Putative pteridine transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AL06_LEIMU

TriTrypDb:

LmxM.06.1260

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AL06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL06

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.405
CLV_NRD_NRD_1	259	261	PF00675	0.330
CLV_NRD_NRD_1	271	273	PF00675	0.344
CLV_NRD_NRD_1	362	364	PF00675	0.399
CLV_PCSK_KEX2_1	132	134	PF00082	0.300
CLV_PCSK_KEX2_1	259	261	PF00082	0.275
CLV_PCSK_KEX2_1	271	273	PF00082	0.301
CLV_PCSK_KEX2_1	362	364	PF00082	0.399
CLV_PCSK_KEX2_1	482	484	PF00082	0.522
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.300
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.522
CLV_PCSK_SKI1_1	261	265	PF00082	0.315
CLV_PCSK_SKI1_1	363	367	PF00082	0.528
CLV_PCSK_SKI1_1	38	42	PF00082	0.293
CLV_PCSK_SKI1_1	458	462	PF00082	0.269
DOC_CDC14_PxL_1	40	48	PF14671	0.524
DOC_CDC14_PxL_1	568	576	PF14671	0.329
DOC_CKS1_1	580	585	PF01111	0.441
DOC_CYCLIN_yCln2_LP_2	382	388	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	580	586	PF00134	0.402
DOC_MAPK_gen_1	132	138	PF00069	0.514
DOC_MAPK_gen_1	259	267	PF00069	0.560
DOC_MAPK_gen_1	456	464	PF00069	0.443
DOC_MAPK_gen_1	482	490	PF00069	0.323
DOC_MAPK_gen_1	596	605	PF00069	0.592
DOC_MAPK_MEF2A_6	225	233	PF00069	0.331
DOC_MAPK_MEF2A_6	390	397	PF00069	0.473
DOC_MAPK_MEF2A_6	62	69	PF00069	0.547
DOC_MAPK_NFAT4_5	62	70	PF00069	0.608
DOC_PP2B_LxvP_1	382	385	PF13499	0.450
DOC_PP2B_LxvP_1	403	406	PF13499	0.385
DOC_PP2B_LxvP_1	585	588	PF13499	0.375
DOC_PP2B_LxvP_1	592	595	PF13499	0.335
DOC_PP4_FxxP_1	313	316	PF00568	0.464
DOC_USP7_MATH_1	155	159	PF00917	0.272
DOC_USP7_MATH_1	541	545	PF00917	0.408
DOC_USP7_MATH_1	548	552	PF00917	0.400
DOC_WW_Pin1_4	579	584	PF00397	0.424
LIG_14-3-3_CanoR_1	103	108	PF00244	0.499
LIG_14-3-3_CanoR_1	483	491	PF00244	0.182
LIG_APCC_ABBA_1	247	252	PF00400	0.415
LIG_APCC_ABBA_1	49	54	PF00400	0.634
LIG_BIR_II_1	1	5	PF00653	0.769
LIG_BIR_III_3	1	5	PF00653	0.608
LIG_BRCT_BRCA1_1	426	430	PF00533	0.325
LIG_DLG_GKlike_1	103	110	PF00625	0.427
LIG_EVH1_2	564	568	PF00568	0.345
LIG_FHA_1	120	126	PF00498	0.562
LIG_FHA_1	345	351	PF00498	0.365
LIG_FHA_1	443	449	PF00498	0.416
LIG_FHA_1	464	470	PF00498	0.358
LIG_FHA_1	525	531	PF00498	0.481
LIG_FHA_1	575	581	PF00498	0.425
LIG_GBD_Chelix_1	464	472	PF00786	0.481
LIG_GBD_Chelix_1	502	510	PF00786	0.507
LIG_LIR_Apic_2	310	316	PF02991	0.537
LIG_LIR_Gen_1	399	409	PF02991	0.358
LIG_LIR_Gen_1	429	438	PF02991	0.331
LIG_LIR_Gen_1	474	481	PF02991	0.345
LIG_LIR_Gen_1	529	538	PF02991	0.518
LIG_LIR_Gen_1	567	576	PF02991	0.271
LIG_LIR_Nem_3	131	137	PF02991	0.502
LIG_LIR_Nem_3	227	231	PF02991	0.325
LIG_LIR_Nem_3	241	247	PF02991	0.355
LIG_LIR_Nem_3	399	405	PF02991	0.338
LIG_LIR_Nem_3	427	431	PF02991	0.303
LIG_LIR_Nem_3	474	479	PF02991	0.347
LIG_LIR_Nem_3	529	535	PF02991	0.480
LIG_LIR_Nem_3	555	560	PF02991	0.298
LIG_LIR_Nem_3	567	571	PF02991	0.266
LIG_NRBOX	396	402	PF00104	0.419
LIG_Pex14_1	204	208	PF04695	0.392
LIG_Pex14_2	168	172	PF04695	0.376
LIG_Pex14_2	243	247	PF04695	0.302
LIG_Pex14_2	426	430	PF04695	0.318
LIG_Pex14_2	450	454	PF04695	0.375
LIG_Pex14_2	59	63	PF04695	0.494
LIG_PTB_Apo_2	567	574	PF02174	0.328
LIG_PTB_Phospho_1	567	573	PF10480	0.328
LIG_REV1ctd_RIR_1	451	460	PF16727	0.388
LIG_SH2_CRK	101	105	PF00017	0.514
LIG_SH2_CRK	135	139	PF00017	0.386
LIG_SH2_CRK	150	154	PF00017	0.337
LIG_SH2_CRK	342	346	PF00017	0.357
LIG_SH2_CRK	367	371	PF00017	0.368
LIG_SH2_CRK	431	435	PF00017	0.311
LIG_SH2_CRK	459	463	PF00017	0.503
LIG_SH2_GRB2like	396	399	PF00017	0.389
LIG_SH2_NCK_1	367	371	PF00017	0.422
LIG_SH2_PTP2	228	231	PF00017	0.208
LIG_SH2_PTP2	48	51	PF00017	0.640
LIG_SH2_SRC	31	34	PF00017	0.630
LIG_SH2_SRC	396	399	PF00017	0.501
LIG_SH2_SRC	573	576	PF00017	0.208
LIG_SH2_STAP1	130	134	PF00017	0.508
LIG_SH2_STAP1	342	346	PF00017	0.404
LIG_SH2_STAP1	459	463	PF00017	0.509
LIG_SH2_STAP1	504	508	PF00017	0.415
LIG_SH2_STAT5	130	133	PF00017	0.510
LIG_SH2_STAT5	228	231	PF00017	0.356
LIG_SH2_STAT5	396	399	PF00017	0.362
LIG_SH2_STAT5	402	405	PF00017	0.354
LIG_SH2_STAT5	413	416	PF00017	0.274
LIG_SH2_STAT5	428	431	PF00017	0.267
LIG_SH2_STAT5	48	51	PF00017	0.592
LIG_SH2_STAT5	496	499	PF00017	0.302
LIG_SH2_STAT5	573	576	PF00017	0.400
LIG_SH2_STAT5	71	74	PF00017	0.528
LIG_SH3_3	280	286	PF00018	0.548
LIG_SH3_3	296	302	PF00018	0.436
LIG_SH3_3	418	424	PF00018	0.287
LIG_SH3_3	621	627	PF00018	0.737
LIG_Sin3_3	590	597	PF02671	0.208
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.373
LIG_SUMO_SIM_anti_2	477	482	PF11976	0.325
LIG_SUMO_SIM_anti_2	582	588	PF11976	0.462
LIG_SUMO_SIM_par_1	294	300	PF11976	0.380
LIG_TRAF2_1	6	9	PF00917	0.768
LIG_TRAF2_1	616	619	PF00917	0.808
LIG_TRFH_1	150	154	PF08558	0.372
LIG_TRFH_1	591	595	PF08558	0.301
LIG_TYR_ITIM	148	153	PF00017	0.392
LIG_TYR_ITIM	226	231	PF00017	0.208
LIG_TYR_ITIM	340	345	PF00017	0.253
LIG_TYR_ITIM	365	370	PF00017	0.385
LIG_TYR_ITIM	400	405	PF00017	0.326
LIG_TYR_ITIM	46	51	PF00017	0.471
LIG_TYR_ITIM	571	576	PF00017	0.396
LIG_TYR_ITSM	427	434	PF00017	0.414
LIG_UBA3_1	217	225	PF00899	0.208
LIG_UBA3_1	246	254	PF00899	0.402
LIG_UBA3_1	475	482	PF00899	0.334
