Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isy1-like splicing family, putative

Species:

Leishmania mexicana

UniProt:

E9AL11_LEIMU

TriTrypDb:

LmxM.07.0020

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0000974	Prp19 complex	2	1
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0071014	post-mRNA release spliceosomal complex	4	1
GO:0071020	post-spliceosomal complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AL11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL11

Function

Biological processes
Term	Name	Level	Count
GO:0000350	generation of catalytic spliceosome for second transesterification step	7	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0022618	ribonucleoprotein complex assembly	6	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0071826	ribonucleoprotein complex subunit organization	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000389	mRNA 3'-splice site recognition	8	1
GO:0006376	mRNA splice site selection	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.559
CLV_NRD_NRD_1	160	162	PF00675	0.308
CLV_NRD_NRD_1	181	183	PF00675	0.346
CLV_NRD_NRD_1	199	201	PF00675	0.271
CLV_NRD_NRD_1	310	312	PF00675	0.289
CLV_NRD_NRD_1	74	76	PF00675	0.287
CLV_NRD_NRD_1	86	88	PF00675	0.301
CLV_PCSK_KEX2_1	201	203	PF00082	0.367
CLV_PCSK_KEX2_1	85	87	PF00082	0.296
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.367
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.296
CLV_PCSK_SKI1_1	183	187	PF00082	0.381
CLV_PCSK_SKI1_1	312	316	PF00082	0.305
CLV_PCSK_SKI1_1	36	40	PF00082	0.599
CLV_PCSK_SKI1_1	92	96	PF00082	0.275
DEG_Nend_UBRbox_1	1	4	PF02207	0.441
DOC_ANK_TNKS_1	201	208	PF00023	0.502
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.426
DOC_MAPK_DCC_7	22	32	PF00069	0.416
DOC_MAPK_gen_1	180	187	PF00069	0.530
DOC_PP1_RVXF_1	166	172	PF00149	0.546
DOC_PP1_RVXF_1	181	188	PF00149	0.392
DOC_PP1_RVXF_1	243	249	PF00149	0.555
DOC_PP2B_LxvP_1	48	51	PF13499	0.435
DOC_USP7_MATH_1	217	221	PF00917	0.564
DOC_USP7_MATH_1	280	284	PF00917	0.470
DOC_USP7_UBL2_3	268	272	PF12436	0.555
DOC_WW_Pin1_4	194	199	PF00397	0.377
DOC_WW_Pin1_4	36	41	PF00397	0.458
LIG_14-3-3_CanoR_1	168	172	PF00244	0.525
LIG_14-3-3_CanoR_1	279	289	PF00244	0.579
LIG_14-3-3_CterR_2	323	326	PF00244	0.610
LIG_Clathr_ClatBox_1	137	141	PF01394	0.496
LIG_Clathr_ClatBox_1	258	262	PF01394	0.530
LIG_FHA_1	127	133	PF00498	0.559
LIG_FHA_1	43	49	PF00498	0.472
LIG_FHA_1	5	11	PF00498	0.440
LIG_HCF-1_HBM_1	239	242	PF13415	0.530
LIG_LIR_Nem_3	34	38	PF02991	0.656
LIG_PCNA_yPIPBox_3	149	159	PF02747	0.496
LIG_PCNA_yPIPBox_3	2	13	PF02747	0.440
LIG_SH2_STAT5	116	119	PF00017	0.513
LIG_SH2_STAT5	242	245	PF00017	0.513
LIG_SH2_STAT5	289	292	PF00017	0.496
LIG_SH3_3	173	179	PF00018	0.502
LIG_SH3_3	224	230	PF00018	0.545
LIG_SH3_3	25	31	PF00018	0.630
LIG_SH3_3	292	298	PF00018	0.465
LIG_SH3_3	99	105	PF00018	0.496
LIG_SUMO_SIM_par_1	136	141	PF11976	0.514
LIG_TRAF2_1	298	301	PF00917	0.470
LIG_UBA3_1	118	122	PF00899	0.513
LIG_UBA3_1	79	85	PF00899	0.496
LIG_WRC_WIRS_1	32	37	PF05994	0.448
MOD_CDC14_SPxK_1	197	200	PF00782	0.377
MOD_CDK_SPxK_1	194	200	PF00069	0.377
MOD_CDK_SPxxK_3	194	201	PF00069	0.377
MOD_DYRK1A_RPxSP_1	36	40	PF00069	0.438
MOD_GlcNHglycan	251	254	PF01048	0.374
MOD_GlcNHglycan	282	285	PF01048	0.326
MOD_GlcNHglycan	55	58	PF01048	0.387
MOD_GSK3_1	65	72	PF00069	0.552
MOD_NEK2_1	249	254	PF00069	0.586
MOD_NEK2_1	285	290	PF00069	0.556
MOD_PIKK_1	205	211	PF00454	0.476
MOD_PIKK_1	4	10	PF00454	0.436
MOD_PIKK_1	42	48	PF00454	0.472
MOD_PKA_1	75	81	PF00069	0.496
MOD_PKA_2	167	173	PF00069	0.586
MOD_Plk_1	133	139	PF00069	0.377
MOD_Plk_4	133	139	PF00069	0.471
MOD_Plk_4	167	173	PF00069	0.565
MOD_Plk_4	272	278	PF00069	0.484
MOD_Plk_4	75	81	PF00069	0.482
MOD_ProDKin_1	194	200	PF00069	0.377
MOD_ProDKin_1	36	42	PF00069	0.457
MOD_SUMO_for_1	121	124	PF00179	0.534
MOD_SUMO_rev_2	106	114	PF00179	0.538
MOD_SUMO_rev_2	262	269	PF00179	0.508
MOD_SUMO_rev_2	288	296	PF00179	0.586
TRG_DiLeu_BaEn_1	154	159	PF01217	0.496
TRG_DiLeu_BaEn_1	221	226	PF01217	0.530
TRG_ENDOCYTIC_2	116	119	PF00928	0.496
TRG_ER_diArg_1	179	182	PF00400	0.565
TRG_ER_diArg_1	199	202	PF00400	0.350
TRG_NLS_Bipartite_1	182	204	PF00514	0.562
TRG_NLS_MonoExtC_3	199	204	PF00514	0.562
TRG_NLS_MonoExtN_4	179	186	PF00514	0.586
TRG_NLS_MonoExtN_4	198	205	PF00514	0.361
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF4	Leptomonas seymouri	64%	100%
A0A1X0NL28	Trypanosomatidae	44%	100%
A0A3R7KL93	Trypanosoma rangeli	43%	100%
A0A3S5H5V5	Leishmania donovani	89%	100%
A4H4U5	Leishmania braziliensis	81%	100%
A4HT23	Leishmania infantum	88%	100%
C9ZUW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4QIU3	Leishmania major	89%	100%
V5B8Q7	Trypanosoma cruzi	41%	100%