LeishMANIAdb
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CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Gene product:
phosphatidylglycerolphosphate synthase, mitochondrial, putative
Species:
Leishmania mexicana
UniProt:
E9AL30_LEIMU
TriTrypDb:
LmxM.07.0200
Length:
752

Annotations

LeishMANIAdb annotations

Overall very similar to animal mitochondrial PGS1 enzymes, with one key difference: instead a a transit signal, the Kinetoplastid variant has membrane anchor.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9AL30
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL30

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 9
GO:0006644 phospholipid metabolic process 4 9
GO:0006650 glycerophospholipid metabolic process 5 9
GO:0006655 phosphatidylglycerol biosynthetic process 6 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0008152 metabolic process 1 9
GO:0008610 lipid biosynthetic process 4 9
GO:0008654 phospholipid biosynthetic process 5 9
GO:0009058 biosynthetic process 2 9
GO:0009987 cellular process 1 9
GO:0019637 organophosphate metabolic process 3 9
GO:0032048 cardiolipin metabolic process 7 9
GO:0032049 cardiolipin biosynthetic process 7 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044249 cellular biosynthetic process 3 9
GO:0044255 cellular lipid metabolic process 3 9
GO:0045017 glycerolipid biosynthetic process 4 9
GO:0046471 phosphatidylglycerol metabolic process 6 9
GO:0046474 glycerophospholipid biosynthetic process 5 9
GO:0046486 glycerolipid metabolic process 4 9
GO:0071704 organic substance metabolic process 2 9
GO:0090407 organophosphate biosynthetic process 4 9
GO:1901576 organic substance biosynthetic process 3 9
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003824 catalytic activity 1 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity 6 9
GO:0016740 transferase activity 2 9
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 9
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 9
GO:0017076 purine nucleotide binding 4 9
GO:0017169 CDP-alcohol phosphatidyltransferase activity 5 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 701 705 PF00656 0.596
CLV_NRD_NRD_1 134 136 PF00675 0.266
CLV_NRD_NRD_1 190 192 PF00675 0.430
CLV_NRD_NRD_1 367 369 PF00675 0.451
CLV_NRD_NRD_1 452 454 PF00675 0.466
CLV_NRD_NRD_1 491 493 PF00675 0.414
CLV_NRD_NRD_1 607 609 PF00675 0.433
CLV_NRD_NRD_1 631 633 PF00675 0.506
CLV_PCSK_KEX2_1 133 135 PF00082 0.374
CLV_PCSK_KEX2_1 491 493 PF00082 0.417
CLV_PCSK_KEX2_1 607 609 PF00082 0.433
CLV_PCSK_KEX2_1 631 633 PF00082 0.505
CLV_PCSK_PC1ET2_1 133 135 PF00082 0.389
CLV_PCSK_SKI1_1 134 138 PF00082 0.386
CLV_PCSK_SKI1_1 141 145 PF00082 0.360
CLV_PCSK_SKI1_1 301 305 PF00082 0.370
CLV_PCSK_SKI1_1 349 353 PF00082 0.404
CLV_PCSK_SKI1_1 373 377 PF00082 0.417
CLV_PCSK_SKI1_1 527 531 PF00082 0.362
CLV_PCSK_SKI1_1 617 621 PF00082 0.417
