RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9AL48_LEIMU

TriTrypDb:

LmxM.07.0370

Length:

919

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AL48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL48

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.508
CLV_C14_Caspase3-7	495	499	PF00656	0.602
CLV_NRD_NRD_1	249	251	PF00675	0.734
CLV_NRD_NRD_1	266	268	PF00675	0.527
CLV_NRD_NRD_1	421	423	PF00675	0.537
CLV_NRD_NRD_1	502	504	PF00675	0.535
CLV_NRD_NRD_1	58	60	PF00675	0.702
CLV_NRD_NRD_1	709	711	PF00675	0.709
CLV_PCSK_FUR_1	247	251	PF00082	0.690
CLV_PCSK_KEX2_1	247	249	PF00082	0.738
CLV_PCSK_KEX2_1	266	268	PF00082	0.509
CLV_PCSK_KEX2_1	421	423	PF00082	0.537
CLV_PCSK_KEX2_1	502	504	PF00082	0.535
CLV_PCSK_KEX2_1	535	537	PF00082	0.419
CLV_PCSK_KEX2_1	58	60	PF00082	0.702
CLV_PCSK_KEX2_1	709	711	PF00082	0.712
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.419
CLV_PCSK_SKI1_1	249	253	PF00082	0.686
CLV_PCSK_SKI1_1	275	279	PF00082	0.643
CLV_PCSK_SKI1_1	432	436	PF00082	0.362
CLV_PCSK_SKI1_1	61	65	PF00082	0.635
CLV_PCSK_SKI1_1	820	824	PF00082	0.461
CLV_PCSK_SKI1_1	858	862	PF00082	0.471
CLV_Separin_Metazoa	581	585	PF03568	0.550
DEG_Nend_UBRbox_1	1	4	PF02207	0.681
DEG_SPOP_SBC_1	124	128	PF00917	0.733
DEG_SPOP_SBC_1	352	356	PF00917	0.651
DOC_CYCLIN_yCln2_LP_2	688	694	PF00134	0.503
DOC_MAPK_MEF2A_6	440	447	PF00069	0.551
DOC_MAPK_MEF2A_6	522	529	PF00069	0.432
DOC_PP1_RVXF_1	852	858	PF00149	0.501
DOC_PP2B_LxvP_1	251	254	PF13499	0.732
DOC_PP2B_LxvP_1	632	635	PF13499	0.512
DOC_PP2B_LxvP_1	688	691	PF13499	0.493
DOC_PP2B_PxIxI_1	524	530	PF00149	0.473
DOC_PP4_FxxP_1	769	772	PF00568	0.533
DOC_USP7_MATH_1	10	14	PF00917	0.658
DOC_USP7_MATH_1	124	128	PF00917	0.595
DOC_USP7_MATH_1	147	151	PF00917	0.584
DOC_USP7_MATH_1	194	198	PF00917	0.590
DOC_USP7_MATH_1	228	232	PF00917	0.575
DOC_USP7_MATH_1	255	259	PF00917	0.725
DOC_USP7_MATH_1	261	265	PF00917	0.648
DOC_USP7_MATH_1	351	355	PF00917	0.670
DOC_USP7_MATH_1	357	361	PF00917	0.611
DOC_USP7_MATH_1	604	608	PF00917	0.676
DOC_USP7_MATH_1	609	613	PF00917	0.679
DOC_USP7_MATH_1	695	699	PF00917	0.531
DOC_WW_Pin1_4	126	131	PF00397	0.681
DOC_WW_Pin1_4	148	153	PF00397	0.537
DOC_WW_Pin1_4	177	182	PF00397	0.633
DOC_WW_Pin1_4	217	222	PF00397	0.582
DOC_WW_Pin1_4	284	289	PF00397	0.653
DOC_WW_Pin1_4	314	319	PF00397	0.597
DOC_WW_Pin1_4	343	348	PF00397	0.581
DOC_WW_Pin1_4	391	396	PF00397	0.511
DOC_WW_Pin1_4	438	443	PF00397	0.525
DOC_WW_Pin1_4	481	486	PF00397	0.460
DOC_WW_Pin1_4	6	11	PF00397	0.678
DOC_WW_Pin1_4	642	647	PF00397	0.651
