Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3735)/Abscisic acid G-protein coupled receptor, putative

Species:

Leishmania mexicana

UniProt:

E9AL43_LEIMU

TriTrypDb:

LmxM.07.0330

Length:

826

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AL43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.376
CLV_NRD_NRD_1	174	176	PF00675	0.455
CLV_NRD_NRD_1	241	243	PF00675	0.718
CLV_NRD_NRD_1	328	330	PF00675	0.788
CLV_NRD_NRD_1	395	397	PF00675	0.292
CLV_NRD_NRD_1	402	404	PF00675	0.364
CLV_NRD_NRD_1	662	664	PF00675	0.492
CLV_PCSK_KEX2_1	144	146	PF00082	0.488
CLV_PCSK_KEX2_1	174	176	PF00082	0.455
CLV_PCSK_KEX2_1	241	243	PF00082	0.718
CLV_PCSK_KEX2_1	328	330	PF00082	0.790
CLV_PCSK_KEX2_1	661	663	PF00082	0.492
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.448
CLV_PCSK_SKI1_1	103	107	PF00082	0.476
CLV_PCSK_SKI1_1	202	206	PF00082	0.430
CLV_PCSK_SKI1_1	328	332	PF00082	0.625
CLV_PCSK_SKI1_1	357	361	PF00082	0.512
CLV_PCSK_SKI1_1	605	609	PF00082	0.376
CLV_PCSK_SKI1_1	700	704	PF00082	0.354
DEG_APCC_DBOX_1	201	209	PF00400	0.605
DEG_APCC_DBOX_1	402	410	PF00400	0.471
DEG_APCC_DBOX_1	699	707	PF00400	0.335
DEG_APCC_DBOX_1	805	813	PF00400	0.610
DEG_SCF_FBW7_1	471	478	PF00400	0.612
DOC_ANK_TNKS_1	661	668	PF00023	0.376
DOC_CKS1_1	432	437	PF01111	0.566
DOC_CKS1_1	472	477	PF01111	0.614
DOC_CYCLIN_RxL_1	325	335	PF00134	0.408
DOC_CYCLIN_RxL_1	580	588	PF00134	0.652
DOC_MAPK_gen_1	200	208	PF00069	0.491
DOC_MAPK_gen_1	248	256	PF00069	0.396
DOC_MAPK_HePTP_8	100	112	PF00069	0.276
DOC_MAPK_MEF2A_6	103	112	PF00069	0.276
DOC_MAPK_MEF2A_6	200	208	PF00069	0.571
DOC_MAPK_MEF2A_6	357	365	PF00069	0.292
DOC_MAPK_MEF2A_6	612	621	PF00069	0.492
DOC_MAPK_MEF2A_6	720	728	PF00069	0.492
DOC_PP1_RVXF_1	198	204	PF00149	0.699
DOC_PP2B_LxvP_1	254	257	PF13499	0.500
DOC_PP2B_LxvP_1	62	65	PF13499	0.356
DOC_PP4_FxxP_1	159	162	PF00568	0.600
DOC_PP4_FxxP_1	381	384	PF00568	0.335
DOC_USP7_MATH_1	162	166	PF00917	0.715
DOC_USP7_MATH_1	339	343	PF00917	0.527
DOC_USP7_MATH_1	353	357	PF00917	0.225
DOC_USP7_MATH_1	458	462	PF00917	0.626
DOC_USP7_MATH_1	475	479	PF00917	0.623
DOC_USP7_MATH_1	491	495	PF00917	0.711
DOC_USP7_MATH_1	509	513	PF00917	0.619
DOC_USP7_MATH_1	545	549	PF00917	0.640
DOC_USP7_MATH_1	58	62	PF00917	0.435
DOC_USP7_MATH_1	67	71	PF00917	0.424
DOC_USP7_MATH_1	750	754	PF00917	0.219
