LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AL34_LEIMU
TriTrypDb:
LmxM.07.0240
Length:
606

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 5
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9AL34
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL34

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 242 246 PF00656 0.395
CLV_NRD_NRD_1 230 232 PF00675 0.700
CLV_NRD_NRD_1 235 237 PF00675 0.669
CLV_NRD_NRD_1 270 272 PF00675 0.601
CLV_NRD_NRD_1 289 291 PF00675 0.599
CLV_NRD_NRD_1 302 304 PF00675 0.639
CLV_NRD_NRD_1 314 316 PF00675 0.566
CLV_NRD_NRD_1 33 35 PF00675 0.395
CLV_NRD_NRD_1 364 366 PF00675 0.705
CLV_NRD_NRD_1 40 42 PF00675 0.504
CLV_NRD_NRD_1 426 428 PF00675 0.810
CLV_NRD_NRD_1 6 8 PF00675 0.446
CLV_PCSK_FUR_1 300 304 PF00082 0.711
CLV_PCSK_KEX2_1 230 232 PF00082 0.702
CLV_PCSK_KEX2_1 235 237 PF00082 0.673
CLV_PCSK_KEX2_1 270 272 PF00082 0.601
CLV_PCSK_KEX2_1 289 291 PF00082 0.483
CLV_PCSK_KEX2_1 302 304 PF00082 0.557
CLV_PCSK_KEX2_1 314 316 PF00082 0.566
CLV_PCSK_KEX2_1 33 35 PF00082 0.391
CLV_PCSK_KEX2_1 363 365 PF00082 0.707
CLV_PCSK_KEX2_1 39 41 PF00082 0.510
CLV_PCSK_KEX2_1 426 428 PF00082 0.810
CLV_PCSK_KEX2_1 6 8 PF00082 0.471
CLV_PCSK_PC7_1 231 237 PF00082 0.682
CLV_PCSK_SKI1_1 270 274 PF00082 0.607
CLV_PCSK_SKI1_1 41 45 PF00082 0.430
CLV_PCSK_SKI1_1 454 458 PF00082 0.718
CLV_PCSK_SKI1_1 46 50 PF00082 0.409
CLV_PCSK_SKI1_1 502 506 PF00082 0.725
DEG_Nend_Nbox_1 1 3 PF02207 0.714
DEG_SPOP_SBC_1 168 172 PF00917 0.439
DOC_CKS1_1 177 182 PF01111 0.535
DOC_CYCLIN_RxL_1 267 276 PF00134 0.407
DOC_CYCLIN_yCln2_LP_2 320 326 PF00134 0.440
DOC_MAPK_gen_1 235 241 PF00069 0.417
DOC_MAPK_gen_1 363 371 PF00069 0.440
DOC_MAPK_gen_1 423 433 PF00069 0.591
DOC_MAPK_MEF2A_6 131 139 PF00069 0.368
DOC_MAPK_MEF2A_6 208 217 PF00069 0.372
DOC_MAPK_RevD_3 351 365 PF00069 0.465
DOC_PP2B_LxvP_1 79 82 PF13499 0.528
DOC_PP4_FxxP_1 326 329 PF00568 0.509
DOC_USP7_MATH_1 168 172 PF00917 0.592
DOC_USP7_MATH_1 458 462 PF00917 0.502
DOC_USP7_MATH_1 571 575 PF00917 0.509
DOC_USP7_MATH_1 580 584 PF00917 0.398
DOC_WW_Pin1_4 17 22 PF00397 0.685
DOC_WW_Pin1_4 176 181 PF00397 0.569
DOC_WW_Pin1_4 197 202 PF00397 0.513
DOC_WW_Pin1_4 209 214 PF00397 0.508
DOC_WW_Pin1_4 273 278 PF00397 0.429
DOC_WW_Pin1_4 294 299 PF00397 0.436
LIG_14-3-3_CanoR_1 131 139 PF00244 0.336
LIG_14-3-3_CanoR_1 166 175 PF00244 0.588
LIG_14-3-3_CanoR_1 270 276 PF00244 0.413
LIG_14-3-3_CanoR_1 330 338 PF00244 0.477
LIG_14-3-3_CanoR_1 373 378 PF00244 0.393
LIG_14-3-3_CanoR_1 426 432 PF00244 0.523
LIG_14-3-3_CanoR_1 46 51 PF00244 0.222
LIG_14-3-3_CanoR_1 475 483 PF00244 0.485
