Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL32_LEIMU

TriTrypDb:

LmxM.07.0220

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL32

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.723
CLV_NRD_NRD_1	123	125	PF00675	0.592
CLV_NRD_NRD_1	138	140	PF00675	0.521
CLV_NRD_NRD_1	304	306	PF00675	0.577
CLV_NRD_NRD_1	582	584	PF00675	0.437
CLV_PCSK_KEX2_1	123	125	PF00082	0.486
CLV_PCSK_KEX2_1	138	140	PF00082	0.578
CLV_PCSK_KEX2_1	582	584	PF00082	0.437
CLV_PCSK_SKI1_1	231	235	PF00082	0.616
CLV_PCSK_SKI1_1	245	249	PF00082	0.607
CLV_PCSK_SKI1_1	436	440	PF00082	0.504
CLV_PCSK_SKI1_1	594	598	PF00082	0.524
CLV_Separin_Metazoa	402	406	PF03568	0.527
DEG_APCC_DBOX_1	20	28	PF00400	0.670
DEG_SCF_FBW7_2	375	381	PF00400	0.310
DOC_CDC14_PxL_1	422	430	PF14671	0.495
DOC_CKS1_1	375	380	PF01111	0.317
DOC_CYCLIN_RxL_1	505	513	PF00134	0.557
DOC_MAPK_gen_1	228	236	PF00069	0.662
DOC_MAPK_gen_1	525	533	PF00069	0.485
DOC_MAPK_gen_1	9	17	PF00069	0.650
DOC_MAPK_MEF2A_6	11	19	PF00069	0.612
DOC_MAPK_MEF2A_6	228	236	PF00069	0.615
DOC_MAPK_MEF2A_6	495	503	PF00069	0.544
DOC_PP2B_LxvP_1	496	499	PF13499	0.529
DOC_PP4_FxxP_1	432	435	PF00568	0.395
DOC_PP4_FxxP_1	453	456	PF00568	0.572
DOC_USP7_MATH_1	190	194	PF00917	0.609
DOC_USP7_MATH_1	203	207	PF00917	0.574
DOC_USP7_MATH_1	414	418	PF00917	0.459
DOC_USP7_MATH_1	468	472	PF00917	0.656
DOC_USP7_MATH_1	595	599	PF00917	0.570
DOC_USP7_MATH_1	624	628	PF00917	0.654
DOC_USP7_UBL2_3	71	75	PF12436	0.792
DOC_WW_Pin1_4	240	245	PF00397	0.678
DOC_WW_Pin1_4	374	379	PF00397	0.330
DOC_WW_Pin1_4	404	409	PF00397	0.457
DOC_WW_Pin1_4	431	436	PF00397	0.383
DOC_WW_Pin1_4	617	622	PF00397	0.698
DOC_WW_Pin1_4	79	84	PF00397	0.758
LIG_14-3-3_CanoR_1	139	149	PF00244	0.626
LIG_14-3-3_CanoR_1	162	172	PF00244	0.468
LIG_14-3-3_CanoR_1	552	559	PF00244	0.484
LIG_14-3-3_CanoR_1	594	600	PF00244	0.610
LIG_14-3-3_CanoR_1	9	18	PF00244	0.392
LIG_14-3-3_CterR_2	631	635	PF00244	0.682
LIG_APCC_ABBA_1	385	390	PF00400	0.478
LIG_BRCT_BRCA1_1	449	453	PF00533	0.396
LIG_deltaCOP1_diTrp_1	568	575	PF00928	0.433
LIG_eIF4E_1	388	394	PF01652	0.474
LIG_FHA_1	10	16	PF00498	0.388
LIG_FHA_1	167	173	PF00498	0.429
LIG_FHA_1	246	252	PF00498	0.525
LIG_FHA_1	314	320	PF00498	0.440
LIG_FHA_1	347	353	PF00498	0.481
LIG_FHA_1	375	381	PF00498	0.529
LIG_FHA_1	405	411	PF00498	0.467
LIG_FHA_1	552	558	PF00498	0.438
