Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic membrane protein family, putative

Species:

Leishmania mexicana

UniProt:

E9AL25_LEIMU

TriTrypDb:

LmxM.07.0150

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AL25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL25

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0032507	maintenance of protein location in cell	3	1
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	1
GO:0045185	maintenance of protein location	3	1
GO:0051179	localization	1	1
GO:0051235	maintenance of location	2	1
GO:0051651	maintenance of location in cell	2	1
GO:0072595	maintenance of protein localization in organelle	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.553
CLV_NRD_NRD_1	162	164	PF00675	0.271
CLV_NRD_NRD_1	209	211	PF00675	0.329
CLV_NRD_NRD_1	69	71	PF00675	0.536
CLV_NRD_NRD_1	81	83	PF00675	0.414
CLV_NRD_NRD_1	9	11	PF00675	0.492
CLV_PCSK_FUR_1	220	224	PF00082	0.317
CLV_PCSK_KEX2_1	123	125	PF00082	0.567
CLV_PCSK_KEX2_1	162	164	PF00082	0.271
CLV_PCSK_KEX2_1	208	210	PF00082	0.329
CLV_PCSK_KEX2_1	222	224	PF00082	0.339
CLV_PCSK_KEX2_1	437	439	PF00082	0.257
CLV_PCSK_KEX2_1	593	595	PF00082	0.547
CLV_PCSK_KEX2_1	69	71	PF00082	0.532
CLV_PCSK_KEX2_1	80	82	PF00082	0.395
CLV_PCSK_KEX2_1	9	11	PF00082	0.516
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.363
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.309
CLV_PCSK_PC1ET2_1	593	595	PF00082	0.547
CLV_PCSK_PC7_1	205	211	PF00082	0.311
CLV_PCSK_SKI1_1	117	121	PF00082	0.634
CLV_PCSK_SKI1_1	223	227	PF00082	0.324
CLV_PCSK_SKI1_1	249	253	PF00082	0.361
CLV_PCSK_SKI1_1	365	369	PF00082	0.271
CLV_PCSK_SKI1_1	434	438	PF00082	0.300
CLV_PCSK_SKI1_1	480	484	PF00082	0.409
DEG_APCC_DBOX_1	123	131	PF00400	0.361
DEG_APCC_DBOX_1	492	500	PF00400	0.609
DEG_APCC_DBOX_1	9	17	PF00400	0.591
DEG_Nend_UBRbox_1	1	4	PF02207	0.612
DEG_SCF_FBW7_1	532	539	PF00400	0.727
DEG_SPOP_SBC_1	59	63	PF00917	0.577
DOC_CDC14_PxL_1	397	405	PF14671	0.561
DOC_CKS1_1	243	248	PF01111	0.561
DOC_CKS1_1	424	429	PF01111	0.561
DOC_CKS1_1	533	538	PF01111	0.660
DOC_CYCLIN_RxL_1	244	255	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.436
DOC_MAPK_DCC_7	567	577	PF00069	0.571
DOC_MAPK_gen_1	162	169	PF00069	0.471
DOC_MAPK_gen_1	80	91	PF00069	0.515
DOC_MAPK_gen_1	9	15	PF00069	0.696
DOC_MAPK_MEF2A_6	128	135	PF00069	0.260
DOC_MAPK_MEF2A_6	162	171	PF00069	0.457
DOC_MAPK_MEF2A_6	324	332	PF00069	0.154
DOC_MAPK_MEF2A_6	571	579	PF00069	0.580
DOC_MAPK_MEF2A_6	85	93	PF00069	0.515
DOC_MAPK_NFAT4_5	128	136	PF00069	0.361
