Present in the outer mitochondrial membrane proteome 33

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL21_LEIMU

TriTrypDb:

LmxM.07.0110

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	4
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1
GO:0016020	membrane	2	3

Expansion

Sequence features

E9AL21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL21

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006811	monoatomic ion transport	4	12
GO:0006812	monoatomic cation transport	5	12
GO:0006816	calcium ion transport	7	12
GO:0006851	mitochondrial calcium ion transmembrane transport	4	12
GO:0009987	cellular process	1	12
GO:0030001	metal ion transport	6	12
GO:0034220	monoatomic ion transmembrane transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0055085	transmembrane transport	2	12
GO:0070588	calcium ion transmembrane transport	6	12
GO:0098655	monoatomic cation transmembrane transport	4	12
GO:0098660	inorganic ion transmembrane transport	4	12
GO:0098662	inorganic cation transmembrane transport	5	12
GO:1990542	mitochondrial transmembrane transport	3	12
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006874	intracellular calcium ion homeostasis	7	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051560	mitochondrial calcium ion homeostasis	8	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055074	calcium ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.305
CLV_C14_Caspase3-7	30	34	PF00656	0.578
CLV_C14_Caspase3-7	61	65	PF00656	0.502
CLV_NRD_NRD_1	136	138	PF00675	0.368
CLV_NRD_NRD_1	2	4	PF00675	0.505
CLV_NRD_NRD_1	249	251	PF00675	0.429
CLV_NRD_NRD_1	25	27	PF00675	0.476
CLV_NRD_NRD_1	265	267	PF00675	0.287
CLV_NRD_NRD_1	326	328	PF00675	0.402
CLV_NRD_NRD_1	373	375	PF00675	0.335
CLV_NRD_NRD_1	413	415	PF00675	0.377
CLV_NRD_NRD_1	427	429	PF00675	0.608
CLV_NRD_NRD_1	433	435	PF00675	0.568
CLV_PCSK_KEX2_1	138	140	PF00082	0.445
CLV_PCSK_KEX2_1	2	4	PF00082	0.484
CLV_PCSK_KEX2_1	249	251	PF00082	0.414
CLV_PCSK_KEX2_1	25	27	PF00082	0.476
CLV_PCSK_KEX2_1	265	267	PF00082	0.275
CLV_PCSK_KEX2_1	326	328	PF00082	0.491
CLV_PCSK_KEX2_1	369	371	PF00082	0.379
CLV_PCSK_KEX2_1	373	375	PF00082	0.373
CLV_PCSK_KEX2_1	433	435	PF00082	0.568
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.430
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.433
CLV_PCSK_SKI1_1	18	22	PF00082	0.444
CLV_PCSK_SKI1_1	231	235	PF00082	0.506
CLV_PCSK_SKI1_1	241	245	PF00082	0.457
CLV_PCSK_SKI1_1	255	259	PF00082	0.299
CLV_PCSK_SKI1_1	310	314	PF00082	0.461
CLV_PCSK_SKI1_1	433	437	PF00082	0.582
DEG_APCC_DBOX_1	1	9	PF00400	0.536
DEG_Nend_UBRbox_1	1	4	PF02207	0.439
DEG_SPOP_SBC_1	32	36	PF00917	0.481
DEG_SPOP_SBC_1	72	76	PF00917	0.424
DOC_CDC14_PxL_1	378	386	PF14671	0.369
DOC_CKS1_1	112	117	PF01111	0.410
DOC_CYCLIN_RxL_1	249	262	PF00134	0.310
DOC_PP1_RVXF_1	81	87	PF00149	0.546
DOC_PP4_FxxP_1	243	246	PF00568	0.307
DOC_USP7_MATH_1	32	36	PF00917	0.569