DOC_USP7_MATH_1	88	92	PF00917	0.366
DOC_WW_Pin1_4	374	379	PF00397	0.335
DOC_WW_Pin1_4	431	436	PF00397	0.680
DOC_WW_Pin1_4	438	443	PF00397	0.675
DOC_WW_Pin1_4	448	453	PF00397	0.721
DOC_WW_Pin1_4	471	476	PF00397	0.641
DOC_WW_Pin1_4	541	546	PF00397	0.715
DOC_WW_Pin1_4	550	555	PF00397	0.706
DOC_WW_Pin1_4	763	768	PF00397	0.276
LIG_14-3-3_CanoR_1	233	240	PF00244	0.516
LIG_14-3-3_CanoR_1	250	254	PF00244	0.437
LIG_14-3-3_CanoR_1	275	279	PF00244	0.486
LIG_14-3-3_CanoR_1	357	362	PF00244	0.311
LIG_14-3-3_CanoR_1	497	503	PF00244	0.641
LIG_14-3-3_CanoR_1	571	576	PF00244	0.619
LIG_14-3-3_CanoR_1	583	588	PF00244	0.566
LIG_14-3-3_CanoR_1	605	610	PF00244	0.576
LIG_14-3-3_CanoR_1	744	748	PF00244	0.376
LIG_14-3-3_CanoR_1	784	792	PF00244	0.330
LIG_14-3-3_CanoR_1	99	107	PF00244	0.456
LIG_Actin_WH2_2	586	603	PF00022	0.566
LIG_Actin_WH2_2	730	746	PF00022	0.453
LIG_BIR_III_4	316	320	PF00653	0.548
LIG_BRCT_BRCA1_1	168	172	PF00533	0.760
LIG_BRCT_BRCA1_1	193	197	PF00533	0.651
LIG_BRCT_BRCA1_1	50	54	PF00533	0.276
LIG_deltaCOP1_diTrp_1	430	437	PF00928	0.642
LIG_deltaCOP1_diTrp_1	787	790	PF00928	0.335
LIG_EH1_1	593	601	PF00400	0.597
LIG_EH1_1	734	742	PF00400	0.335
LIG_eIF4E_1	14	20	PF01652	0.331
LIG_eIF4E_1	735	741	PF01652	0.335
LIG_FHA_1	104	110	PF00498	0.255
LIG_FHA_1	249	255	PF00498	0.487
LIG_FHA_1	353	359	PF00498	0.292
LIG_FHA_1	40	46	PF00498	0.335
LIG_FHA_1	520	526	PF00498	0.664
LIG_FHA_1	553	559	PF00498	0.773
LIG_FHA_1	646	652	PF00498	0.292
LIG_FHA_1	655	661	PF00498	0.300
LIG_FHA_1	678	684	PF00498	0.353
LIG_FHA_1	721	727	PF00498	0.476
LIG_FHA_1	764	770	PF00498	0.271
LIG_FHA_2	462	468	PF00498	0.618
LIG_FHA_2	650	656	PF00498	0.276
LIG_FHA_2	672	678	PF00498	0.376
LIG_IBAR_NPY_1	470	472	PF08397	0.732
LIG_LIR_Apic_2	157	162	PF02991	0.598
LIG_LIR_Apic_2	430	435	PF02991	0.630
LIG_LIR_Gen_1	104	115	PF02991	0.325
LIG_LIR_Gen_1	370	380	PF02991	0.453
LIG_LIR_Gen_1	48	58	PF02991	0.335
LIG_LIR_Gen_1	582	591	PF02991	0.588
LIG_LIR_Gen_1	622	631	PF02991	0.294
LIG_LIR_Gen_1	786	792	PF02991	0.339
LIG_LIR_Gen_1	9	16	PF02991	0.328
LIG_LIR_Nem_3	104	110	PF02991	0.378
LIG_LIR_Nem_3	370	375	PF02991	0.453
LIG_LIR_Nem_3	464	469	PF02991	0.617
LIG_LIR_Nem_3	474	479	PF02991	0.644
LIG_LIR_Nem_3	48	53	PF02991	0.335
LIG_LIR_Nem_3	582	587	PF02991	0.589
LIG_LIR_Nem_3	588	593	PF02991	0.535
