LeishMANIAdb
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HTH araC/xylS-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
HTH araC/xylS-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AL53_LEIMU
TriTrypDb:
LmxM.07.0420
Length:
109

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AL53
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL53

PDB structure(s): 7aih_BF , 7am2_BF , 7ane_BF

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 104 106 PF00675 0.549
CLV_NRD_NRD_1 2 4 PF00675 0.633
CLV_NRD_NRD_1 26 28 PF00675 0.536
CLV_NRD_NRD_1 89 91 PF00675 0.498
CLV_PCSK_KEX2_1 104 106 PF00082 0.549
CLV_PCSK_KEX2_1 2 4 PF00082 0.602
CLV_PCSK_KEX2_1 26 28 PF00082 0.536
CLV_PCSK_KEX2_1 89 91 PF00082 0.468
DEG_Nend_UBRbox_1 1 4 PF02207 0.678
DOC_CYCLIN_yCln2_LP_2 49 55 PF00134 0.418
DOC_MAPK_gen_1 89 100 PF00069 0.545
LIG_14-3-3_CanoR_1 2 6 PF00244 0.635
LIG_14-3-3_CterR_2 104 109 PF00244 0.537
LIG_LIR_Nem_3 48 53 PF02991 0.501
LIG_LIR_Nem_3 82 88 PF02991 0.518
LIG_Pex14_2 12 16 PF04695 0.654
LIG_SH2_CRK 50 54 PF00017 0.421
LIG_SH2_STAP1 55 59 PF00017 0.406
LIG_SH2_STAT5 45 48 PF00017 0.412
LIG_SH2_STAT5 55 58 PF00017 0.398
LIG_WRC_WIRS_1 9 14 PF05994 0.657
MOD_GSK3_1 69 76 PF00069 0.515
MOD_LATS_1 103 109 PF00433 0.604
MOD_NEK2_1 1 6 PF00069 0.649
MOD_NEK2_1 53 58 PF00069 0.403
MOD_NEK2_2 45 50 PF00069 0.520
MOD_NEK2_2 55 60 PF00069 0.566
MOD_PKA_2 1 7 PF00069 0.664
MOD_PKA_2 69 75 PF00069 0.503
MOD_Plk_1 17 23 PF00069 0.633
MOD_Plk_4 45 51 PF00069 0.512
TRG_ENDOCYTIC_2 50 53 PF00928 0.428
TRG_ENDOCYTIC_2 9 12 PF00928 0.689
TRG_ER_diArg_1 1 3 PF00400 0.631
TRG_ER_diArg_1 104 106 PF00400 0.551
TRG_ER_diArg_1 26 29 PF00400 0.531
TRG_ER_diArg_1 88 90 PF00400 0.517

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7D7 Leptomonas seymouri 84% 100%
A0A0S4J1X9 Bodo saltans 55% 100%
A0A1X0NKJ1 Trypanosomatidae 63% 100%
A0A3R7KZA1 Trypanosoma rangeli 62% 74%
A0A3S5H5X8 Leishmania donovani 100% 100%
A4H4Y8 Leishmania braziliensis 97% 100%
A4HT64 Leishmania infantum 100% 100%
C9ZJ32 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
Q4QIQ1 Leishmania major 99% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS