EamA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EamA-like transporter family, putative

Species:

Leishmania mexicana

UniProt:

E9AL51_LEIMU

TriTrypDb:

LmxM.07.0400

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AL51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL51

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.780
CLV_NRD_NRD_1	123	125	PF00675	0.420
CLV_NRD_NRD_1	341	343	PF00675	0.436
CLV_NRD_NRD_1	362	364	PF00675	0.474
CLV_NRD_NRD_1	369	371	PF00675	0.447
CLV_NRD_NRD_1	374	376	PF00675	0.272
CLV_NRD_NRD_1	379	381	PF00675	0.272
CLV_PCSK_FUR_1	121	125	PF00082	0.416
CLV_PCSK_FUR_1	367	371	PF00082	0.449
CLV_PCSK_FUR_1	372	376	PF00082	0.272
CLV_PCSK_KEX2_1	123	125	PF00082	0.420
CLV_PCSK_KEX2_1	341	343	PF00082	0.436
CLV_PCSK_KEX2_1	361	363	PF00082	0.421
CLV_PCSK_KEX2_1	369	371	PF00082	0.447
CLV_PCSK_KEX2_1	374	376	PF00082	0.272
CLV_PCSK_KEX2_1	379	381	PF00082	0.272
CLV_PCSK_PC7_1	365	371	PF00082	0.491
CLV_PCSK_PC7_1	375	381	PF00082	0.243
CLV_PCSK_SKI1_1	268	272	PF00082	0.572
CLV_PCSK_SKI1_1	383	387	PF00082	0.377
CLV_PCSK_SKI1_1	97	101	PF00082	0.472
DEG_APCC_DBOX_1	34	42	PF00400	0.591
DEG_APCC_DBOX_1	374	382	PF00400	0.472
DOC_CDC14_PxL_1	50	58	PF14671	0.527
DOC_CKS1_1	249	254	PF01111	0.699
DOC_CKS1_1	572	577	PF01111	0.308
DOC_CYCLIN_RxL_1	265	275	PF00134	0.688
DOC_CYCLIN_yClb5_NLxxxL_5	544	553	PF00134	0.308
DOC_CYCLIN_yCln2_LP_2	560	566	PF00134	0.308
DOC_CYCLIN_yCln2_LP_2	572	578	PF00134	0.308
DOC_MAPK_gen_1	379	388	PF00069	0.522
DOC_MAPK_gen_1	436	444	PF00069	0.401
DOC_MAPK_MEF2A_6	291	298	PF00069	0.687
DOC_MAPK_MEF2A_6	316	324	PF00069	0.669
DOC_MAPK_MEF2A_6	436	444	PF00069	0.456
DOC_MAPK_MEF2A_6	64	73	PF00069	0.515
DOC_PP4_FxxP_1	117	120	PF00568	0.362
DOC_PP4_FxxP_1	488	491	PF00568	0.542
DOC_PP4_FxxP_1	512	515	PF00568	0.289
DOC_PP4_FxxP_1	528	531	PF00568	0.392
DOC_PP4_FxxP_1	95	98	PF00568	0.392
DOC_USP7_MATH_1	172	176	PF00917	0.703
DOC_USP7_MATH_1	2	6	PF00917	0.585
DOC_USP7_MATH_1	33	37	PF00917	0.607
DOC_USP7_MATH_1	481	485	PF00917	0.308
DOC_WW_Pin1_4	116	121	PF00397	0.437
DOC_WW_Pin1_4	122	127	PF00397	0.690
DOC_WW_Pin1_4	179	184	PF00397	0.689
DOC_WW_Pin1_4	205	210	PF00397	0.694
DOC_WW_Pin1_4	232	237	PF00397	0.655
DOC_WW_Pin1_4	244	249	PF00397	0.712
DOC_WW_Pin1_4	3	8	PF00397	0.752
DOC_WW_Pin1_4	559	564	PF00397	0.308
DOC_WW_Pin1_4	571	576	PF00397	0.308
LIG_14-3-3_CanoR_1	190	196	PF00244	0.666
LIG_14-3-3_CanoR_1	234	242	PF00244	0.661
LIG_14-3-3_CanoR_1	291	295	PF00244	0.736
LIG_14-3-3_CanoR_1	374	379	PF00244	0.492
LIG_14-3-3_CanoR_1	495	499	PF00244	0.468
LIG_14-3-3_CanoR_1	57	63	PF00244	0.586
LIG_BIR_III_4	24	28	PF00653	0.678
LIG_BRCT_BRCA1_1	181	185	PF00533	0.603
LIG_BRCT_BRCA1_1	4	8	PF00533	0.634
LIG_BRCT_BRCA1_1	474	478	PF00533	0.325
LIG_BRCT_BRCA1_1	91	95	PF00533	0.366
LIG_BRCT_BRCA1_2	91	97	PF00533	0.365
LIG_CSL_BTD_1	252	255	PF09270	0.613
LIG_FHA_1	131	137	PF00498	0.715
LIG_FHA_1	17	23	PF00498	0.759
LIG_FHA_1	249	255	PF00498	0.698
LIG_FHA_1	291	297	PF00498	0.735
LIG_FHA_1	415	421	PF00498	0.308
LIG_FHA_1	447	453	PF00498	0.308
LIG_FHA_1	481	487	PF00498	0.336
LIG_FHA_1	559	565	PF00498	0.308
LIG_FHA_1	571	577	PF00498	0.351
LIG_FHA_1	68	74	PF00498	0.319
LIG_FHA_2	123	129	PF00498	0.638
LIG_FHA_2	149	155	PF00498	0.636
LIG_FHA_2	323	329	PF00498	0.641
LIG_FHA_2	338	344	PF00498	0.663
LIG_FHA_2	521	527	PF00498	0.411
LIG_GBD_Chelix_1	564	572	PF00786	0.308
LIG_LIR_Apic_2	250	256	PF02991	0.705
LIG_LIR_Apic_2	304	308	PF02991	0.628
LIG_LIR_Apic_2	526	531	PF02991	0.349
LIG_LIR_Apic_2	92	98	PF02991	0.356
LIG_LIR_Gen_1	418	429	PF02991	0.291
LIG_LIR_Gen_1	43	54	PF02991	0.607
LIG_LIR_Gen_1	532	541	PF02991	0.322
LIG_LIR_Nem_3	418	424	PF02991	0.309
LIG_LIR_Nem_3	43	49	PF02991	0.514
LIG_LIR_Nem_3	532	536	PF02991	0.389
LIG_LIR_Nem_3	61	65	PF02991	0.518
LIG_LIR_Nem_3	82	88	PF02991	0.432
LIG_MLH1_MIPbox_1	474	478	PF16413	0.308
LIG_MYND_1	252	256	PF01753	0.692
LIG_MYND_1	54	58	PF01753	0.535
LIG_PDZ_Class_2	606	611	PF00595	0.393
LIG_Pex14_1	112	116	PF04695	0.308
LIG_Pex14_2	100	104	PF04695	0.286
LIG_Pex14_2	388	392	PF04695	0.308
LIG_Pex14_2	510	514	PF04695	0.209
LIG_Pex14_2	95	99	PF04695	0.355
LIG_PTB_Apo_2	110	117	PF02174	0.308
LIG_PTB_Apo_2	393	400	PF02174	0.308
LIG_PTB_Apo_2	506	513	PF02174	0.284
LIG_SH2_CRK	305	309	PF00017	0.632
LIG_SH2_CRK	482	486	PF00017	0.308
LIG_SH2_GRB2like	103	106	PF00017	0.308
LIG_SH2_NCK_1	305	309	PF00017	0.653
LIG_SH2_STAP1	482	486	PF00017	0.308
LIG_SH2_STAT5	103	106	PF00017	0.253
LIG_SH2_STAT5	397	400	PF00017	0.329
LIG_SH2_STAT5	482	485	PF00017	0.313
LIG_SH2_STAT5	593	596	PF00017	0.377
LIG_SH2_STAT5	88	91	PF00017	0.426
LIG_SH3_3	246	252	PF00018	0.693
LIG_SH3_3	384	390	PF00018	0.448
LIG_Sin3_3	595	602	PF02671	0.209
LIG_SUMO_SIM_anti_2	317	325	PF11976	0.667
LIG_SUMO_SIM_par_1	442	447	PF11976	0.325
LIG_SUMO_SIM_par_1	469	475	PF11976	0.284
LIG_SUMO_SIM_par_1	516	521	PF11976	0.377
LIG_TRAF2_1	150	153	PF00917	0.750
LIG_TRAF2_1	315	318	PF00917	0.672
LIG_TRFH_1	116	120	PF08558	0.207
LIG_UBA3_1	89	97	PF00899	0.411
LIG_WRC_WIRS_1	59	64	PF05994	0.420
LIG_WW_1	224	227	PF00397	0.685
LIG_WW_3	358	362	PF00397	0.650
MOD_CDK_SPK_2	116	121	PF00069	0.362
MOD_CDK_SPxxK_3	116	123	PF00069	0.369
MOD_CDK_SPxxK_3	3	10	PF00069	0.592
MOD_CK1_1	179	185	PF00069	0.771
MOD_CK1_1	208	214	PF00069	0.621
MOD_CK1_1	235	241	PF00069	0.662
MOD_CK1_1	3	9	PF00069	0.550
MOD_CK1_1	306	312	PF00069	0.584
MOD_CK1_1	404	410	PF00069	0.308
MOD_CK1_1	415	421	PF00069	0.308
MOD_CK1_1	571	577	PF00069	0.308
MOD_CK2_1	146	152	PF00069	0.690
MOD_CK2_1	191	197	PF00069	0.601
MOD_CK2_1	311	317	PF00069	0.581
MOD_CK2_1	337	343	PF00069	0.578
MOD_CK2_1	520	526	PF00069	0.430
MOD_CMANNOS	530	533	PF00535	0.479
MOD_GlcNHglycan	11	14	PF01048	0.704
MOD_GlcNHglycan	178	181	PF01048	0.787
MOD_GlcNHglycan	261	264	PF01048	0.511
MOD_GlcNHglycan	313	316	PF01048	0.581
MOD_GlcNHglycan	446	449	PF01048	0.487
MOD_GlcNHglycan	474	477	PF01048	0.424
MOD_GlcNHglycan	589	592	PF01048	0.340
MOD_GSK3_1	142	149	PF00069	0.748
MOD_GSK3_1	172	179	PF00069	0.713
MOD_GSK3_1	2	9	PF00069	0.556
MOD_GSK3_1	208	215	PF00069	0.629
MOD_GSK3_1	244	251	PF00069	0.723
MOD_GSK3_1	259	266	PF00069	0.746
MOD_GSK3_1	303	310	PF00069	0.583
MOD_GSK3_1	318	325	PF00069	0.589
MOD_GSK3_1	399	406	PF00069	0.349
MOD_GSK3_1	409	416	PF00069	0.354
MOD_GSK3_1	442	449	PF00069	0.500
MOD_GSK3_1	540	547	PF00069	0.424
MOD_GSK3_1	554	561	PF00069	0.233
MOD_GSK3_1	564	571	PF00069	0.308
MOD_GSK3_1	99	106	PF00069	0.326
MOD_N-GLC_1	104	109	PF02516	0.322
MOD_N-GLC_1	353	358	PF02516	0.647
MOD_N-GLC_1	399	404	PF02516	0.308
MOD_N-GLC_1	547	552	PF02516	0.326
MOD_N-GLC_2	205	207	PF02516	0.541
MOD_NEK2_1	200	205	PF00069	0.629
MOD_NEK2_1	311	316	PF00069	0.564
MOD_NEK2_1	399	404	PF00069	0.308
MOD_NEK2_1	414	419	PF00069	0.308
MOD_NEK2_1	423	428	PF00069	0.308
MOD_NEK2_1	444	449	PF00069	0.377
MOD_NEK2_1	520	525	PF00069	0.420
MOD_NEK2_1	540	545	PF00069	0.183
MOD_NEK2_1	568	573	PF00069	0.308
MOD_NEK2_1	60	65	PF00069	0.640
MOD_NEK2_1	67	72	PF00069	0.349
MOD_NEK2_1	73	78	PF00069	0.294
MOD_NEK2_1	99	104	PF00069	0.313
MOD_PIKK_1	128	134	PF00454	0.672
MOD_PIKK_1	219	225	PF00454	0.686
MOD_PKA_1	374	380	PF00069	0.377
MOD_PKA_2	290	296	PF00069	0.677
MOD_PKA_2	374	380	PF00069	0.308
MOD_PKA_2	494	500	PF00069	0.309
MOD_PKA_2	9	15	PF00069	0.604
MOD_PKB_1	372	380	PF00069	0.377
MOD_Plk_1	303	309	PF00069	0.583
MOD_Plk_1	399	405	PF00069	0.308
MOD_Plk_4	26	32	PF00069	0.512
MOD_Plk_4	318	324	PF00069	0.590
MOD_Plk_4	409	415	PF00069	0.308
MOD_Plk_4	416	422	PF00069	0.308
MOD_Plk_4	446	452	PF00069	0.344
MOD_Plk_4	481	487	PF00069	0.311
MOD_Plk_4	540	546	PF00069	0.377
MOD_Plk_4	67	73	PF00069	0.367
MOD_Plk_4	80	86	PF00069	0.329
MOD_Plk_4	99	105	PF00069	0.204
MOD_ProDKin_1	116	122	PF00069	0.440
MOD_ProDKin_1	179	185	PF00069	0.612
MOD_ProDKin_1	205	211	PF00069	0.620
MOD_ProDKin_1	232	238	PF00069	0.565
MOD_ProDKin_1	244	250	PF00069	0.644
MOD_ProDKin_1	3	9	PF00069	0.702
MOD_ProDKin_1	559	565	PF00069	0.308
MOD_ProDKin_1	571	577	PF00069	0.308
TRG_DiLeu_BaEn_2	434	440	PF01217	0.209
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.308
TRG_ENDOCYTIC_2	46	49	PF00928	0.356
TRG_ENDOCYTIC_2	482	485	PF00928	0.308
TRG_ER_diArg_1	122	124	PF00400	0.507
TRG_ER_diArg_1	35	38	PF00400	0.538
TRG_ER_diArg_1	360	363	PF00400	0.585
TRG_ER_diArg_1	364	367	PF00400	0.574
TRG_ER_diArg_1	369	372	PF00400	0.542
TRG_ER_diArg_1	373	375	PF00400	0.297
TRG_ER_diArg_1	378	380	PF00400	0.308
TRG_ER_diArg_1	436	439	PF00400	0.254
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM12	Leptomonas seymouri	57%	94%
A0A3S7WPT7	Leishmania donovani	89%	100%
A4H4Y6	Leishmania braziliensis	68%	100%
A4HT28	Leishmania infantum	89%	100%
Q4QIQ3	Leishmania major	87%	100%