Putative Golgi/lysosome glycoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi/lysosome glycoprotein 1, putative

Species:

Leishmania mexicana

UniProt:

E9AL18_LEIMU

TriTrypDb:

LmxM.07.0080

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005765	lysosomal membrane	7	1
GO:0005773	vacuole	5	1
GO:0005774	vacuolar membrane	5	1
GO:0005794	Golgi apparatus	5	1
GO:0031090	organelle membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098852	lytic vacuole membrane	6	1

Expansion

Sequence features

E9AL18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL18

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.420
CLV_NRD_NRD_1	320	322	PF00675	0.641
CLV_NRD_NRD_1	571	573	PF00675	0.486
CLV_PCSK_KEX2_1	31	33	PF00082	0.739
CLV_PCSK_KEX2_1	381	383	PF00082	0.562
CLV_PCSK_KEX2_1	465	467	PF00082	0.674
CLV_PCSK_KEX2_1	571	573	PF00082	0.486
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.739
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.562
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.671
CLV_PCSK_PC7_1	567	573	PF00082	0.481
CLV_PCSK_SKI1_1	157	161	PF00082	0.646
CLV_PCSK_SKI1_1	192	196	PF00082	0.569
CLV_PCSK_SKI1_1	439	443	PF00082	0.549
CLV_PCSK_SKI1_1	466	470	PF00082	0.587
CLV_PCSK_SKI1_1	5	9	PF00082	0.653
CLV_Separin_Metazoa	610	614	PF03568	0.575
DEG_COP1_1	405	415	PF00400	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.712
DOC_CKS1_1	412	417	PF01111	0.509
DOC_CYCLIN_RxL_1	151	163	PF00134	0.390
DOC_MAPK_gen_1	136	143	PF00069	0.387
DOC_MAPK_gen_1	3	12	PF00069	0.633
DOC_MAPK_gen_1	381	387	PF00069	0.400
DOC_MAPK_gen_1	437	445	PF00069	0.397
DOC_MAPK_gen_1	475	485	PF00069	0.285
DOC_MAPK_gen_1	571	578	PF00069	0.637
DOC_MAPK_MEF2A_6	3	11	PF00069	0.610
DOC_MAPK_MEF2A_6	481	488	PF00069	0.361
DOC_PP1_RVXF_1	326	333	PF00149	0.444
DOC_PP1_RVXF_1	479	486	PF00149	0.435
DOC_PP4_FxxP_1	257	260	PF00568	0.438
DOC_SPAK_OSR1_1	138	142	PF12202	0.290
DOC_USP7_MATH_1	134	138	PF00917	0.374
DOC_USP7_MATH_1	170	174	PF00917	0.370
DOC_USP7_MATH_1	190	194	PF00917	0.440
DOC_USP7_MATH_1	269	273	PF00917	0.471
DOC_USP7_MATH_1	403	407	PF00917	0.501
DOC_USP7_MATH_1	593	597	PF00917	0.558
DOC_USP7_UBL2_3	377	381	PF12436	0.320
DOC_USP7_UBL2_3	442	446	PF12436	0.333
DOC_WW_Pin1_4	178	183	PF00397	0.388
DOC_WW_Pin1_4	186	191	PF00397	0.378
DOC_WW_Pin1_4	337	342	PF00397	0.409
DOC_WW_Pin1_4	411	416	PF00397	0.467
DOC_WW_Pin1_4	603	608	PF00397	0.580
LIG_14-3-3_CanoR_1	157	163	PF00244	0.352
LIG_14-3-3_CanoR_1	247	253	PF00244	0.433
LIG_14-3-3_CanoR_1	268	278	PF00244	0.424
LIG_14-3-3_CanoR_1	3	8	PF00244	0.655
LIG_14-3-3_CanoR_1	466	472	PF00244	0.450
LIG_14-3-3_CanoR_1	60	65	PF00244	0.400
LIG_14-3-3_CanoR_1	613	619	PF00244	0.644
LIG_Actin_WH2_2	451	467	PF00022	0.439
LIG_BIR_III_2	604	608	PF00653	0.578
LIG_BRCT_BRCA1_1	139	143	PF00533	0.316
LIG_deltaCOP1_diTrp_1	432	438	PF00928	0.487
LIG_DLG_GKlike_1	122	129	PF00625	0.402
LIG_DLG_GKlike_1	3	10	PF00625	0.680
LIG_FHA_1	20	26	PF00498	0.662
LIG_FHA_1	206	212	PF00498	0.435
LIG_FHA_1	238	244	PF00498	0.452
LIG_FHA_1	260	266	PF00498	0.364
LIG_FHA_1	273	279	PF00498	0.326
LIG_FHA_1	360	366	PF00498	0.378
LIG_FHA_1	445	451	PF00498	0.280
LIG_FHA_1	528	534	PF00498	0.477
LIG_FHA_1	59	65	PF00498	0.364
LIG_FHA_2	254	260	PF00498	0.442
LIG_FHA_2	367	373	PF00498	0.441
LIG_FHA_2	418	424	PF00498	0.456
LIG_FHA_2	79	85	PF00498	0.446
LIG_LIR_Apic_2	255	260	PF02991	0.427
LIG_LIR_Gen_1	137	147	PF02991	0.377
LIG_LIR_Gen_1	191	201	PF02991	0.239
LIG_LIR_Gen_1	232	241	PF02991	0.448
LIG_LIR_Gen_1	326	335	PF02991	0.474
LIG_LIR_Gen_1	590	599	PF02991	0.556
LIG_LIR_Nem_3	137	142	PF02991	0.371
LIG_LIR_Nem_3	191	197	PF02991	0.274
LIG_LIR_Nem_3	227	233	PF02991	0.422
LIG_LIR_Nem_3	310	316	PF02991	0.337
LIG_LIR_Nem_3	326	332	PF02991	0.414
LIG_LIR_Nem_3	432	438	PF02991	0.387
LIG_LIR_Nem_3	590	594	PF02991	0.548
LIG_LIR_Nem_3	82	88	PF02991	0.456
LIG_NRBOX	457	463	PF00104	0.420
LIG_PCNA_yPIPBox_3	151	160	PF02747	0.419
LIG_Pex14_2	139	143	PF04695	0.368
LIG_PTB_Apo_2	284	291	PF02174	0.359
LIG_PTB_Phospho_1	284	290	PF10480	0.359
LIG_Rb_pABgroove_1	583	591	PF01858	0.724
LIG_SH2_CRK	234	238	PF00017	0.311
LIG_SH2_CRK	291	295	PF00017	0.398
LIG_SH2_CRK	85	89	PF00017	0.440
LIG_SH2_NCK_1	234	238	PF00017	0.255
LIG_SH2_NCK_1	291	295	PF00017	0.439
LIG_SH2_NCK_1	71	75	PF00017	0.427
LIG_SH2_STAP1	589	593	PF00017	0.724
LIG_SH2_STAP1	96	100	PF00017	0.399
LIG_SH2_STAT3	267	270	PF00017	0.397
LIG_SH2_STAT5	104	107	PF00017	0.254
LIG_SH2_STAT5	234	237	PF00017	0.431
LIG_SH2_STAT5	509	512	PF00017	0.334
LIG_SH2_STAT5	85	88	PF00017	0.438
LIG_SH3_3	409	415	PF00018	0.434
LIG_SUMO_SIM_anti_2	207	215	PF11976	0.276
LIG_SUMO_SIM_par_1	176	181	PF11976	0.371
LIG_SUMO_SIM_par_1	207	215	PF11976	0.379
LIG_SUMO_SIM_par_1	21	28	PF11976	0.558
LIG_SUMO_SIM_par_1	617	623	PF11976	0.687
LIG_SxIP_EBH_1	167	180	PF03271	0.273
LIG_TYR_ITIM	69	74	PF00017	0.423
LIG_UBA3_1	1	8	PF00899	0.691
LIG_UBA3_1	461	465	PF00899	0.386
LIG_WRC_WIRS_1	54	59	PF05994	0.390
MOD_CDC14_SPxK_1	189	192	PF00782	0.272
MOD_CDK_SPxK_1	186	192	PF00069	0.266
MOD_CK1_1	137	143	PF00069	0.336
MOD_CK1_1	173	179	PF00069	0.401
MOD_CK1_1	181	187	PF00069	0.391
MOD_CK1_1	21	27	PF00069	0.601
MOD_CK1_1	217	223	PF00069	0.485
MOD_CK1_1	272	278	PF00069	0.376
MOD_CK1_1	45	51	PF00069	0.449
MOD_CK1_1	456	462	PF00069	0.395
MOD_CK1_1	467	473	PF00069	0.373
MOD_CK1_1	58	64	PF00069	0.288
MOD_CK2_1	122	128	PF00069	0.437
MOD_CK2_1	366	372	PF00069	0.432
MOD_CK2_1	417	423	PF00069	0.434
MOD_CK2_1	499	505	PF00069	0.448
MOD_CK2_1	614	620	PF00069	0.749
MOD_Cter_Amidation	29	32	PF01082	0.672
MOD_GlcNHglycan	165	170	PF01048	0.547
