SIN1_PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL52_LEIMU

TriTrypDb:

LmxM.07.0410

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.617
CLV_NRD_NRD_1	476	478	PF00675	0.392
CLV_NRD_NRD_1	479	481	PF00675	0.394
CLV_PCSK_KEX2_1	155	157	PF00082	0.483
CLV_PCSK_KEX2_1	476	478	PF00082	0.412
CLV_PCSK_KEX2_1	481	483	PF00082	0.414
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.499
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.453
CLV_PCSK_PC7_1	477	483	PF00082	0.468
CLV_PCSK_SKI1_1	236	240	PF00082	0.493
CLV_PCSK_SKI1_1	243	247	PF00082	0.538
CLV_PCSK_SKI1_1	334	338	PF00082	0.408
CLV_PCSK_SKI1_1	363	367	PF00082	0.735
CLV_PCSK_SKI1_1	424	428	PF00082	0.340
CLV_PCSK_SKI1_1	499	503	PF00082	0.565
CLV_PCSK_SKI1_1	72	76	PF00082	0.691
CLV_PCSK_SKI1_1	85	89	PF00082	0.466
CLV_Separin_Metazoa	360	364	PF03568	0.676
DOC_MAPK_FxFP_2	238	241	PF00069	0.502
DOC_MAPK_gen_1	155	161	PF00069	0.619
DOC_MAPK_gen_1	424	434	PF00069	0.421
DOC_MAPK_MEF2A_6	155	163	PF00069	0.505
DOC_MAPK_MEF2A_6	252	260	PF00069	0.546
DOC_PP1_RVXF_1	111	118	PF00149	0.590
DOC_PP4_FxxP_1	238	241	PF00568	0.510
DOC_SPAK_OSR1_1	341	345	PF12202	0.400
DOC_USP7_MATH_1	412	416	PF00917	0.447
LIG_14-3-3_CanoR_1	144	150	PF00244	0.415
LIG_14-3-3_CanoR_1	156	162	PF00244	0.415
LIG_14-3-3_CanoR_1	191	199	PF00244	0.417
LIG_14-3-3_CanoR_1	334	340	PF00244	0.402
LIG_14-3-3_CanoR_1	411	419	PF00244	0.333
LIG_14-3-3_CanoR_1	72	80	PF00244	0.671
LIG_APCC_ABBA_1	432	437	PF00400	0.365
LIG_BRCT_BRCA1_1	128	132	PF00533	0.677
LIG_BRCT_BRCA1_1	448	452	PF00533	0.365
LIG_BRCT_BRCA1_1	505	509	PF00533	0.530
LIG_Clathr_ClatBox_1	399	403	PF01394	0.421
LIG_deltaCOP1_diTrp_1	35	43	PF00928	0.670
LIG_FHA_1	138	144	PF00498	0.555
LIG_FHA_1	156	162	PF00498	0.376
LIG_FHA_1	182	188	PF00498	0.572
LIG_FHA_1	242	248	PF00498	0.546
LIG_FHA_1	249	255	PF00498	0.527
LIG_FHA_1	357	363	PF00498	0.665
LIG_FHA_1	364	370	PF00498	0.468
LIG_FHA_1	86	92	PF00498	0.649
LIG_FHA_2	206	212	PF00498	0.412
LIG_FHA_2	248	254	PF00498	0.516
LIG_FHA_2	423	429	PF00498	0.389
LIG_FHA_2	59	65	PF00498	0.576
LIG_FHA_2	7	13	PF00498	0.649
LIG_HCF-1_HBM_1	405	408	PF13415	0.421
LIG_Integrin_isoDGR_2	350	352	PF01839	0.530
LIG_LIR_Gen_1	35	45	PF02991	0.730
LIG_LIR_Gen_1	380	389	PF02991	0.317
LIG_LIR_Nem_3	316	320	PF02991	0.470
LIG_LIR_Nem_3	35	40	PF02991	0.733
LIG_LIR_Nem_3	380	384	PF02991	0.317
LIG_LIR_Nem_3	77	83	PF02991	0.450
LIG_PCNA_yPIPBox_3	191	202	PF02747	0.450
LIG_SH2_CRK	26	30	PF00017	0.657
LIG_SH2_GRB2like	317	320	PF00017	0.473
LIG_SH2_STAP1	103	107	PF00017	0.442
LIG_SH2_STAP1	50	54	PF00017	0.521
LIG_SH2_STAT3	103	106	PF00017	0.445
