WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL61_LEIMU

TriTrypDb:

LmxM.07.0490

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AL61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.682
CLV_C14_Caspase3-7	179	183	PF00656	0.654
CLV_NRD_NRD_1	102	104	PF00675	0.403
CLV_NRD_NRD_1	147	149	PF00675	0.449
CLV_NRD_NRD_1	211	213	PF00675	0.412
CLV_NRD_NRD_1	299	301	PF00675	0.435
CLV_NRD_NRD_1	99	101	PF00675	0.385
CLV_PCSK_KEX2_1	147	149	PF00082	0.428
CLV_PCSK_KEX2_1	211	213	PF00082	0.404
CLV_PCSK_KEX2_1	224	226	PF00082	0.338
CLV_PCSK_KEX2_1	299	301	PF00082	0.412
CLV_PCSK_KEX2_1	98	100	PF00082	0.392
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.433
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.426
CLV_PCSK_PC7_1	94	100	PF00082	0.390
CLV_PCSK_SKI1_1	112	116	PF00082	0.502
CLV_PCSK_SKI1_1	299	303	PF00082	0.407
CLV_PCSK_SKI1_1	58	62	PF00082	0.585
CLV_PCSK_SKI1_1	87	91	PF00082	0.383
DEG_MDM2_SWIB_1	40	47	PF02201	0.316
DEG_SPOP_SBC_1	25	29	PF00917	0.438
DEG_SPOP_SBC_1	31	35	PF00917	0.469
DEG_SPOP_SBC_1	382	386	PF00917	0.685
DOC_MAPK_DCC_7	58	68	PF00069	0.424
DOC_MAPK_FxFP_2	205	208	PF00069	0.651
DOC_MAPK_gen_1	160	170	PF00069	0.566
DOC_MAPK_gen_1	311	319	PF00069	0.690
DOC_MAPK_MEF2A_6	154	161	PF00069	0.592
DOC_MAPK_RevD_3	84	99	PF00069	0.640
DOC_PP1_RVXF_1	56	62	PF00149	0.420
DOC_PP2B_LxvP_1	66	69	PF13499	0.440
DOC_PP4_FxxP_1	205	208	PF00568	0.561
DOC_USP7_MATH_1	229	233	PF00917	0.682
DOC_USP7_MATH_1	24	28	PF00917	0.549
DOC_USP7_MATH_1	250	254	PF00917	0.748
DOC_USP7_MATH_1	272	276	PF00917	0.716
DOC_USP7_MATH_1	31	35	PF00917	0.527
DOC_USP7_MATH_1	320	324	PF00917	0.714
DOC_USP7_MATH_1	334	338	PF00917	0.722
DOC_USP7_MATH_1	368	372	PF00917	0.784
DOC_USP7_UBL2_3	211	215	PF12436	0.645
DOC_WW_Pin1_4	246	251	PF00397	0.769
DOC_WW_Pin1_4	27	32	PF00397	0.425
DOC_WW_Pin1_4	274	279	PF00397	0.777
DOC_WW_Pin1_4	5	10	PF00397	0.549
LIG_14-3-3_CanoR_1	154	158	PF00244	0.578
LIG_14-3-3_CanoR_1	173	181	PF00244	0.530
LIG_14-3-3_CanoR_1	188	196	PF00244	0.479
LIG_14-3-3_CanoR_1	233	239	PF00244	0.714
LIG_14-3-3_CanoR_1	299	305	PF00244	0.694
LIG_14-3-3_CanoR_1	373	379	PF00244	0.727
LIG_14-3-3_CanoR_1	381	388	PF00244	0.645
LIG_14-3-3_CanoR_1	46	53	PF00244	0.418
LIG_BRCT_BRCA1_1	294	298	PF00533	0.712
LIG_BRCT_BRCA1_1	336	340	PF00533	0.728
LIG_BRCT_BRCA1_1	36	40	PF00533	0.428
LIG_CaM_NSCaTE_8	43	50	PF13499	0.428
LIG_CSL_BTD_1	66	69	PF09270	0.401
LIG_FHA_1	199	205	PF00498	0.581
LIG_FHA_1	377	383	PF00498	0.690
LIG_FHA_1	77	83	PF00498	0.350
LIG_FHA_2	177	183	PF00498	0.675
LIG_FHA_2	50	56	PF00498	0.353
LIG_LIR_Apic_2	203	209	PF02991	0.566
LIG_LIR_Gen_1	102	111	PF02991	0.628
LIG_LIR_Gen_1	41	50	PF02991	0.434
LIG_LIR_Gen_1	79	89	PF02991	0.542
LIG_LIR_Nem_3	102	108	PF02991	0.597
LIG_LIR_Nem_3	182	187	PF02991	0.555
LIG_LIR_Nem_3	295	301	PF02991	0.597
LIG_LIR_Nem_3	377	383	PF02991	0.692
LIG_LIR_Nem_3	41	47	PF02991	0.436
LIG_LIR_Nem_3	79	84	PF02991	0.440
LIG_Pex14_1	44	48	PF04695	0.424
LIG_Pex14_2	298	302	PF04695	0.606
LIG_Pex14_2	40	44	PF04695	0.391
LIG_Pex14_2	89	93	PF04695	0.551
LIG_SH2_CRK	380	384	PF00017	0.686
LIG_SH2_STAT5	304	307	PF00017	0.602
LIG_SH2_STAT5	81	84	PF00017	0.331
