Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL42_LEIMU

TriTrypDb:

LmxM.07.0320

Length:

1032

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AL42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.720
CLV_C14_Caspase3-7	616	620	PF00656	0.703
CLV_C14_Caspase3-7	709	713	PF00656	0.677
CLV_C14_Caspase3-7	758	762	PF00656	0.734
CLV_C14_Caspase3-7	787	791	PF00656	0.487
CLV_C14_Caspase3-7	840	844	PF00656	0.664
CLV_C14_Caspase3-7	959	963	PF00656	0.450
CLV_NRD_NRD_1	1003	1005	PF00675	0.557
CLV_NRD_NRD_1	2	4	PF00675	0.554
CLV_NRD_NRD_1	257	259	PF00675	0.543
CLV_NRD_NRD_1	89	91	PF00675	0.702
CLV_NRD_NRD_1	907	909	PF00675	0.512
CLV_PCSK_KEX2_1	1003	1005	PF00082	0.557
CLV_PCSK_KEX2_1	2	4	PF00082	0.557
CLV_PCSK_KEX2_1	89	91	PF00082	0.702
CLV_PCSK_SKI1_1	258	262	PF00082	0.438
CLV_PCSK_SKI1_1	423	427	PF00082	0.414
CLV_PCSK_SKI1_1	993	997	PF00082	0.401
CLV_Separin_Metazoa	1006	1010	PF03568	0.324
DEG_APCC_DBOX_1	257	265	PF00400	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.633
DEG_SCF_FBW7_1	649	656	PF00400	0.457
DEG_SCF_FBW7_2	284	290	PF00400	0.562
DEG_SPOP_SBC_1	684	688	PF00917	0.662
DOC_AGCK_PIF_1	56	61	PF00069	0.281
DOC_CDC14_PxL_1	942	950	PF14671	0.420
DOC_CKS1_1	284	289	PF01111	0.583
DOC_CKS1_1	309	314	PF01111	0.501
DOC_CYCLIN_RxL_1	558	567	PF00134	0.686
DOC_MAPK_DCC_7	360	368	PF00069	0.457
DOC_MAPK_gen_1	1000	1010	PF00069	0.511
DOC_MAPK_gen_1	258	264	PF00069	0.539
DOC_MAPK_gen_1	360	368	PF00069	0.365
DOC_MAPK_gen_1	418	427	PF00069	0.444
DOC_MAPK_gen_1	493	501	PF00069	0.623
DOC_MAPK_gen_1	559	568	PF00069	0.685
DOC_MAPK_MEF2A_6	169	176	PF00069	0.259
DOC_MAPK_MEF2A_6	362	370	PF00069	0.378
DOC_PP1_RVXF_1	559	566	PF00149	0.683
DOC_PP1_RVXF_1	947	954	PF00149	0.446
DOC_PP2B_LxvP_1	157	160	PF13499	0.499
DOC_PP4_FxxP_1	309	312	PF00568	0.421
DOC_USP7_MATH_1	489	493	PF00917	0.693
DOC_USP7_MATH_1	628	632	PF00917	0.738
DOC_USP7_MATH_1	653	657	PF00917	0.616
DOC_USP7_MATH_1	684	688	PF00917	0.701
DOC_USP7_MATH_1	735	739	PF00917	0.686
DOC_USP7_MATH_1	78	82	PF00917	0.770
DOC_USP7_MATH_1	814	818	PF00917	0.685
DOC_USP7_MATH_1	84	88	PF00917	0.800
DOC_USP7_MATH_1	91	95	PF00917	0.750
DOC_USP7_UBL2_3	165	169	PF12436	0.448
DOC_WW_Pin1_4	1013	1018	PF00397	0.518
DOC_WW_Pin1_4	20	25	PF00397	0.439
DOC_WW_Pin1_4	264	269	PF00397	0.505
DOC_WW_Pin1_4	283	288	PF00397	0.615
DOC_WW_Pin1_4	308	313	PF00397	0.448