MOD_GlcNHglycan	439	442	PF01048	0.586
MOD_GlcNHglycan	44	47	PF01048	0.617
MOD_GlcNHglycan	537	543	PF01048	0.729
MOD_GlcNHglycan	57	60	PF01048	0.632
MOD_GlcNHglycan	596	599	PF01048	0.550
MOD_GSK3_1	124	131	PF00069	0.390
MOD_GSK3_1	137	144	PF00069	0.413
MOD_GSK3_1	165	172	PF00069	0.338
MOD_GSK3_1	186	193	PF00069	0.419
MOD_GSK3_1	205	212	PF00069	0.443
MOD_GSK3_1	232	239	PF00069	0.356
MOD_GSK3_1	248	255	PF00069	0.226
MOD_GSK3_1	368	375	PF00069	0.427
MOD_GSK3_1	37	44	PF00069	0.441
MOD_GSK3_1	413	420	PF00069	0.462
MOD_GSK3_1	45	52	PF00069	0.391
MOD_GSK3_1	453	460	PF00069	0.377
MOD_GSK3_1	522	529	PF00069	0.408
MOD_GSK3_1	58	65	PF00069	0.271
MOD_N-GLC_1	114	119	PF02516	0.633
MOD_N-GLC_1	205	210	PF02516	0.512
MOD_N-GLC_1	359	364	PF02516	0.686
MOD_N-GLC_2	334	336	PF02516	0.470
MOD_NEK2_1	129	134	PF00069	0.307
MOD_NEK2_1	19	24	PF00069	0.596
MOD_NEK2_1	454	459	PF00069	0.366
MOD_NEK2_1	464	469	PF00069	0.344
MOD_NEK2_1	550	555	PF00069	0.419
MOD_NEK2_1	64	69	PF00069	0.355
MOD_NEK2_2	248	253	PF00069	0.320
MOD_NEK2_2	279	284	PF00069	0.403
MOD_PIKK_1	214	220	PF00454	0.447
MOD_PIKK_1	269	275	PF00454	0.424
MOD_PIKK_1	405	411	PF00454	0.563
MOD_PIKK_1	45	51	PF00454	0.425
MOD_PK_1	114	120	PF00069	0.432
MOD_PKA_2	137	143	PF00069	0.416
MOD_PKA_2	252	258	PF00069	0.373
MOD_PKA_2	474	480	PF00069	0.304
MOD_Plk_1	114	120	PF00069	0.421
MOD_Plk_1	190	196	PF00069	0.400
MOD_Plk_1	307	313	PF00069	0.359
MOD_Plk_1	359	365	PF00069	0.458
MOD_Plk_1	499	505	PF00069	0.457
MOD_Plk_2-3	209	215	PF00069	0.444
MOD_Plk_2-3	500	506	PF00069	0.441
MOD_Plk_4	108	114	PF00069	0.309
MOD_Plk_4	13	19	PF00069	0.509
MOD_Plk_4	173	179	PF00069	0.356
MOD_Plk_4	181	187	PF00069	0.350
MOD_Plk_4	209	215	PF00069	0.442
MOD_Plk_4	361	367	PF00069	0.356
MOD_Plk_4	457	463	PF00069	0.365
MOD_Plk_4	50	56	PF00069	0.351
MOD_Plk_4	550	556	PF00069	0.356
MOD_Plk_4	614	620	PF00069	0.749
MOD_ProDKin_1	178	184	PF00069	0.387
MOD_ProDKin_1	186	192	PF00069	0.376
MOD_ProDKin_1	337	343	PF00069	0.408
MOD_ProDKin_1	411	417	PF00069	0.462
MOD_ProDKin_1	603	609	PF00069	0.579
MOD_SUMO_rev_2	161	168	PF00179	0.325
MOD_SUMO_rev_2	325	330	PF00179	0.430
MOD_SUMO_rev_2	477	483	PF00179	0.438
TRG_DiLeu_BaEn_1	83	88	PF01217	0.472
TRG_ENDOCYTIC_2	234	237	PF00928	0.316
TRG_ENDOCYTIC_2	290	293	PF00928	0.336
TRG_ENDOCYTIC_2	71	74	PF00928	0.430
TRG_ENDOCYTIC_2	85	88	PF00928	0.387
TRG_ER_diArg_1	136	139	PF00400	0.410
TRG_ER_diArg_1	154	157	PF00400	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P769	Leptomonas seymouri	50%	98%
A0A1X0NKD5	Trypanosomatidae	37%	100%
A0A3R7KSB6	Trypanosoma rangeli	38%	100%
A0A3S7WPQ4	Leishmania donovani	86%	100%
A4H4V1	Leishmania braziliensis	74%	100%
A4HT61	Leishmania infantum	86%	100%
C9ZUW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QIT6	Leishmania major	87%	100%
V5BDE1	Trypanosoma cruzi	37%	100%