Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AL26_LEIMU

TriTrypDb:

LmxM.07.0160

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL26

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.393
CLV_NRD_NRD_1	326	328	PF00675	0.745
CLV_NRD_NRD_1	483	485	PF00675	0.758
CLV_NRD_NRD_1	490	492	PF00675	0.787
CLV_NRD_NRD_1	536	538	PF00675	0.714
CLV_NRD_NRD_1	653	655	PF00675	0.619
CLV_NRD_NRD_1	678	680	PF00675	0.728
CLV_NRD_NRD_1	703	705	PF00675	0.540
CLV_NRD_NRD_1	794	796	PF00675	0.446
CLV_PCSK_FUR_1	792	796	PF00082	0.631
CLV_PCSK_KEX2_1	328	330	PF00082	0.629
CLV_PCSK_KEX2_1	34	36	PF00082	0.411
CLV_PCSK_KEX2_1	442	444	PF00082	0.668
CLV_PCSK_KEX2_1	490	492	PF00082	0.773
CLV_PCSK_KEX2_1	536	538	PF00082	0.710
CLV_PCSK_KEX2_1	566	568	PF00082	0.827
CLV_PCSK_KEX2_1	653	655	PF00082	0.619
CLV_PCSK_KEX2_1	678	680	PF00082	0.731
CLV_PCSK_KEX2_1	702	704	PF00082	0.543
CLV_PCSK_KEX2_1	794	796	PF00082	0.630
CLV_PCSK_KEX2_1	817	819	PF00082	0.615
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.629
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.411
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.668
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.761
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.827
CLV_PCSK_PC1ET2_1	817	819	PF00082	0.615
CLV_PCSK_SKI1_1	123	127	PF00082	0.361
CLV_PCSK_SKI1_1	246	250	PF00082	0.443
CLV_PCSK_SKI1_1	253	257	PF00082	0.485
CLV_PCSK_SKI1_1	329	333	PF00082	0.635
CLV_PCSK_SKI1_1	492	496	PF00082	0.559
CLV_PCSK_SKI1_1	566	570	PF00082	0.828
CLV_PCSK_SKI1_1	818	822	PF00082	0.548
DEG_SCF_FBW7_1	370	375	PF00400	0.843
DEG_SPOP_SBC_1	339	343	PF00917	0.604
DEG_SPOP_SBC_1	348	352	PF00917	0.721
DOC_ANK_TNKS_1	666	673	PF00023	0.535
DOC_CKS1_1	463	468	PF01111	0.552
DOC_CKS1_1	697	702	PF01111	0.816
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	509	515	PF00134	0.550
DOC_MAPK_DCC_7	287	296	PF00069	0.538
DOC_MAPK_gen_1	123	132	PF00069	0.411
DOC_MAPK_gen_1	51	60	PF00069	0.374
DOC_MAPK_gen_1	817	828	PF00069	0.742
DOC_MAPK_MEF2A_6	287	296	PF00069	0.538
DOC_MAPK_MEF2A_6	424	431	PF00069	0.600
DOC_MAPK_MEF2A_6	464	473	PF00069	0.746
DOC_MAPK_MEF2A_6	821	830	PF00069	0.688
DOC_MAPK_RevD_3	427	443	PF00069	0.536
DOC_PP2B_LxvP_1	509	512	PF13499	0.550
DOC_PP2B_LxvP_1	541	544	PF13499	0.739
DOC_PP4_FxxP_1	199	202	PF00568	0.411
DOC_PP4_FxxP_1	686	689	PF00568	0.737
DOC_PP4_MxPP_1	698	701	PF00568	0.682
DOC_USP7_MATH_1	265	269	PF00917	0.669
DOC_USP7_MATH_1	277	281	PF00917	0.706
DOC_USP7_MATH_1	314	318	PF00917	0.810
DOC_USP7_MATH_1	335	339	PF00917	0.629
DOC_USP7_MATH_1	340	344	PF00917	0.750
DOC_USP7_MATH_1	359	363	PF00917	0.556
DOC_USP7_MATH_1	372	376	PF00917	0.652
DOC_USP7_MATH_1	395	399	PF00917	0.754
DOC_USP7_MATH_1	748	752	PF00917	0.743
DOC_USP7_UBL2_3	486	490	PF12436	0.781
DOC_USP7_UBL2_3	553	557	PF12436	0.737