DOC_WW_Pin1_4	320	325	PF00397	0.452
DOC_WW_Pin1_4	361	366	PF00397	0.576
DOC_WW_Pin1_4	50	55	PF00397	0.667
DOC_WW_Pin1_4	525	530	PF00397	0.785
DOC_WW_Pin1_4	538	543	PF00397	0.479
DOC_WW_Pin1_4	580	585	PF00397	0.707
DOC_WW_Pin1_4	649	654	PF00397	0.691
DOC_WW_Pin1_4	664	669	PF00397	0.566
DOC_WW_Pin1_4	67	72	PF00397	0.614
DOC_WW_Pin1_4	748	753	PF00397	0.539
DOC_WW_Pin1_4	823	828	PF00397	0.742
LIG_14-3-3_CanoR_1	208	213	PF00244	0.390
LIG_14-3-3_CanoR_1	215	219	PF00244	0.375
LIG_14-3-3_CanoR_1	244	253	PF00244	0.506
LIG_14-3-3_CanoR_1	423	428	PF00244	0.420
LIG_14-3-3_CanoR_1	594	599	PF00244	0.722
LIG_14-3-3_CanoR_1	630	634	PF00244	0.657
LIG_14-3-3_CanoR_1	689	693	PF00244	0.725
LIG_14-3-3_CanoR_1	750	756	PF00244	0.759
LIG_14-3-3_CanoR_1	901	906	PF00244	0.535
LIG_14-3-3_CanoR_1	95	101	PF00244	0.679
LIG_14-3-3_CanoR_1	993	1001	PF00244	0.495
LIG_Actin_WH2_2	186	202	PF00022	0.605
LIG_Actin_WH2_2	326	341	PF00022	0.598
LIG_Actin_WH2_2	934	951	PF00022	0.439
LIG_Actin_WH2_2	994	1011	PF00022	0.324
LIG_BIR_III_2	518	522	PF00653	0.714
LIG_BRCT_BRCA1_1	52	56	PF00533	0.553
LIG_BRCT_BRCA1_1	644	648	PF00533	0.540
LIG_deltaCOP1_diTrp_1	4	11	PF00928	0.464
LIG_EH1_1	229	237	PF00400	0.375
LIG_eIF4E_1	256	262	PF01652	0.498
LIG_eIF4E_1	468	474	PF01652	0.458
LIG_FHA_1	140	146	PF00498	0.521
LIG_FHA_1	283	289	PF00498	0.580
LIG_FHA_1	325	331	PF00498	0.519
LIG_FHA_1	335	341	PF00498	0.431
LIG_FHA_1	417	423	PF00498	0.542
LIG_FHA_1	60	66	PF00498	0.386
LIG_FHA_1	638	644	PF00498	0.666
LIG_FHA_1	650	656	PF00498	0.707
LIG_FHA_1	797	803	PF00498	0.781
LIG_FHA_1	808	814	PF00498	0.594
LIG_FHA_1	828	834	PF00498	0.552
LIG_FHA_1	915	921	PF00498	0.463
LIG_FHA_1	994	1000	PF00498	0.400
LIG_FHA_2	130	136	PF00498	0.683
LIG_FHA_2	215	221	PF00498	0.527
LIG_FHA_2	246	252	PF00498	0.452
LIG_FHA_2	46	52	PF00498	0.735
LIG_FHA_2	973	979	PF00498	0.548
LIG_GBD_Chelix_1	440	448	PF00786	0.553
LIG_LIR_Apic_2	152	158	PF02991	0.498
LIG_LIR_Gen_1	27	38	PF02991	0.597
LIG_LIR_Gen_1	341	351	PF02991	0.559
LIG_LIR_Gen_1	386	397	PF02991	0.426
LIG_LIR_Gen_1	53	61	PF02991	0.589
LIG_LIR_Nem_3	27	33	PF02991	0.514
LIG_LIR_Nem_3	276	282	PF02991	0.545
LIG_LIR_Nem_3	293	298	PF02991	0.313
LIG_LIR_Nem_3	341	346	PF02991	0.488
LIG_LIR_Nem_3	386	392	PF02991	0.455
LIG_LIR_Nem_3	426	432	PF02991	0.467
LIG_LIR_Nem_3	53	59	PF02991	0.590
LIG_LYPXL_yS_3	380	383	PF13949	0.498
