
TRG_ENDOCYTIC_2	213	216	PF00928	0.482
TRG_ER_diArg_1	103	105	PF00400	0.459
TRG_ER_diArg_1	265	267	PF00400	0.411
TRG_ER_diArg_1	276	279	PF00400	0.444
TRG_ER_diArg_1	5	7	PF00400	0.447
TRG_NLS_Bipartite_1	266	287	PF00514	0.451
TRG_NLS_MonoCore_2	95	100	PF00514	0.455
TRG_NLS_MonoExtC_3	137	142	PF00514	0.512
TRG_NLS_MonoExtN_4	135	142	PF00514	0.502
TRG_NLS_MonoExtN_4	96	101	PF00514	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HQX1	Leptomonas seymouri	95%	100%
A0A0S4IQB8	Bodo saltans	78%	100%
A0A1D8PF11	Candida albicans (strain SC5314 / ATCC MYA-2876)	45%	100%
A0A1X0NEX8	Trypanosomatidae	88%	100%
A0A1X0NPC4	Trypanosomatidae	88%	100%
A0A3S7WPW6	Leishmania donovani	97%	100%
A4H500	Leishmania braziliensis	92%	100%
A4HT77	Leishmania infantum	96%	90%
A4HT78	Leishmania infantum	97%	86%
C9ZUQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AL62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O13672	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
O57592	Takifugu rubripes	46%	100%
O76732	Anopheles gambiae	44%	100%
P0DJ14	Tetrahymena thermophila	46%	100%
P0DKK7	Oryza sativa subsp. japonica	45%	100%
P12970	Mus musculus	48%	100%
P17076	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P29453	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P32429	Gallus gallus	48%	100%
P35685	Oryza sativa subsp. japonica	45%	100%
P46223	Drosophila melanogaster	48%	100%
P49692	Arabidopsis thaliana	44%	100%
P62424	Homo sapiens	48%	100%
P62425	Rattus norvegicus	48%	100%
Q2TBQ5	Bos taurus	48%	100%
Q4QIP1	Leishmania major	97%	100%
Q4R5C2	Macaca fascicularis	48%	100%
Q54ZD1	Dictyostelium discoideum	45%	100%
Q5ANA1	Candida albicans (strain SC5314 / ATCC MYA-2876)	47%	100%
Q90YW2	Ictalurus punctatus	47%	100%
Q966C6	Caenorhabditis elegans	42%	100%
Q9LZH9	Arabidopsis thaliana	42%	100%
V5DPU1	Trypanosoma cruzi	84%	97%