MPN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0172), putative

Species:

Leishmania mexicana

UniProt:

E9AL39_LEIMU

TriTrypDb:

LmxM.07.0290

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	10
GO:0072546	EMC complex	3	10
GO:0098796	membrane protein complex	2	10
GO:0140534	endoplasmic reticulum protein-containing complex	2	10
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AL39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.613
CLV_PCSK_KEX2_1	130	132	PF00082	0.180
CLV_PCSK_KEX2_1	37	39	PF00082	0.282
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.180
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.282
CLV_PCSK_SKI1_1	130	134	PF00082	0.398
CLV_PCSK_SKI1_1	17	21	PF00082	0.282
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.398
DOC_PP1_RVXF_1	143	150	PF00149	0.398
DOC_USP7_MATH_1	164	168	PF00917	0.356
DOC_USP7_MATH_1	205	209	PF00917	0.323
DOC_USP7_MATH_1	47	51	PF00917	0.352
DOC_WW_Pin1_4	123	128	PF00397	0.306
DOC_WW_Pin1_4	155	160	PF00397	0.351
DOC_WW_Pin1_4	8	13	PF00397	0.398
LIG_14-3-3_CanoR_1	119	127	PF00244	0.317
LIG_14-3-3_CanoR_1	139	149	PF00244	0.155
LIG_14-3-3_CanoR_1	172	179	PF00244	0.406
LIG_14-3-3_CanoR_1	190	194	PF00244	0.200
LIG_14-3-3_CanoR_1	195	203	PF00244	0.398
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_BIR_III_2	75	79	PF00653	0.282
LIG_eIF4E_1	242	248	PF01652	0.355
LIG_FHA_1	14	20	PF00498	0.372
LIG_FHA_1	142	148	PF00498	0.353
LIG_FHA_1	176	182	PF00498	0.255
LIG_FHA_1	68	74	PF00498	0.419
LIG_FHA_2	204	210	PF00498	0.222
LIG_FHA_2	239	245	PF00498	0.333
LIG_HP1_1	246	250	PF01393	0.264
LIG_LIR_Gen_1	93	103	PF02991	0.288
LIG_LIR_Nem_3	221	226	PF02991	0.361
LIG_LIR_Nem_3	93	99	PF02991	0.290
LIG_SH2_CRK	23	27	PF00017	0.398
LIG_SH2_NCK_1	96	100	PF00017	0.282
LIG_SH2_SRC	96	99	PF00017	0.355
LIG_SH2_STAP1	15	19	PF00017	0.342
LIG_SH2_STAT3	242	245	PF00017	0.282
LIG_SH2_STAT3	25	28	PF00017	0.282
LIG_SH2_STAT5	114	117	PF00017	0.282
LIG_SH2_STAT5	15	18	PF00017	0.340
LIG_SH2_STAT5	242	245	PF00017	0.282
LIG_SH2_STAT5	72	75	PF00017	0.355
LIG_SH3_1	23	29	PF00018	0.398
LIG_SH3_3	23	29	PF00018	0.398
LIG_SH3_3	6	12	PF00018	0.398
LIG_SUMO_SIM_par_1	177	183	PF11976	0.423
LIG_SUMO_SIM_par_1	246	252	PF11976	0.268
LIG_TYR_ITIM	94	99	PF00017	0.282
MOD_CDK_SPxxK_3	123	130	PF00069	0.398
MOD_CK1_1	126	132	PF00069	0.301
MOD_CK1_1	180	186	PF00069	0.377
MOD_CK1_1	2	8	PF00069	0.474
MOD_CK1_1	208	214	PF00069	0.463
MOD_CK1_1	238	244	PF00069	0.180
MOD_CK1_1	55	61	PF00069	0.343
MOD_CK1_1	64	70	PF00069	0.455
MOD_CK2_1	183	189	PF00069	0.428
MOD_CK2_1	203	209	PF00069	0.411
MOD_CK2_1	238	244	PF00069	0.364
MOD_Cter_Amidation	35	38	PF01082	0.282
MOD_GlcNHglycan	1	4	PF01048	0.544
MOD_GlcNHglycan	185	188	PF01048	0.447
MOD_GlcNHglycan	49	52	PF01048	0.396
MOD_GlcNHglycan	63	66	PF01048	0.420
MOD_GSK3_1	102	109	PF00069	0.296
MOD_GSK3_1	171	178	PF00069	0.235
MOD_GSK3_1	208	215	PF00069	0.349
MOD_GSK3_1	4	11	PF00069	0.426
MOD_GSK3_1	47	54	PF00069	0.422
MOD_GSK3_1	61	68	PF00069	0.373
MOD_GSK3_1	79	86	PF00069	0.264
MOD_N-GLC_1	175	180	PF02516	0.255
MOD_N-GLC_2	153	155	PF02516	0.383
MOD_NEK2_1	163	168	PF00069	0.453
MOD_NEK2_1	235	240	PF00069	0.193
MOD_NEK2_1	4	9	PF00069	0.420
MOD_NEK2_1	79	84	PF00069	0.323
MOD_PIKK_1	180	186	PF00454	0.369
MOD_PKA_1	37	43	PF00069	0.266
MOD_PKA_2	118	124	PF00069	0.317
MOD_PKA_2	171	177	PF00069	0.372
MOD_PKA_2	189	195	PF00069	0.175
MOD_PKA_2	37	43	PF00069	0.266
MOD_Plk_1	175	181	PF00069	0.319
MOD_Plk_1	203	209	PF00069	0.355
MOD_Plk_1	235	241	PF00069	0.180
MOD_Plk_4	106	112	PF00069	0.398
MOD_Plk_4	208	214	PF00069	0.317
MOD_Plk_4	4	10	PF00069	0.398
MOD_ProDKin_1	123	129	PF00069	0.306
MOD_ProDKin_1	155	161	PF00069	0.351
MOD_ProDKin_1	8	14	PF00069	0.398
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.293
TRG_ENDOCYTIC_2	96	99	PF00928	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7U5	Leptomonas seymouri	77%	100%
A0A1X0NP88	Trypanosomatidae	39%	95%
A0A3S7WPT3	Leishmania donovani	95%	100%
A0A422NDI1	Trypanosoma rangeli	45%	100%
A4H4X4	Leishmania braziliensis	86%	100%
A4HT47	Leishmania infantum	95%	100%
C9ZUT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
Q4QIR5	Leishmania major	93%	100%