LIG_PCNA_yPIPBox_3	447	457	PF02747	0.502
LIG_Pex14_1	26	30	PF04695	0.437
LIG_Pex14_2	7	11	PF04695	0.428
LIG_Rb_LxCxE_1	364	376	PF01857	0.552
LIG_RPA_C_Fungi	488	500	PF08784	0.675
LIG_SH2_CRK	155	159	PF00017	0.475
LIG_SH2_CRK	265	269	PF00017	0.515
LIG_SH2_CRK	279	283	PF00017	0.581
LIG_SH2_GRB2like	952	955	PF00017	0.424
LIG_SH2_NCK_1	265	269	PF00017	0.465
LIG_SH2_NCK_1	736	740	PF00017	0.482
LIG_SH2_NCK_1	968	972	PF00017	0.463
LIG_SH2_SRC	228	231	PF00017	0.375
LIG_SH2_SRC	300	303	PF00017	0.522
LIG_SH2_STAP1	343	347	PF00017	0.532
LIG_SH2_STAP1	61	65	PF00017	0.511
LIG_SH2_STAP1	736	740	PF00017	0.598
LIG_SH2_STAP1	859	863	PF00017	0.625
LIG_SH2_STAT3	468	471	PF00017	0.438
LIG_SH2_STAT3	479	482	PF00017	0.498
LIG_SH2_STAT5	155	158	PF00017	0.436
LIG_SH2_STAT5	216	219	PF00017	0.462
LIG_SH2_STAT5	228	231	PF00017	0.379
LIG_SH2_STAT5	241	244	PF00017	0.383
LIG_SH2_STAT5	256	259	PF00017	0.410
LIG_SH2_STAT5	300	303	PF00017	0.423
LIG_SH2_STAT5	454	457	PF00017	0.470
LIG_SH2_STAT5	468	471	PF00017	0.354
LIG_SH2_STAT5	479	482	PF00017	0.523
LIG_SH2_STAT5	61	64	PF00017	0.499
LIG_SH2_STAT5	770	773	PF00017	0.502
LIG_SH2_STAT5	905	908	PF00017	0.497
LIG_SH2_STAT5	929	932	PF00017	0.419
LIG_SH2_STAT5	952	955	PF00017	0.424
LIG_SH3_1	908	914	PF00018	0.417
LIG_SH3_2	312	317	PF14604	0.428
LIG_SH3_3	120	126	PF00018	0.720
LIG_SH3_3	257	263	PF00018	0.545
LIG_SH3_3	309	315	PF00018	0.405
LIG_SH3_3	404	410	PF00018	0.487
LIG_SH3_3	44	50	PF00018	0.448
LIG_SH3_3	526	532	PF00018	0.617
LIG_SH3_3	578	584	PF00018	0.749
LIG_SH3_3	65	71	PF00018	0.615
LIG_SH3_3	908	914	PF00018	0.440
LIG_SUMO_SIM_anti_2	62	70	PF11976	0.378
LIG_TRAF2_1	583	586	PF00917	0.658
LIG_TRAF2_1	731	734	PF00917	0.692
LIG_TRAF2_1	919	922	PF00917	0.534
MOD_CDC14_SPxK_1	267	270	PF00782	0.528
MOD_CDC14_SPxK_1	323	326	PF00782	0.656
MOD_CDK_SPxK_1	264	270	PF00069	0.515
MOD_CDK_SPxK_1	320	326	PF00069	0.625
MOD_CK1_1	116	122	PF00069	0.730
MOD_CK1_1	411	417	PF00069	0.358
MOD_CK1_1	531	537	PF00069	0.800
MOD_CK1_1	632	638	PF00069	0.629
MOD_CK1_1	642	648	PF00069	0.614
MOD_CK1_1	683	689	PF00069	0.600
MOD_CK1_1	742	748	PF00069	0.735
MOD_CK1_1	754	760	PF00069	0.729
MOD_CK1_1	782	788	PF00069	0.782
MOD_CK1_1	804	810	PF00069	0.530
MOD_CK1_1	94	100	PF00069	0.801
MOD_CK1_1	988	994	PF00069	0.449
MOD_CK2_1	245	251	PF00069	0.412
MOD_CK2_1	338	344	PF00069	0.565
MOD_CK2_1	45	51	PF00069	0.659