DOC_USP7_UBL2_3	595	599	PF12436	0.754
DOC_USP7_UBL2_3	817	821	PF12436	0.503
DOC_WW_Pin1_4	159	164	PF00397	0.411
DOC_WW_Pin1_4	214	219	PF00397	0.511
DOC_WW_Pin1_4	263	268	PF00397	0.582
DOC_WW_Pin1_4	287	292	PF00397	0.818
DOC_WW_Pin1_4	299	304	PF00397	0.807
DOC_WW_Pin1_4	305	310	PF00397	0.523
DOC_WW_Pin1_4	321	326	PF00397	0.714
DOC_WW_Pin1_4	343	348	PF00397	0.784
DOC_WW_Pin1_4	368	373	PF00397	0.838
DOC_WW_Pin1_4	396	401	PF00397	0.804
DOC_WW_Pin1_4	407	412	PF00397	0.781
DOC_WW_Pin1_4	453	458	PF00397	0.748
DOC_WW_Pin1_4	462	467	PF00397	0.643
DOC_WW_Pin1_4	513	518	PF00397	0.698
DOC_WW_Pin1_4	582	587	PF00397	0.735
DOC_WW_Pin1_4	678	683	PF00397	0.708
DOC_WW_Pin1_4	685	690	PF00397	0.782
DOC_WW_Pin1_4	696	701	PF00397	0.777
DOC_WW_Pin1_4	709	714	PF00397	0.690
DOC_WW_Pin1_4	729	734	PF00397	0.704
DOC_WW_Pin1_4	836	841	PF00397	0.563
LIG_14-3-3_CanoR_1	196	202	PF00244	0.393
LIG_14-3-3_CanoR_1	242	249	PF00244	0.411
LIG_14-3-3_CanoR_1	287	291	PF00244	0.735
LIG_14-3-3_CanoR_1	394	400	PF00244	0.743
LIG_14-3-3_CanoR_1	491	501	PF00244	0.644
LIG_14-3-3_CanoR_1	507	512	PF00244	0.565
LIG_14-3-3_CanoR_1	526	534	PF00244	0.786
LIG_14-3-3_CanoR_1	536	544	PF00244	0.668
LIG_14-3-3_CanoR_1	703	713	PF00244	0.726
LIG_14-3-3_CanoR_1	736	741	PF00244	0.810
LIG_14-3-3_CanoR_1	754	759	PF00244	0.525
LIG_14-3-3_CanoR_1	775	779	PF00244	0.697
LIG_14-3-3_CanoR_1	94	104	PF00244	0.420
LIG_BRCT_BRCA1_1	758	762	PF00533	0.739
LIG_deltaCOP1_diTrp_1	181	189	PF00928	0.411
LIG_FHA_1	134	140	PF00498	0.471
LIG_FHA_1	150	156	PF00498	0.266
LIG_FHA_1	38	44	PF00498	0.459
LIG_FHA_1	528	534	PF00498	0.733
LIG_FHA_1	536	542	PF00498	0.746
LIG_FHA_1	550	556	PF00498	0.806
LIG_FHA_1	96	102	PF00498	0.411
LIG_FHA_2	339	345	PF00498	0.761
LIG_FHA_2	350	356	PF00498	0.623
LIG_Integrin_isoDGR_2	763	765	PF01839	0.729
LIG_LIR_Apic_2	162	168	PF02991	0.411
LIG_LIR_Apic_2	684	689	PF02991	0.706
LIG_LIR_Gen_1	203	211	PF02991	0.411
LIG_LIR_Gen_1	4	12	PF02991	0.483
LIG_LIR_Gen_1	69	76	PF02991	0.448
LIG_LIR_LC3C_4	28	32	PF02991	0.477
LIG_LIR_LC3C_4	428	432	PF02991	0.545
LIG_LIR_Nem_3	203	207	PF02991	0.411
LIG_LIR_Nem_3	212	216	PF02991	0.411
LIG_LIR_Nem_3	4	9	PF02991	0.457
LIG_LIR_Nem_3	83	89	PF02991	0.374
LIG_MAD2	553	561	PF02301	0.815
LIG_PALB2_WD40_1	100	108	PF16756	0.411
LIG_Pex14_2	60	64	PF04695	0.411
LIG_SH2_CRK	6	10	PF00017	0.454
LIG_SH2_NCK_1	190	194	PF00017	0.511
LIG_SH2_STAP1	176	180	PF00017	0.406
LIG_SH2_STAT3	635	638	PF00017	0.537
LIG_SH2_STAT3	740	743	PF00017	0.746
LIG_SH2_STAT3	88	91	PF00017	0.511
LIG_SH2_STAT5	114	117	PF00017	0.511
LIG_SH2_STAT5	140	143	PF00017	0.361
LIG_SH2_STAT5	6	9	PF00017	0.466
LIG_SH2_STAT5	635	638	PF00017	0.563
LIG_SH2_STAT5	838	841	PF00017	0.572
LIG_SH2_STAT5	88	91	PF00017	0.407
LIG_SH3_1	300	306	PF00018	0.738
LIG_SH3_3	233	239	PF00018	0.511
LIG_SH3_3	293	299	PF00018	0.724