CLV_PCSK_SKI1_1 707 711 PF00082 0.235
CLV_PCSK_SKI1_1 86 90 PF00082 0.410
CLV_Separin_Metazoa 708 712 PF03568 0.431
DEG_APCC_DBOX_1 190 198 PF00400 0.598
DEG_APCC_DBOX_1 710 718 PF00400 0.532
DOC_CYCLIN_RxL_1 521 534 PF00134 0.582
DOC_CYCLIN_RxL_1 83 90 PF00134 0.445
DOC_CYCLIN_yCln2_LP_2 122 128 PF00134 0.596
DOC_MAPK_FxFP_2 507 510 PF00069 0.565
DOC_MAPK_gen_1 191 197 PF00069 0.596
DOC_MAPK_gen_1 299 306 PF00069 0.578
DOC_MAPK_gen_1 453 460 PF00069 0.631
DOC_MAPK_MEF2A_6 736 743 PF00069 0.611
DOC_PP1_RVXF_1 164 170 PF00149 0.605
DOC_PP1_RVXF_1 496 502 PF00149 0.558
DOC_PP1_RVXF_1 615 622 PF00149 0.590
DOC_PP2B_LxvP_1 293 296 PF13499 0.668
DOC_PP4_FxxP_1 507 510 PF00568 0.565
DOC_USP7_MATH_1 113 117 PF00917 0.586
DOC_USP7_MATH_1 139 143 PF00917 0.603
DOC_USP7_MATH_1 222 226 PF00917 0.772
DOC_USP7_MATH_1 264 268 PF00917 0.738
DOC_USP7_MATH_1 271 275 PF00917 0.745
DOC_USP7_MATH_1 400 404 PF00917 0.764
DOC_USP7_MATH_1 411 415 PF00917 0.754
DOC_USP7_MATH_1 418 422 PF00917 0.649
DOC_USP7_MATH_1 437 441 PF00917 0.713
DOC_USP7_MATH_1 44 48 PF00917 0.780
DOC_USP7_MATH_1 636 640 PF00917 0.631
DOC_USP7_MATH_1 678 682 PF00917 0.531
DOC_USP7_MATH_2 667 673 PF00917 0.613
DOC_USP7_UBL2_3 369 373 PF12436 0.506
DOC_WW_Pin1_4 223 228 PF00397 0.799
DOC_WW_Pin1_4 383 388 PF00397 0.800
DOC_WW_Pin1_4 398 403 PF00397 0.715
DOC_WW_Pin1_4 40 45 PF00397 0.732
DOC_WW_Pin1_4 432 437 PF00397 0.668
DOC_WW_Pin1_4 445 450 PF00397 0.623
DOC_WW_Pin1_4 47 52 PF00397 0.746
DOC_WW_Pin1_4 540 545 PF00397 0.516
DOC_WW_Pin1_4 637 642 PF00397 0.774
LIG_14-3-3_CanoR_1 134 143 PF00244 0.546
LIG_14-3-3_CanoR_1 230 236 PF00244 0.761
LIG_14-3-3_CanoR_1 360 364 PF00244 0.625
LIG_14-3-3_CanoR_1 531 539 PF00244 0.538
LIG_14-3-3_CanoR_1 631 641 PF00244 0.609
LIG_Actin_WH2_2 592 609 PF00022 0.640
LIG_APCC_ABBA_1 19 24 PF00400 0.646
LIG_APCC_ABBAyCdc20_2 516 522 PF00400 0.525
LIG_BRCT_BRCA1_1 15 19 PF00533 0.201
LIG_BRCT_BRCA1_1 155 159 PF00533 0.566
LIG_BRCT_BRCA1_1 237 241 PF00533 0.734
LIG_CaM_NSCaTE_8 489 496 PF13499 0.517
LIG_deltaCOP1_diTrp_1 500 507 PF00928 0.596
LIG_EH1_1 176 184 PF00400 0.594
LIG_FHA_1 116 122 PF00498 0.581
LIG_FHA_1 16 22 PF00498 0.353
LIG_FHA_1 178 184 PF00498 0.542
LIG_FHA_1 208 214 PF00498 0.729
LIG_FHA_1 350 356 PF00498 0.614
LIG_FHA_1 437 443 PF00498 0.781
LIG_FHA_1 558 564 PF00498 0.562
LIG_FHA_1 565 571 PF00498 0.524
LIG_FHA_1 725 731 PF00498 0.548
LIG_FHA_2 331 337 PF00498 0.562
LIG_FHA_2 532 538 PF00498 0.591
LIG_FHA_2 60 66 PF00498 0.803
LIG_FHA_2 699 705 PF00498 0.563
LIG_LIR_Apic_2 505 510 PF02991 0.569
LIG_LIR_Gen_1 16 25 PF02991 0.436
LIG_LIR_Gen_1 184 190 PF02991 0.551
LIG_LIR_Gen_1 288 297 PF02991 0.644
LIG_LIR_Gen_1 336 346 PF02991 0.531
LIG_LIR_Gen_1 543 553 PF02991 0.520
LIG_LIR_Nem_3 16 22 PF02991 0.436
LIG_LIR_Nem_3 288 293 PF02991 0.627
LIG_LIR_Nem_3 336 341 PF02991 0.509
LIG_LIR_Nem_3 500 504 PF02991 0.557
