Leucine-rich repeat-containing protein 51

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL40_LEIMU

TriTrypDb:

LmxM.07.0300

Length:

865

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AL40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.620
CLV_C14_Caspase3-7	229	233	PF00656	0.556
CLV_C14_Caspase3-7	515	519	PF00656	0.707
CLV_NRD_NRD_1	10	12	PF00675	0.494
CLV_NRD_NRD_1	127	129	PF00675	0.573
CLV_NRD_NRD_1	151	153	PF00675	0.600
CLV_NRD_NRD_1	219	221	PF00675	0.680
CLV_NRD_NRD_1	270	272	PF00675	0.554
CLV_NRD_NRD_1	363	365	PF00675	0.543
CLV_NRD_NRD_1	431	433	PF00675	0.562
CLV_NRD_NRD_1	674	676	PF00675	0.457
CLV_NRD_NRD_1	785	787	PF00675	0.359
CLV_PCSK_KEX2_1	10	12	PF00082	0.494
CLV_PCSK_KEX2_1	126	128	PF00082	0.590
CLV_PCSK_KEX2_1	151	153	PF00082	0.452
CLV_PCSK_KEX2_1	219	221	PF00082	0.684
CLV_PCSK_KEX2_1	270	272	PF00082	0.554
CLV_PCSK_KEX2_1	306	308	PF00082	0.752
CLV_PCSK_KEX2_1	431	433	PF00082	0.562
CLV_PCSK_KEX2_1	674	676	PF00082	0.457
CLV_PCSK_KEX2_1	785	787	PF00082	0.590
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.590
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.752
CLV_PCSK_PC7_1	123	129	PF00082	0.701
CLV_PCSK_SKI1_1	11	15	PF00082	0.484
CLV_PCSK_SKI1_1	130	134	PF00082	0.581
CLV_PCSK_SKI1_1	200	204	PF00082	0.565
CLV_PCSK_SKI1_1	365	369	PF00082	0.592
CLV_PCSK_SKI1_1	418	422	PF00082	0.519
CLV_PCSK_SKI1_1	431	435	PF00082	0.402
CLV_PCSK_SKI1_1	785	789	PF00082	0.416
DEG_APCC_DBOX_1	784	792	PF00400	0.289
DEG_Nend_UBRbox_2	1	3	PF02207	0.541
DEG_ODPH_VHL_1	725	736	PF01847	0.454
DOC_CDC14_PxL_1	694	702	PF14671	0.504
DOC_CDC14_PxL_1	725	733	PF14671	0.460
DOC_CYCLIN_RxL_1	126	137	PF00134	0.572
DOC_MAPK_DCC_7	724	733	PF00069	0.517
DOC_MAPK_FxFP_2	39	42	PF00069	0.518
DOC_MAPK_gen_1	785	792	PF00069	0.475
DOC_MAPK_HePTP_8	721	733	PF00069	0.521
DOC_MAPK_MEF2A_6	724	733	PF00069	0.517
DOC_MAPK_MEF2A_6	785	792	PF00069	0.475
DOC_MAPK_NFAT4_5	785	793	PF00069	0.480
DOC_MAPK_RevD_3	349	365	PF00069	0.515
DOC_PP1_RVXF_1	403	409	PF00149	0.474
DOC_PP1_RVXF_1	800	807	PF00149	0.529
DOC_PP2B_LxvP_1	203	206	PF13499	0.552
DOC_PP2B_LxvP_1	265	268	PF13499	0.774
DOC_PP2B_LxvP_1	374	377	PF13499	0.551
DOC_PP4_FxxP_1	39	42	PF00568	0.518
DOC_USP7_MATH_1	290	294	PF00917	0.480
DOC_USP7_MATH_1	40	44	PF00917	0.575
DOC_USP7_MATH_1	496	500	PF00917	0.622
DOC_USP7_MATH_1	704	708	PF00917	0.473
