Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AL09_LEIMU

TriTrypDb:

LmxM.06.1290

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

E9AL09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL09

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.587
CLV_PCSK_KEX2_1	100	102	PF00082	0.433
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.417
DEG_Nend_UBRbox_3	1	3	PF02207	0.627
DOC_MAPK_gen_1	15	25	PF00069	0.454
DOC_MAPK_gen_1	98	107	PF00069	0.633
DOC_MAPK_MEF2A_6	100	109	PF00069	0.608
DOC_MAPK_MEF2A_6	18	25	PF00069	0.497
DOC_USP7_MATH_1	31	35	PF00917	0.443
DOC_USP7_UBL2_3	47	51	PF12436	0.454
DOC_USP7_UBL2_3	94	98	PF12436	0.647
LIG_deltaCOP1_diTrp_1	64	72	PF00928	0.580
LIG_EH1_1	108	116	PF00400	0.255
LIG_FHA_2	114	120	PF00498	0.235
LIG_GBD_Chelix_1	107	115	PF00786	0.203
LIG_LIR_Gen_1	46	56	PF02991	0.470
LIG_LIR_Gen_1	99	109	PF02991	0.605
LIG_LIR_Nem_3	99	105	PF02991	0.605
LIG_SH2_CRK	19	23	PF00017	0.492
LIG_SH3_3	72	78	PF00018	0.601
MOD_CK1_1	113	119	PF00069	0.239
MOD_CK1_1	96	102	PF00069	0.600
MOD_CK2_1	113	119	PF00069	0.235
MOD_GlcNHglycan	83	86	PF01048	0.479
MOD_GSK3_1	2	9	PF00069	0.581
MOD_GSK3_1	77	84	PF00069	0.688
MOD_N-GLC_1	52	57	PF02516	0.307
MOD_PKA_1	93	99	PF00069	0.677
MOD_Plk_1	52	58	PF00069	0.498
MOD_Plk_4	110	116	PF00069	0.363
MOD_Plk_4	32	38	PF00069	0.494
TRG_NES_CRM1_1	50	64	PF08389	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U0	Leptomonas seymouri	28%	92%
A0A0N1IH82	Leptomonas seymouri	36%	100%
A0A3Q8ICI2	Leishmania donovani	38%	100%
A0A3Q8IG43	Leishmania donovani	28%	92%
A0A3Q8ILC3	Leishmania donovani	89%	100%
A0A3S7WPP2	Leishmania donovani	89%	100%
A0A3S7X4C9	Leishmania donovani	30%	100%
A4H4U1	Leishmania braziliensis	75%	99%
A4HJ97	Leishmania braziliensis	30%	100%
A4HJ98	Leishmania braziliensis	37%	95%
A4HT20	Leishmania infantum	89%	100%
A4I6P2	Leishmania infantum	30%	100%
A4I6P3	Leishmania infantum	38%	100%
A4I6P6	Leishmania infantum	29%	92%
E9ACS1	Leishmania major	85%	100%
E9AGY1	Leishmania infantum	89%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B1R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	91%
Q4Q6E3	Leishmania major	28%	100%
Q4Q6E6	Leishmania major	36%	95%
Q4QIU6	Leishmania major	87%	100%