MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL46_LEIMU

TriTrypDb:

LmxM.07.0350

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.594
CLV_NRD_NRD_1	263	265	PF00675	0.692
CLV_NRD_NRD_1	579	581	PF00675	0.787
CLV_NRD_NRD_1	599	601	PF00675	0.364
CLV_PCSK_KEX2_1	124	126	PF00082	0.594
CLV_PCSK_KEX2_1	247	249	PF00082	0.731
CLV_PCSK_KEX2_1	263	265	PF00082	0.692
CLV_PCSK_KEX2_1	275	277	PF00082	0.566
CLV_PCSK_KEX2_1	47	49	PF00082	0.764
CLV_PCSK_KEX2_1	579	581	PF00082	0.787
CLV_PCSK_KEX2_1	599	601	PF00082	0.364
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.731
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.639
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.764
CLV_PCSK_SKI1_1	148	152	PF00082	0.530
DEG_COP1_1	288	298	PF00400	0.534
DEG_SCF_FBW7_1	452	458	PF00400	0.660
DOC_ANK_TNKS_1	533	540	PF00023	0.719
DOC_CKS1_1	388	393	PF01111	0.524
DOC_CKS1_1	433	438	PF01111	0.722
DOC_CKS1_1	444	449	PF01111	0.773
DOC_CKS1_1	452	457	PF01111	0.633
DOC_CYCLIN_yCln2_LP_2	352	358	PF00134	0.534
DOC_MAPK_gen_1	624	633	PF00069	0.511
DOC_PP1_RVXF_1	41	47	PF00149	0.701
DOC_PP2B_LxvP_1	352	355	PF13499	0.534
DOC_PP4_FxxP_1	8	11	PF00568	0.756
DOC_USP7_MATH_1	381	385	PF00917	0.784
DOC_USP7_MATH_1	439	443	PF00917	0.782
DOC_USP7_MATH_1	450	454	PF00917	0.708
DOC_USP7_MATH_1	504	508	PF00917	0.837
DOC_USP7_MATH_1	619	623	PF00917	0.784
DOC_USP7_MATH_1	64	68	PF00917	0.698
DOC_USP7_UBL2_3	148	152	PF12436	0.677
DOC_USP7_UBL2_3	188	192	PF12436	0.839
DOC_USP7_UBL2_3	193	197	PF12436	0.681
DOC_USP7_UBL2_3	255	259	PF12436	0.733
DOC_USP7_UBL2_3	43	47	PF12436	0.736
DOC_WW_Pin1_4	387	392	PF00397	0.518
DOC_WW_Pin1_4	432	437	PF00397	0.764
DOC_WW_Pin1_4	443	448	PF00397	0.725
DOC_WW_Pin1_4	451	456	PF00397	0.591
DOC_WW_Pin1_4	500	505	PF00397	0.825
DOC_WW_Pin1_4	538	543	PF00397	0.815
DOC_WW_Pin1_4	580	585	PF00397	0.761
LIG_14-3-3_CanoR_1	383	387	PF00244	0.817
LIG_14-3-3_CanoR_1	423	433	PF00244	0.523
LIG_14-3-3_CanoR_1	624	630	PF00244	0.726
LIG_Actin_WH2_2	151	168	PF00022	0.519
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	550	554	PF00533	0.801
LIG_BRCT_BRCA1_1	621	625	PF00533	0.794
LIG_BRCT_BRCA1_1	650	654	PF00533	0.621
LIG_deltaCOP1_diTrp_1	33	39	PF00928	0.716
LIG_deltaCOP1_diTrp_1	644	654	PF00928	0.721
LIG_FHA_1	168	174	PF00498	0.510
LIG_FHA_1	199	205	PF00498	0.527
LIG_FHA_1	282	288	PF00498	0.617
LIG_FHA_1	313	319	PF00498	0.546
LIG_FHA_1	344	350	PF00498	0.653
LIG_FHA_1	425	431	PF00498	0.569
LIG_FHA_1	512	518	PF00498	0.816
LIG_FHA_1	626	632	PF00498	0.725
LIG_FHA_1	71	77	PF00498	0.685
LIG_FHA_1	90	96	PF00498	0.345
LIG_LIR_Apic_2	60	64	PF02991	0.731
LIG_LIR_Apic_2	639	645	PF02991	0.610
LIG_LIR_Apic_2	7	11	PF02991	0.601
LIG_LIR_Gen_1	141	150	PF02991	0.631
LIG_LIR_Gen_1	585	594	PF02991	0.717
LIG_LIR_Gen_1	67	76	PF02991	0.689
LIG_LIR_Nem_3	141	146	PF02991	0.618
LIG_LIR_Nem_3	585	591	PF02991	0.726
LIG_LIR_Nem_3	67	72	PF02991	0.597
LIG_MYND_1	538	542	PF01753	0.738
LIG_PCNA_yPIPBox_3	225	235	PF02747	0.681
LIG_Pex14_1	35	39	PF04695	0.718
LIG_Pex14_2	625	629	PF04695	0.804
LIG_SH2_CRK	132	136	PF00017	0.585
LIG_SH2_CRK	162	166	PF00017	0.618
LIG_SH2_CRK	569	573	PF00017	0.797
LIG_SH2_CRK	588	592	PF00017	0.397
LIG_SH2_PTP2	61	64	PF00017	0.726
LIG_SH2_SRC	61	64	PF00017	0.726
LIG_SH2_STAP1	132	136	PF00017	0.585
