Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL50_LEIMU

TriTrypDb:

LmxM.07.0390

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.561
CLV_C14_Caspase3-7	541	545	PF00656	0.515
CLV_C14_Caspase3-7	829	833	PF00656	0.372
CLV_NRD_NRD_1	435	437	PF00675	0.519
CLV_NRD_NRD_1	466	468	PF00675	0.598
CLV_NRD_NRD_1	7	9	PF00675	0.644
CLV_NRD_NRD_1	782	784	PF00675	0.661
CLV_PCSK_KEX2_1	435	437	PF00082	0.519
CLV_PCSK_KEX2_1	466	468	PF00082	0.598
CLV_PCSK_KEX2_1	7	9	PF00082	0.644
CLV_PCSK_KEX2_1	782	784	PF00082	0.759
CLV_PCSK_KEX2_1	787	789	PF00082	0.692
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.697
CLV_PCSK_PC7_1	783	789	PF00082	0.691
CLV_PCSK_SKI1_1	202	206	PF00082	0.454
CLV_PCSK_SKI1_1	273	277	PF00082	0.767
CLV_PCSK_SKI1_1	473	477	PF00082	0.581
CLV_PCSK_SKI1_1	571	575	PF00082	0.542
CLV_PCSK_SKI1_1	603	607	PF00082	0.595
CLV_PCSK_SKI1_1	665	669	PF00082	0.622
CLV_PCSK_SKI1_1	761	765	PF00082	0.790
CLV_PCSK_SKI1_1	825	829	PF00082	0.540
DEG_APCC_DBOX_1	201	209	PF00400	0.600
DEG_APCC_DBOX_1	472	480	PF00400	0.576
DEG_Kelch_Keap1_1	497	502	PF01344	0.577
DEG_Nend_UBRbox_2	1	3	PF02207	0.577
DEG_SCF_FBW7_2	236	243	PF00400	0.710
DEG_SPOP_SBC_1	176	180	PF00917	0.685
DEG_SPOP_SBC_1	384	388	PF00917	0.412
DOC_CKS1_1	237	242	PF01111	0.606
DOC_MAPK_gen_1	52	61	PF00069	0.479
DOC_MAPK_gen_1	662	670	PF00069	0.627
DOC_MAPK_MEF2A_6	662	670	PF00069	0.627
DOC_PP2B_LxvP_1	165	168	PF13499	0.469
DOC_PP2B_LxvP_1	321	324	PF13499	0.648
DOC_PP2B_LxvP_1	516	519	PF13499	0.733
DOC_PP2B_LxvP_1	576	579	PF13499	0.524
DOC_PP2B_LxvP_1	645	648	PF13499	0.596
DOC_PP2B_LxvP_1	668	671	PF13499	0.612
DOC_PP2B_LxvP_1	85	88	PF13499	0.533
DOC_USP7_MATH_1	142	146	PF00917	0.733
DOC_USP7_MATH_1	177	181	PF00917	0.611
DOC_USP7_MATH_1	189	193	PF00917	0.550
DOC_USP7_MATH_1	254	258	PF00917	0.650
DOC_USP7_MATH_1	261	265	PF00917	0.591
DOC_USP7_MATH_1	324	328	PF00917	0.622
DOC_USP7_MATH_1	341	345	PF00917	0.697
DOC_USP7_MATH_1	402	406	PF00917	0.598
DOC_USP7_MATH_1	408	412	PF00917	0.642
DOC_USP7_MATH_1	540	544	PF00917	0.771
DOC_USP7_MATH_1	556	560	PF00917	0.569
DOC_USP7_MATH_1	684	688	PF00917	0.593
DOC_USP7_MATH_1	804	808	PF00917	0.648
DOC_USP7_MATH_1	841	845	PF00917	0.594
DOC_USP7_MATH_1	88	92	PF00917	0.679
DOC_USP7_MATH_1	98	102	PF00917	0.676
DOC_WW_Pin1_4	124	129	PF00397	0.707
DOC_WW_Pin1_4	134	139	PF00397	0.613
DOC_WW_Pin1_4	184	189	PF00397	0.486
DOC_WW_Pin1_4	236	241	PF00397	0.594
DOC_WW_Pin1_4	265	270	PF00397	0.675
DOC_WW_Pin1_4	32	37	PF00397	0.459
DOC_WW_Pin1_4	552	557	PF00397	0.817
DOC_WW_Pin1_4	700	705	PF00397	0.733
DOC_WW_Pin1_4	715	720	PF00397	0.711
LIG_14-3-3_CanoR_1	113	119	PF00244	0.656
LIG_14-3-3_CanoR_1	21	26	PF00244	0.593