DOC_USP7_MATH_1	43	47	PF00917	0.443
DOC_USP7_MATH_2	425	431	PF00917	0.483
DOC_WW_Pin1_4	111	116	PF00397	0.422
DOC_WW_Pin1_4	155	160	PF00397	0.466
LIG_14-3-3_CanoR_1	18	23	PF00244	0.591
LIG_14-3-3_CanoR_1	193	199	PF00244	0.391
LIG_14-3-3_CanoR_1	265	270	PF00244	0.343
LIG_14-3-3_CanoR_1	298	304	PF00244	0.431
LIG_14-3-3_CanoR_1	373	379	PF00244	0.493
LIG_14-3-3_CanoR_1	38	43	PF00244	0.535
LIG_14-3-3_CanoR_1	428	432	PF00244	0.602
LIG_BIR_III_2	64	68	PF00653	0.419
LIG_BIR_III_4	180	184	PF00653	0.261
LIG_deltaCOP1_diTrp_1	282	288	PF00928	0.297
LIG_DLG_GKlike_1	265	272	PF00625	0.483
LIG_FHA_1	102	108	PF00498	0.553
LIG_FHA_1	114	120	PF00498	0.535
LIG_FHA_1	218	224	PF00498	0.405
LIG_FHA_1	352	358	PF00498	0.322
LIG_FHA_1	386	392	PF00498	0.391
LIG_FHA_2	145	151	PF00498	0.295
LIG_FHA_2	232	238	PF00498	0.491
LIG_FHA_2	298	304	PF00498	0.483
LIG_FHA_2	366	372	PF00498	0.506
LIG_LIR_Apic_2	114	120	PF02991	0.349
LIG_LIR_Apic_2	242	246	PF02991	0.304
LIG_LIR_Gen_1	184	194	PF02991	0.259
LIG_LIR_Gen_1	224	233	PF02991	0.361
LIG_LIR_Gen_1	302	312	PF02991	0.440
LIG_LIR_Gen_1	390	397	PF02991	0.352
LIG_LIR_Gen_1	407	417	PF02991	0.275
LIG_LIR_Nem_3	128	133	PF02991	0.305
LIG_LIR_Nem_3	184	189	PF02991	0.259
LIG_LIR_Nem_3	191	195	PF02991	0.230
LIG_LIR_Nem_3	207	213	PF02991	0.353
LIG_LIR_Nem_3	224	229	PF02991	0.155
LIG_LIR_Nem_3	268	272	PF02991	0.369
LIG_LIR_Nem_3	287	291	PF02991	0.290
LIG_LIR_Nem_3	302	307	PF02991	0.343
LIG_LIR_Nem_3	338	343	PF02991	0.338
LIG_LIR_Nem_3	371	375	PF02991	0.421
LIG_LIR_Nem_3	390	396	PF02991	0.329
LIG_LIR_Nem_3	407	412	PF02991	0.257
LIG_NRBOX	194	200	PF00104	0.246
LIG_PCNA_yPIPBox_3	245	258	PF02747	0.442
LIG_Pex14_1	284	288	PF04695	0.295
LIG_SH2_CRK	133	137	PF00017	0.371
LIG_SH2_CRK	421	425	PF00017	0.597
LIG_SH2_NCK_1	112	116	PF00017	0.481
LIG_SH2_NCK_1	421	425	PF00017	0.597
LIG_SH2_SRC	117	120	PF00017	0.368
LIG_SH2_STAT5	117	120	PF00017	0.321
LIG_SH2_STAT5	122	125	PF00017	0.330
LIG_SH2_STAT5	186	189	PF00017	0.320
LIG_SH2_STAT5	211	214	PF00017	0.212
LIG_SH2_STAT5	320	323	PF00017	0.404
LIG_SH2_STAT5	421	424	PF00017	0.341
LIG_SH2_STAT5	441	444	PF00017	0.338
LIG_SH3_3	379	385	PF00018	0.473
LIG_SUMO_SIM_anti_2	388	393	PF11976	0.237
LIG_SUMO_SIM_anti_2	407	414	PF11976	0.149
LIG_SUMO_SIM_par_1	218	225	PF11976	0.391
LIG_SUMO_SIM_par_1	333	338	PF11976	0.343
LIG_TRAF2_1	222	225	PF00917	0.311
LIG_TRAF2_1	300	303	PF00917	0.492
LIG_TYR_ITIM	131	136	PF00017	0.377
LIG_TYR_ITIM	317	322	PF00017	0.498
LIG_UBA3_1	209	217	PF00899	0.278
LIG_WRC_WIRS_1	240	245	PF05994	0.291
MOD_CDC14_SPxK_1	158	161	PF00782	0.500
MOD_CDK_SPxK_1	155	161	PF00069	0.471
MOD_CK1_1	101	107	PF00069	0.421
MOD_CK1_1	197	203	PF00069	0.483
MOD_CK1_1	278	284	PF00069	0.491
MOD_CK1_1	31	37	PF00069	0.636
MOD_CK1_1	363	369	PF00069	0.453
MOD_CK1_1	41	47	PF00069	0.493
MOD_CK1_1	75	81	PF00069	0.478
MOD_CK2_1	185	191	PF00069	0.261
MOD_CK2_1	219	225	PF00069	0.335
MOD_CK2_1	231	237	PF00069	0.409