DOC_PP1_RVXF_1	299	306	PF00149	0.291
DOC_PP2B_LxvP_1	112	115	PF13499	0.330
DOC_USP7_MATH_1	225	229	PF00917	0.463
DOC_USP7_MATH_1	407	411	PF00917	0.469
DOC_USP7_MATH_1	51	55	PF00917	0.780
DOC_USP7_MATH_1	510	514	PF00917	0.763
DOC_USP7_MATH_1	58	62	PF00917	0.704
DOC_WW_Pin1_4	242	247	PF00397	0.561
DOC_WW_Pin1_4	306	311	PF00397	0.361
DOC_WW_Pin1_4	423	428	PF00397	0.509
DOC_WW_Pin1_4	499	504	PF00397	0.649
DOC_WW_Pin1_4	528	533	PF00397	0.625
DOC_WW_Pin1_4	536	541	PF00397	0.675
DOC_WW_Pin1_4	551	556	PF00397	0.675
DOC_WW_Pin1_4	570	575	PF00397	0.648
DOC_WW_Pin1_4	60	65	PF00397	0.787
LIG_14-3-3_CanoR_1	162	167	PF00244	0.470
LIG_14-3-3_CanoR_1	342	348	PF00244	0.361
LIG_14-3-3_CanoR_1	381	389	PF00244	0.488
LIG_14-3-3_CanoR_1	493	497	PF00244	0.628
LIG_14-3-3_CanoR_1	9	14	PF00244	0.651
LIG_Actin_WH2_2	112	130	PF00022	0.489
LIG_Actin_WH2_2	285	303	PF00022	0.332
LIG_BRCT_BRCA1_1	301	305	PF00533	0.214
LIG_BRCT_BRCA1_2	301	307	PF00533	0.152
LIG_EH1_1	106	114	PF00400	0.455
LIG_eIF4E_1	383	389	PF01652	0.537
LIG_EVH1_1	506	510	PF00568	0.621
LIG_EVH1_2	376	380	PF00568	0.505
LIG_FHA_1	10	16	PF00498	0.714
LIG_FHA_1	130	136	PF00498	0.410
LIG_FHA_1	148	154	PF00498	0.197
LIG_FHA_1	162	168	PF00498	0.412
LIG_FHA_1	274	280	PF00498	0.266
LIG_FHA_1	496	502	PF00498	0.616
LIG_FHA_1	515	521	PF00498	0.747
LIG_FHA_1	571	577	PF00498	0.565
LIG_FHA_2	414	420	PF00498	0.552
LIG_GBD_Chelix_1	178	186	PF00786	0.224
LIG_LIR_Apic_2	395	401	PF02991	0.477
LIG_LIR_Gen_1	151	161	PF02991	0.494
LIG_LIR_Gen_1	164	173	PF02991	0.449
LIG_LIR_Gen_1	192	203	PF02991	0.561
LIG_LIR_Gen_1	341	351	PF02991	0.288
LIG_LIR_Gen_1	38	48	PF02991	0.717
LIG_LIR_Gen_1	73	83	PF02991	0.603
LIG_LIR_Gen_1	88	98	PF02991	0.444
LIG_LIR_LC3C_4	498	501	PF02991	0.637
LIG_LIR_Nem_3	151	157	PF02991	0.509
LIG_LIR_Nem_3	164	169	PF02991	0.467
LIG_LIR_Nem_3	192	198	PF02991	0.537
LIG_LIR_Nem_3	341	346	PF02991	0.271
LIG_LIR_Nem_3	350	355	PF02991	0.125
LIG_LIR_Nem_3	378	383	PF02991	0.494
LIG_LIR_Nem_3	4	8	PF02991	0.676
LIG_LIR_Nem_3	505	509	PF02991	0.685
LIG_LIR_Nem_3	73	79	PF02991	0.619
LIG_LIR_Nem_3	94	99	PF02991	0.352
LIG_MYND_3	400	404	PF01753	0.561
LIG_NRBOX	107	113	PF00104	0.332
LIG_NRBOX	267	273	PF00104	0.424
LIG_NRBOX	287	293	PF00104	0.125
LIG_NRBOX	575	581	PF00104	0.558
LIG_Pex14_2	368	372	PF04695	0.457
LIG_Rb_LxCxE_1	350	362	PF01857	0.455
LIG_SH2_CRK	154	158	PF00017	0.495
LIG_SH2_CRK	383	387	PF00017	0.471
LIG_SH2_CRK	446	450	PF00017	0.353
LIG_SH2_CRK	76	80	PF00017	0.674
LIG_SH2_NCK_1	195	199	PF00017	0.561
LIG_SH2_PTP2	327	330	PF00017	0.152
LIG_SH2_SRC	156	159	PF00017	0.471