LIG_FHA_1	595	601	PF00498	0.514
LIG_FHA_1	609	615	PF00498	0.481
LIG_FHA_2	84	90	PF00498	0.759
LIG_FHA_2	97	103	PF00498	0.450
LIG_LIR_Apic_2	430	435	PF02991	0.390
LIG_LIR_Apic_2	450	456	PF02991	0.284
LIG_LIR_Gen_1	290	299	PF02991	0.565
LIG_LIR_Gen_1	318	329	PF02991	0.485
LIG_LIR_Gen_1	366	375	PF02991	0.636
LIG_LIR_Gen_1	398	409	PF02991	0.522
LIG_LIR_Nem_3	290	294	PF02991	0.574
LIG_LIR_Nem_3	298	303	PF02991	0.494
LIG_LIR_Nem_3	318	324	PF02991	0.392
LIG_LIR_Nem_3	366	371	PF02991	0.653
LIG_LIR_Nem_3	398	404	PF02991	0.504
LIG_LIR_Nem_3	424	428	PF02991	0.511
LIG_LIR_Nem_3	490	494	PF02991	0.609
LIG_LYPXL_yS_3	425	428	PF13949	0.520
LIG_PCNA_yPIPBox_3	582	591	PF02747	0.572
LIG_Pex14_1	160	164	PF04695	0.681
LIG_SH2_CRK	300	304	PF00017	0.510
LIG_SH2_CRK	321	325	PF00017	0.483
LIG_SH2_CRK	491	495	PF00017	0.631
LIG_SH2_SRC	291	294	PF00017	0.551
LIG_SH2_STAP1	300	304	PF00017	0.498
LIG_SH2_STAP1	321	325	PF00017	0.460
LIG_SH2_STAP1	388	392	PF00017	0.472
LIG_SH2_STAT5	164	167	PF00017	0.735
LIG_SH2_STAT5	246	249	PF00017	0.630
LIG_SH2_STAT5	351	354	PF00017	0.557
LIG_SH2_STAT5	4	7	PF00017	0.535
LIG_SH2_STAT5	427	430	PF00017	0.516
LIG_SH2_STAT5	437	440	PF00017	0.489
LIG_SH2_STAT5	539	542	PF00017	0.433
LIG_SH3_3	350	356	PF00018	0.508
LIG_SUMO_SIM_anti_2	12	19	PF11976	0.609
LIG_TRAF2_1	445	448	PF00917	0.550
LIG_TYR_ITIM	319	324	PF00017	0.521
LIG_TYR_ITIM	423	428	PF00017	0.518
LIG_TYR_ITSM	296	303	PF00017	0.518
LIG_UBA3_1	379	386	PF00899	0.400
LIG_UBA3_1	517	525	PF00899	0.555
LIG_WRC_WIRS_1	368	373	PF05994	0.656
MOD_CDK_SPK_2	240	245	PF00069	0.656
MOD_CDK_SPK_2	431	436	PF00069	0.383
MOD_CK1_1	163	169	PF00069	0.653
MOD_CK1_1	217	223	PF00069	0.718
MOD_CK1_1	369	375	PF00069	0.682
MOD_CK1_1	487	493	PF00069	0.441
MOD_CK1_1	66	72	PF00069	0.758
MOD_CK2_1	152	158	PF00069	0.661
MOD_CK2_1	367	373	PF00069	0.700
MOD_CK2_1	442	448	PF00069	0.536
MOD_CK2_1	624	630	PF00069	0.670
MOD_CK2_1	83	89	PF00069	0.698
MOD_CK2_1	96	102	PF00069	0.557
MOD_GlcNHglycan	154	157	PF01048	0.672
MOD_GlcNHglycan	184	187	PF01048	0.636
MOD_GlcNHglycan	192	195	PF01048	0.653
MOD_GlcNHglycan	217	220	PF01048	0.760
MOD_GlcNHglycan	283	286	PF01048	0.538
MOD_GlcNHglycan	300	303	PF01048	0.461
MOD_GlcNHglycan	40	44	PF01048	0.676
MOD_GlcNHglycan	465	468	PF01048	0.662
MOD_GlcNHglycan	486	489	PF01048	0.456