LIG_UBA3_1	107	115	PF00899	0.619
LIG_WRC_WIRS_1	81	86	PF05994	0.467
MOD_CDC14_SPxK_1	249	252	PF00782	0.802
MOD_CDK_SPxK_1	246	252	PF00069	0.798
MOD_CK1_1	246	252	PF00069	0.753
MOD_CK1_1	261	267	PF00069	0.678
MOD_CK1_1	27	33	PF00069	0.505
MOD_CK1_1	333	339	PF00069	0.744
MOD_CK1_1	34	40	PF00069	0.437
MOD_CK1_1	371	377	PF00069	0.781
MOD_CK1_1	384	390	PF00069	0.642
MOD_CK1_1	4	10	PF00069	0.519
MOD_CK1_1	49	55	PF00069	0.293
MOD_CK2_1	261	267	PF00069	0.805
MOD_CK2_1	319	325	PF00069	0.715
MOD_CK2_1	49	55	PF00069	0.397
MOD_GlcNHglycan	189	192	PF01048	0.388
MOD_GlcNHglycan	19	22	PF01048	0.691
MOD_GlcNHglycan	263	266	PF01048	0.574
MOD_GlcNHglycan	273	277	PF01048	0.515
MOD_GlcNHglycan	3	6	PF01048	0.775
MOD_GlcNHglycan	332	335	PF01048	0.541
MOD_GlcNHglycan	336	339	PF01048	0.520
MOD_GlcNHglycan	341	344	PF01048	0.498
MOD_GlcNHglycan	345	348	PF01048	0.455
MOD_GlcNHglycan	349	352	PF01048	0.424
MOD_GlcNHglycan	357	360	PF01048	0.428
MOD_GlcNHglycan	36	39	PF01048	0.723
MOD_GlcNHglycan	374	377	PF01048	0.445
MOD_GlcNHglycan	48	51	PF01048	0.640
MOD_GSK3_1	1	8	PF00069	0.546
MOD_GSK3_1	242	249	PF00069	0.717
MOD_GSK3_1	25	32	PF00069	0.551
MOD_GSK3_1	257	264	PF00069	0.693
MOD_GSK3_1	268	275	PF00069	0.619
MOD_GSK3_1	320	327	PF00069	0.690
MOD_GSK3_1	330	337	PF00069	0.704
MOD_GSK3_1	339	346	PF00069	0.617
MOD_GSK3_1	34	41	PF00069	0.345
MOD_GSK3_1	368	375	PF00069	0.768
MOD_GSK3_1	72	79	PF00069	0.471
MOD_N-GLC_1	234	239	PF02516	0.492
MOD_N-GLC_1	243	248	PF02516	0.499
MOD_NEK2_1	153	158	PF00069	0.559
MOD_NEK2_1	176	181	PF00069	0.614
MOD_NEK2_1	186	191	PF00069	0.513
MOD_NEK2_1	243	248	PF00069	0.751
MOD_NEK2_1	258	263	PF00069	0.760
MOD_NEK2_1	294	299	PF00069	0.666
MOD_NEK2_1	319	324	PF00069	0.716
MOD_NEK2_2	80	85	PF00069	0.327
MOD_PIKK_1	198	204	PF00454	0.573
MOD_PIKK_1	252	258	PF00454	0.745
MOD_PIKK_1	38	44	PF00454	0.341
MOD_PK_1	324	330	PF00069	0.738
MOD_PKA_2	153	159	PF00069	0.569
MOD_PKA_2	187	193	PF00069	0.560
MOD_PKA_2	320	326	PF00069	0.688
MOD_PKA_2	372	378	PF00069	0.773
MOD_Plk_1	140	146	PF00069	0.648
MOD_Plk_1	234	240	PF00069	0.712
MOD_Plk_1	243	249	PF00069	0.718
MOD_Plk_4	324	330	PF00069	0.738
MOD_Plk_4	76	82	PF00069	0.396
MOD_ProDKin_1	246	252	PF00069	0.770
MOD_ProDKin_1	27	33	PF00069	0.422
MOD_ProDKin_1	274	280	PF00069	0.779
MOD_ProDKin_1	5	11	PF00069	0.546
MOD_SUMO_rev_2	303	313	PF00179	0.632
TRG_ENDOCYTIC_2	105	108	PF00928	0.611
TRG_ENDOCYTIC_2	380	383	PF00928	0.688
TRG_ENDOCYTIC_2	81	84	PF00928	0.373
TRG_ER_diArg_1	298	300	PF00400	0.636
TRG_ER_diArg_1	84	87	PF00400	0.532
TRG_ER_diArg_1	98	100	PF00400	0.561
TRG_NES_CRM1_1	165	178	PF08389	0.549
TRG_NLS_Bipartite_1	211	227	PF00514	0.631
TRG_NLS_MonoExtC_3	222	227	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	173	178	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSU4	Leptomonas seymouri	74%	100%
A0A0S4IXL3	Bodo saltans	32%	100%
A0A1X0NPE0	Trypanosomatidae	37%	100%
A0A3R7NBC4	Trypanosoma rangeli	44%	100%
A0A3S7WPV5	Leishmania donovani	95%	99%
A4H4Z9	Leishmania braziliensis	86%	99%
A4HT79	Leishmania infantum	95%	100%
C9ZUQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QIP3	Leishmania major	94%	100%
V5B859	Trypanosoma cruzi	43%	100%