MOD_CK1_1	106	112	PF00069	0.361
MOD_CK1_1	198	204	PF00069	0.344
MOD_CK1_1	53	59	PF00069	0.228
MOD_CK2_1	185	191	PF00069	0.202
MOD_CK2_1	294	300	PF00069	0.289
MOD_GlcNHglycan	138	141	PF01048	0.373
MOD_GlcNHglycan	157	161	PF01048	0.368
MOD_GlcNHglycan	2	5	PF01048	0.692
MOD_GlcNHglycan	233	236	PF01048	0.382
MOD_GlcNHglycan	289	292	PF01048	0.432
MOD_GlcNHglycan	539	542	PF01048	0.408
MOD_GlcNHglycan	560	563	PF01048	0.388
MOD_GSK3_1	106	113	PF00069	0.402
MOD_GSK3_1	204	211	PF00069	0.322
MOD_GSK3_1	426	433	PF00069	0.390
MOD_GSK3_1	448	455	PF00069	0.325
MOD_GSK3_1	537	544	PF00069	0.386
MOD_N-GLC_1	254	259	PF02516	0.390
MOD_N-GLC_1	82	87	PF02516	0.403
MOD_NEK2_1	110	115	PF00069	0.378
MOD_NEK2_1	117	122	PF00069	0.358
MOD_NEK2_1	128	133	PF00069	0.291
MOD_NEK2_1	136	141	PF00069	0.338
MOD_NEK2_1	172	177	PF00069	0.360
MOD_NEK2_1	185	190	PF00069	0.379
MOD_NEK2_1	208	213	PF00069	0.337
MOD_NEK2_1	344	349	PF00069	0.364
MOD_NEK2_1	426	431	PF00069	0.374
MOD_NEK2_1	463	468	PF00069	0.375
MOD_NEK2_1	508	513	PF00069	0.377
MOD_NEK2_1	574	579	PF00069	0.464
MOD_NEK2_1	63	68	PF00069	0.443
MOD_NEK2_1	69	74	PF00069	0.462
MOD_PIKK_1	178	184	PF00454	0.337
MOD_PIKK_1	349	355	PF00454	0.204
MOD_PK_1	294	300	PF00069	0.181
MOD_PKA_2	524	530	PF00069	0.346
MOD_Plk_4	103	109	PF00069	0.281
MOD_Plk_4	195	201	PF00069	0.350
MOD_Plk_4	204	210	PF00069	0.348
MOD_Plk_4	224	230	PF00069	0.327
MOD_Plk_4	238	244	PF00069	0.200
MOD_Plk_4	294	300	PF00069	0.421
MOD_Plk_4	396	402	PF00069	0.365
MOD_Plk_4	426	432	PF00069	0.470
MOD_Plk_4	464	470	PF00069	0.335
MOD_Plk_4	471	477	PF00069	0.328
MOD_Plk_4	508	514	PF00069	0.326
MOD_Plk_4	548	554	PF00069	0.350
MOD_Plk_4	620	626	PF00069	0.665
MOD_ProDKin_1	579	585	PF00069	0.424
MOD_SUMO_for_1	29	32	PF00179	0.363
MOD_SUMO_rev_2	222	227	PF00179	0.419
MOD_SUMO_rev_2	289	296	PF00179	0.207
MOD_SUMO_rev_2	644	651	PF00179	0.532
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.388
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.369
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.331
TRG_ENDOCYTIC_2	101	104	PF00928	0.329
TRG_ENDOCYTIC_2	135	138	PF00928	0.364
TRG_ENDOCYTIC_2	150	153	PF00928	0.352
TRG_ENDOCYTIC_2	228	231	PF00928	0.208
TRG_ENDOCYTIC_2	342	345	PF00928	0.358
TRG_ENDOCYTIC_2	367	370	PF00928	0.364
TRG_ENDOCYTIC_2	402	405	PF00928	0.355
TRG_ENDOCYTIC_2	431	434	PF00928	0.355
TRG_ENDOCYTIC_2	459	462	PF00928	0.349
TRG_ENDOCYTIC_2	48	51	PF00928	0.480
TRG_ENDOCYTIC_2	573	576	PF00928	0.428
TRG_ER_diArg_1	271	273	PF00400	0.349
TRG_NES_CRM1_1	238	252	PF08389	0.382
