Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX family hydrolase, putative

Species:

Leishmania mexicana

UniProt:

E9AL44_LEIMU

TriTrypDb:

LmxM.07.0335

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AL44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL44

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006195	purine nucleotide catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009154	purine ribonucleotide catabolic process	6	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009261	ribonucleotide catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015938	coenzyme A catabolic process	7	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033869	nucleoside bisphosphate catabolic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034031	ribonucleoside bisphosphate catabolic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034034	purine nucleoside bisphosphate catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0010945	CoA pyrophosphatase activity	6	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0003986	acetyl-CoA hydrolase activity	6	1
GO:0016289	CoA hydrolase activity	5	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.594
CLV_C14_Caspase3-7	325	329	PF00656	0.619
CLV_C14_Caspase3-7	427	431	PF00656	0.596
CLV_C14_Caspase3-7	573	577	PF00656	0.672
CLV_C14_Caspase3-7	583	587	PF00656	0.689
CLV_MEL_PAP_1	39	45	PF00089	0.343
CLV_NRD_NRD_1	120	122	PF00675	0.326
CLV_NRD_NRD_1	150	152	PF00675	0.310
CLV_NRD_NRD_1	23	25	PF00675	0.346
CLV_NRD_NRD_1	33	35	PF00675	0.302
CLV_NRD_NRD_1	453	455	PF00675	0.361
CLV_NRD_NRD_1	463	465	PF00675	0.390
CLV_NRD_NRD_1	532	534	PF00675	0.426
CLV_NRD_NRD_1	548	550	PF00675	0.449
CLV_NRD_NRD_1	64	66	PF00675	0.429
CLV_NRD_NRD_1	641	643	PF00675	0.507
CLV_NRD_NRD_1	722	724	PF00675	0.568
CLV_NRD_NRD_1	762	764	PF00675	0.472
CLV_PCSK_FUR_1	451	455	PF00082	0.308
CLV_PCSK_FUR_1	546	550	PF00082	0.494
CLV_PCSK_KEX2_1	120	122	PF00082	0.326
CLV_PCSK_KEX2_1	143	145	PF00082	0.257
CLV_PCSK_KEX2_1	150	152	PF00082	0.272
CLV_PCSK_KEX2_1	23	25	PF00082	0.346
CLV_PCSK_KEX2_1	33	35	PF00082	0.302
CLV_PCSK_KEX2_1	453	455	PF00082	0.361
CLV_PCSK_KEX2_1	463	465	PF00082	0.390
CLV_PCSK_KEX2_1	531	533	PF00082	0.428
CLV_PCSK_KEX2_1	548	550	PF00082	0.555
CLV_PCSK_KEX2_1	64	66	PF00082	0.429
CLV_PCSK_KEX2_1	640	642	PF00082	0.507
CLV_PCSK_KEX2_1	722	724	PF00082	0.568
CLV_PCSK_KEX2_1	762	764	PF00082	0.472
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.244
CLV_PCSK_PC7_1	449	455	PF00082	0.311
CLV_PCSK_PC7_1	528	534	PF00082	0.366
CLV_PCSK_SKI1_1	190	194	PF00082	0.266
CLV_PCSK_SKI1_1	217	221	PF00082	0.263
CLV_PCSK_SKI1_1	453	457	PF00082	0.373
CLV_PCSK_SKI1_1	59	63	PF00082	0.346
CLV_PCSK_SKI1_1	691	695	PF00082	0.488
