Protoporphyrinogen oxidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protoporphyrinogen oxidase-like protein

Species:

Leishmania mexicana

UniProt:

E9AL08_LEIMU

TriTrypDb:

LmxM.06.1280

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AL08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL08

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006778	porphyrin-containing compound metabolic process	5	7
GO:0006779	porphyrin-containing compound biosynthetic process	6	7
GO:0006782	protoporphyrinogen IX biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0033013	tetrapyrrole metabolic process	4	7
GO:0033014	tetrapyrrole biosynthetic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046501	protoporphyrinogen IX metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0006783	heme biosynthetic process	4	1
GO:0042168	heme metabolic process	3	1
GO:0042440	pigment metabolic process	2	1
GO:0046148	pigment biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity	5	7
GO:0005488	binding	1	7
GO:0010181	FMN binding	4	7
GO:0016491	oxidoreductase activity	2	7
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	7
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	7
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	4	7
GO:0032553	ribonucleotide binding	3	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0070818	protoporphyrinogen oxidase activity	4	7
GO:0070819	menaquinone-dependent protoporphyrinogen oxidase activity	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.423
CLV_C14_Caspase3-7	42	46	PF00656	0.474
CLV_NRD_NRD_1	111	113	PF00675	0.262
CLV_NRD_NRD_1	171	173	PF00675	0.449
CLV_NRD_NRD_1	97	99	PF00675	0.224
CLV_PCSK_KEX2_1	171	173	PF00082	0.433
CLV_PCSK_KEX2_1	229	231	PF00082	0.413
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.377
CLV_PCSK_SKI1_1	112	116	PF00082	0.223
CLV_PCSK_SKI1_1	207	211	PF00082	0.413
CLV_PCSK_SKI1_1	56	60	PF00082	0.223
DEG_APCC_DBOX_1	206	214	PF00400	0.233
DOC_CYCLIN_RxL_1	53	62	PF00134	0.474
DOC_MAPK_gen_1	35	43	PF00069	0.441
DOC_MAPK_MEF2A_6	142	149	PF00069	0.149
DOC_MAPK_NFAT4_5	142	150	PF00069	0.149
DOC_MAPK_RevD_3	217	230	PF00069	0.295
DOC_PP2B_LxvP_1	182	185	PF13499	0.348
DOC_USP7_MATH_1	188	192	PF00917	0.350
DOC_USP7_MATH_1	97	101	PF00917	0.442
DOC_WW_Pin1_4	115	120	PF00397	0.454
LIG_14-3-3_CanoR_1	187	196	PF00244	0.331
LIG_14-3-3_CanoR_1	98	106	PF00244	0.383
LIG_APCC_ABBAyCdc20_2	160	166	PF00400	0.281
LIG_BRCT_BRCA1_1	68	72	PF00533	0.562
LIG_BRCT_BRCA1_1	87	91	PF00533	0.340
LIG_CSL_BTD_1	119	122	PF09270	0.203
LIG_deltaCOP1_diTrp_1	166	173	PF00928	0.264
LIG_FHA_1	157	163	PF00498	0.312
LIG_FHA_1	17	23	PF00498	0.424
LIG_FHA_1	221	227	PF00498	0.156
LIG_FHA_2	150	156	PF00498	0.229
LIG_FHA_2	19	25	PF00498	0.423
LIG_LIR_Gen_1	165	174	PF02991	0.276
LIG_LIR_Gen_1	176	185	PF02991	0.404
LIG_LIR_Nem_3	165	170	PF02991	0.289
LIG_LIR_Nem_3	176	180	PF02991	0.330
LIG_LIR_Nem_3	62	68	PF02991	0.408
LIG_LIR_Nem_3	69	75	PF02991	0.402
LIG_LIR_Nem_3	88	93	PF02991	0.340
LIG_MLH1_MIPbox_1	87	91	PF16413	0.400
LIG_PCNA_yPIPBox_3	98	110	PF02747	0.383
LIG_Pex14_1	133	137	PF04695	0.227
LIG_Pex14_2	173	177	PF04695	0.247
LIG_Pex14_2	68	72	PF04695	0.441
LIG_REV1ctd_RIR_1	137	146	PF16727	0.223
LIG_SH2_STAP1	110	114	PF00017	0.453
LIG_SH2_STAP1	164	168	PF00017	0.282
LIG_SH2_STAP1	54	58	PF00017	0.453
LIG_SH2_STAT3	75	78	PF00017	0.474
LIG_SH2_STAT5	110	113	PF00017	0.423
LIG_SH2_STAT5	164	167	PF00017	0.282
LIG_SH2_STAT5	49	52	PF00017	0.431
LIG_SH2_STAT5	75	78	PF00017	0.429
LIG_SH2_STAT5	8	11	PF00017	0.412
LIG_SH3_3	116	122	PF00018	0.383
LIG_SH3_3	182	188	PF00018	0.350
LIG_SUMO_SIM_anti_2	81	88	PF11976	0.349
LIG_SUMO_SIM_par_1	39	45	PF11976	0.474
LIG_UBA3_1	144	150	PF00899	0.208
LIG_UBA3_1	22	28	PF00899	0.374
LIG_WW_3	184	188	PF00397	0.330
MOD_CK1_1	118	124	PF00069	0.319
MOD_CK1_1	81	87	PF00069	0.392
MOD_CK2_1	149	155	PF00069	0.223
MOD_GlcNHglycan	190	193	PF01048	0.582
MOD_GlcNHglycan	201	204	PF01048	0.658
MOD_GlcNHglycan	215	218	PF01048	0.284
MOD_GlcNHglycan	68	71	PF01048	0.368
MOD_GlcNHglycan	87	90	PF01048	0.191
MOD_GSK3_1	12	19	PF00069	0.423
MOD_GSK3_1	149	156	PF00069	0.251
MOD_GSK3_1	81	88	PF00069	0.492
MOD_GSK3_1	89	96	PF00069	0.484
MOD_GSK3_1	97	104	PF00069	0.380
MOD_N-GLC_1	115	120	PF02516	0.241
MOD_N-GLC_1	93	98	PF02516	0.223
MOD_NEK2_1	10	15	PF00069	0.430
MOD_NEK2_1	149	154	PF00069	0.243
MOD_NEK2_1	59	64	PF00069	0.434
MOD_PKA_2	97	103	PF00069	0.433
MOD_Plk_1	81	87	PF00069	0.424
MOD_Plk_4	18	24	PF00069	0.423
MOD_Plk_4	45	51	PF00069	0.450
MOD_Plk_4	81	87	PF00069	0.359
MOD_ProDKin_1	115	121	PF00069	0.454
MOD_SUMO_rev_2	32	36	PF00179	0.441
TRG_ENDOCYTIC_2	137	140	PF00928	0.223
TRG_ENDOCYTIC_2	54	57	PF00928	0.447
TRG_ENDOCYTIC_2	65	68	PF00928	0.466
TRG_ENDOCYTIC_2	8	11	PF00928	0.412
TRG_ER_diArg_1	170	172	PF00400	0.231
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q7	Leptomonas seymouri	64%	100%
A0A3S5H5V3	Leishmania donovani	87%	100%
A4H4U0	Leishmania braziliensis	80%	100%
A4HT19	Leishmania infantum	87%	100%
P0ACB4	Escherichia coli (strain K12)	50%	100%
P0ACB5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	50%	100%
P0ACB6	Escherichia coli O157:H7	50%	100%
Q4QIU7	Leishmania major	89%	100%
Q9L6L1	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	51%	100%