LIG_LIR_Nem_3 506 512 PF02991 0.496
LIG_LIR_Nem_3 593 599 PF02991 0.558
LIG_NRBOX 713 719 PF00104 0.538
LIG_OCRL_FandH_1 313 325 PF00620 0.560
LIG_PALB2_WD40_1 346 354 PF16756 0.556
LIG_PCNA_PIPBox_1 98 107 PF02747 0.564
LIG_PCNA_yPIPBox_3 337 351 PF02747 0.562
LIG_PCNA_yPIPBox_3 703 711 PF02747 0.481
LIG_PCNA_yPIPBox_3 91 105 PF02747 0.643
LIG_PDZ_Class_3 747 752 PF00595 0.642
LIG_Pex14_1 290 294 PF04695 0.658
LIG_RPA_C_Fungi 487 499 PF08784 0.378
LIG_SH2_CRK 284 288 PF00017 0.475
LIG_SH2_CRK 603 607 PF00017 0.511
LIG_SH2_CRK 686 690 PF00017 0.489
LIG_SH2_GRB2like 284 287 PF00017 0.473
LIG_SH2_GRB2like 545 548 PF00017 0.401
LIG_SH2_SRC 284 287 PF00017 0.473
LIG_SH2_SRC 7 10 PF00017 0.298
LIG_SH2_STAP1 504 508 PF00017 0.413
LIG_SH2_STAP1 549 553 PF00017 0.323
LIG_SH2_STAT5 149 152 PF00017 0.403
LIG_SH2_STAT5 330 333 PF00017 0.417
LIG_SH2_STAT5 545 548 PF00017 0.409
LIG_SH2_STAT5 562 565 PF00017 0.387
LIG_SH2_STAT5 589 592 PF00017 0.415
LIG_SH2_STAT5 598 601 PF00017 0.441
LIG_SH2_STAT5 675 678 PF00017 0.407
LIG_SH2_STAT5 7 10 PF00017 0.482
LIG_SH3_3 431 437 PF00018 0.603
LIG_SH3_3 662 668 PF00018 0.576
LIG_SUMO_SIM_anti_2 178 184 PF11976 0.432
LIG_SUMO_SIM_anti_2 455 461 PF11976 0.433
LIG_SUMO_SIM_par_1 178 184 PF11976 0.479
LIG_SUMO_SIM_par_1 50 55 PF11976 0.499
LIG_TYR_ITIM 127 132 PF00017 0.452
LIG_TYR_ITIM 5 10 PF00017 0.438
LIG_WRC_WIRS_1 101 106 PF05994 0.478
LIG_WRC_WIRS_1 504 509 PF05994 0.458
LIG_WRC_WIRS_1 549 554 PF05994 0.353
MOD_CDC14_SPxK_1 640 643 PF00782 0.492
MOD_CDK_SPxK_1 383 389 PF00069 0.790
MOD_CDK_SPxK_1 637 643 PF00069 0.479
MOD_CDK_SPxxK_3 223 230 PF00069 0.601
MOD_CDK_SPxxK_3 398 405 PF00069 0.518
MOD_CK1_1 209 215 PF00069 0.564
MOD_CK1_1 226 232 PF00069 0.757
MOD_CK1_1 263 269 PF00069 0.790
MOD_CK1_1 398 404 PF00069 0.742
MOD_CK1_1 440 446 PF00069 0.661
MOD_CK1_1 469 475 PF00069 0.502
MOD_CK1_1 47 53 PF00069 0.767
MOD_CK1_1 569 575 PF00069 0.441
MOD_CK1_1 87 93 PF00069 0.443
MOD_CK2_1 411 417 PF00069 0.685
MOD_CK2_1 440 446 PF00069 0.700
MOD_CK2_1 530 536 PF00069 0.447
MOD_CK2_1 73 79 PF00069 0.683
MOD_Cter_Amidation 629 632 PF01082 0.577
MOD_DYRK1A_RPxSP_1 432 436 PF00069 0.725
MOD_GlcNHglycan 145 148 PF01048 0.407
MOD_GlcNHglycan 262 265 PF01048 0.747
MOD_GlcNHglycan 266 269 PF01048 0.700
MOD_GlcNHglycan 397 400 PF01048 0.727
MOD_GlcNHglycan 40 43 PF01048 0.561
MOD_GlcNHglycan 413 416 PF01048 0.514
MOD_GlcNHglycan 46 49 PF01048 0.679
MOD_GlcNHglycan 634 637 PF01048 0.670
MOD_GlcNHglycan 671 674 PF01048 0.455
MOD_GlcNHglycan 78 82 PF01048 0.606
MOD_GSK3_1 139 146 PF00069 0.489
MOD_GSK3_1 222 229 PF00069 0.783
MOD_GSK3_1 230 237 PF00069 0.742
MOD_GSK3_1 256 263 PF00069 0.786
MOD_GSK3_1 38 45 PF00069 0.611
MOD_GSK3_1 394 401 PF00069 0.730
MOD_GSK3_1 407 414 PF00069 0.720
MOD_GSK3_1 432 439 PF00069 0.680
MOD_GSK3_1 632 639 PF00069 0.537
MOD_GSK3_1 718 725 PF00069 0.411
MOD_GSK3_1 73 80 PF00069 0.570
MOD_LATS_1 610 616 PF00433 0.427
MOD_N-GLC_1 222 227 PF02516 0.726
MOD_N-GLC_1 324 329 PF02516 0.357
MOD_N-GLC_1 411 416 PF02516 0.717
MOD_NEK2_1 177 182 PF00069 0.430
MOD_NEK2_1 235 240 PF00069 0.781
MOD_NEK2_1 38 43 PF00069 0.541
MOD_NEK2_1 393 398 PF00069 0.731
MOD_NEK2_1 530 535 PF00069 0.454
MOD_NEK2_1 548 553 PF00069 0.257
MOD_NEK2_1 557 562 PF00069 0.362
MOD_NEK2_1 592 597 PF00069 0.432
MOD_NEK2_1 698 703 PF00069 0.394
MOD_NEK2_1 718 723 PF00069 0.237
MOD_NEK2_1 729 734 PF00069 0.577
MOD_NEK2_2 236 241 PF00069 0.661
MOD_NEK2_2 685 690 PF00069 0.407
MOD_PIKK_1 349 355 PF00454 0.501
MOD_PIKK_1 440 446 PF00454 0.686
MOD_PIKK_1 724 730 PF00454 0.526
MOD_PK_1 612 618 PF00069 0.500
MOD_PKA_1 134 140 PF00069 0.440
MOD_PKA_1 631 637 PF00069 0.403
MOD_PKA_2 134 140 PF00069 0.440
MOD_PKA_2 316 322 PF00069 0.438
MOD_PKA_2 359 365 PF00069 0.508
MOD_PKA_2 452 458 PF00069 0.547
MOD_PKA_2 530 536 PF00069 0.421
MOD_PKA_2 631 637 PF00069 0.403
MOD_Plk_1 592 598 PF00069 0.440
MOD_Plk_1 612 618 PF00069 0.224
MOD_Plk_4 236 242 PF00069 0.756
MOD_Plk_4 316 322 PF00069 0.391
MOD_Plk_4 418 424 PF00069 0.527
MOD_Plk_4 437 443 PF00069 0.777
MOD_Plk_4 503 509 PF00069 0.386
MOD_Plk_4 520 526 PF00069 0.380
MOD_Plk_4 548 554 PF00069 0.486
MOD_Plk_4 558 564 PF00069 0.487
MOD_Plk_4 84 90 PF00069 0.504
MOD_ProDKin_1 223 229 PF00069 0.775
MOD_ProDKin_1 383 389 PF00069 0.775
MOD_ProDKin_1 398 404 PF00069 0.655
MOD_ProDKin_1 40 46 PF00069 0.686
MOD_ProDKin_1 432 438 PF00069 0.595
MOD_ProDKin_1 445 451 PF00069 0.520
MOD_ProDKin_1 47 53 PF00069 0.701
MOD_ProDKin_1 540 546 PF00069 0.379
MOD_ProDKin_1 637 643 PF00069 0.741
MOD_SUMO_rev_2 184 194 PF00179 0.521
MOD_SUMO_rev_2 53 62 PF00179 0.614
TRG_DiLeu_BaEn_1 342 347 PF01217 0.409
TRG_DiLeu_BaEn_1 713 718 PF01217 0.431
TRG_DiLeu_BaEn_2 535 541 PF01217 0.473
TRG_DiLeu_BaEn_2 693 699 PF01217 0.383
TRG_DiLeu_BaEn_2 99 105 PF01217 0.439
TRG_ENDOCYTIC_2 129 132 PF00928 0.444
TRG_ENDOCYTIC_2 185 188 PF00928 0.410
TRG_ENDOCYTIC_2 338 341 PF00928 0.379
TRG_ENDOCYTIC_2 504 507 PF00928 0.416
TRG_ENDOCYTIC_2 545 548 PF00928 0.376
TRG_ENDOCYTIC_2 549 552 PF00928 0.381
TRG_ENDOCYTIC_2 589 592 PF00928 0.410
TRG_ENDOCYTIC_2 597 600 PF00928 0.420
TRG_ENDOCYTIC_2 603 606 PF00928 0.433
TRG_ENDOCYTIC_2 686 689 PF00928 0.490
TRG_ENDOCYTIC_2 7 10 PF00928 0.401
TRG_ER_diArg_1 134 136 PF00400 0.310
TRG_ER_diArg_1 166 169 PF00400 0.511
TRG_ER_diArg_1 491 493 PF00400 0.468
TRG_ER_diArg_1 606 608 PF00400 0.506
TRG_NES_CRM1_1 712 726 PF08389 0.490
TRG_Pf-PMV_PEXEL_1 198 202 PF00026 0.441

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILX1 Leptomonas seymouri 62% 100%
A0A0S4JQL9 Bodo saltans 37% 100%
A0A3S5H5W5 Leishmania donovani 90% 100%
A4H4W4 Leishmania braziliensis 78% 100%
A4HT38 Leishmania infantum 90% 100%
C9ZUU6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
Q4QIS4 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS