Paraflagellar rod component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein, putative

Species:

Leishmania mexicana

UniProt:

E9AL41_LEIMU

TriTrypDb:

LmxM.07.0310

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0031514	motile cilium	5	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

E9AL41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL41

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005516	calmodulin binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.560
CLV_C14_Caspase3-7	551	555	PF00656	0.355
CLV_C14_Caspase3-7	689	693	PF00656	0.732
CLV_NRD_NRD_1	261	263	PF00675	0.495
CLV_NRD_NRD_1	267	269	PF00675	0.643
CLV_NRD_NRD_1	388	390	PF00675	0.532
CLV_NRD_NRD_1	5	7	PF00675	0.563
CLV_NRD_NRD_1	708	710	PF00675	0.504
CLV_PCSK_FUR_1	580	584	PF00082	0.395
CLV_PCSK_KEX2_1	131	133	PF00082	0.540
CLV_PCSK_KEX2_1	261	263	PF00082	0.540
CLV_PCSK_KEX2_1	337	339	PF00082	0.537
CLV_PCSK_KEX2_1	388	390	PF00082	0.545
CLV_PCSK_KEX2_1	5	7	PF00082	0.563
CLV_PCSK_KEX2_1	582	584	PF00082	0.357
CLV_PCSK_KEX2_1	708	710	PF00082	0.591
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.390
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.601
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.395
CLV_PCSK_SKI1_1	255	259	PF00082	0.550
CLV_PCSK_SKI1_1	28	32	PF00082	0.607
CLV_PCSK_SKI1_1	280	284	PF00082	0.475
CLV_PCSK_SKI1_1	317	321	PF00082	0.541
CLV_PCSK_SKI1_1	373	377	PF00082	0.472
CLV_PCSK_SKI1_1	410	414	PF00082	0.455
CLV_PCSK_SKI1_1	421	425	PF00082	0.440
CLV_PCSK_SKI1_1	542	546	PF00082	0.322
CLV_PCSK_SKI1_1	652	656	PF00082	0.373
CLV_PCSK_SKI1_1	74	78	PF00082	0.453
CLV_PCSK_SKI1_1	800	804	PF00082	0.537
DEG_APCC_DBOX_1	188	196	PF00400	0.413
DEG_APCC_DBOX_1	209	217	PF00400	0.462
DEG_APCC_DBOX_1	372	380	PF00400	0.375
DEG_APCC_DBOX_1	409	417	PF00400	0.306
DEG_APCC_DBOX_1	656	664	PF00400	0.456
DEG_APCC_DBOX_1	782	790	PF00400	0.535
DEG_ODPH_VHL_1	223	235	PF01847	0.610
DEG_SCF_FBW7_2	188	194	PF00400	0.660
DOC_CKS1_1	176	181	PF01111	0.595
DOC_CKS1_1	188	193	PF01111	0.659
DOC_CKS1_1	676	681	PF01111	0.678
DOC_CYCLIN_RxL_1	78	89	PF00134	0.613
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.619
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.586
DOC_MAPK_DCC_7	189	197	PF00069	0.592
DOC_MAPK_gen_1	371	379	PF00069	0.379
DOC_MAPK_gen_1	385	394	PF00069	0.414
DOC_MAPK_gen_1	780	788	PF00069	0.345
DOC_MAPK_MEF2A_6	189	197	PF00069	0.592
DOC_MAPK_MEF2A_6	624	633	PF00069	0.410
DOC_PP2B_LxvP_1	222	225	PF13499	0.611
DOC_PP2B_LxvP_1	99	102	PF13499	0.591
DOC_PP2B_PxIxI_1	192	198	PF00149	0.537
DOC_USP7_MATH_1	148	152	PF00917	0.558
DOC_USP7_MATH_1	375	379	PF00917	0.446
DOC_USP7_MATH_1	412	416	PF00917	0.439
DOC_USP7_MATH_1	65	69	PF00917	0.719
DOC_USP7_MATH_1	686	690	PF00917	0.745
DOC_USP7_MATH_1	698	702	PF00917	0.751
DOC_USP7_MATH_1	711	715	PF00917	0.562
DOC_USP7_MATH_1	752	756	PF00917	0.523
DOC_USP7_MATH_2	102	108	PF00917	0.572
DOC_WW_Pin1_4	175	180	PF00397	0.614
DOC_WW_Pin1_4	187	192	PF00397	0.568
DOC_WW_Pin1_4	216	221	PF00397	0.607