DOC_WW_Pin1_4	659	664	PF00397	0.523
DOC_WW_Pin1_4	744	749	PF00397	0.648
LIG_14-3-3_CanoR_1	2	10	PF00244	0.538
LIG_14-3-3_CanoR_1	266	272	PF00244	0.705
LIG_14-3-3_CanoR_1	275	284	PF00244	0.601
LIG_14-3-3_CanoR_1	307	313	PF00244	0.652
LIG_14-3-3_CanoR_1	38	46	PF00244	0.692
LIG_14-3-3_CanoR_1	422	428	PF00244	0.362
LIG_14-3-3_CanoR_1	432	437	PF00244	0.281
LIG_14-3-3_CanoR_1	464	470	PF00244	0.460
LIG_14-3-3_CanoR_1	471	477	PF00244	0.483
LIG_14-3-3_CanoR_1	536	545	PF00244	0.397
LIG_14-3-3_CanoR_1	586	592	PF00244	0.482
LIG_14-3-3_CanoR_1	710	720	PF00244	0.671
LIG_14-3-3_CanoR_1	820	830	PF00244	0.509
LIG_14-3-3_CanoR_1	894	898	PF00244	0.510
LIG_Actin_WH2_2	298	315	PF00022	0.526
LIG_Actin_WH2_2	538	554	PF00022	0.322
LIG_APCC_ABBA_1	844	849	PF00400	0.485
LIG_APCC_ABBA_1	859	864	PF00400	0.312
LIG_APCC_ABBAyCdc20_2	858	864	PF00400	0.427
LIG_BRCT_BRCA1_1	818	822	PF00533	0.510
LIG_BRCT_MDC1_1	915	919	PF00533	0.525
LIG_FHA_1	164	170	PF00498	0.568
LIG_FHA_1	34	40	PF00498	0.547
LIG_FHA_1	357	363	PF00498	0.670
LIG_FHA_1	364	370	PF00498	0.616
LIG_FHA_1	433	439	PF00498	0.362
LIG_FHA_1	623	629	PF00498	0.601
LIG_FHA_1	662	668	PF00498	0.664
LIG_FHA_1	699	705	PF00498	0.544
LIG_FHA_1	737	743	PF00498	0.658
LIG_FHA_1	766	772	PF00498	0.663
LIG_FHA_2	276	282	PF00498	0.644
LIG_FHA_2	356	362	PF00498	0.709
LIG_FHA_2	392	398	PF00498	0.487
LIG_FHA_2	489	495	PF00498	0.641
LIG_LIR_Apic_2	677	683	PF02991	0.648
LIG_LIR_Apic_2	768	772	PF02991	0.665
LIG_LIR_Gen_1	801	811	PF02991	0.506
LIG_LIR_Nem_3	335	340	PF02991	0.663
LIG_LIR_Nem_3	570	576	PF02991	0.430
LIG_LIR_Nem_3	679	685	PF02991	0.619
LIG_LIR_Nem_3	801	806	PF02991	0.499
LIG_LIR_Nem_3	856	860	PF02991	0.474
LIG_NRBOX	443	449	PF00104	0.363
LIG_Pex14_1	877	881	PF04695	0.563
LIG_Pex14_2	891	895	PF04695	0.500
LIG_PTB_Apo_2	331	338	PF02174	0.503
LIG_SH2_CRK	292	296	PF00017	0.642
LIG_SH2_CRK	573	577	PF00017	0.434
LIG_SH2_PTP2	526	529	PF00017	0.414
LIG_SH2_PTP2	830	833	PF00017	0.360
LIG_SH2_SRC	526	529	PF00017	0.414
LIG_SH2_SRC	692	695	PF00017	0.513
LIG_SH2_STAP1	614	618	PF00017	0.646
LIG_SH2_STAP1	818	822	PF00017	0.460
LIG_SH2_STAT5	292	295	PF00017	0.641
LIG_SH2_STAT5	526	529	PF00017	0.414
LIG_SH2_STAT5	830	833	PF00017	0.473
LIG_SH2_STAT5	845	848	PF00017	0.313
LIG_SH2_STAT5	881	884	PF00017	0.554
LIG_SH3_3	117	123	PF00018	0.689
LIG_SH3_3	146	152	PF00018	0.533
LIG_SH3_3	315	321	PF00018	0.611
LIG_SH3_3	323	329	PF00018	0.675
LIG_SH3_3	590	596	PF00018	0.672
LIG_SH3_3	675	681	PF00018	0.586
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.506