LIG_Actin_WH2_2 115 133 PF00022 0.411
LIG_Actin_WH2_2 523 538 PF00022 0.578
LIG_APCC_ABBA_1 353 358 PF00400 0.382
LIG_BRCT_BRCA1_1 187 191 PF00533 0.555
LIG_FHA_1 107 113 PF00498 0.421
LIG_FHA_1 260 266 PF00498 0.422
LIG_FHA_1 3 9 PF00498 0.760
LIG_FHA_1 341 347 PF00498 0.471
LIG_FHA_1 458 464 PF00498 0.545
LIG_FHA_1 521 527 PF00498 0.479
LIG_FHA_1 62 68 PF00498 0.389
LIG_FHA_2 416 422 PF00498 0.540
LIG_FHA_2 85 91 PF00498 0.462
LIG_Integrin_isoDGR_2 406 408 PF01839 0.741
LIG_LIR_Apic_2 497 503 PF02991 0.319
LIG_LIR_Gen_1 248 254 PF02991 0.404
LIG_LIR_Gen_1 354 362 PF02991 0.383
LIG_LIR_Gen_1 486 495 PF02991 0.460
LIG_LIR_Nem_3 248 252 PF02991 0.409
LIG_LIR_Nem_3 354 359 PF02991 0.381
LIG_LIR_Nem_3 435 441 PF02991 0.509
LIG_LIR_Nem_3 486 490 PF02991 0.450
LIG_LIR_Nem_3 89 94 PF02991 0.404
LIG_MYND_1 378 382 PF01753 0.436
LIG_MYND_1 96 100 PF01753 0.421
LIG_PCNA_PIPBox_1 73 82 PF02747 0.445
LIG_PCNA_yPIPBox_3 69 80 PF02747 0.437
LIG_Pex14_2 121 125 PF04695 0.414
LIG_PTB_Apo_2 243 250 PF02174 0.419
LIG_PTB_Phospho_1 243 249 PF10480 0.414
LIG_REV1ctd_RIR_1 27 38 PF16727 0.651
LIG_SH2_CRK 500 504 PF00017 0.317
LIG_SH2_NCK_1 132 136 PF00017 0.365
LIG_SH2_NCK_1 249 253 PF00017 0.423
LIG_SH2_SRC 434 437 PF00017 0.505
LIG_SH2_SRC 555 558 PF00017 0.514
LIG_SH2_STAP1 132 136 PF00017 0.365
LIG_SH2_STAP1 434 438 PF00017 0.471
LIG_SH2_STAT3 549 552 PF00017 0.431
LIG_SH2_STAT5 285 288 PF00017 0.385
LIG_SH2_STAT5 495 498 PF00017 0.295
LIG_SH2_STAT5 61 64 PF00017 0.411
LIG_SH2_STAT5 86 89 PF00017 0.461
LIG_SH3_1 452 458 PF00018 0.558
LIG_SH3_3 135 141 PF00018 0.374
LIG_SH3_3 15 21 PF00018 0.769
LIG_SH3_3 154 160 PF00018 0.577
LIG_SH3_3 204 210 PF00018 0.527
LIG_SH3_3 375 381 PF00018 0.581
LIG_SH3_3 407 413 PF00018 0.600
LIG_SH3_3 452 458 PF00018 0.558
LIG_SH3_5 82 86 PF00018 0.567
LIG_SH3_CIN85_PxpxPR_1 203 208 PF14604 0.420
LIG_SUMO_SIM_anti_2 102 107 PF11976 0.375
LIG_SUMO_SIM_anti_2 133 139 PF11976 0.356
LIG_SUMO_SIM_par_1 271 276 PF11976 0.425
LIG_TRAF2_1 602 605 PF00917 0.610
LIG_TYR_ITIM 130 135 PF00017 0.448
LIG_UBA3_1 240 247 PF00899 0.453
LIG_ULM_U2AF65_1 363 369 PF00076 0.635
LIG_WRC_WIRS_1 122 127 PF05994 0.522
MOD_CDK_SPxK_1 294 300 PF00069 0.535
MOD_CDK_SPxxK_3 17 24 PF00069 0.658
MOD_CDK_SPxxK_3 176 183 PF00069 0.679
MOD_CK1_1 520 526 PF00069 0.425
MOD_CK1_1 559 565 PF00069 0.499
MOD_CK2_1 344 350 PF00069 0.482
MOD_CK2_1 398 404 PF00069 0.791
MOD_CK2_1 458 464 PF00069 0.663
MOD_Cter_Amidation 312 315 PF01082 0.524
MOD_GlcNHglycan 14 17 PF01048 0.618
MOD_GlcNHglycan 277 280 PF01048 0.648
MOD_GlcNHglycan 398 401 PF01048 0.714
MOD_GSK3_1 106 113 PF00069 0.496
MOD_GSK3_1 271 278 PF00069 0.626