MOD_CK2_1	265	271	PF00069	0.387
MOD_CK2_1	297	303	PF00069	0.491
MOD_GlcNHglycan	100	103	PF01048	0.439
MOD_GlcNHglycan	216	220	PF01048	0.402
MOD_GlcNHglycan	29	33	PF01048	0.750
MOD_GlcNHglycan	330	333	PF01048	0.453
MOD_GlcNHglycan	362	365	PF01048	0.393
MOD_GlcNHglycan	5	8	PF01048	0.399
MOD_GlcNHglycan	77	80	PF01048	0.619
MOD_GSK3_1	194	201	PF00069	0.379
MOD_GSK3_1	215	222	PF00069	0.357
MOD_GSK3_1	24	31	PF00069	0.642
MOD_GSK3_1	32	39	PF00069	0.572
MOD_GSK3_1	359	366	PF00069	0.518
MOD_GSK3_1	71	78	PF00069	0.673
MOD_GSK3_1	98	105	PF00069	0.436
MOD_N-GLC_1	36	41	PF02516	0.471
MOD_NEK2_1	194	199	PF00069	0.328
MOD_NEK2_1	359	364	PF00069	0.434
MOD_NEK2_1	365	370	PF00069	0.362
MOD_NEK2_1	42	47	PF00069	0.628
MOD_NEK2_1	436	441	PF00069	0.307
MOD_NEK2_1	50	55	PF00069	0.683
MOD_NEK2_1	71	76	PF00069	0.539
MOD_NEK2_1	85	90	PF00069	0.363
MOD_NEK2_1	98	103	PF00069	0.349
MOD_OFUCOSY	47	52	PF10250	0.390
MOD_PKA_1	25	31	PF00069	0.494
MOD_PKA_1	265	271	PF00069	0.435
MOD_PKA_2	24	30	PF00069	0.639
MOD_PKA_2	265	271	PF00069	0.353
MOD_PKA_2	297	303	PF00069	0.488
MOD_PKA_2	427	433	PF00069	0.598
MOD_Plk_1	436	442	PF00069	0.309
MOD_Plk_2-3	333	339	PF00069	0.335
MOD_Plk_4	102	108	PF00069	0.497
MOD_Plk_4	113	119	PF00069	0.451
MOD_Plk_4	194	200	PF00069	0.333
MOD_Plk_4	205	211	PF00069	0.460
MOD_Plk_4	408	414	PF00069	0.220
MOD_Plk_4	437	443	PF00069	0.313
MOD_ProDKin_1	111	117	PF00069	0.416
MOD_ProDKin_1	155	161	PF00069	0.471
TRG_DiLeu_BaEn_1	191	196	PF01217	0.246
TRG_DiLeu_BaEn_1	303	308	PF01217	0.412
TRG_DiLeu_BaEn_2	404	410	PF01217	0.251
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.404
TRG_ENDOCYTIC_2	133	136	PF00928	0.333
TRG_ENDOCYTIC_2	186	189	PF00928	0.276
TRG_ENDOCYTIC_2	319	322	PF00928	0.532
TRG_ER_diArg_1	1	3	PF00400	0.511
TRG_ER_diArg_1	126	129	PF00400	0.435
TRG_ER_diArg_1	136	139	PF00400	0.389
TRG_ER_diArg_1	264	266	PF00400	0.484
TRG_ER_diArg_1	325	327	PF00400	0.444
TRG_ER_diArg_1	372	374	PF00400	0.382
TRG_ER_diArg_1	432	434	PF00400	0.570
TRG_ER_diArg_1	81	84	PF00400	0.670
TRG_NLS_MonoCore_2	136	141	PF00514	0.503
TRG_NLS_MonoExtN_4	137	142	PF00514	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P773	Leptomonas seymouri	74%	100%
A0A0S4IPF8	Bodo saltans	44%	100%
A0A1X0NK53	Trypanosomatidae	49%	100%
A0A3S5H5W0	Leishmania donovani	95%	100%
A0A422NT64	Trypanosoma rangeli	44%	100%
A4H4V4	Leishmania braziliensis	86%	100%
A4HT58	Leishmania infantum	94%	100%
A4IG32	Danio rerio	22%	92%
B1H2N3	Xenopus tropicalis	20%	95%
C9ZUW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	94%
D2HZB0	Ailuropoda melanoleuca	21%	93%
Q0IIL1	Bos taurus	20%	94%
Q4QIT3	Leishmania major	93%	100%
Q4R518	Macaca fascicularis	22%	94%
Q6P6Q9	Rattus norvegicus	21%	94%
Q86XE3	Homo sapiens	20%	85%
Q8CD10	Mus musculus	21%	100%
Q8IYU8	Homo sapiens	22%	100%
Q8VCX5	Mus musculus	21%	94%
Q99P63	Rattus norvegicus	21%	100%
Q9BPX6	Homo sapiens	22%	94%
Q9CTY5	Mus musculus	22%	86%
V5B8U7	Trypanosoma cruzi	47%	97%