MOD_CK2_1	580	586	PF00069	0.765
MOD_CK2_1	728	734	PF00069	0.775
MOD_CK2_1	916	922	PF00069	0.554
MOD_CK2_1	972	978	PF00069	0.426
MOD_GlcNHglycan	458	461	PF01048	0.539
MOD_GlcNHglycan	486	490	PF01048	0.685
MOD_GlcNHglycan	621	624	PF01048	0.676
MOD_GlcNHglycan	634	637	PF01048	0.697
MOD_GlcNHglycan	655	658	PF01048	0.726
MOD_GlcNHglycan	682	685	PF01048	0.633
MOD_GlcNHglycan	700	703	PF01048	0.601
MOD_GlcNHglycan	717	720	PF01048	0.718
MOD_GlcNHglycan	737	740	PF01048	0.620
MOD_GlcNHglycan	758	761	PF01048	0.747
MOD_GlcNHglycan	774	777	PF01048	0.719
MOD_GlcNHglycan	803	806	PF01048	0.585
MOD_GlcNHglycan	81	84	PF01048	0.617
MOD_GlcNHglycan	815	819	PF01048	0.690
MOD_GlcNHglycan	924	928	PF01048	0.552
MOD_GSK3_1	109	116	PF00069	0.565
MOD_GSK3_1	282	289	PF00069	0.594
MOD_GSK3_1	320	327	PF00069	0.540
MOD_GSK3_1	334	341	PF00069	0.418
MOD_GSK3_1	383	390	PF00069	0.421
MOD_GSK3_1	45	52	PF00069	0.593
MOD_GSK3_1	485	492	PF00069	0.631
MOD_GSK3_1	524	531	PF00069	0.798
MOD_GSK3_1	533	540	PF00069	0.770
MOD_GSK3_1	594	601	PF00069	0.680
MOD_GSK3_1	619	626	PF00069	0.616
MOD_GSK3_1	628	635	PF00069	0.590
MOD_GSK3_1	637	644	PF00069	0.669
MOD_GSK3_1	649	656	PF00069	0.747
MOD_GSK3_1	679	686	PF00069	0.658
MOD_GSK3_1	698	705	PF00069	0.501
MOD_GSK3_1	735	742	PF00069	0.668
MOD_GSK3_1	803	810	PF00069	0.687
MOD_GSK3_1	823	830	PF00069	0.695
MOD_GSK3_1	833	840	PF00069	0.720
MOD_N-GLC_1	411	416	PF02516	0.457
MOD_N-GLC_1	827	832	PF02516	0.490
MOD_N-GLC_1	954	959	PF02516	0.470
MOD_N-GLC_1	972	977	PF02516	0.341
MOD_NEK2_1	1010	1015	PF00069	0.403
MOD_NEK2_1	214	219	PF00069	0.400
MOD_NEK2_1	224	229	PF00069	0.437
MOD_NEK2_1	33	38	PF00069	0.661
MOD_NEK2_1	338	343	PF00069	0.526
MOD_NEK2_1	439	444	PF00069	0.391
MOD_NEK2_1	448	453	PF00069	0.392
MOD_NEK2_1	639	644	PF00069	0.683
MOD_NEK2_1	680	685	PF00069	0.608
MOD_NEK2_1	698	703	PF00069	0.575
MOD_NEK2_1	746	751	PF00069	0.801
MOD_NEK2_1	779	784	PF00069	0.685
MOD_NEK2_1	833	838	PF00069	0.702
MOD_NEK2_2	84	89	PF00069	0.718
MOD_PIKK_1	1025	1031	PF00454	0.416
MOD_PIKK_1	45	51	PF00454	0.659
MOD_PIKK_1	796	802	PF00454	0.701
MOD_PK_1	594	600	PF00069	0.498
MOD_PKA_1	89	95	PF00069	0.582
MOD_PKA_2	214	220	PF00069	0.414
MOD_PKA_2	245	251	PF00069	0.568
MOD_PKA_2	489	495	PF00069	0.685
MOD_PKA_2	629	635	PF00069	0.683
MOD_PKA_2	688	694	PF00069	0.673
MOD_PKA_2	772	778	PF00069	0.666
MOD_PKA_2	89	95	PF00069	0.706