DOC_WW_Pin1_4	675	680	PF00397	0.715
DOC_WW_Pin1_4	693	698	PF00397	0.566
LIG_14-3-3_CanoR_1	132	140	PF00244	0.395
LIG_14-3-3_CanoR_1	170	177	PF00244	0.565
LIG_14-3-3_CanoR_1	210	214	PF00244	0.425
LIG_14-3-3_CanoR_1	486	491	PF00244	0.173
LIG_14-3-3_CanoR_1	583	590	PF00244	0.361
LIG_14-3-3_CanoR_1	595	599	PF00244	0.350
LIG_14-3-3_CanoR_1	603	610	PF00244	0.264
LIG_14-3-3_CanoR_1	657	661	PF00244	0.508
LIG_14-3-3_CanoR_1	74	84	PF00244	0.582
LIG_14-3-3_CanoR_1	88	94	PF00244	0.557
LIG_Actin_WH2_2	619	636	PF00022	0.246
LIG_Actin_WH2_2	765	782	PF00022	0.561
LIG_APCC_ABBA_1	377	382	PF00400	0.443
LIG_BIR_III_2	692	696	PF00653	0.749
LIG_Clathr_ClatBox_1	802	806	PF01394	0.583
LIG_CtBP_PxDLS_1	732	736	PF00389	0.591
LIG_eIF4E_1	17	23	PF01652	0.549
LIG_FHA_1	154	160	PF00498	0.605
LIG_FHA_1	252	258	PF00498	0.630
LIG_FHA_1	277	283	PF00498	0.655
LIG_FHA_1	422	428	PF00498	0.355
LIG_FHA_1	676	682	PF00498	0.662
LIG_FHA_1	743	749	PF00498	0.510
LIG_FHA_2	176	182	PF00498	0.594
LIG_FHA_2	270	276	PF00498	0.690
LIG_FHA_2	286	292	PF00498	0.721
LIG_FHA_2	521	527	PF00498	0.350
LIG_FHA_2	583	589	PF00498	0.410
LIG_FHA_2	663	669	PF00498	0.662
LIG_FHA_2	700	706	PF00498	0.823
LIG_LIR_Gen_1	509	519	PF02991	0.362
LIG_LIR_Nem_3	509	515	PF02991	0.362
LIG_LIR_Nem_3	773	779	PF02991	0.551
LIG_NRBOX	212	218	PF00104	0.480
LIG_SH2_SRC	165	168	PF00017	0.439
LIG_SH2_SRC	535	538	PF00017	0.292
LIG_SH2_STAP1	408	412	PF00017	0.410
LIG_SH2_STAP1	569	573	PF00017	0.355
LIG_SH2_STAP1	8	12	PF00017	0.572
LIG_SH2_STAT3	757	760	PF00017	0.521
LIG_SH2_STAT5	165	168	PF00017	0.514
LIG_SH2_STAT5	221	224	PF00017	0.554
LIG_SH2_STAT5	535	538	PF00017	0.254
LIG_SH2_STAT5	565	568	PF00017	0.279
LIG_SH2_STAT5	63	66	PF00017	0.689
LIG_SH2_STAT5	632	635	PF00017	0.297
LIG_SH2_STAT5	757	760	PF00017	0.577
LIG_SH3_1	18	24	PF00018	0.693
LIG_SH3_1	694	700	PF00018	0.573
LIG_SH3_3	18	24	PF00018	0.560
LIG_SH3_3	199	205	PF00018	0.635
LIG_SH3_3	694	700	PF00018	0.573
LIG_SH3_3	736	742	PF00018	0.537
LIG_SH3_3	802	808	PF00018	0.487
LIG_SH3_4	259	266	PF00018	0.653
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.584
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.469
LIG_SUMO_SIM_anti_2	365	370	PF11976	0.350
LIG_SUMO_SIM_par_1	29	36	PF11976	0.425
LIG_SUMO_SIM_par_1	375	384	PF11976	0.453
LIG_TRAF2_1	272	275	PF00917	0.583
LIG_TRAF2_1	288	291	PF00917	0.767
LIG_TRAF2_1	549	552	PF00917	0.355
LIG_TRAF2_1	575	578	PF00917	0.279
LIG_TRAF2_1	666	669	PF00917	0.593
LIG_TRAF2_1	782	785	PF00917	0.533
LIG_TRFH_1	221	225	PF08558	0.626
LIG_TYR_ITIM	38	43	PF00017	0.687
LIG_UBA3_1	366	371	PF00899	0.273
MOD_CK1_1	161	167	PF00069	0.621
MOD_CK1_1	276	282	PF00069	0.604
MOD_CK1_1	378	384	PF00069	0.446
MOD_CK1_1	398	404	PF00069	0.433
MOD_CK1_1	69	75	PF00069	0.706
MOD_CK1_1	696	702	PF00069	0.757
MOD_CK2_1	175	181	PF00069	0.701
MOD_CK2_1	269	275	PF00069	0.610
MOD_CK2_1	285	291	PF00069	0.748
MOD_CK2_1	486	492	PF00069	0.410
MOD_CK2_1	634	640	PF00069	0.440
MOD_CK2_1	662	668	PF00069	0.662
MOD_CK2_1	699	705	PF00069	0.744
MOD_CK2_1	779	785	PF00069	0.595
MOD_GlcNHglycan	133	136	PF01048	0.536
