CIAPIN1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis, putative

Species:

Leishmania mexicana

UniProt:

E9AL33_LEIMU

TriTrypDb:

LmxM.07.0230

Length:

119

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005758	mitochondrial intermembrane space	6	12
GO:0031970	organelle envelope lumen	5	12
GO:0031974	membrane-enclosed lumen	2	12
GO:0043233	organelle lumen	3	12
GO:0070013	intracellular organelle lumen	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AL33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL33

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016226	iron-sulfur cluster assembly	4	12
GO:0022607	cellular component assembly	4	12
GO:0031163	metallo-sulfur cluster assembly	5	12
GO:0044237	cellular metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051539	4 iron, 4 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0051537	2 iron, 2 sulfur cluster binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.492
CLV_NRD_NRD_1	46	48	PF00675	0.417
CLV_NRD_NRD_1	60	62	PF00675	0.397
CLV_PCSK_KEX2_1	45	47	PF00082	0.451
CLV_PCSK_SKI1_1	31	35	PF00082	0.504
DOC_PP4_FxxP_1	74	77	PF00568	0.368
DOC_USP7_UBL2_3	34	38	PF12436	0.528
LIG_FHA_1	110	116	PF00498	0.434
LIG_FHA_2	25	31	PF00498	0.469
LIG_FHA_2	35	41	PF00498	0.539
LIG_LIR_Apic_2	72	77	PF02991	0.378
LIG_PDZ_Class_3	114	119	PF00595	0.510
MOD_CK1_1	12	18	PF00069	0.496
MOD_CK1_1	3	9	PF00069	0.526
MOD_CK2_1	34	40	PF00069	0.525
MOD_GlcNHglycan	3	6	PF01048	0.585
MOD_GSK3_1	1	8	PF00069	0.567
MOD_GSK3_1	109	116	PF00069	0.526
MOD_N-GLC_1	113	118	PF02516	0.549
MOD_N-GLC_1	82	87	PF02516	0.322
MOD_NEK2_1	1	6	PF00069	0.529
MOD_PIKK_1	5	11	PF00454	0.529
MOD_SUMO_rev_2	104	112	PF00179	0.606
MOD_SUMO_rev_2	58	63	PF00179	0.501
MOD_SUMO_rev_2	64	69	PF00179	0.576
TRG_DiLeu_BaEn_4	28	34	PF01217	0.598
TRG_ER_diArg_1	45	47	PF00400	0.439
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0W2	Leptomonas seymouri	88%	100%
A0A0S4JP81	Bodo saltans	59%	100%
A0A1X0ND50	Trypanosomatidae	74%	100%
A0A3S5IRT3	Trypanosoma rangeli	76%	100%
A0A3S7WPS2	Leishmania donovani	91%	100%
A4H4W7	Leishmania braziliensis	90%	100%
A4HT41	Leishmania infantum	96%	100%
C9ZUU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	96%
Q4D3B7	Trypanosoma cruzi (strain CL Brener)	79%	100%
Q4DER6	Trypanosoma cruzi (strain CL Brener)	78%	100%
Q4QIS1	Leishmania major	89%	95%
Q582A7	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	69%	96%
Q8SWE5	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
V5BDG5	Trypanosoma cruzi	78%	100%