MOD_PKB_1	421	429	PF00069	0.424
MOD_Plk_1	275	281	PF00069	0.566
MOD_Plk_1	33	39	PF00069	0.538
MOD_Plk_1	373	379	PF00069	0.528
MOD_Plk_1	411	417	PF00069	0.358
MOD_Plk_1	693	699	PF00069	0.728
MOD_Plk_1	742	748	PF00069	0.618
MOD_Plk_1	914	920	PF00069	0.538
MOD_Plk_1	954	960	PF00069	0.378
MOD_Plk_1	972	978	PF00069	0.505
MOD_Plk_4	1015	1021	PF00069	0.454
MOD_Plk_4	139	145	PF00069	0.495
MOD_Plk_4	224	230	PF00069	0.399
MOD_Plk_4	338	344	PF00069	0.468
MOD_Plk_4	440	446	PF00069	0.440
MOD_Plk_4	542	548	PF00069	0.784
MOD_Plk_4	629	635	PF00069	0.709
MOD_Plk_4	774	780	PF00069	0.630
MOD_Plk_4	878	884	PF00069	0.617
MOD_Plk_4	901	907	PF00069	0.455
MOD_ProDKin_1	1013	1019	PF00069	0.517
MOD_ProDKin_1	20	26	PF00069	0.435
MOD_ProDKin_1	264	270	PF00069	0.510
MOD_ProDKin_1	283	289	PF00069	0.610
MOD_ProDKin_1	308	314	PF00069	0.450
MOD_ProDKin_1	320	326	PF00069	0.461
MOD_ProDKin_1	361	367	PF00069	0.572
MOD_ProDKin_1	50	56	PF00069	0.659
MOD_ProDKin_1	525	531	PF00069	0.785
MOD_ProDKin_1	538	544	PF00069	0.475
MOD_ProDKin_1	580	586	PF00069	0.707
MOD_ProDKin_1	649	655	PF00069	0.693
MOD_ProDKin_1	664	670	PF00069	0.566
MOD_ProDKin_1	67	73	PF00069	0.619
MOD_ProDKin_1	748	754	PF00069	0.539
MOD_ProDKin_1	823	829	PF00069	0.742
MOD_SUMO_rev_2	161	167	PF00179	0.261
MOD_SUMO_rev_2	385	395	PF00179	0.510
MOD_SUMO_rev_2	399	407	PF00179	0.371
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.587
TRG_ENDOCYTIC_2	279	282	PF00928	0.492
TRG_ENDOCYTIC_2	28	31	PF00928	0.550
TRG_ENDOCYTIC_2	343	346	PF00928	0.532
TRG_ENDOCYTIC_2	380	383	PF00928	0.479
TRG_ENDOCYTIC_2	389	392	PF00928	0.404
TRG_ENDOCYTIC_2	429	432	PF00928	0.466
TRG_ENDOCYTIC_2	859	862	PF00928	0.639
TRG_ER_diArg_1	1	3	PF00400	0.585
TRG_ER_diArg_1	1003	1005	PF00400	0.557
TRG_ER_diArg_1	243	246	PF00400	0.533
TRG_ER_diArg_1	494	497	PF00400	0.750
TRG_ER_diArg_1	88	90	PF00400	0.716
TRG_ER_diArg_1	946	949	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	856	860	PF00026	0.681
TRG_Pf-PMV_PEXEL_1	908	913	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D4	Leptomonas seymouri	56%	90%
A0A3R7MCX5	Trypanosoma rangeli	39%	100%
A0A3S5H5X2	Leishmania donovani	88%	99%
A4H4X7	Leishmania braziliensis	72%	100%
A4HT50	Leishmania infantum	88%	99%
C9ZUS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QIR2	Leishmania major	87%	100%
V5D8R0	Trypanosoma cruzi	39%	100%