LIG_SH2_STAP1	154	158	PF00017	0.462
LIG_SH2_STAP1	37	41	PF00017	0.709
LIG_SH2_STAP1	383	387	PF00017	0.509
LIG_SH2_STAP1	446	450	PF00017	0.353
LIG_SH2_STAT5	156	159	PF00017	0.513
LIG_SH2_STAT5	327	330	PF00017	0.335
LIG_SH2_STAT5	460	463	PF00017	0.366
LIG_SH2_STAT5	96	99	PF00017	0.375
LIG_SH3_2	64	69	PF14604	0.547
LIG_SH3_3	497	503	PF00018	0.642
LIG_SH3_3	504	510	PF00018	0.700
LIG_SH3_3	61	67	PF00018	0.564
LIG_Sin3_3	332	339	PF02671	0.152
LIG_SUMO_SIM_anti_2	12	17	PF11976	0.721
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.488
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.422
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.125
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.488
LIG_SUMO_SIM_anti_2	402	408	PF11976	0.488
LIG_SUMO_SIM_par_1	168	174	PF11976	0.475
LIG_SUMO_SIM_par_1	387	392	PF11976	0.542
LIG_SUMO_SIM_par_1	497	502	PF11976	0.589
LIG_SUMO_SIM_par_1	561	568	PF11976	0.656
LIG_TYR_ITIM	193	198	PF00017	0.561
LIG_TYR_ITIM	444	449	PF00017	0.330
LIG_UBA3_1	111	117	PF00899	0.340
LIG_UBA3_1	172	181	PF00899	0.561
LIG_UBA3_1	471	480	PF00899	0.431
LIG_UBA3_1	575	581	PF00899	0.631
LIG_WW_2	507	510	PF00397	0.623
MOD_CDK_SPK_2	532	537	PF00069	0.721
MOD_CDK_SPxxK_3	242	249	PF00069	0.561
MOD_CK1_1	147	153	PF00069	0.183
MOD_CK1_1	184	190	PF00069	0.458
MOD_CK1_1	264	270	PF00069	0.344
MOD_CK1_1	312	318	PF00069	0.324
MOD_CK1_1	392	398	PF00069	0.477
MOD_CK1_1	502	508	PF00069	0.676
MOD_CK1_1	519	525	PF00069	0.659
MOD_CK1_1	531	537	PF00069	0.656
MOD_CK1_1	54	60	PF00069	0.782
MOD_CK2_1	305	311	PF00069	0.342
MOD_CK2_1	413	419	PF00069	0.544
MOD_Cter_Amidation	67	70	PF01082	0.494
MOD_GlcNHglycan	227	230	PF01048	0.351
MOD_GlcNHglycan	237	240	PF01048	0.284
MOD_GlcNHglycan	254	257	PF01048	0.275
MOD_GlcNHglycan	407	410	PF01048	0.339
MOD_GlcNHglycan	411	414	PF01048	0.306
MOD_GlcNHglycan	43	46	PF01048	0.510
MOD_GlcNHglycan	512	515	PF01048	0.503
MOD_GlcNHglycan	53	56	PF01048	0.594
MOD_GlcNHglycan	560	563	PF01048	0.539
MOD_GSK3_1	144	151	PF00069	0.308
MOD_GSK3_1	260	267	PF00069	0.370
MOD_GSK3_1	273	280	PF00069	0.226
MOD_GSK3_1	295	302	PF00069	0.306
MOD_GSK3_1	305	312	PF00069	0.317
MOD_GSK3_1	405	412	PF00069	0.539
MOD_GSK3_1	495	502	PF00069	0.611
MOD_GSK3_1	510	517	PF00069	0.732
MOD_GSK3_1	528	535	PF00069	0.565
MOD_GSK3_1	54	61	PF00069	0.758
MOD_GSK3_1	547	554	PF00069	0.590
MOD_N-GLC_1	277	282	PF02516	0.552
MOD_N-GLC_1	295	300	PF02516	0.455
MOD_NEK2_1	134	139	PF00069	0.411
MOD_NEK2_1	148	153	PF00069	0.242
MOD_NEK2_1	171	176	PF00069	0.569
MOD_NEK2_1	252	257	PF00069	0.344