LIG_SUMO_SIM_anti_2	557	563	PF11976	0.513
LIG_SUMO_SIM_anti_2	579	584	PF11976	0.544
LIG_SUMO_SIM_par_1	286	293	PF11976	0.492
LIG_SUMO_SIM_par_1	441	446	PF11976	0.352
LIG_SUMO_SIM_par_1	557	563	PF11976	0.513
LIG_TRAF2_2	391	396	PF00917	0.574
LIG_WW_3	786	790	PF00397	0.580
MOD_CDC14_SPxK_1	662	665	PF00782	0.665
MOD_CDK_SPxK_1	659	665	PF00069	0.664
MOD_CK1_1	107	113	PF00069	0.661
MOD_CK1_1	129	135	PF00069	0.689
MOD_CK1_1	150	156	PF00069	0.526
MOD_CK1_1	177	183	PF00069	0.618
MOD_CK1_1	209	215	PF00069	0.645
MOD_CK1_1	270	276	PF00069	0.671
MOD_CK1_1	314	320	PF00069	0.719
MOD_CK1_1	346	352	PF00069	0.648
MOD_CK1_1	356	362	PF00069	0.595
MOD_CK1_1	365	371	PF00069	0.593
MOD_CK1_1	376	382	PF00069	0.438
MOD_CK1_1	41	47	PF00069	0.579
MOD_CK1_1	470	476	PF00069	0.532
MOD_CK1_1	612	618	PF00069	0.684
MOD_CK1_1	639	645	PF00069	0.613
MOD_CK1_1	69	75	PF00069	0.675
MOD_CK1_1	698	704	PF00069	0.544
MOD_CK1_1	77	83	PF00069	0.641
MOD_CK1_1	821	827	PF00069	0.461
MOD_CK2_1	180	186	PF00069	0.549
MOD_CK2_1	355	361	PF00069	0.710
MOD_CK2_1	73	79	PF00069	0.534
MOD_Cter_Amidation	264	267	PF01082	0.664
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.678
MOD_GlcNHglycan	144	147	PF01048	0.653
MOD_GlcNHglycan	152	155	PF01048	0.623
MOD_GlcNHglycan	166	169	PF01048	0.635
MOD_GlcNHglycan	171	174	PF01048	0.604
MOD_GlcNHglycan	197	200	PF01048	0.708
MOD_GlcNHglycan	211	215	PF01048	0.558
MOD_GlcNHglycan	261	264	PF01048	0.664
MOD_GlcNHglycan	275	278	PF01048	0.538
MOD_GlcNHglycan	29	32	PF01048	0.681
MOD_GlcNHglycan	313	316	PF01048	0.690
MOD_GlcNHglycan	348	351	PF01048	0.678
MOD_GlcNHglycan	355	358	PF01048	0.585
MOD_GlcNHglycan	481	484	PF01048	0.641
MOD_GlcNHglycan	538	541	PF01048	0.455
MOD_GlcNHglycan	641	644	PF01048	0.635
MOD_GlcNHglycan	659	662	PF01048	0.581
MOD_GlcNHglycan	674	677	PF01048	0.500
MOD_GlcNHglycan	726	729	PF01048	0.649
MOD_GlcNHglycan	784	787	PF01048	0.693
MOD_GlcNHglycan	795	798	PF01048	0.544
MOD_GlcNHglycan	915	918	PF01048	0.435
MOD_GSK3_1	107	114	PF00069	0.650
MOD_GSK3_1	124	131	PF00069	0.573
MOD_GSK3_1	177	184	PF00069	0.678
MOD_GSK3_1	195	202	PF00069	0.586
MOD_GSK3_1	206	213	PF00069	0.580
MOD_GSK3_1	229	236	PF00069	0.626
MOD_GSK3_1	255	262	PF00069	0.692
MOD_GSK3_1	267	274	PF00069	0.607
MOD_GSK3_1	280	287	PF00069	0.553
MOD_GSK3_1	328	335	PF00069	0.564
MOD_GSK3_1	342	349	PF00069	0.657
MOD_GSK3_1	351	358	PF00069	0.568
MOD_GSK3_1	587	594	PF00069	0.519
MOD_GSK3_1	6	13	PF00069	0.671
MOD_GSK3_1	609	616	PF00069	0.532
MOD_GSK3_1	657	664	PF00069	0.517
MOD_GSK3_1	66	73	PF00069	0.670
MOD_GSK3_1	695	702	PF00069	0.673