LIG_LIR_Nem_3	622	627	PF02991	0.294
LIG_LIR_Nem_3	776	782	PF02991	0.341
LIG_LIR_Nem_3	786	791	PF02991	0.284
LIG_LIR_Nem_3	85	89	PF02991	0.399
LIG_LIR_Nem_3	9	13	PF02991	0.352
LIG_NRBOX	107	113	PF00104	0.339
LIG_NRBOX	204	210	PF00104	0.453
LIG_Pex14_2	184	188	PF04695	0.641
LIG_Pex14_2	39	43	PF04695	0.335
LIG_Pex14_2	50	54	PF04695	0.335
LIG_PTB_Apo_2	178	185	PF02174	0.604
LIG_SH2_CRK	372	376	PF00017	0.335
LIG_SH2_CRK	425	429	PF00017	0.590
LIG_SH2_CRK	466	470	PF00017	0.750
LIG_SH2_CRK	472	476	PF00017	0.763
LIG_SH2_CRK	614	618	PF00017	0.335
LIG_SH2_CRK	624	628	PF00017	0.335
LIG_SH2_CRK	782	786	PF00017	0.292
LIG_SH2_NCK_1	372	376	PF00017	0.335
LIG_SH2_STAP1	10	14	PF00017	0.335
LIG_SH2_STAT3	780	783	PF00017	0.292
LIG_SH2_STAT5	15	18	PF00017	0.507
LIG_SH2_STAT5	244	247	PF00017	0.549
LIG_SH2_STAT5	385	388	PF00017	0.497
LIG_SH2_STAT5	408	411	PF00017	0.565
LIG_SH2_STAT5	5	8	PF00017	0.310
LIG_SH2_STAT5	590	593	PF00017	0.556
LIG_SH2_STAT5	735	738	PF00017	0.335
LIG_SH2_STAT5	814	817	PF00017	0.683
LIG_SH2_STAT5	823	826	PF00017	0.666
LIG_SH3_2	324	329	PF14604	0.578
LIG_SH3_3	115	121	PF00018	0.389
LIG_SH3_3	22	28	PF00018	0.550
LIG_SH3_3	296	302	PF00018	0.528
LIG_SH3_3	305	311	PF00018	0.546
LIG_SH3_3	321	327	PF00018	0.474
LIG_SH3_3	372	378	PF00018	0.389
LIG_SH3_3	465	471	PF00018	0.735
LIG_SH3_3	503	509	PF00018	0.696
LIG_SH3_3	548	554	PF00018	0.700
LIG_SH3_3	555	561	PF00018	0.677
LIG_Sin3_3	60	67	PF02671	0.445
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.356
LIG_SUMO_SIM_par_1	108	114	PF11976	0.391
LIG_SUMO_SIM_par_1	739	746	PF11976	0.335
LIG_TRAF2_1	277	280	PF00917	0.549
LIG_TYR_ITIM	423	428	PF00017	0.580
LIG_TYR_ITSM	620	627	PF00017	0.278
LIG_WRC_WIRS_1	476	481	PF05994	0.621
LIG_WRC_WIRS_1	668	673	PF05994	0.262
MOD_CDC14_SPxK_1	451	454	PF00782	0.717
MOD_CDK_SPxK_1	448	454	PF00069	0.697
MOD_CK1_1	101	107	PF00069	0.231
MOD_CK1_1	127	133	PF00069	0.379
MOD_CK1_1	149	155	PF00069	0.648
MOD_CK1_1	165	171	PF00069	0.668
MOD_CK1_1	236	242	PF00069	0.471
MOD_CK1_1	433	439	PF00069	0.619
MOD_CK1_1	443	449	PF00069	0.668
MOD_CK1_1	461	467	PF00069	0.623
MOD_CK1_1	48	54	PF00069	0.385
MOD_CK1_1	544	550	PF00069	0.709
MOD_CK1_1	553	559	PF00069	0.686
MOD_CK1_1	579	585	PF00069	0.650
MOD_CK1_1	639	645	PF00069	0.205
MOD_CK1_1	716	722	PF00069	0.436
MOD_CK2_1	173	179	PF00069	0.690
MOD_CK2_1	274	280	PF00069	0.554
MOD_CK2_1	283	289	PF00069	0.443
MOD_CK2_1	339	345	PF00069	0.366
MOD_CK2_1	649	655	PF00069	0.276
MOD_CK2_1	671	677	PF00069	0.417
MOD_CK2_1	716	722	PF00069	0.404
MOD_CK2_1	814	820	PF00069	0.607
MOD_CMANNOS	83	86	PF00535	0.724
MOD_Cter_Amidation	142	145	PF01082	0.498
MOD_Cter_Amidation	172	175	PF01082	0.423
MOD_GlcNHglycan	100	103	PF01048	0.665
MOD_GlcNHglycan	154	157	PF01048	0.485
MOD_GlcNHglycan	162	165	PF01048	0.485
MOD_GlcNHglycan	224	227	PF01048	0.598
MOD_GlcNHglycan	265	268	PF01048	0.812
MOD_GlcNHglycan	285	288	PF01048	0.683
MOD_GlcNHglycan	341	344	PF01048	0.679
MOD_GlcNHglycan	369	372	PF01048	0.494
MOD_GlcNHglycan	445	448	PF01048	0.500
MOD_GlcNHglycan	460	463	PF01048	0.525
MOD_GlcNHglycan	480	484	PF01048	0.531
MOD_GlcNHglycan	50	53	PF01048	0.351
MOD_GlcNHglycan	555	558	PF01048	0.503
MOD_GlcNHglycan	578	581	PF01048	0.403
MOD_GlcNHglycan	65	68	PF01048	0.668
MOD_GlcNHglycan	70	73	PF01048	0.688
MOD_GlcNHglycan	713	716	PF01048	0.298
MOD_GlcNHglycan	816	819	PF01048	0.395
MOD_GSK3_1	134	141	PF00069	0.705
MOD_GSK3_1	145	152	PF00069	0.651
MOD_GSK3_1	160	167	PF00069	0.638
MOD_GSK3_1	173	180	PF00069	0.708
MOD_GSK3_1	232	239	PF00069	0.499
MOD_GSK3_1	242	249	PF00069	0.533
MOD_GSK3_1	261	268	PF00069	0.425
MOD_GSK3_1	269	276	PF00069	0.573
MOD_GSK3_1	353	360	PF00069	0.337
MOD_GSK3_1	39	46	PF00069	0.352
MOD_GSK3_1	446	453	PF00069	0.648
MOD_GSK3_1	471	478	PF00069	0.723
MOD_GSK3_1	541	548	PF00069	0.817
MOD_GSK3_1	552	559	PF00069	0.680
MOD_GSK3_1	579	586	PF00069	0.591
MOD_GSK3_1	63	70	PF00069	0.515
MOD_GSK3_1	632	639	PF00069	0.334
MOD_GSK3_1	645	652	PF00069	0.270
MOD_GSK3_1	667	674	PF00069	0.376
MOD_GSK3_1	707	714	PF00069	0.492
MOD_GSK3_1	716	723	PF00069	0.492
MOD_GSK3_1	808	815	PF00069	0.587
MOD_NEK2_1	111	116	PF00069	0.284
MOD_NEK2_1	124	129	PF00069	0.324
MOD_NEK2_1	39	44	PF00069	0.345
MOD_NEK2_1	45	50	PF00069	0.341
MOD_NEK2_1	479	484	PF00069	0.702
MOD_NEK2_1	496	501	PF00069	0.710
MOD_NEK2_1	585	590	PF00069	0.570
MOD_NEK2_1	636	641	PF00069	0.293
MOD_NEK2_1	654	659	PF00069	0.287
MOD_NEK2_1	671	676	PF00069	0.212
MOD_NEK2_1	695	700	PF00069	0.327
MOD_NEK2_1	707	712	PF00069	0.519
MOD_NEK2_1	713	718	PF00069	0.580
MOD_NEK2_1	742	747	PF00069	0.354
MOD_NEK2_1	805	810	PF00069	0.681
MOD_NEK2_1	98	103	PF00069	0.464
MOD_NEK2_2	545	550	PF00069	0.618
