Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL24_LEIMU

TriTrypDb:

LmxM.07.0140

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AL24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL24

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	7
GO:0016192	vesicle-mediated transport	4	7
GO:0048193	Golgi vesicle transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.644
CLV_NRD_NRD_1	218	220	PF00675	0.459
CLV_NRD_NRD_1	252	254	PF00675	0.550
CLV_NRD_NRD_1	327	329	PF00675	0.485
CLV_PCSK_KEX2_1	218	220	PF00082	0.459
CLV_PCSK_KEX2_1	252	254	PF00082	0.473
CLV_PCSK_KEX2_1	327	329	PF00082	0.485
CLV_PCSK_SKI1_1	218	222	PF00082	0.515
CLV_PCSK_SKI1_1	260	264	PF00082	0.491
CLV_PCSK_SKI1_1	322	326	PF00082	0.439
CLV_PCSK_SKI1_1	34	38	PF00082	0.567
CLV_PCSK_SKI1_1	50	54	PF00082	0.662
DEG_APCC_DBOX_1	167	175	PF00400	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.723
DEG_SCF_FBW7_1	276	282	PF00400	0.804
DEG_SPOP_SBC_1	298	302	PF00917	0.761
DOC_CKS1_1	276	281	PF01111	0.808
DOC_CYCLIN_RxL_1	257	266	PF00134	0.710
DOC_CYCLIN_yCln2_LP_2	262	265	PF00134	0.790
DOC_MAPK_FxFP_2	233	236	PF00069	0.678
DOC_MAPK_gen_1	158	166	PF00069	0.680
DOC_MAPK_MEF2A_6	61	68	PF00069	0.211
DOC_MAPK_RevD_3	203	219	PF00069	0.436
DOC_PP2B_LxvP_1	262	265	PF13499	0.790
DOC_PP4_FxxP_1	233	236	PF00568	0.678
DOC_PP4_FxxP_1	261	264	PF00568	0.729
DOC_USP7_MATH_1	223	227	PF00917	0.743
DOC_USP7_MATH_1	336	340	PF00917	0.692
DOC_USP7_MATH_1	75	79	PF00917	0.443
DOC_USP7_MATH_1	82	86	PF00917	0.584
DOC_WW_Pin1_4	2	7	PF00397	0.653
DOC_WW_Pin1_4	254	259	PF00397	0.702
DOC_WW_Pin1_4	275	280	PF00397	0.788
LIG_14-3-3_CanoR_1	115	119	PF00244	0.409
LIG_14-3-3_CanoR_1	149	157	PF00244	0.635
LIG_14-3-3_CanoR_1	50	55	PF00244	0.449
LIG_Actin_WH2_2	101	117	PF00022	0.513
LIG_Actin_WH2_2	144	162	PF00022	0.583
LIG_Actin_WH2_2	227	242	PF00022	0.755
LIG_FHA_1	104	110	PF00498	0.380
LIG_FHA_1	15	21	PF00498	0.416
LIG_FHA_1	300	306	PF00498	0.814
LIG_FHA_1	51	57	PF00498	0.459
LIG_FHA_1	68	74	PF00498	0.513
LIG_FHA_1	88	94	PF00498	0.425
LIG_FHA_1	97	103	PF00498	0.395
LIG_FHA_2	307	313	PF00498	0.769
LIG_LIR_Apic_2	231	236	PF02991	0.754
LIG_LIR_Gen_1	199	209	PF02991	0.318
LIG_LIR_Gen_1	41	52	PF02991	0.440
LIG_LIR_Gen_1	85	93	PF02991	0.619
LIG_LIR_Nem_3	41	47	PF02991	0.502
LIG_LIR_Nem_3	85	91	PF02991	0.619
LIG_NRBOX	25	31	PF00104	0.398
LIG_Pex14_2	47	51	PF04695	0.426
LIG_RPA_C_Fungi	313	325	PF08784	0.708
LIG_SH2_STAP1	216	220	PF00017	0.578
LIG_SH2_STAP1	88	92	PF00017	0.411
LIG_SH2_STAT5	131	134	PF00017	0.420
LIG_SUMO_SIM_anti_2	181	187	PF11976	0.513
LIG_SUMO_SIM_par_1	101	107	PF11976	0.439
LIG_SUMO_SIM_par_1	25	33	PF11976	0.507
LIG_SUMO_SIM_par_1	53	59	PF11976	0.324
LIG_TRAF2_1	310	313	PF00917	0.629
LIG_TRFH_1	261	265	PF08558	0.672
LIG_TRFH_1	44	48	PF08558	0.636
LIG_UBA3_1	26	34	PF00899	0.338
LIG_WRC_WIRS_1	88	93	PF05994	0.436
MOD_CDC14_SPxK_1	257	260	PF00782	0.547
MOD_CDK_SPxK_1	254	260	PF00069	0.537
MOD_CDK_SPxxK_3	2	9	PF00069	0.514
MOD_CK1_1	293	299	PF00069	0.690
MOD_CK1_1	337	343	PF00069	0.712
MOD_CK2_1	306	312	PF00069	0.629
MOD_CK2_1	337	343	PF00069	0.667
MOD_GlcNHglycan	151	154	PF01048	0.594
MOD_GlcNHglycan	189	192	PF01048	0.608
MOD_GlcNHglycan	225	228	PF01048	0.596
MOD_GlcNHglycan	292	295	PF01048	0.592
MOD_GlcNHglycan	334	337	PF01048	0.678
MOD_GlcNHglycan	339	342	PF01048	0.641
MOD_GlcNHglycan	346	349	PF01048	0.585
MOD_GlcNHglycan	77	80	PF01048	0.580
MOD_GSK3_1	275	282	PF00069	0.639
MOD_GSK3_1	286	293	PF00069	0.591
MOD_GSK3_1	30	37	PF00069	0.641
MOD_GSK3_1	332	339	PF00069	0.622
MOD_GSK3_1	344	351	PF00069	0.615
MOD_GSK3_1	83	90	PF00069	0.514
MOD_GSK3_1	92	99	PF00069	0.313
MOD_N-GLC_1	121	126	PF02516	0.531
MOD_NEK2_1	1	6	PF00069	0.632
MOD_NEK2_1	114	119	PF00069	0.457
MOD_NEK2_1	210	215	PF00069	0.449
MOD_NEK2_1	28	33	PF00069	0.380
MOD_NEK2_1	56	61	PF00069	0.613
MOD_NEK2_1	92	97	PF00069	0.513
MOD_PKA_1	218	224	PF00069	0.580
MOD_PKA_2	114	120	PF00069	0.461
MOD_PKA_2	218	224	PF00069	0.580
MOD_PKB_1	147	155	PF00069	0.553
MOD_Plk_1	34	40	PF00069	0.605
MOD_Plk_4	114	120	PF00069	0.480
MOD_Plk_4	181	187	PF00069	0.513
MOD_Plk_4	210	216	PF00069	0.513
MOD_Plk_4	38	44	PF00069	0.570
MOD_Plk_4	87	93	PF00069	0.473
MOD_ProDKin_1	2	8	PF00069	0.551
MOD_ProDKin_1	254	260	PF00069	0.634
MOD_ProDKin_1	275	281	PF00069	0.750
TRG_DiLeu_BaEn_1	315	320	PF01217	0.583
TRG_DiLeu_BaEn_2	86	92	PF01217	0.513
TRG_DiLeu_LyEn_5	315	320	PF01217	0.583
TRG_ENDOCYTIC_2	131	134	PF00928	0.411
TRG_ENDOCYTIC_2	44	47	PF00928	0.559
TRG_ENDOCYTIC_2	88	91	PF00928	0.513
TRG_ER_diArg_1	157	160	PF00400	0.603
TRG_ER_diArg_1	218	220	PF00400	0.569
TRG_ER_diArg_1	252	254	PF00400	0.622
TRG_ER_diArg_1	316	319	PF00400	0.667
TRG_ER_diArg_1	327	329	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF2	Leptomonas seymouri	37%	94%
A0A3S5H5W2	Leishmania donovani	89%	100%
A4H4V7	Leishmania braziliensis	71%	100%
A4HT54	Leishmania infantum	89%	100%
Q4QIT0	Leishmania major	87%	100%