LIG_14-3-3_CanoR_1	345	351	PF00244	0.599
LIG_14-3-3_CanoR_1	429	438	PF00244	0.383
LIG_14-3-3_CanoR_1	466	476	PF00244	0.677
LIG_14-3-3_CanoR_1	520	525	PF00244	0.519
LIG_14-3-3_CanoR_1	539	543	PF00244	0.610
LIG_14-3-3_CanoR_1	580	589	PF00244	0.670
LIG_14-3-3_CanoR_1	788	797	PF00244	0.758
LIG_14-3-3_CanoR_1	825	831	PF00244	0.646
LIG_APCC_ABBA_1	201	206	PF00400	0.497
LIG_APCC_ABBA_1	846	851	PF00400	0.692
LIG_BIR_III_2	407	411	PF00653	0.581
LIG_BIR_III_2	57	61	PF00653	0.642
LIG_BIR_III_4	102	106	PF00653	0.778
LIG_BIR_III_4	710	714	PF00653	0.778
LIG_BRCT_BRCA1_1	686	690	PF00533	0.733
LIG_CaM_NSCaTE_8	305	312	PF13499	0.735
LIG_CaM_NSCaTE_8	348	355	PF13499	0.473
LIG_CaM_NSCaTE_8	881	888	PF13499	0.506
LIG_CSL_BTD_1	645	648	PF09270	0.596
LIG_deltaCOP1_diTrp_1	420	430	PF00928	0.633
LIG_EVH1_1	165	169	PF00568	0.479
LIG_FHA_1	12	18	PF00498	0.591
LIG_FHA_1	213	219	PF00498	0.645
LIG_FHA_1	22	28	PF00498	0.607
LIG_FHA_1	237	243	PF00498	0.610
LIG_FHA_1	438	444	PF00498	0.677
LIG_FHA_1	520	526	PF00498	0.518
LIG_FHA_1	582	588	PF00498	0.604
LIG_FHA_1	593	599	PF00498	0.502
LIG_FHA_1	728	734	PF00498	0.623
LIG_FHA_1	77	83	PF00498	0.488
LIG_FHA_1	821	827	PF00498	0.602
LIG_FHA_1	848	854	PF00498	0.661
LIG_FHA_1	862	868	PF00498	0.638
LIG_FHA_2	177	183	PF00498	0.651
LIG_FHA_2	219	225	PF00498	0.598
LIG_FHA_2	457	463	PF00498	0.500
LIG_FHA_2	606	612	PF00498	0.503
LIG_FHA_2	748	754	PF00498	0.682
LIG_FHA_2	790	796	PF00498	0.514
LIG_FHA_2	874	880	PF00498	0.467
LIG_Integrin_RGD_1	55	57	PF01839	0.677
LIG_LIR_Apic_2	234	240	PF02991	0.584
LIG_LIR_Apic_2	411	417	PF02991	0.716
LIG_LIR_Gen_1	67	78	PF02991	0.600
LIG_LIR_Gen_1	674	685	PF02991	0.472
LIG_LIR_Gen_1	687	698	PF02991	0.657
LIG_LIR_Gen_1	815	822	PF02991	0.664
LIG_LIR_LC3C_4	584	589	PF02991	0.638
LIG_LIR_Nem_3	245	250	PF02991	0.667
LIG_LIR_Nem_3	346	351	PF02991	0.644
LIG_LIR_Nem_3	415	419	PF02991	0.520
LIG_LIR_Nem_3	674	680	PF02991	0.589
LIG_LIR_Nem_3	687	693	PF02991	0.644
LIG_LIR_Nem_3	815	820	PF02991	0.540
LIG_LIR_Nem_3	83	89	PF02991	0.384
LIG_NRP_CendR_1	894	895	PF00754	0.805
LIG_Pex14_2	200	204	PF04695	0.444
LIG_REV1ctd_RIR_1	198	206	PF16727	0.429
LIG_SH2_CRK	237	241	PF00017	0.594
LIG_SH2_CRK	414	418	PF00017	0.691
LIG_SH2_CRK	677	681	PF00017	0.637
LIG_SH2_GRB2like	677	680	PF00017	0.461
LIG_SH2_NCK_1	310	314	PF00017	0.661
LIG_SH2_SRC	641	644	PF00017	0.730
LIG_SH2_SRC	677	680	PF00017	0.461
LIG_SH2_STAP1	89	93	PF00017	0.438
LIG_SH2_STAT3	572	575	PF00017	0.512
LIG_SH2_STAT5	351	354	PF00017	0.671
LIG_SH2_STAT5	524	527	PF00017	0.593
LIG_SH2_STAT5	572	575	PF00017	0.465
LIG_SH2_STAT5	746	749	PF00017	0.576
LIG_SH2_STAT5	81	84	PF00017	0.527
LIG_SH3_1	637	643	PF00018	0.628