TRG_NES_CRM1_1	317	331	PF08389	0.227
TRG_NES_CRM1_1	500	516	PF08389	0.208
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.181
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	92%
A0A0N1HY49	Leptomonas seymouri	45%	97%
A0A0N1HZ06	Leptomonas seymouri	47%	100%
A0A0N1IHL1	Leptomonas seymouri	41%	91%
A0A0N1PAY4	Leptomonas seymouri	40%	74%
A0A0N1PB77	Leptomonas seymouri	43%	100%
A0A0N1PBZ2	Leptomonas seymouri	42%	97%
A0A0N1PCC1	Leptomonas seymouri	44%	97%
A0A0S4IKN0	Bodo saltans	33%	100%
A0A381MBI0	Leishmania infantum	43%	99%
A0A3Q8I8X7	Leishmania donovani	43%	99%
A0A3Q8IAZ0	Leishmania donovani	43%	93%
A0A3Q8IH50	Leishmania donovani	44%	90%
A0A3Q8IVN0	Leishmania donovani	46%	100%
A0A3R7M4J1	Trypanosoma rangeli	45%	100%
A0A3S5H5P4	Leishmania donovani	46%	96%
A0A3S5H5V2	Leishmania donovani	90%	100%
A0A3S5H6F6	Leishmania donovani	43%	93%
A0A3S5H763	Leishmania donovani	44%	97%
A0A3S7WR10	Leishmania donovani	46%	100%
A0A3S7WR14	Leishmania donovani	43%	95%
A0A3S7WR15	Leishmania donovani	41%	77%
A0A3S7WR24	Leishmania donovani	43%	92%
A4H4T8	Leishmania braziliensis	82%	100%
A4H5Y4	Leishmania braziliensis	44%	100%
A4H617	Leishmania braziliensis	43%	100%
A4H618	Leishmania braziliensis	44%	100%
A4H619	Leishmania braziliensis	44%	100%
A4H620	Leishmania braziliensis	46%	100%
A4H6C3	Leishmania braziliensis	44%	100%
A4HNH7	Leishmania braziliensis	45%	100%
A4HSS2	Leishmania infantum	46%	96%
A4HUE4	Leishmania infantum	46%	100%
A4HUE5	Leishmania infantum	40%	94%
A4HUE6	Leishmania infantum	43%	95%
A4HUE7	Leishmania infantum	43%	93%
A4HUE8	Leishmania infantum	43%	92%
A4HUF4	Leishmania infantum	43%	93%
A4HUF5	Leishmania infantum	43%	99%
A4HYA9	Leishmania infantum	44%	97%
A4IC33	Leishmania infantum	46%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AG72	Leishmania infantum	89%	100%
E9AI40	Leishmania braziliensis	43%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	87%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	99%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	91%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	99%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	97%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4QDC4	Leishmania major	45%	100%
Q4QH81	Leishmania major	45%	100%
Q4QHH7	Leishmania major	44%	100%
Q4QHH8	Leishmania major	43%	100%
Q4QHH9	Leishmania major	43%	100%
Q4QHI0	Leishmania major	43%	100%
Q4QHI1	Leishmania major	45%	100%
Q4QHI2	Leishmania major	41%	100%
Q4QIU9	Leishmania major	90%	100%
Q4QJ48	Leishmania major	47%	100%
Q7KIP2	Leishmania major	45%	100%