CLV_Separin_Metazoa	621	625	PF03568	0.611
DEG_SCF_FBW7_1	293	300	PF00400	0.569
DEG_SCF_FBW7_2	479	486	PF00400	0.470
DEG_SCF_FBW7_2	578	583	PF00400	0.595
DEG_SPOP_SBC_1	298	302	PF00917	0.764
DEG_SPOP_SBC_1	685	689	PF00917	0.647
DEG_SPOP_SBC_1	766	770	PF00917	0.604
DEG_SPOP_SBC_1	92	96	PF00917	0.626
DOC_CKS1_1	294	299	PF01111	0.574
DOC_CKS1_1	480	485	PF01111	0.482
DOC_MAPK_gen_1	150	158	PF00069	0.483
DOC_MAPK_gen_1	33	41	PF00069	0.574
DOC_MAPK_MEF2A_6	34	43	PF00069	0.502
DOC_MAPK_MEF2A_6	752	761	PF00069	0.617
DOC_PP2B_LxvP_1	291	294	PF13499	0.563
DOC_PP2B_LxvP_1	477	480	PF13499	0.253
DOC_PP4_FxxP_1	265	268	PF00568	0.607
DOC_PP4_FxxP_1	361	364	PF00568	0.600
DOC_USP7_MATH_1	236	240	PF00917	0.440
DOC_USP7_MATH_1	261	265	PF00917	0.613
DOC_USP7_MATH_1	297	301	PF00917	0.721
DOC_USP7_MATH_1	552	556	PF00917	0.815
DOC_USP7_MATH_1	584	588	PF00917	0.609
DOC_USP7_MATH_1	628	632	PF00917	0.742
DOC_USP7_MATH_1	666	670	PF00917	0.742
DOC_USP7_MATH_1	693	697	PF00917	0.667
DOC_USP7_MATH_1	730	734	PF00917	0.700
DOC_USP7_MATH_1	75	79	PF00917	0.707
DOC_USP7_MATH_1	80	84	PF00917	0.712
DOC_USP7_MATH_1	92	96	PF00917	0.620
DOC_WW_Pin1_4	224	229	PF00397	0.463
DOC_WW_Pin1_4	293	298	PF00397	0.549
DOC_WW_Pin1_4	299	304	PF00397	0.624
DOC_WW_Pin1_4	330	335	PF00397	0.689
DOC_WW_Pin1_4	479	484	PF00397	0.474
DOC_WW_Pin1_4	537	542	PF00397	0.581
DOC_WW_Pin1_4	576	581	PF00397	0.608
DOC_WW_Pin1_4	624	629	PF00397	0.613
DOC_WW_Pin1_4	678	683	PF00397	0.714
LIG_14-3-3_CanoR_1	33	41	PF00244	0.501
LIG_14-3-3_CanoR_1	395	404	PF00244	0.556
LIG_14-3-3_CanoR_1	437	442	PF00244	0.742
LIG_14-3-3_CanoR_1	617	623	PF00244	0.656
LIG_14-3-3_CanoR_1	642	652	PF00244	0.794
LIG_14-3-3_CanoR_1	684	692	PF00244	0.649
LIG_14-3-3_CanoR_1	84	91	PF00244	0.619
LIG_Actin_WH2_2	609	626	PF00022	0.596
LIG_Actin_WH2_2	744	760	PF00022	0.632
LIG_BRCT_BRCA1_1	81	85	PF00533	0.664
LIG_Clathr_ClatBox_1	352	356	PF01394	0.497
LIG_deltaCOP1_diTrp_1	104	113	PF00928	0.557
LIG_deltaCOP1_diTrp_1	362	365	PF00928	0.575
LIG_FHA_1	105	111	PF00498	0.581
LIG_FHA_1	225	231	PF00498	0.494
LIG_FHA_1	483	489	PF00498	0.287
LIG_FHA_1	50	56	PF00498	0.631
LIG_FHA_1	617	623	PF00498	0.816
LIG_FHA_2	143	149	PF00498	0.483
LIG_FHA_2	176	182	PF00498	0.481
LIG_FHA_2	323	329	PF00498	0.747
LIG_FHA_2	346	352	PF00498	0.545
LIG_FHA_2	404	410	PF00498	0.504
LIG_FHA_2	604	610	PF00498	0.688
LIG_FHA_2	685	691	PF00498	0.627
LIG_FHA_2	71	77	PF00498	0.641
LIG_FHA_2	716	722	PF00498	0.610
LIG_FXI_DFP_1	168	172	PF00024	0.317
LIG_HCF-1_HBM_1	713	716	PF13415	0.612
LIG_Integrin_RGD_1	326	328	PF01839	0.418
LIG_LIR_Apic_2	104	109	PF02991	0.576
LIG_LIR_Apic_2	264	268	PF02991	0.612
LIG_LIR_Apic_2	589	594	PF02991	0.590
LIG_LIR_Gen_1	169	179	PF02991	0.476
LIG_LIR_Gen_1	191	199	PF02991	0.496
LIG_LIR_Gen_1	284	293	PF02991	0.581
LIG_LIR_Gen_1	462	472	PF02991	0.506
LIG_LIR_Gen_1	496	505	PF02991	0.252
LIG_LIR_Nem_3	169	174	PF02991	0.469
LIG_LIR_Nem_3	177	182	PF02991	0.454
LIG_LIR_Nem_3	191	195	PF02991	0.442
LIG_LIR_Nem_3	239	245	PF02991	0.506
LIG_LIR_Nem_3	284	288	PF02991	0.566
LIG_LIR_Nem_3	362	366	PF02991	0.606
LIG_LIR_Nem_3	386	392	PF02991	0.501
LIG_LIR_Nem_3	462	468	PF02991	0.483
LIG_LIR_Nem_3	496	500	PF02991	0.252
LIG_MAD2	758	766	PF02301	0.590
LIG_NBox_RRM_1	491	501	PF00076	0.188
LIG_Pex14_2	361	365	PF04695	0.573
LIG_SH2_CRK	375	379	PF00017	0.532
LIG_SH2_CRK	465	469	PF00017	0.360
LIG_SH2_NCK_1	179	183	PF00017	0.517
LIG_SH2_NCK_1	503	507	PF00017	0.376
LIG_SH2_NCK_1	67	71	PF00017	0.682
LIG_SH2_SRC	179	182	PF00017	0.483
LIG_SH2_SRC	67	70	PF00017	0.680
LIG_SH2_STAP1	385	389	PF00017	0.493
LIG_SH2_STAP1	503	507	PF00017	0.376
LIG_SH2_STAT5	115	118	PF00017	0.575
LIG_SH2_STAT5	285	288	PF00017	0.497
LIG_SH2_STAT5	503	506	PF00017	0.360
LIG_SH3_3	24	30	PF00018	0.540
LIG_SH3_3	255	261	PF00018	0.550
LIG_SH3_3	291	297	PF00018	0.594
LIG_SH3_3	331	337	PF00018	0.696
LIG_SH3_3	374	380	PF00018	0.571
LIG_SH3_3	477	483	PF00018	0.360
LIG_SH3_3	729	735	PF00018	0.757
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.564
LIG_SUMO_SIM_par_1	351	357	PF11976	0.524
LIG_SUMO_SIM_par_1	475	482	PF11976	0.195
LIG_TRAF2_1	178	181	PF00917	0.483
LIG_TYR_ITIM	373	378	PF00017	0.532
LIG_UBA3_1	139	143	PF00899	0.506
LIG_WRC_WIRS_1	262	267	PF05994	0.616
LIG_WRC_WIRS_1	488	493	PF05994	0.274
LIG_WRC_WIRS_1	55	60	PF05994	0.562
MOD_CDC14_SPxK_1	681	684	PF00782	0.650
MOD_CDK_SPxK_1	576	582	PF00069	0.596
MOD_CDK_SPxK_1	678	684	PF00069	0.653
MOD_CDK_SPxxK_3	333	340	PF00069	0.583
MOD_CK1_1	287	293	PF00069	0.576
MOD_CK1_1	302	308	PF00069	0.680
MOD_CK1_1	32	38	PF00069	0.574
MOD_CK1_1	330	336	PF00069	0.717
MOD_CK1_1	354	360	PF00069	0.700
MOD_CK1_1	431	437	PF00069	0.768
MOD_CK1_1	443	449	PF00069	0.595
MOD_CK1_1	683	689	PF00069	0.736
MOD_CK1_1	696	702	PF00069	0.635
MOD_CK1_1	83	89	PF00069	0.761
MOD_CK2_1	142	148	PF00069	0.483
MOD_CK2_1	175	181	PF00069	0.481
MOD_CK2_1	345	351	PF00069	0.504
MOD_CK2_1	429	435	PF00069	0.634
MOD_CK2_1	456	462	PF00069	0.577
MOD_CK2_1	603	609	PF00069	0.691
MOD_CK2_1	615	621	PF00069	0.703
MOD_CK2_1	70	76	PF00069	0.639
MOD_CK2_1	715	721	PF00069	0.620
MOD_CMANNOS	339	342	PF00535	0.354
MOD_CMANNOS	394	397	PF00535	0.357
MOD_CMANNOS	590	593	PF00535	0.430
MOD_GlcNHglycan	152	155	PF01048	0.306
MOD_GlcNHglycan	2	5	PF01048	0.378
MOD_GlcNHglycan	330	333	PF01048	0.497
MOD_GlcNHglycan	34	37	PF01048	0.300
MOD_GlcNHglycan	470	473	PF01048	0.360
MOD_GlcNHglycan	554	557	PF01048	0.510
MOD_GlcNHglycan	572	575	PF01048	0.531
MOD_GlcNHglycan	603	606	PF01048	0.461
MOD_GlcNHglycan	612	615	PF01048	0.567