DOC_USP7_MATH_1	85	89	PF00917	0.732
DOC_USP7_UBL2_3	590	594	PF12436	0.600
DOC_USP7_UBL2_3	852	856	PF12436	0.636
DOC_WW_Pin1_4	27	32	PF00397	0.483
DOC_WW_Pin1_4	280	285	PF00397	0.543
DOC_WW_Pin1_4	340	345	PF00397	0.368
DOC_WW_Pin1_4	447	452	PF00397	0.767
DOC_WW_Pin1_4	541	546	PF00397	0.553
DOC_WW_Pin1_4	791	796	PF00397	0.505
LIG_14-3-3_CanoR_1	10	18	PF00244	0.459
LIG_14-3-3_CanoR_1	103	113	PF00244	0.592
LIG_14-3-3_CanoR_1	140	147	PF00244	0.661
LIG_14-3-3_CanoR_1	270	278	PF00244	0.717
LIG_14-3-3_CanoR_1	431	437	PF00244	0.580
LIG_14-3-3_CanoR_1	563	570	PF00244	0.697
LIG_14-3-3_CanoR_1	649	657	PF00244	0.294
LIG_BRCT_BRCA1_1	273	277	PF00533	0.673
LIG_BRCT_BRCA1_1	330	334	PF00533	0.553
LIG_deltaCOP1_diTrp_1	778	784	PF00928	0.362
LIG_DLG_GKlike_1	146	153	PF00625	0.607
LIG_DLG_GKlike_1	220	228	PF00625	0.556
LIG_eIF4E_1	332	338	PF01652	0.566
LIG_FHA_1	12	18	PF00498	0.466
LIG_FHA_1	346	352	PF00498	0.444
LIG_FHA_1	408	414	PF00498	0.548
LIG_FHA_1	684	690	PF00498	0.492
LIG_FHA_1	814	820	PF00498	0.407
LIG_FHA_2	211	217	PF00498	0.844
LIG_FHA_2	320	326	PF00498	0.520
LIG_FHA_2	380	386	PF00498	0.561
LIG_FHA_2	433	439	PF00498	0.588
LIG_FHA_2	451	457	PF00498	0.509
LIG_FHA_2	513	519	PF00498	0.726
LIG_FHA_2	743	749	PF00498	0.710
LIG_FHA_2	808	814	PF00498	0.522
LIG_LIR_Apic_2	37	42	PF02991	0.501
LIG_LIR_Gen_1	144	153	PF02991	0.383
LIG_LIR_Gen_1	2	8	PF02991	0.500
LIG_LIR_Gen_1	24	34	PF02991	0.471
LIG_LIR_Gen_1	385	394	PF02991	0.520
LIG_LIR_Gen_1	500	510	PF02991	0.644
LIG_LIR_Gen_1	521	532	PF02991	0.518
LIG_LIR_Gen_1	805	814	PF02991	0.527
LIG_LIR_Nem_3	144	150	PF02991	0.561
LIG_LIR_Nem_3	2	6	PF02991	0.504
LIG_LIR_Nem_3	24	29	PF02991	0.462
LIG_LIR_Nem_3	331	337	PF02991	0.542
LIG_LIR_Nem_3	385	390	PF02991	0.534
LIG_LIR_Nem_3	500	506	PF02991	0.649
LIG_LIR_Nem_3	507	512	PF02991	0.613
LIG_LIR_Nem_3	521	527	PF02991	0.505
LIG_LIR_Nem_3	528	532	PF02991	0.471
LIG_LIR_Nem_3	717	721	PF02991	0.497
LIG_LIR_Nem_3	805	809	PF02991	0.533
LIG_MAD2	719	727	PF02301	0.490
LIG_NRBOX	786	792	PF00104	0.471
LIG_PCNA_PIPBox_1	32	41	PF02747	0.577
LIG_PCNA_yPIPBox_3	656	670	PF02747	0.492
LIG_SH2_CRK	26	30	PF00017	0.560
LIG_SH2_CRK	387	391	PF00017	0.632
LIG_SH2_NCK_1	3	7	PF00017	0.495
LIG_SH2_NCK_1	814	818	PF00017	0.535
LIG_SH2_SRC	317	320	PF00017	0.647
LIG_SH2_SRC	613	616	PF00017	0.793
LIG_SH2_STAP1	317	321	PF00017	0.637
LIG_SH2_STAT3	601	604	PF00017	0.673
LIG_SH2_STAT5	160	163	PF00017	0.476
LIG_SH2_STAT5	730	733	PF00017	0.587
LIG_SH2_STAT5	8	11	PF00017	0.372
LIG_SH3_3	338	344	PF00018	0.344
LIG_SH3_3	370	376	PF00018	0.582
LIG_SH3_CIN85_PxpxPR_1	376	381	PF14604	0.376
LIG_SUMO_SIM_anti_2	699	704	PF11976	0.541
LIG_SUMO_SIM_par_1	32	37	PF11976	0.461
LIG_SUMO_SIM_par_1	355	360	PF11976	0.608
LIG_SUMO_SIM_par_1	432	438	PF11976	0.488
LIG_SUMO_SIM_par_1	680	686	PF11976	0.461
LIG_TRAF2_1	382	385	PF00917	0.664
LIG_TYR_ITIM	728	733	PF00017	0.581
LIG_WRC_WIRS_1	147	152	PF05994	0.663
MOD_CDC14_SPxK_1	794	797	PF00782	0.523
MOD_CDK_SPK_2	447	452	PF00069	0.626
MOD_CDK_SPxK_1	791	797	PF00069	0.501
MOD_CDK_SPxxK_3	340	347	PF00069	0.391
MOD_CK1_1	121	127	PF00069	0.616
MOD_CK1_1	280	286	PF00069	0.699
MOD_CK1_1	45	51	PF00069	0.592
MOD_CK1_1	450	456	PF00069	0.670
MOD_CK1_1	461	467	PF00069	0.659
MOD_CK1_1	582	588	PF00069	0.611
MOD_CK1_1	854	860	PF00069	0.770
MOD_CK2_1	319	325	PF00069	0.535
MOD_CK2_1	379	385	PF00069	0.566
MOD_CK2_1	432	438	PF00069	0.488
MOD_CK2_1	450	456	PF00069	0.704
MOD_CK2_1	608	614	PF00069	0.677
MOD_CK2_1	742	748	PF00069	0.696
MOD_CMANNOS	781	784	PF00535	0.332
MOD_GlcNHglycan	106	109	PF01048	0.517
MOD_GlcNHglycan	120	123	PF01048	0.523
MOD_GlcNHglycan	178	182	PF01048	0.649
MOD_GlcNHglycan	228	231	PF01048	0.758
MOD_GlcNHglycan	239	242	PF01048	0.666
MOD_GlcNHglycan	285	288	PF01048	0.751
MOD_GlcNHglycan	292	295	PF01048	0.623
MOD_GlcNHglycan	42	45	PF01048	0.693
MOD_GlcNHglycan	494	497	PF01048	0.483
MOD_GlcNHglycan	546	549	PF01048	0.613
MOD_GlcNHglycan	581	584	PF01048	0.597
MOD_GlcNHglycan	657	660	PF01048	0.449
MOD_GlcNHglycan	71	74	PF01048	0.652
MOD_GlcNHglycan	856	859	PF01048	0.816
MOD_GlcNHglycan	88	91	PF01048	0.498
MOD_GSK3_1	220	227	PF00069	0.649
MOD_GSK3_1	269	276	PF00069	0.760
MOD_GSK3_1	434	441	PF00069	0.492
MOD_GSK3_1	446	453	PF00069	0.763
MOD_GSK3_1	460	467	PF00069	0.775
MOD_GSK3_1	492	499	PF00069	0.687
MOD_GSK3_1	683	690	PF00069	0.409
MOD_GSK3_1	833	840	PF00069	0.565
MOD_GSK3_1	847	854	PF00069	0.687
MOD_LATS_1	430	436	PF00433	0.567
MOD_N-GLC_1	232	237	PF02516	0.619
MOD_N-GLC_1	472	477	PF02516	0.533
MOD_N-GLC_1	650	655	PF02516	0.315
MOD_N-GLC_1	692	697	PF02516	0.539
MOD_N-GLC_1	752	757	PF02516	0.706
MOD_NEK2_1	224	229	PF00069	0.651
MOD_NEK2_1	328	333	PF00069	0.473
MOD_NEK2_1	34	39	PF00069	0.458
MOD_NEK2_1	512	517	PF00069	0.598
MOD_NEK2_1	527	532	PF00069	0.517
MOD_NEK2_1	579	584	PF00069	0.531
MOD_NEK2_1	687	692	PF00069	0.463
MOD_NEK2_1	837	842	PF00069	0.730
MOD_NEK2_2	680	685	PF00069	0.562
MOD_NEK2_2	704	709	PF00069	0.577
MOD_NEK2_2	732	737	PF00069	0.514
MOD_PIKK_1	121	127	PF00454	0.730
MOD_PIKK_1	139	145	PF00454	0.362
MOD_PIKK_1	16	22	PF00454	0.558
MOD_PIKK_1	461	467	PF00454	0.597
MOD_PIKK_1	562	568	PF00454	0.708
MOD_PIKK_1	602	608	PF00454	0.685
MOD_PIKK_1	687	693	PF00454	0.472
MOD_PKA_2	139	145	PF00069	0.658
MOD_PKA_2	269	275	PF00069	0.716
MOD_PKA_2	467	473	PF00069	0.822
MOD_PKA_2	562	568	PF00069	0.708
MOD_PKA_2	655	661	PF00069	0.475
MOD_PKB_1	271	279	PF00069	0.754
MOD_Plk_1	527	533	PF00069	0.513
MOD_Plk_1	650	656	PF00069	0.483
MOD_Plk_1	692	698	PF00069	0.597
MOD_Plk_2-3	319	325	PF00069	0.535
MOD_Plk_4	273	279	PF00069	0.773
MOD_Plk_4	535	541	PF00069	0.577
MOD_Plk_4	698	704	PF00069	0.537
MOD_ProDKin_1	27	33	PF00069	0.476
MOD_ProDKin_1	280	286	PF00069	0.543
MOD_ProDKin_1	340	346	PF00069	0.380
MOD_ProDKin_1	447	453	PF00069	0.769
MOD_ProDKin_1	541	547	PF00069	0.553
MOD_ProDKin_1	791	797	PF00069	0.501
MOD_SUMO_rev_2	319	329	PF00179	0.593
MOD_SUMO_rev_2	343	349	PF00179	0.624
MOD_SUMO_rev_2	411	420	PF00179	0.497
MOD_SUMO_rev_2	717	726	PF00179	0.303
TRG_AP2beta_CARGO_1	507	516	PF09066	0.453
TRG_DiLeu_BaEn_1	325	330	PF01217	0.478
TRG_DiLeu_BaEn_1	536	541	PF01217	0.494
TRG_DiLeu_BaEn_2	415	421	PF01217	0.254
TRG_DiLeu_BaLyEn_6	783	788	PF01217	0.584
TRG_ENDOCYTIC_2	147	150	PF00928	0.557
TRG_ENDOCYTIC_2	25	28	PF00928	0.489
TRG_ENDOCYTIC_2	3	6	PF00928	0.504
TRG_ENDOCYTIC_2	332	335	PF00928	0.547
TRG_ENDOCYTIC_2	387	390	PF00928	0.529
TRG_ENDOCYTIC_2	503	506	PF00928	0.644
TRG_ENDOCYTIC_2	730	733	PF00928	0.587
TRG_ENDOCYTIC_2	820	823	PF00928	0.628
TRG_ER_diArg_1	10	12	PF00400	0.494
TRG_ER_diArg_1	127	130	PF00400	0.674
TRG_ER_diArg_1	150	152	PF00400	0.437
TRG_ER_diArg_1	270	273	PF00400	0.655
TRG_ER_diArg_1	431	433	PF00400	0.562
TRG_ER_diArg_1	673	675	PF00400	0.457
TRG_ER_diArg_1	784	786	PF00400	0.310
TRG_NLS_MonoExtC_3	125	130	PF00514	0.583
TRG_NLS_MonoExtN_4	123	130	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.746

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I156	Leptomonas seymouri	46%	100%
A0A3S7WPS7	Leishmania donovani	87%	100%
A4H4X5	Leishmania braziliensis	67%	97%
A4HT48	Leishmania infantum	86%	100%
Q4QIR4	Leishmania major	86%	98%