MOD_PIKK_1	509	515	PF00454	0.736
MOD_PIKK_1	640	646	PF00454	0.276
MOD_PK_1	233	239	PF00069	0.523
MOD_PKA_2	134	140	PF00069	0.756
MOD_PKA_2	149	155	PF00069	0.625
MOD_PKA_2	173	179	PF00069	0.698
MOD_PKA_2	222	228	PF00069	0.469
MOD_PKA_2	232	238	PF00069	0.513
MOD_PKA_2	249	255	PF00069	0.402
MOD_PKA_2	274	280	PF00069	0.567
MOD_PKA_2	496	502	PF00069	0.735
MOD_PKA_2	743	749	PF00069	0.376
MOD_PKA_2	783	789	PF00069	0.330
MOD_PKA_2	805	811	PF00069	0.636
MOD_PKA_2	98	104	PF00069	0.463
MOD_PKB_1	175	183	PF00069	0.651
MOD_Plk_1	58	64	PF00069	0.508
MOD_Plk_1	654	660	PF00069	0.392
MOD_Plk_4	111	117	PF00069	0.336
MOD_Plk_4	249	255	PF00069	0.589
MOD_Plk_4	383	389	PF00069	0.576
MOD_Plk_4	45	51	PF00069	0.335
MOD_Plk_4	545	551	PF00069	0.618
MOD_Plk_4	58	64	PF00069	0.424
MOD_Plk_4	585	591	PF00069	0.563
MOD_Plk_4	605	611	PF00069	0.619
MOD_Plk_4	619	625	PF00069	0.338
MOD_Plk_4	632	638	PF00069	0.309
MOD_Plk_4	649	655	PF00069	0.338
MOD_Plk_4	726	732	PF00069	0.335
MOD_Plk_4	808	814	PF00069	0.582
MOD_Plk_4	82	88	PF00069	0.522
MOD_ProDKin_1	374	380	PF00069	0.335
MOD_ProDKin_1	431	437	PF00069	0.686
MOD_ProDKin_1	438	444	PF00069	0.678
MOD_ProDKin_1	448	454	PF00069	0.722
MOD_ProDKin_1	471	477	PF00069	0.640
MOD_ProDKin_1	541	547	PF00069	0.716
MOD_ProDKin_1	550	556	PF00069	0.703
MOD_ProDKin_1	763	769	PF00069	0.276
MOD_SUMO_for_1	306	309	PF00179	0.577
MOD_SUMO_rev_2	259	265	PF00179	0.559
TRG_DiLeu_BaEn_1	59	64	PF01217	0.341
TRG_ENDOCYTIC_2	10	13	PF00928	0.335
TRG_ENDOCYTIC_2	244	247	PF00928	0.478
TRG_ENDOCYTIC_2	372	375	PF00928	0.335
TRG_ENDOCYTIC_2	425	428	PF00928	0.587
TRG_ENDOCYTIC_2	466	469	PF00928	0.782
TRG_ENDOCYTIC_2	476	479	PF00928	0.668
TRG_ENDOCYTIC_2	590	593	PF00928	0.570
TRG_ENDOCYTIC_2	614	617	PF00928	0.335
TRG_ENDOCYTIC_2	624	627	PF00928	0.335
TRG_ENDOCYTIC_2	782	785	PF00928	0.292
TRG_ER_diArg_1	174	177	PF00400	0.688
TRG_ER_diArg_1	200	203	PF00400	0.667
TRG_ER_diArg_1	240	242	PF00400	0.476
TRG_ER_diArg_1	327	329	PF00400	0.577
TRG_ER_diArg_1	388	391	PF00400	0.492
TRG_ER_diArg_1	660	663	PF00400	0.292
TRG_Pf-PMV_PEXEL_1	573	578	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R5	Leptomonas seymouri	52%	100%
A0A3S7WPT2	Leishmania donovani	83%	99%
A4H4X8	Leishmania braziliensis	68%	100%
A4HT51	Leishmania infantum	83%	99%
Q4QIR1	Leishmania major	84%	100%