MOD_GlcNHglycan	632	635	PF01048	0.571
MOD_GlcNHglycan	645	648	PF01048	0.408
MOD_GlcNHglycan	695	698	PF01048	0.613
MOD_GlcNHglycan	701	704	PF01048	0.559
MOD_GlcNHglycan	710	713	PF01048	0.432
MOD_GlcNHglycan	76	80	PF01048	0.513
MOD_GlcNHglycan	86	89	PF01048	0.400
MOD_GSK3_1	293	300	PF00069	0.730
MOD_GSK3_1	302	309	PF00069	0.635
MOD_GSK3_1	424	431	PF00069	0.724
MOD_GSK3_1	433	440	PF00069	0.691
MOD_GSK3_1	49	56	PF00069	0.566
MOD_GSK3_1	578	585	PF00069	0.699
MOD_GSK3_1	624	631	PF00069	0.615
MOD_GSK3_1	674	681	PF00069	0.721
MOD_GSK3_1	692	699	PF00069	0.678
MOD_GSK3_1	75	82	PF00069	0.733
MOD_NEK2_1	142	147	PF00069	0.483
MOD_NEK2_1	365	370	PF00069	0.533
MOD_NEK2_1	429	434	PF00069	0.715
MOD_NEK2_1	456	461	PF00069	0.556
MOD_NEK2_1	692	697	PF00069	0.799
MOD_NEK2_1	91	96	PF00069	0.576
MOD_NEK2_2	236	241	PF00069	0.440
MOD_NEK2_2	342	347	PF00069	0.574
MOD_NEK2_2	54	59	PF00069	0.563
MOD_PIKK_1	14	20	PF00454	0.547
MOD_PIKK_1	44	50	PF00454	0.588
MOD_PKA_1	150	156	PF00069	0.505
MOD_PKA_2	14	20	PF00069	0.441
MOD_PKA_2	150	156	PF00069	0.458
MOD_PKA_2	175	181	PF00069	0.517
MOD_PKA_2	32	38	PF00069	0.616
MOD_PKA_2	436	442	PF00069	0.690
MOD_PKA_2	616	622	PF00069	0.654
MOD_PKA_2	683	689	PF00069	0.643
MOD_PKA_2	83	89	PF00069	0.689
MOD_Plk_2-3	351	357	PF00069	0.547
MOD_Plk_2-3	557	563	PF00069	0.689
MOD_Plk_4	281	287	PF00069	0.552
MOD_Plk_4	437	443	PF00069	0.635
MOD_Plk_4	540	546	PF00069	0.699
MOD_Plk_4	567	573	PF00069	0.686
MOD_ProDKin_1	224	230	PF00069	0.463
MOD_ProDKin_1	293	299	PF00069	0.560
MOD_ProDKin_1	330	336	PF00069	0.677
MOD_ProDKin_1	479	485	PF00069	0.477
MOD_ProDKin_1	537	543	PF00069	0.582
MOD_ProDKin_1	576	582	PF00069	0.609
MOD_ProDKin_1	624	630	PF00069	0.615
MOD_ProDKin_1	678	684	PF00069	0.715
MOD_SUMO_rev_2	750	760	PF00179	0.659
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.579
TRG_ENDOCYTIC_2	179	182	PF00928	0.506
TRG_ENDOCYTIC_2	285	288	PF00928	0.497
TRG_ENDOCYTIC_2	375	378	PF00928	0.573
TRG_ENDOCYTIC_2	384	387	PF00928	0.464
TRG_ENDOCYTIC_2	465	468	PF00928	0.300
TRG_ER_diArg_1	150	152	PF00400	0.481
TRG_ER_diArg_1	23	25	PF00400	0.546
TRG_ER_diArg_1	255	258	PF00400	0.617
TRG_ER_diArg_1	402	405	PF00400	0.602
TRG_ER_diArg_1	449	452	PF00400	0.597
TRG_ER_diArg_1	453	455	PF00400	0.564
TRG_ER_diArg_1	463	465	PF00400	0.558
TRG_ER_diArg_1	531	533	PF00400	0.659
TRG_ER_diArg_1	545	548	PF00400	0.737
TRG_ER_diArg_1	640	642	PF00400	0.707
TRG_ER_diArg_1	761	763	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.188

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6E0	Leptomonas seymouri	40%	100%
A0A1X0NPA0	Trypanosomatidae	34%	100%
A0A3S7WPU2	Leishmania donovani	83%	99%
A4H4X9	Leishmania braziliensis	63%	100%
A4HT52	Leishmania infantum	84%	84%
Q4QIR0	Leishmania major	81%	100%