Homoserine dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

homoserine dehydrogenase-like protein

Species:

Leishmania mexicana

UniProt:

E9AL36_LEIMU

TriTrypDb:

LmxM.07.0260

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AL36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL36

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	5
GO:0000097	sulfur amino acid biosynthetic process	5	5
GO:0006082	organic acid metabolic process	3	6
GO:0006520	amino acid metabolic process	3	6
GO:0006549	isoleucine metabolic process	5	5
GO:0006555	methionine metabolic process	5	5
GO:0006566	threonine metabolic process	6	5
GO:0006790	sulfur compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0008652	amino acid biosynthetic process	4	5
GO:0009058	biosynthetic process	2	5
GO:0009066	aspartate family amino acid metabolic process	5	5
GO:0009067	aspartate family amino acid biosynthetic process	6	5
GO:0009081	branched-chain amino acid metabolic process	4	5
GO:0009082	branched-chain amino acid biosynthetic process	5	5
GO:0009086	methionine biosynthetic process	6	5
GO:0009088	threonine biosynthetic process	7	5
GO:0009097	isoleucine biosynthetic process	6	5
GO:0009987	cellular process	1	6
GO:0016053	organic acid biosynthetic process	4	5
GO:0019752	carboxylic acid metabolic process	5	6
GO:0043436	oxoacid metabolic process	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	5
GO:0044272	sulfur compound biosynthetic process	4	5
GO:0044281	small molecule metabolic process	2	6
GO:0044283	small molecule biosynthetic process	3	5
GO:0046394	carboxylic acid biosynthetic process	5	5
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5
GO:1901605	alpha-amino acid metabolic process	4	5
GO:1901607	alpha-amino acid biosynthetic process	5	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	6
GO:0004412	homoserine dehydrogenase activity	5	6
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	6
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	6
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	6
GO:0036094	small molecule binding	2	5
GO:0050661	NADP binding	4	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.237
CLV_C14_Caspase3-7	243	247	PF00656	0.193
CLV_NRD_NRD_1	167	169	PF00675	0.318
CLV_NRD_NRD_1	25	27	PF00675	0.313
CLV_NRD_NRD_1	365	367	PF00675	0.507
CLV_NRD_NRD_1	50	52	PF00675	0.301
CLV_PCSK_KEX2_1	191	193	PF00082	0.224
CLV_PCSK_KEX2_1	25	27	PF00082	0.313
CLV_PCSK_KEX2_1	365	367	PF00082	0.507
CLV_PCSK_KEX2_1	49	51	PF00082	0.307
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.193
CLV_PCSK_PC7_1	46	52	PF00082	0.313
CLV_PCSK_SKI1_1	111	115	PF00082	0.481
CLV_PCSK_SKI1_1	307	311	PF00082	0.342
CLV_PCSK_SKI1_1	5	9	PF00082	0.336
CLV_PCSK_SKI1_1	64	68	PF00082	0.313
DEG_SPOP_SBC_1	130	134	PF00917	0.370
DOC_ANK_TNKS_1	52	59	PF00023	0.248
DOC_MAPK_MEF2A_6	222	231	PF00069	0.313
DOC_MAPK_MEF2A_6	75	82	PF00069	0.313
DOC_PP1_RVXF_1	109	115	PF00149	0.313
DOC_USP7_MATH_1	130	134	PF00917	0.490
DOC_USP7_MATH_1	235	239	PF00917	0.357
DOC_USP7_MATH_1	280	284	PF00917	0.312
DOC_WW_Pin1_4	126	131	PF00397	0.474
DOC_WW_Pin1_4	246	251	PF00397	0.357
LIG_BRCT_BRCA1_1	131	135	PF00533	0.367
LIG_FHA_1	209	215	PF00498	0.313
LIG_FHA_1	237	243	PF00498	0.357
LIG_FHA_1	301	307	PF00498	0.265
LIG_FHA_1	322	328	PF00498	0.352
LIG_FHA_1	329	335	PF00498	0.315
LIG_FHA_1	65	71	PF00498	0.313
LIG_FHA_2	241	247	PF00498	0.313