LIG_SH2_STAT5	157	160	PF00017	0.586
LIG_SH2_STAT5	525	528	PF00017	0.770
LIG_SH2_STAT5	61	64	PF00017	0.726
LIG_SH3_1	306	312	PF00018	0.632
LIG_SH3_1	449	455	PF00018	0.783
LIG_SH3_2	301	306	PF14604	0.548
LIG_SH3_2	444	449	PF14604	0.858
LIG_SH3_3	290	296	PF00018	0.824
LIG_SH3_3	298	304	PF00018	0.699
LIG_SH3_3	306	312	PF00018	0.582
LIG_SH3_3	385	391	PF00018	0.517
LIG_SH3_3	399	405	PF00018	0.483
LIG_SH3_3	441	447	PF00018	0.846
LIG_SH3_3	449	455	PF00018	0.728
LIG_TYR_ITIM	130	135	PF00017	0.571
LIG_UBA3_1	146	152	PF00899	0.656
LIG_UBA3_1	235	244	PF00899	0.701
LIG_WRC_WIRS_1	5	10	PF05994	0.766
LIG_WRC_WIRS_1	94	99	PF05994	0.648
LIG_WW_2	301	304	PF00397	0.535
MOD_CDC14_SPxK_1	583	586	PF00782	0.675
MOD_CDK_SPK_2	432	437	PF00069	0.721
MOD_CDK_SPxK_1	443	449	PF00069	0.857
MOD_CDK_SPxK_1	580	586	PF00069	0.759
MOD_CK1_1	288	294	PF00069	0.751
MOD_CK1_1	323	329	PF00069	0.723
MOD_CK1_1	382	388	PF00069	0.811
MOD_CK1_1	424	430	PF00069	0.558
MOD_CK1_1	548	554	PF00069	0.797
MOD_CK1_1	636	642	PF00069	0.631
MOD_CK2_1	617	623	PF00069	0.783
MOD_GlcNHglycan	174	177	PF01048	0.745
MOD_GlcNHglycan	180	183	PF01048	0.696
MOD_GlcNHglycan	184	187	PF01048	0.623
MOD_GlcNHglycan	322	325	PF01048	0.726
MOD_GlcNHglycan	328	331	PF01048	0.681
MOD_GlcNHglycan	408	411	PF01048	0.554
MOD_GlcNHglycan	423	426	PF01048	0.696
MOD_GlcNHglycan	487	490	PF01048	0.789
MOD_GlcNHglycan	550	553	PF01048	0.720
MOD_GSK3_1	178	185	PF00069	0.774
MOD_GSK3_1	238	245	PF00069	0.656
MOD_GSK3_1	281	288	PF00069	0.648
MOD_GSK3_1	31	38	PF00069	0.709
MOD_GSK3_1	312	319	PF00069	0.559
MOD_GSK3_1	343	350	PF00069	0.734
MOD_GSK3_1	354	361	PF00069	0.636
MOD_GSK3_1	417	424	PF00069	0.743
MOD_GSK3_1	435	442	PF00069	0.585
MOD_GSK3_1	450	457	PF00069	0.564
MOD_GSK3_1	496	503	PF00069	0.758
MOD_GSK3_1	648	655	PF00069	0.798
MOD_GSK3_1	89	96	PF00069	0.670
MOD_N-GLC_1	182	187	PF02516	0.772
MOD_N-GLC_1	97	102	PF02516	0.565
MOD_NEK2_1	146	151	PF00069	0.651
MOD_NEK2_1	289	294	PF00069	0.633
MOD_NEK2_1	495	500	PF00069	0.752
MOD_NEK2_1	625	630	PF00069	0.512
MOD_NEK2_1	76	81	PF00069	0.660
MOD_NEK2_1	97	102	PF00069	0.576
MOD_PIKK_1	602	608	PF00454	0.405
MOD_PIKK_1	62	68	PF00454	0.590
MOD_PIKK_1	70	76	PF00454	0.615
MOD_PKA_1	280	286	PF00069	0.721
MOD_PKA_2	382	388	PF00069	0.811
MOD_PKA_2	602	608	PF00069	0.405
MOD_PKA_2	625	631	PF00069	0.511
MOD_Plk_1	70	76	PF00069	0.687
MOD_Plk_2-3	87	93	PF00069	0.669
MOD_Plk_4	35	41	PF00069	0.729
MOD_ProDKin_1	387	393	PF00069	0.523
MOD_ProDKin_1	432	438	PF00069	0.764
MOD_ProDKin_1	443	449	PF00069	0.729
MOD_ProDKin_1	451	457	PF00069	0.592
MOD_ProDKin_1	500	506	PF00069	0.824
MOD_ProDKin_1	538	544	PF00069	0.816
MOD_ProDKin_1	580	586	PF00069	0.759
MOD_SUMO_for_1	274	277	PF00179	0.796
MOD_SUMO_for_1	279	282	PF00179	0.709
MOD_SUMO_for_1	591	594	PF00179	0.620
MOD_SUMO_rev_2	541	548	PF00179	0.726
TRG_ENDOCYTIC_2	132	135	PF00928	0.575
TRG_ENDOCYTIC_2	162	165	PF00928	0.607
TRG_ENDOCYTIC_2	569	572	PF00928	0.799
TRG_ENDOCYTIC_2	588	591	PF00928	0.400
TRG_ER_diArg_1	124	126	PF00400	0.594
TRG_ER_diArg_1	263	265	PF00400	0.692
TRG_ER_diArg_1	579	581	PF00400	0.787
TRG_ER_diArg_1	598	600	PF00400	0.387
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5X4	Leishmania donovani	89%	100%
A4H4Y1	Leishmania braziliensis	69%	97%
A4HT32	Leishmania infantum	89%	100%
Q4QIQ8	Leishmania major	89%	100%