LIG_SH3_3	163	169	PF00018	0.557
LIG_SH3_3	284	290	PF00018	0.656
LIG_SH3_3	43	49	PF00018	0.537
LIG_SH3_3	490	496	PF00018	0.758
LIG_SH3_3	509	515	PF00018	0.420
LIG_SH3_3	637	643	PF00018	0.628
LIG_SH3_3	698	704	PF00018	0.549
LIG_SH3_3	716	722	PF00018	0.701
LIG_SH3_3	763	769	PF00018	0.692
LIG_SUMO_SIM_par_1	158	163	PF11976	0.656
LIG_SUMO_SIM_par_1	23	29	PF11976	0.708
LIG_SUMO_SIM_par_1	239	245	PF11976	0.549
LIG_TRAF2_1	877	880	PF00917	0.573
MOD_CDK_SPK_2	702	707	PF00069	0.534
MOD_CDK_SPxK_1	32	38	PF00069	0.470
MOD_CDK_SPxxK_3	700	707	PF00069	0.740
MOD_CK1_1	101	107	PF00069	0.676
MOD_CK1_1	134	140	PF00069	0.671
MOD_CK1_1	216	222	PF00069	0.667
MOD_CK1_1	268	274	PF00069	0.687
MOD_CK1_1	279	285	PF00069	0.687
MOD_CK1_1	308	314	PF00069	0.641
MOD_CK1_1	346	352	PF00069	0.758
MOD_CK1_1	412	418	PF00069	0.600
MOD_CK1_1	469	475	PF00069	0.700
MOD_CK1_1	497	503	PF00069	0.675
MOD_CK1_1	559	565	PF00069	0.528
MOD_CK1_1	592	598	PF00069	0.353
MOD_CK1_1	64	70	PF00069	0.653
MOD_CK1_1	718	724	PF00069	0.817
MOD_CK2_1	445	451	PF00069	0.740
MOD_CK2_1	456	462	PF00069	0.625
MOD_CK2_1	496	502	PF00069	0.586
MOD_CK2_1	605	611	PF00069	0.502
MOD_CK2_1	69	75	PF00069	0.715
MOD_CK2_1	747	753	PF00069	0.680
MOD_CK2_1	767	773	PF00069	0.476
MOD_CK2_1	789	795	PF00069	0.509
MOD_CK2_1	868	874	PF00069	0.656
MOD_GlcNHglycan	102	106	PF01048	0.698
MOD_GlcNHglycan	133	136	PF01048	0.792
MOD_GlcNHglycan	144	147	PF01048	0.596
MOD_GlcNHglycan	179	182	PF01048	0.727
MOD_GlcNHglycan	215	218	PF01048	0.678
MOD_GlcNHglycan	252	255	PF01048	0.598
MOD_GlcNHglycan	256	259	PF01048	0.583
MOD_GlcNHglycan	263	266	PF01048	0.632
MOD_GlcNHglycan	302	305	PF01048	0.734
MOD_GlcNHglycan	310	313	PF01048	0.714
MOD_GlcNHglycan	353	356	PF01048	0.665
MOD_GlcNHglycan	365	368	PF01048	0.586
MOD_GlcNHglycan	404	407	PF01048	0.660
MOD_GlcNHglycan	499	502	PF01048	0.643
MOD_GlcNHglycan	550	553	PF01048	0.597
MOD_GlcNHglycan	619	622	PF01048	0.585
MOD_GlcNHglycan	656	659	PF01048	0.628
MOD_GlcNHglycan	662	665	PF01048	0.639
MOD_GlcNHglycan	741	744	PF01048	0.517
MOD_GlcNHglycan	797	800	PF01048	0.703
MOD_GlcNHglycan	814	817	PF01048	0.342
MOD_GSK3_1	120	127	PF00069	0.580
MOD_GSK3_1	183	190	PF00069	0.616
MOD_GSK3_1	212	219	PF00069	0.659
MOD_GSK3_1	232	239	PF00069	0.348
MOD_GSK3_1	250	257	PF00069	0.451
MOD_GSK3_1	26	33	PF00069	0.706
MOD_GSK3_1	261	268	PF00069	0.662
MOD_GSK3_1	37	44	PF00069	0.705
MOD_GSK3_1	408	415	PF00069	0.592
MOD_GSK3_1	445	452	PF00069	0.728
MOD_GSK3_1	497	504	PF00069	0.654
MOD_GSK3_1	548	555	PF00069	0.785
MOD_GSK3_1	589	596	PF00069	0.443
MOD_GSK3_1	60	67	PF00069	0.693
MOD_GSK3_1	654	661	PF00069	0.676
MOD_GSK3_1	684	691	PF00069	0.735
MOD_GSK3_1	69	76	PF00069	0.558