LIG_SH3_3	300	306	PF00018	0.775
LIG_SH3_3	308	314	PF00018	0.693
LIG_SH3_3	334	340	PF00018	0.756
LIG_SH3_3	409	415	PF00018	0.717
LIG_SH3_3	576	582	PF00018	0.791
LIG_SH3_3	668	674	PF00018	0.589
LIG_SH3_3	686	692	PF00018	0.744
LIG_SH3_3	694	700	PF00018	0.684
LIG_SH3_3	708	714	PF00018	0.755
LIG_SH3_4	599	606	PF00018	0.798
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.355
LIG_SUMO_SIM_anti_2	428	433	PF11976	0.547
LIG_SUMO_SIM_par_1	233	238	PF11976	0.377
LIG_SUMO_SIM_par_1	354	363	PF11976	0.754
LIG_SUMO_SIM_par_1	428	433	PF11976	0.547
LIG_TRAF2_1	777	780	PF00917	0.642
LIG_WRC_WIRS_1	61	66	PF05994	0.411
LIG_WW_3	284	288	PF00397	0.733
LIG_WW_3	324	328	PF00397	0.740
LIG_WW_3	577	581	PF00397	0.820
LIG_WW_3	699	703	PF00397	0.812
MOD_CDC14_SPxK_1	585	588	PF00782	0.733
MOD_CDK_SPxK_1	321	327	PF00069	0.740
MOD_CDK_SPxK_1	582	588	PF00069	0.736
MOD_CDK_SPxK_1	696	702	PF00069	0.824
MOD_CDK_SPxxK_3	321	328	PF00069	0.741
MOD_CDK_SPxxK_3	678	685	PF00069	0.686
MOD_CDK_SPxxK_3	696	703	PF00069	0.516
MOD_CDK_SPxxK_3	729	736	PF00069	0.741
MOD_CK1_1	133	139	PF00069	0.356
MOD_CK1_1	146	152	PF00069	0.366
MOD_CK1_1	153	159	PF00069	0.183
MOD_CK1_1	200	206	PF00069	0.411
MOD_CK1_1	266	272	PF00069	0.652
MOD_CK1_1	279	285	PF00069	0.639
MOD_CK1_1	317	323	PF00069	0.838
MOD_CK1_1	338	344	PF00069	0.829
MOD_CK1_1	351	357	PF00069	0.692
MOD_CK1_1	375	381	PF00069	0.854
MOD_CK1_1	399	405	PF00069	0.752
MOD_CK1_1	516	522	PF00069	0.725
MOD_CK1_1	529	535	PF00069	0.824
MOD_CK1_1	545	551	PF00069	0.821
MOD_CK1_1	681	687	PF00069	0.680
MOD_CK1_1	75	81	PF00069	0.471
MOD_CK1_1	753	759	PF00069	0.733
MOD_CK2_1	287	293	PF00069	0.733
MOD_CK2_1	338	344	PF00069	0.563
MOD_CK2_1	453	459	PF00069	0.554
MOD_CK2_1	774	780	PF00069	0.665
MOD_GlcNHglycan	145	148	PF01048	0.383
MOD_GlcNHglycan	199	202	PF01048	0.411
MOD_GlcNHglycan	253	256	PF01048	0.329
MOD_GlcNHglycan	279	282	PF01048	0.701
MOD_GlcNHglycan	319	322	PF01048	0.784
MOD_GlcNHglycan	383	386	PF01048	0.672
MOD_GlcNHglycan	401	404	PF01048	0.525
MOD_GlcNHglycan	480	483	PF01048	0.551
MOD_GlcNHglycan	548	551	PF01048	0.689
MOD_GlcNHglycan	674	677	PF01048	0.741
MOD_GlcNHglycan	716	719	PF01048	0.710
MOD_GlcNHglycan	77	80	PF01048	0.511
MOD_GlcNHglycan	806	809	PF01048	0.670
MOD_GSK3_1	146	153	PF00069	0.411
MOD_GSK3_1	155	162	PF00069	0.411
MOD_GSK3_1	226	233	PF00069	0.511
MOD_GSK3_1	276	283	PF00069	0.703
MOD_GSK3_1	305	312	PF00069	0.707
MOD_GSK3_1	313	320	PF00069	0.786
MOD_GSK3_1	335	342	PF00069	0.794
MOD_GSK3_1	343	350	PF00069	0.697
MOD_GSK3_1	368	375	PF00069	0.847
MOD_GSK3_1	395	402	PF00069	0.750
MOD_GSK3_1	472	479	PF00069	0.742
MOD_GSK3_1	542	549	PF00069	0.744
MOD_GSK3_1	681	688	PF00069	0.725
MOD_GSK3_1	750	757	PF00069	0.722
MOD_GSK3_1	832	839	PF00069	0.485
MOD_N-GLC_1	153	158	PF02516	0.411
MOD_N-GLC_1	46	51	PF02516	0.403