MOD_NEK2_1	277	282	PF00069	0.250
MOD_NEK2_1	305	310	PF00069	0.263
MOD_NEK2_1	41	46	PF00069	0.716
MOD_NEK2_1	481	486	PF00069	0.332
MOD_NEK2_1	516	521	PF00069	0.717
MOD_NEK2_1	541	546	PF00069	0.646
MOD_NEK2_1	547	552	PF00069	0.644
MOD_NEK2_1	97	102	PF00069	0.330
MOD_NEK2_2	237	242	PF00069	0.352
MOD_NEK2_2	492	497	PF00069	0.625
MOD_OFUCOSY	260	265	PF10250	0.455
MOD_PIKK_1	117	123	PF00454	0.376
MOD_PIKK_1	148	154	PF00454	0.383
MOD_PIKK_1	184	190	PF00454	0.488
MOD_PIKK_1	25	31	PF00454	0.723
MOD_PIKK_1	381	387	PF00454	0.488
MOD_PKA_1	162	168	PF00069	0.471
MOD_PKA_1	9	15	PF00069	0.641
MOD_PKA_2	161	167	PF00069	0.471
MOD_PKA_2	341	347	PF00069	0.361
MOD_PKA_2	492	498	PF00069	0.625
MOD_PKA_2	9	15	PF00069	0.674
MOD_Plk_1	277	283	PF00069	0.236
MOD_Plk_4	139	145	PF00069	0.332
MOD_Plk_4	152	158	PF00069	0.416
MOD_Plk_4	162	168	PF00069	0.496
MOD_Plk_4	266	272	PF00069	0.326
MOD_Plk_4	284	290	PF00069	0.246
MOD_Plk_4	299	305	PF00069	0.224
MOD_Plk_4	375	381	PF00069	0.452
MOD_Plk_4	482	488	PF00069	0.403
MOD_ProDKin_1	242	248	PF00069	0.561
MOD_ProDKin_1	306	312	PF00069	0.361
MOD_ProDKin_1	423	429	PF00069	0.509
MOD_ProDKin_1	499	505	PF00069	0.657
MOD_ProDKin_1	528	534	PF00069	0.628
MOD_ProDKin_1	536	542	PF00069	0.674
MOD_ProDKin_1	551	557	PF00069	0.682
MOD_ProDKin_1	570	576	PF00069	0.644
MOD_ProDKin_1	60	66	PF00069	0.784
MOD_SUMO_rev_2	28	36	PF00179	0.677
TRG_DiLeu_BaEn_1	284	289	PF01217	0.271
TRG_DiLeu_BaEn_1	420	425	PF01217	0.561
TRG_DiLeu_BaLyEn_6	571	576	PF01217	0.639
TRG_ENDOCYTIC_2	154	157	PF00928	0.496
TRG_ENDOCYTIC_2	158	161	PF00928	0.509
TRG_ENDOCYTIC_2	195	198	PF00928	0.561
TRG_ENDOCYTIC_2	327	330	PF00928	0.360
TRG_ENDOCYTIC_2	37	40	PF00928	0.712
TRG_ENDOCYTIC_2	383	386	PF00928	0.459
TRG_ENDOCYTIC_2	446	449	PF00928	0.305
TRG_ENDOCYTIC_2	76	79	PF00928	0.675
TRG_ENDOCYTIC_2	96	99	PF00928	0.125
TRG_ER_diArg_1	122	124	PF00400	0.455
TRG_ER_diArg_1	161	163	PF00400	0.471
TRG_ER_diArg_1	208	210	PF00400	0.527
TRG_ER_diArg_1	69	72	PF00400	0.730
TRG_ER_diArg_1	79	82	PF00400	0.600
TRG_ER_diArg_1	8	10	PF00400	0.634
TRG_ER_diLys_1	591	596	PF00400	0.747
TRG_NES_CRM1_1	350	362	PF08389	0.167

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JBJ3	Bodo saltans	34%	100%
A0A1X0NLV9	Trypanosomatidae	39%	100%
A0A3S7WPS5	Leishmania donovani	88%	97%
A0A422NTF0	Trypanosoma rangeli	42%	100%
A4H4V9	Leishmania braziliensis	76%	100%
A4HT53	Leishmania infantum	88%	97%
C9ZUV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
Q4QIS9	Leishmania major	87%	100%
Q5ZLG8	Gallus gallus	25%	100%
V5D9E0	Trypanosoma cruzi	37%	100%