MOD_GlcNHglycan	52	55	PF01048	0.555
MOD_GlcNHglycan	57	60	PF01048	0.738
MOD_GlcNHglycan	578	581	PF01048	0.446
MOD_GlcNHglycan	61	64	PF01048	0.774
MOD_GSK3_1	166	173	PF00069	0.698
MOD_GSK3_1	174	181	PF00069	0.746
MOD_GSK3_1	182	189	PF00069	0.553
MOD_GSK3_1	199	206	PF00069	0.650
MOD_GSK3_1	213	220	PF00069	0.630
MOD_GSK3_1	277	284	PF00069	0.506
MOD_GSK3_1	438	445	PF00069	0.503
MOD_GSK3_1	483	490	PF00069	0.655
MOD_GSK3_1	55	62	PF00069	0.647
MOD_GSK3_1	590	597	PF00069	0.510
MOD_GSK3_1	79	86	PF00069	0.765
MOD_N-GLC_1	240	245	PF02516	0.572
MOD_N-GLC_1	442	447	PF02516	0.564
MOD_N-GLC_1	607	612	PF02516	0.650
MOD_N-GLC_1	617	622	PF02516	0.710
MOD_NEK2_1	182	187	PF00069	0.623
MOD_NEK2_1	295	300	PF00069	0.503
MOD_NEK2_1	313	318	PF00069	0.319
MOD_NEK2_1	367	372	PF00069	0.603
MOD_NEK2_1	379	384	PF00069	0.536
MOD_NEK2_1	438	443	PF00069	0.513
MOD_NEK2_1	463	468	PF00069	0.702
MOD_NEK2_1	532	537	PF00069	0.462
MOD_NEK2_1	616	621	PF00069	0.632
MOD_NEK2_2	315	320	PF00069	0.446
MOD_PIKK_1	456	462	PF00454	0.593
MOD_PKA_2	199	205	PF00069	0.758
MOD_PKA_2	551	557	PF00069	0.438
MOD_Plk_1	166	172	PF00069	0.429
MOD_Plk_1	447	453	PF00069	0.582
MOD_Plk_1	66	72	PF00069	0.560
MOD_Plk_4	379	385	PF00069	0.559
MOD_Plk_4	595	601	PF00069	0.597
MOD_ProDKin_1	240	246	PF00069	0.675
MOD_ProDKin_1	374	380	PF00069	0.327
MOD_ProDKin_1	404	410	PF00069	0.466
MOD_ProDKin_1	431	437	PF00069	0.390
MOD_ProDKin_1	617	623	PF00069	0.702
MOD_ProDKin_1	79	85	PF00069	0.754
MOD_SUMO_rev_2	254	264	PF00179	0.581
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.454
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.471
TRG_ENDOCYTIC_2	291	294	PF00928	0.551
TRG_ENDOCYTIC_2	300	303	PF00928	0.522
TRG_ENDOCYTIC_2	321	324	PF00928	0.498
TRG_ENDOCYTIC_2	425	428	PF00928	0.520
TRG_ENDOCYTIC_2	491	494	PF00928	0.606
TRG_ER_diArg_1	137	139	PF00400	0.606
TRG_ER_diArg_1	21	24	PF00400	0.675
TRG_ER_diArg_1	268	271	PF00400	0.349
TRG_ER_diArg_1	581	583	PF00400	0.470
TRG_ER_diArg_1	8	11	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7J6	Leptomonas seymouri	61%	99%
A0A3R7NMJ1	Trypanosoma rangeli	33%	100%
A0A3S5H5W7	Leishmania donovani	91%	100%
A4H4W6	Leishmania braziliensis	74%	97%
A4HT40	Leishmania infantum	91%	100%
C9ZUU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QIS2	Leishmania major	91%	100%
V5B8V4	Trypanosoma cruzi	36%	100%