MOD_GSK3_1 340 347 PF00069 0.602
MOD_GSK3_1 380 387 PF00069 0.773
MOD_GSK3_1 555 562 PF00069 0.627
MOD_N-GLC_1 256 261 PF02516 0.639
MOD_N-GLC_1 580 585 PF02516 0.547
MOD_NEK2_1 106 111 PF00069 0.449
MOD_NEK2_1 121 126 PF00069 0.373
MOD_NEK2_1 130 135 PF00069 0.426
MOD_NEK2_1 2 7 PF00069 0.624
MOD_NEK2_1 316 321 PF00069 0.541
MOD_NEK2_1 476 481 PF00069 0.648
MOD_PIKK_1 330 336 PF00454 0.586
MOD_PK_1 271 277 PF00069 0.560
MOD_PKA_2 106 112 PF00069 0.445
MOD_PKA_2 130 136 PF00069 0.445
MOD_PKA_2 192 198 PF00069 0.721
MOD_PKA_2 2 8 PF00069 0.620
MOD_PKA_2 372 378 PF00069 0.464
MOD_PKA_2 425 431 PF00069 0.767
MOD_PKA_2 476 482 PF00069 0.646
MOD_PKA_2 585 591 PF00069 0.483
MOD_PKB_1 183 191 PF00069 0.626
MOD_Plk_1 316 322 PF00069 0.639
MOD_Plk_1 458 464 PF00069 0.663
MOD_Plk_1 520 526 PF00069 0.425
MOD_Plk_1 555 561 PF00069 0.533
MOD_Plk_1 580 586 PF00069 0.552
MOD_Plk_1 84 90 PF00069 0.596
MOD_Plk_4 316 322 PF00069 0.537
MOD_Plk_4 458 464 PF00069 0.663
MOD_Plk_4 571 577 PF00069 0.633
MOD_Plk_4 75 81 PF00069 0.357
MOD_ProDKin_1 17 23 PF00069 0.609
MOD_ProDKin_1 176 182 PF00069 0.714
MOD_ProDKin_1 197 203 PF00069 0.644
MOD_ProDKin_1 209 215 PF00069 0.634
MOD_ProDKin_1 273 279 PF00069 0.528
MOD_ProDKin_1 294 300 PF00069 0.535
MOD_SUMO_rev_2 85 94 PF00179 0.611
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.598
TRG_DiLeu_BaLyEn_6 452 457 PF01217 0.771
TRG_ENDOCYTIC_2 132 135 PF00928 0.440
TRG_ENDOCYTIC_2 23 26 PF00928 0.456
TRG_ENDOCYTIC_2 249 252 PF00928 0.494
TRG_ENDOCYTIC_2 283 286 PF00928 0.485
TRG_ENDOCYTIC_2 356 359 PF00928 0.460
TRG_ENDOCYTIC_2 438 441 PF00928 0.660
TRG_ER_diArg_1 182 185 PF00400 0.695
TRG_ER_diArg_1 230 232 PF00400 0.635
TRG_ER_diArg_1 234 236 PF00400 0.622
TRG_ER_diArg_1 270 272 PF00400 0.489
TRG_ER_diArg_1 288 290 PF00400 0.482
TRG_ER_diArg_1 302 304 PF00400 0.541
TRG_ER_diArg_1 314 316 PF00400 0.416
TRG_ER_diArg_1 33 35 PF00400 0.501
TRG_ER_diArg_1 362 365 PF00400 0.614
TRG_ER_diArg_1 38 41 PF00400 0.632
TRG_ER_diArg_1 426 429 PF00400 0.776
TRG_ER_diArg_1 474 477 PF00400 0.679
TRG_ER_diArg_1 480 483 PF00400 0.653
TRG_ER_diArg_1 6 8 PF00400 0.551
TRG_Pf-PMV_PEXEL_1 185 189 PF00026 0.623
TRG_Pf-PMV_PEXEL_1 454 459 PF00026 0.807
TRG_Pf-PMV_PEXEL_1 502 507 PF00026 0.585
TRG_Pf-PMV_PEXEL_1 6 10 PF00026 0.601
TRG_Pf-PMV_PEXEL_1 69 73 PF00026 0.506

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE68 Leptomonas seymouri 54% 100%
A0A3S5H5W8 Leishmania donovani 91% 100%
A4H4W9 Leishmania braziliensis 78% 98%
A4HT42 Leishmania infantum 91% 100%
Q4QIS0 Leishmania major 90% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS