Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL24_LEIMU

TriTrypDb:

LmxM.07.0140

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	7
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

E9AL24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL24

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	7
GO:0016192	vesicle-mediated transport	4	7
GO:0048193	Golgi vesicle transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.644
CLV_NRD_NRD_1	218	220	PF00675	0.459
CLV_NRD_NRD_1	252	254	PF00675	0.550
CLV_NRD_NRD_1	327	329	PF00675	0.485
CLV_PCSK_KEX2_1	218	220	PF00082	0.459
CLV_PCSK_KEX2_1	252	254	PF00082	0.473
CLV_PCSK_KEX2_1	327	329	PF00082	0.485
CLV_PCSK_SKI1_1	218	222	PF00082	0.515
CLV_PCSK_SKI1_1	260	264	PF00082	0.491
CLV_PCSK_SKI1_1	322	326	PF00082	0.439

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF2	Leptomonas seymouri	37%	94%
A0A3S5H5W2	Leishmania donovani	89%	100%
A4H4V7	Leishmania braziliensis	71%	100%
A4HT54	Leishmania infantum	89%	100%
Q4QIT0	Leishmania major	87%	100%

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