MOD_GlcNHglycan	14	17	PF01048	0.625
MOD_GlcNHglycan	150	153	PF01048	0.650
MOD_GlcNHglycan	244	247	PF01048	0.691
MOD_GlcNHglycan	508	511	PF01048	0.397
MOD_GlcNHglycan	56	59	PF01048	0.584
MOD_GlcNHglycan	688	691	PF01048	0.686
MOD_GlcNHglycan	713	716	PF01048	0.686
MOD_GlcNHglycan	77	80	PF01048	0.580
MOD_GSK3_1	142	149	PF00069	0.541
MOD_GSK3_1	205	212	PF00069	0.567
MOD_GSK3_1	269	276	PF00069	0.604
MOD_GSK3_1	50	57	PF00069	0.654
MOD_GSK3_1	65	72	PF00069	0.500
MOD_GSK3_1	707	714	PF00069	0.662
MOD_GSK3_1	727	734	PF00069	0.643
MOD_GSK3_1	752	759	PF00069	0.546
MOD_GSK3_1	8	15	PF00069	0.583
MOD_GSK3_1	83	90	PF00069	0.483
MOD_LATS_1	129	135	PF00433	0.514
MOD_NEK2_1	153	158	PF00069	0.614
MOD_NEK2_1	33	38	PF00069	0.570
MOD_NEK2_1	54	59	PF00069	0.658
MOD_NEK2_1	593	598	PF00069	0.299
MOD_NEK2_1	735	740	PF00069	0.580
MOD_NEK2_2	158	163	PF00069	0.555
MOD_NEK2_2	205	210	PF00069	0.506
MOD_NEK2_2	375	380	PF00069	0.440
MOD_PIKK_1	196	202	PF00454	0.627
MOD_PIKK_1	427	433	PF00454	0.333
MOD_PIKK_1	582	588	PF00454	0.428
MOD_PIKK_1	756	762	PF00454	0.519
MOD_PIKK_1	87	93	PF00454	0.669
MOD_PKA_1	131	137	PF00069	0.376
MOD_PKA_1	582	588	PF00069	0.410
MOD_PKA_2	131	137	PF00069	0.383
MOD_PKA_2	169	175	PF00069	0.537
MOD_PKA_2	209	215	PF00069	0.423
MOD_PKA_2	582	588	PF00069	0.313
MOD_PKA_2	594	600	PF00069	0.378
MOD_PKA_2	602	608	PF00069	0.204
MOD_PKA_2	656	662	PF00069	0.608
MOD_PKA_2	707	713	PF00069	0.563
MOD_PKA_2	779	785	PF00069	0.539
MOD_PKA_2	87	93	PF00069	0.717
MOD_Plk_1	269	275	PF00069	0.600
MOD_Plk_1	276	282	PF00069	0.549
MOD_Plk_4	104	110	PF00069	0.666
MOD_Plk_4	161	167	PF00069	0.589
MOD_Plk_4	231	237	PF00069	0.599
MOD_Plk_4	50	56	PF00069	0.650
MOD_Plk_4	594	600	PF00069	0.355
MOD_ProDKin_1	175	181	PF00069	0.614
MOD_ProDKin_1	187	193	PF00069	0.566
MOD_ProDKin_1	216	222	PF00069	0.608
MOD_ProDKin_1	675	681	PF00069	0.714
MOD_ProDKin_1	693	699	PF00069	0.567
MOD_SUMO_rev_2	313	322	PF00179	0.539
MOD_SUMO_rev_2	689	696	PF00179	0.745
MOD_SUMO_rev_2	768	777	PF00179	0.490
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.410
TRG_ENDOCYTIC_2	40	43	PF00928	0.693
TRG_ENDOCYTIC_2	408	411	PF00928	0.371
TRG_ENDOCYTIC_2	512	515	PF00928	0.300
TRG_ENDOCYTIC_2	569	572	PF00928	0.282
TRG_ER_diArg_1	260	262	PF00400	0.469
TRG_ER_diArg_1	387	389	PF00400	0.353
TRG_ER_diArg_1	480	483	PF00400	0.306
TRG_ER_diArg_1	5	7	PF00400	0.563
TRG_ER_diArg_1	589	592	PF00400	0.410
TRG_NLS_MonoCore_2	257	262	PF00514	0.605
TRG_NLS_MonoExtC_3	257	262	PF00514	0.472
TRG_NLS_MonoExtN_4	255	262	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	354	359	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	624	628	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV3	Leptomonas seymouri	54%	100%
A0A1X0NP77	Trypanosomatidae	31%	98%
A0A3R7K8M9	Trypanosoma rangeli	34%	100%
A0A3S7WPT1	Leishmania donovani	87%	100%
A4H4X6	Leishmania braziliensis	78%	100%
A4HT49	Leishmania infantum	87%	100%
C9ZUS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QIR3	Leishmania major	86%	100%
V5ASS7	Trypanosoma cruzi	33%	100%