MOD_GSK3_1	737	744	PF00069	0.702
MOD_GSK3_1	805	812	PF00069	0.513
MOD_GSK3_1	816	823	PF00069	0.396
MOD_N-GLC_1	104	109	PF02516	0.673
MOD_N-GLC_1	39	44	PF02516	0.693
MOD_N-GLC_1	430	435	PF02516	0.299
MOD_N-GLC_1	69	74	PF02516	0.553
MOD_N-GLC_2	26	28	PF02516	0.669
MOD_N-GLC_2	905	907	PF02516	0.331
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	226	231	PF00069	0.657
MOD_NEK2_1	342	347	PF00069	0.624
MOD_NEK2_1	362	367	PF00069	0.699
MOD_NEK2_1	39	44	PF00069	0.556
MOD_NEK2_1	551	556	PF00069	0.439
MOD_NEK2_1	560	565	PF00069	0.503
MOD_NEK2_1	613	618	PF00069	0.507
MOD_NEK2_1	742	747	PF00069	0.581
MOD_NEK2_2	308	313	PF00069	0.672
MOD_NEK2_2	33	38	PF00069	0.545
MOD_NEK2_2	609	614	PF00069	0.652
MOD_PIKK_1	129	135	PF00454	0.689
MOD_PIKK_1	171	177	PF00454	0.683
MOD_PIKK_1	470	476	PF00454	0.532
MOD_PIKK_1	560	566	PF00454	0.517
MOD_PIKK_1	63	69	PF00454	0.630
MOD_PKA_2	1	7	PF00069	0.682
MOD_PKA_2	209	215	PF00069	0.676
MOD_PKA_2	265	271	PF00069	0.657
MOD_PKA_2	470	476	PF00069	0.532
MOD_PKA_2	77	83	PF00069	0.652
MOD_PKA_2	893	899	PF00069	0.517
MOD_PKB_1	59	67	PF00069	0.634
MOD_Plk_1	280	286	PF00069	0.643
MOD_Plk_1	33	39	PF00069	0.545
MOD_Plk_1	729	735	PF00069	0.652
MOD_Plk_1	737	743	PF00069	0.586
MOD_Plk_4	365	371	PF00069	0.614
MOD_Plk_4	373	379	PF00069	0.643
MOD_Plk_4	423	429	PF00069	0.437
MOD_Plk_4	609	615	PF00069	0.690
MOD_ProDKin_1	126	132	PF00069	0.682
MOD_ProDKin_1	148	154	PF00069	0.538
MOD_ProDKin_1	177	183	PF00069	0.634
MOD_ProDKin_1	217	223	PF00069	0.581
MOD_ProDKin_1	284	290	PF00069	0.652
MOD_ProDKin_1	314	320	PF00069	0.596
MOD_ProDKin_1	343	349	PF00069	0.582
MOD_ProDKin_1	391	397	PF00069	0.505
MOD_ProDKin_1	438	444	PF00069	0.529
MOD_ProDKin_1	481	487	PF00069	0.464
MOD_ProDKin_1	6	12	PF00069	0.672
MOD_ProDKin_1	642	648	PF00069	0.653
MOD_ProDKin_1	659	665	PF00069	0.526
MOD_ProDKin_1	744	750	PF00069	0.650
MOD_SUMO_rev_2	331	340	PF00179	0.562
TRG_DiLeu_BaEn_2	897	903	PF01217	0.502
TRG_ENDOCYTIC_2	292	295	PF00928	0.641
TRG_ENDOCYTIC_2	526	529	PF00928	0.414
TRG_ENDOCYTIC_2	573	576	PF00928	0.436
TRG_ENDOCYTIC_2	830	833	PF00928	0.473
TRG_ER_diArg_1	247	250	PF00400	0.691
TRG_ER_diArg_1	389	392	PF00400	0.418
TRG_ER_diArg_1	46	49	PF00400	0.697
TRG_ER_diArg_1	57	59	PF00400	0.599
TRG_ER_diArg_1	583	586	PF00400	0.585
TRG_ER_diArg_1	708	710	PF00400	0.712
TRG_Pf-PMV_PEXEL_1	574	579	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPU3	Leishmania donovani	83%	100%
A4H4Y3	Leishmania braziliensis	64%	97%
A4HT31	Leishmania infantum	83%	100%
Q4QIQ6	Leishmania major	83%	100%