LIG_FHA_2	83	89	PF00498	0.313
LIG_GBD_Chelix_1	40	48	PF00786	0.313
LIG_LIR_Gen_1	190	200	PF02991	0.313
LIG_LIR_Gen_1	218	228	PF02991	0.313
LIG_LIR_Gen_1	89	100	PF02991	0.313
LIG_LIR_Nem_3	138	144	PF02991	0.374
LIG_LIR_Nem_3	190	196	PF02991	0.313
LIG_LIR_Nem_3	218	223	PF02991	0.313
LIG_LIR_Nem_3	328	333	PF02991	0.355
LIG_LIR_Nem_3	89	95	PF02991	0.313
LIG_SH2_NCK_1	19	23	PF00017	0.259
LIG_SH2_NCK_1	205	209	PF00017	0.357
LIG_SH2_SRC	205	208	PF00017	0.357
LIG_SH2_STAP1	357	361	PF00017	0.374
LIG_SH2_STAT5	141	144	PF00017	0.345
LIG_SH2_STAT5	180	183	PF00017	0.357
LIG_SH2_STAT5	333	336	PF00017	0.357
LIG_SH2_STAT5	347	350	PF00017	0.227
LIG_SH2_STAT5	94	97	PF00017	0.313
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.313
LIG_SUMO_SIM_par_1	335	340	PF11976	0.357
LIG_TRAF2_1	120	123	PF00917	0.313
LIG_TYR_ITIM	261	266	PF00017	0.357
LIG_TYR_ITSM	329	336	PF00017	0.357
MOD_CK1_1	236	242	PF00069	0.313
MOD_CK1_1	278	284	PF00069	0.193
MOD_CK1_1	325	331	PF00069	0.313
MOD_CK2_1	281	287	PF00069	0.313
MOD_CK2_1	82	88	PF00069	0.313
MOD_GlcNHglycan	213	217	PF01048	0.291
MOD_GlcNHglycan	267	270	PF01048	0.313
MOD_GlcNHglycan	283	286	PF01048	0.200
MOD_GlcNHglycan	324	327	PF01048	0.313
MOD_GlcNHglycan	339	342	PF01048	0.207
MOD_GlcNHglycan	350	353	PF01048	0.235
MOD_GSK3_1	124	131	PF00069	0.456
MOD_GSK3_1	208	215	PF00069	0.291
MOD_GSK3_1	236	243	PF00069	0.313
MOD_GSK3_1	274	281	PF00069	0.253
MOD_GSK3_1	288	295	PF00069	0.196
MOD_GSK3_1	321	328	PF00069	0.324
MOD_N-GLC_1	174	179	PF02516	0.357
MOD_N-GLC_2	160	162	PF02516	0.313
MOD_NEK2_1	124	129	PF00069	0.449
MOD_NEK2_1	144	149	PF00069	0.376
MOD_NEK2_1	302	307	PF00069	0.357
MOD_NEK2_1	320	325	PF00069	0.190
MOD_NEK2_1	346	351	PF00069	0.338
MOD_NEK2_1	361	366	PF00069	0.355
MOD_NEK2_1	82	87	PF00069	0.368
MOD_PIKK_1	288	294	PF00454	0.193
MOD_PKA_1	49	55	PF00069	0.303
MOD_PKA_2	236	242	PF00069	0.357
MOD_PKA_2	49	55	PF00069	0.193
MOD_Plk_1	144	150	PF00069	0.335
MOD_Plk_1	82	88	PF00069	0.313
MOD_Plk_4	102	108	PF00069	0.313
MOD_Plk_4	325	331	PF00069	0.313
MOD_ProDKin_1	126	132	PF00069	0.471
MOD_ProDKin_1	246	252	PF00069	0.357
MOD_SUMO_rev_2	57	66	PF00179	0.313
TRG_ENDOCYTIC_2	141	144	PF00928	0.345
TRG_ENDOCYTIC_2	263	266	PF00928	0.357
TRG_ENDOCYTIC_2	333	336	PF00928	0.357
TRG_ER_diArg_1	365	367	PF00400	0.501
TRG_ER_diArg_1	48	51	PF00400	0.313
TRG_NES_CRM1_1	68	83	PF08389	0.259
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPS1	Leishmania donovani	93%	100%
A4H4X1	Leishmania braziliensis	72%	100%
A4HT44	Leishmania infantum	93%	100%
O94671	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	98%
P08499	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	30%	82%
P19582	Bacillus subtilis (strain 168)	32%	85%
P29365	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	32%	85%
P37144	Methylobacillus glycogenes	30%	89%
P46806	Mycobacterium leprae (strain TN)	33%	83%
P52985	Lactococcus lactis subsp. cremoris	33%	86%
P52986	Synechocystis sp. (strain PCC 6803 / Kazusa)	33%	85%
P56429	Helicobacter pylori (strain ATCC 700392 / 26695)	29%	87%
P63630	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	83%
P9WPX0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	83%
P9WPX1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	83%
Q4QIR8	Leishmania major	91%	100%
Q9CGD8	Lactococcus lactis subsp. lactis (strain IL1403)	31%	86%
Q9ZL20	Helicobacter pylori (strain J99 / ATCC 700824)	29%	87%