MOD_N-GLC_1	492	497	PF02516	0.560
MOD_N-GLC_1	545	550	PF02516	0.694
MOD_N-GLC_1	66	71	PF02516	0.423
MOD_NEK2_1	108	113	PF00069	0.210
MOD_NEK2_1	12	17	PF00069	0.560
MOD_NEK2_1	150	155	PF00069	0.386
MOD_NEK2_1	171	176	PF00069	0.371
MOD_NEK2_1	46	51	PF00069	0.369
MOD_NEK2_1	471	476	PF00069	0.704
MOD_NEK2_1	478	483	PF00069	0.710
MOD_NEK2_1	60	65	PF00069	0.411
MOD_NEK2_1	758	763	PF00069	0.700
MOD_NEK2_1	89	94	PF00069	0.423
MOD_NEK2_2	66	71	PF00069	0.511
MOD_PIKK_1	309	315	PF00454	0.749
MOD_PIKK_1	37	43	PF00454	0.403
MOD_PIKK_1	383	389	PF00454	0.753
MOD_PIKK_1	599	605	PF00454	0.549
MOD_PIKK_1	87	93	PF00454	0.411
MOD_PK_1	507	513	PF00069	0.835
MOD_PKA_2	241	247	PF00069	0.411
MOD_PKA_2	286	292	PF00069	0.767
MOD_PKA_2	535	541	PF00069	0.662
MOD_PKA_2	753	759	PF00069	0.732
MOD_PKA_2	774	780	PF00069	0.765
MOD_PKB_1	327	335	PF00069	0.633
MOD_PKB_1	505	513	PF00069	0.835
MOD_PKB_1	702	710	PF00069	0.741
MOD_Plk_1	46	52	PF00069	0.411
MOD_Plk_4	108	114	PF00069	0.347
MOD_Plk_4	146	152	PF00069	0.419
MOD_Plk_4	155	161	PF00069	0.406
MOD_Plk_4	226	232	PF00069	0.413
MOD_Plk_4	425	431	PF00069	0.566
MOD_Plk_4	60	66	PF00069	0.393
MOD_Plk_4	97	103	PF00069	0.354
MOD_ProDKin_1	159	165	PF00069	0.411
MOD_ProDKin_1	214	220	PF00069	0.511
MOD_ProDKin_1	263	269	PF00069	0.590
MOD_ProDKin_1	287	293	PF00069	0.737
MOD_ProDKin_1	299	305	PF00069	0.802
MOD_ProDKin_1	321	327	PF00069	0.753
MOD_ProDKin_1	343	349	PF00069	0.782
MOD_ProDKin_1	368	374	PF00069	0.840
MOD_ProDKin_1	396	402	PF00069	0.807
MOD_ProDKin_1	407	413	PF00069	0.780
MOD_ProDKin_1	453	459	PF00069	0.751
MOD_ProDKin_1	462	468	PF00069	0.642
MOD_ProDKin_1	513	519	PF00069	0.698
MOD_ProDKin_1	582	588	PF00069	0.736
MOD_ProDKin_1	678	684	PF00069	0.709
MOD_ProDKin_1	685	691	PF00069	0.783
MOD_ProDKin_1	696	702	PF00069	0.780
MOD_ProDKin_1	709	715	PF00069	0.694
MOD_ProDKin_1	729	735	PF00069	0.702
MOD_ProDKin_1	836	842	PF00069	0.565
MOD_SUMO_for_1	441	444	PF00179	0.681
MOD_SUMO_rev_2	133	139	PF00179	0.354
MOD_SUMO_rev_2	362	366	PF00179	0.762
MOD_SUMO_rev_2	642	647	PF00179	0.651
TRG_DiLeu_BaEn_2	519	525	PF01217	0.828
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.842
TRG_ENDOCYTIC_2	6	9	PF00928	0.451
TRG_ER_diArg_1	326	329	PF00400	0.620
TRG_ER_diArg_1	50	53	PF00400	0.411
TRG_ER_diArg_1	504	507	PF00400	0.832
TRG_ER_diArg_1	701	704	PF00400	0.818
TRG_ER_diArg_1	799	802	PF00400	0.598
TRG_NLS_MonoExtC_3	813	818	PF00514	0.584
TRG_NLS_MonoExtN_4	325	331	PF00514	0.616
TRG_NLS_MonoExtN_4	489	494	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.750
TRG_Pf-PMV_PEXEL_1	704	708	PF00026	0.826

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD87	Leptomonas seymouri	48%	100%
A0A3S7WPQ0	Leishmania donovani	86%	100%
A4H4W0	Leishmania braziliensis	66%	96%
A4HT34	Leishmania infantum	86%	100%
Q4QIS8	Leishmania major	86%	100%