MOD_GSK3_1	714	721	PF00069	0.836
MOD_GSK3_1	723	730	PF00069	0.730
MOD_GSK3_1	755	762	PF00069	0.649
MOD_GSK3_1	787	794	PF00069	0.645
MOD_N-GLC_1	50	55	PF02516	0.753
MOD_N-GLC_2	108	110	PF02516	0.388
MOD_N-GLC_2	729	731	PF02516	0.650
MOD_NEK2_1	114	119	PF00069	0.654
MOD_NEK2_1	250	255	PF00069	0.654
MOD_NEK2_1	383	388	PF00069	0.550
MOD_NEK2_1	468	473	PF00069	0.656
MOD_NEK2_1	61	66	PF00069	0.739
MOD_NEK2_1	727	732	PF00069	0.649
MOD_NEK2_1	73	78	PF00069	0.515
MOD_NEK2_1	747	752	PF00069	0.499
MOD_NEK2_1	755	760	PF00069	0.592
MOD_NEK2_1	826	831	PF00069	0.647
MOD_NEK2_2	305	310	PF00069	0.778
MOD_NEK2_2	50	55	PF00069	0.717
MOD_NEK2_2	501	506	PF00069	0.677
MOD_OFUCOSY	724	731	PF10250	0.674
MOD_PIKK_1	279	285	PF00454	0.651
MOD_PIKK_1	429	435	PF00454	0.577
MOD_PIKK_1	767	773	PF00454	0.653
MOD_PKA_1	466	472	PF00069	0.710
MOD_PKA_1	787	793	PF00069	0.768
MOD_PKA_2	114	120	PF00069	0.663
MOD_PKA_2	131	137	PF00069	0.633
MOD_PKA_2	466	472	PF00069	0.710
MOD_PKA_2	519	525	PF00069	0.528
MOD_PKA_2	538	544	PF00069	0.515
MOD_PKA_2	787	793	PF00069	0.780
MOD_Plk_1	160	166	PF00069	0.599
MOD_Plk_1	450	456	PF00069	0.542
MOD_Plk_1	50	56	PF00069	0.707
MOD_Plk_1	501	507	PF00069	0.653
MOD_Plk_1	747	753	PF00069	0.606
MOD_Plk_1	873	879	PF00069	0.463
MOD_Plk_4	114	120	PF00069	0.663
MOD_Plk_4	232	238	PF00069	0.674
MOD_Plk_4	276	282	PF00069	0.678
MOD_Plk_4	305	311	PF00069	0.693
MOD_Plk_4	409	415	PF00069	0.658
MOD_Plk_4	520	526	PF00069	0.502
MOD_Plk_4	593	599	PF00069	0.565
MOD_Plk_4	641	647	PF00069	0.555
MOD_Plk_4	692	698	PF00069	0.696
MOD_Plk_4	759	765	PF00069	0.793
MOD_Plk_4	76	82	PF00069	0.550
MOD_Plk_4	841	847	PF00069	0.566
MOD_ProDKin_1	124	130	PF00069	0.711
MOD_ProDKin_1	134	140	PF00069	0.611
MOD_ProDKin_1	184	190	PF00069	0.479
MOD_ProDKin_1	236	242	PF00069	0.604
MOD_ProDKin_1	265	271	PF00069	0.675
MOD_ProDKin_1	32	38	PF00069	0.470
MOD_ProDKin_1	552	558	PF00069	0.818
MOD_ProDKin_1	700	706	PF00069	0.736
MOD_ProDKin_1	715	721	PF00069	0.707
MOD_SUMO_rev_2	851	859	PF00179	0.594
TRG_DiLeu_BaEn_4	569	575	PF01217	0.629
TRG_DiLeu_BaLyEn_6	662	667	PF01217	0.732
TRG_ENDOCYTIC_2	677	680	PF00928	0.627
TRG_ER_diArg_1	465	467	PF00400	0.592
TRG_ER_diArg_1	6	8	PF00400	0.640
TRG_ER_diArg_1	781	783	PF00400	0.685
TRG_NLS_MonoCore_2	782	787	PF00514	0.589
TRG_NLS_MonoExtC_3	782	787	PF00514	0.644
TRG_NLS_MonoExtN_4	782	787	PF00514	0.662
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	441	446	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF8	Leptomonas seymouri	40%	100%
A0A3S5H5X7	Leishmania donovani	89%	96%
A4H4Y5	Leishmania braziliensis	72%	98%
A4HT29	Leishmania infantum	89%	96%
Q4QIQ4	Leishmania major	85%	100%