Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL17_LEIMU

TriTrypDb:

LmxM.07.0070

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL17

PDB structure(s): 7aih_Av , 7am2_Av , 7ane_Av

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.474
CLV_NRD_NRD_1	50	52	PF00675	0.466
CLV_NRD_NRD_1	63	65	PF00675	0.465
CLV_PCSK_FUR_1	48	52	PF00082	0.528
CLV_PCSK_KEX2_1	146	148	PF00082	0.476
CLV_PCSK_KEX2_1	175	177	PF00082	0.623
CLV_PCSK_KEX2_1	19	21	PF00082	0.500
CLV_PCSK_KEX2_1	50	52	PF00082	0.504
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.476
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.646
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.519
CLV_PCSK_PC7_1	171	177	PF00082	0.584
CLV_PCSK_SKI1_1	138	142	PF00082	0.473
DEG_Nend_Nbox_1	1	3	PF02207	0.608
DOC_CKS1_1	185	190	PF01111	0.715
DOC_MAPK_MEF2A_6	81	90	PF00069	0.421
DOC_PP1_RVXF_1	149	155	PF00149	0.465
DOC_PP4_FxxP_1	132	135	PF00568	0.448
DOC_USP7_MATH_1	12	16	PF00917	0.581
DOC_USP7_UBL2_3	19	23	PF12436	0.497
DOC_WW_Pin1_4	131	136	PF00397	0.452
DOC_WW_Pin1_4	184	189	PF00397	0.715
DOC_WW_Pin1_4	4	9	PF00397	0.602
LIG_14-3-3_CanoR_1	155	159	PF00244	0.546
LIG_APCC_ABBA_1	88	93	PF00400	0.471
LIG_BRCT_BRCA1_1	128	132	PF00533	0.606
LIG_deltaCOP1_diTrp_1	102	109	PF00928	0.580
LIG_FHA_1	12	18	PF00498	0.550
LIG_FHA_1	161	167	PF00498	0.592
LIG_FHA_1	5	11	PF00498	0.596
LIG_FHA_2	40	46	PF00498	0.452
LIG_LIR_Apic_2	102	106	PF02991	0.444
LIG_LIR_Apic_2	129	135	PF02991	0.460
LIG_LIR_Nem_3	102	108	PF02991	0.435
LIG_LIR_Nem_3	29	33	PF02991	0.488
LIG_LYPXL_yS_3	105	108	PF13949	0.432
LIG_Pex14_2	132	136	PF04695	0.451
LIG_Rb_pABgroove_1	118	126	PF01858	0.527
LIG_SH2_CRK	30	34	PF00017	0.450
LIG_SH2_NCK_1	37	41	PF00017	0.454
LIG_SH2_STAT5	34	37	PF00017	0.436
LIG_SH2_STAT5	77	80	PF00017	0.467
LIG_SH3_3	182	188	PF00018	0.777
LIG_SH3_3	30	36	PF00018	0.440
LIG_SH3_3	95	101	PF00018	0.415
LIG_SUMO_SIM_par_1	65	71	PF11976	0.484
LIG_UBA3_1	158	162	PF00899	0.565
MOD_CDK_SPK_2	4	9	PF00069	0.602
MOD_CDK_SPxxK_3	131	138	PF00069	0.468
MOD_CDK_SPxxK_3	184	191	PF00069	0.717
MOD_CK2_1	39	45	PF00069	0.459
MOD_Cter_Amidation	189	192	PF01082	0.678
MOD_GlcNHglycan	14	17	PF01048	0.601
MOD_GlcNHglycan	20	23	PF01048	0.569
MOD_GlcNHglycan	57	60	PF01048	0.578
MOD_GSK3_1	82	89	PF00069	0.484
MOD_NEK2_1	11	16	PF00069	0.551
MOD_NEK2_1	18	23	PF00069	0.501
MOD_NEK2_1	2	7	PF00069	0.610
MOD_PKA_2	154	160	PF00069	0.529
MOD_Plk_1	101	107	PF00069	0.435
MOD_Plk_4	154	160	PF00069	0.554
MOD_ProDKin_1	131	137	PF00069	0.445
MOD_ProDKin_1	184	190	PF00069	0.715
MOD_ProDKin_1	4	10	PF00069	0.602
MOD_SUMO_rev_2	26	33	PF00179	0.471
MOD_SUMO_rev_2	62	72	PF00179	0.498
TRG_DiLeu_BaEn_2	48	54	PF01217	0.565
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.594
TRG_ENDOCYTIC_2	105	108	PF00928	0.432
TRG_ENDOCYTIC_2	30	33	PF00928	0.453
TRG_ER_diArg_1	147	149	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW8	Leptomonas seymouri	87%	97%
A0A0S4IMH9	Bodo saltans	61%	100%
A0A1X0NKH3	Trypanosomatidae	68%	100%
A0A3R7MVH7	Trypanosoma rangeli	69%	99%
A0A3S5H5V7	Leishmania donovani	98%	100%
A4H4V0	Leishmania braziliensis	92%	100%
A4HT62	Leishmania infantum	98%	100%
C9ZUW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
Q4QIT7	Leishmania major	97%	100%