LIG_SH2_STAT5	207	210	PF00017	0.540
LIG_SH2_STAT5	408	411	PF00017	0.315
LIG_SH2_STAT5	446	449	PF00017	0.336
LIG_SH3_3	259	265	PF00018	0.480
LIG_SH3_3	324	330	PF00018	0.618
LIG_TRAF2_1	208	211	PF00917	0.398
LIG_TRAF2_1	353	356	PF00917	0.603
LIG_WRC_WIRS_1	146	151	PF05994	0.425
MOD_CK1_1	126	132	PF00069	0.674
MOD_CK2_1	136	142	PF00069	0.628
MOD_CK2_1	180	186	PF00069	0.372
MOD_CK2_1	205	211	PF00069	0.404
MOD_CK2_1	447	453	PF00069	0.287
MOD_CK2_1	58	64	PF00069	0.593
MOD_Cter_Amidation	153	156	PF01082	0.481
MOD_GlcNHglycan	295	298	PF01048	0.535
MOD_GSK3_1	119	126	PF00069	0.738
MOD_GSK3_1	157	164	PF00069	0.592
MOD_GSK3_1	186	193	PF00069	0.463
MOD_GSK3_1	281	288	PF00069	0.597
MOD_GSK3_1	418	425	PF00069	0.405
MOD_GSK3_1	44	51	PF00069	0.656
MOD_GSK3_1	499	506	PF00069	0.608
MOD_N-GLC_1	161	166	PF02516	0.593
MOD_N-GLC_1	222	227	PF02516	0.395
MOD_N-GLC_1	247	252	PF02516	0.629
MOD_N-GLC_1	254	259	PF02516	0.475
MOD_N-GLC_1	412	417	PF02516	0.421
MOD_N-GLC_1	492	497	PF02516	0.518
MOD_NEK2_1	246	251	PF00069	0.642
MOD_NEK2_1	285	290	PF00069	0.535
MOD_NEK2_1	457	462	PF00069	0.405
MOD_NEK2_1	74	79	PF00069	0.412
MOD_PIKK_1	102	108	PF00454	0.699
MOD_PIKK_1	161	167	PF00454	0.604
MOD_PIKK_1	186	192	PF00454	0.582
MOD_PK_1	93	99	PF00069	0.599
MOD_PKA_1	155	161	PF00069	0.509
MOD_PKA_2	107	113	PF00069	0.530
MOD_PKA_2	155	161	PF00069	0.560
MOD_PKA_2	190	196	PF00069	0.463
MOD_Plk_1	222	228	PF00069	0.386
MOD_Plk_1	254	260	PF00069	0.496
MOD_Plk_1	285	291	PF00069	0.539
MOD_Plk_1	332	338	PF00069	0.409
MOD_Plk_1	422	428	PF00069	0.405
MOD_Plk_1	492	498	PF00069	0.494
MOD_Plk_4	145	151	PF00069	0.544
MOD_Plk_4	335	341	PF00069	0.421
MOD_SUMO_for_1	491	494	PF00179	0.589
MOD_SUMO_rev_2	147	157	PF00179	0.533
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.421
TRG_ENDOCYTIC_2	168	171	PF00928	0.501
TRG_ENDOCYTIC_2	199	202	PF00928	0.454
TRG_ENDOCYTIC_2	317	320	PF00928	0.517
TRG_ENDOCYTIC_2	441	444	PF00928	0.295
TRG_ER_diArg_1	475	477	PF00400	0.434
TRG_ER_diArg_1	479	482	PF00400	0.459
TRG_ER_diArg_1	504	507	PF00400	0.563
TRG_NES_CRM1_1	364	377	PF08389	0.588
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	398	403	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9I2	Leptomonas seymouri	72%	98%
A0A0S4ILP7	Bodo saltans	41%	100%
A0A1X0NPY0	Trypanosomatidae	49%	100%
A0A3R7KA86	Trypanosoma rangeli	50%	100%
A0A3S7WPU9	Leishmania donovani	94%	100%
A4H4Y7	Leishmania braziliensis	83%	100%
C9ZUR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AG73	Leishmania infantum	94%	100%
Q4QIQ2	Leishmania major	93%	100%
V5D8S1	Trypanosoma cruzi	49%	100%