Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL05_LEIMU

TriTrypDb:

LmxM.06.1250

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AL05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.405
CLV_NRD_NRD_1	24	26	PF00675	0.400
CLV_PCSK_KEX2_1	11	13	PF00082	0.414
CLV_PCSK_KEX2_1	167	169	PF00082	0.505
CLV_PCSK_KEX2_1	19	21	PF00082	0.375
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.466
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.543
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.425
DOC_MAPK_DCC_7	125	134	PF00069	0.423
DOC_MAPK_MEF2A_6	125	134	PF00069	0.447
DOC_MAPK_MEF2A_6	199	208	PF00069	0.539
DOC_MAPK_MEF2A_6	53	62	PF00069	0.516
DOC_MAPK_NFAT4_5	199	207	PF00069	0.551
DOC_PP1_RVXF_1	154	161	PF00149	0.720
DOC_PP2B_PxIxI_1	55	61	PF00149	0.369
DOC_PP4_FxxP_1	93	96	PF00568	0.673
DOC_USP7_MATH_2	96	102	PF00917	0.536
DOC_WW_Pin1_4	151	156	PF00397	0.643
DOC_WW_Pin1_4	47	52	PF00397	0.677
LIG_14-3-3_CanoR_1	114	123	PF00244	0.553
LIG_14-3-3_CanoR_1	159	165	PF00244	0.712
LIG_14-3-3_CanoR_1	170	175	PF00244	0.726
LIG_Actin_WH2_2	146	161	PF00022	0.629
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BRCT_BRCA1_1	153	157	PF00533	0.657
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.292
LIG_eIF4E_1	137	143	PF01652	0.485
LIG_FAT_LD_1	200	208	PF03623	0.561
LIG_FHA_1	103	109	PF00498	0.357
LIG_FHA_1	50	56	PF00498	0.643
LIG_LIR_Apic_2	117	123	PF02991	0.457
LIG_LIR_Gen_1	154	164	PF02991	0.723
LIG_LIR_Gen_1	181	192	PF02991	0.658
LIG_LIR_Gen_1	31	42	PF02991	0.661
LIG_LIR_Gen_1	75	84	PF02991	0.306
LIG_LIR_Gen_1	97	107	PF02991	0.510
LIG_LIR_Nem_3	154	160	PF02991	0.704
LIG_LIR_Nem_3	181	187	PF02991	0.662
LIG_LIR_Nem_3	232	237	PF02991	0.412
LIG_LIR_Nem_3	31	37	PF02991	0.645
LIG_LIR_Nem_3	75	79	PF02991	0.331
LIG_LIR_Nem_3	97	102	PF02991	0.504
LIG_NRBOX	199	205	PF00104	0.561
LIG_NRBOX	58	64	PF00104	0.485
LIG_NRBOX	84	90	PF00104	0.424
LIG_Pex14_2	111	115	PF04695	0.374
LIG_REV1ctd_RIR_1	108	118	PF16727	0.355
LIG_SH2_CRK	120	124	PF00017	0.487
LIG_SH2_NCK_1	120	124	PF00017	0.458
LIG_SH2_PTP2	137	140	PF00017	0.432
LIG_SH2_PTP2	152	155	PF00017	0.474
LIG_SH2_PTP2	217	220	PF00017	0.272
LIG_SH2_SRC	34	37	PF00017	0.658
LIG_SH2_STAT5	137	140	PF00017	0.389
LIG_SH2_STAT5	149	152	PF00017	0.311
LIG_SH2_STAT5	217	220	PF00017	0.444
LIG_SH2_STAT5	34	37	PF00017	0.656
LIG_SH3_3	124	130	PF00018	0.408
LIG_SH3_3	62	68	PF00018	0.396
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.627
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.657
LIG_SUMO_SIM_anti_2	97	105	PF11976	0.535
LIG_TYR_ITIM	135	140	PF00017	0.420
LIG_TYR_ITIM	215	220	PF00017	0.444
MOD_CDC14_SPxK_1	50	53	PF00782	0.674
MOD_CDK_SPK_2	151	156	PF00069	0.643
MOD_CDK_SPxK_1	47	53	PF00069	0.680
MOD_CK1_1	101	107	PF00069	0.429
MOD_CK1_1	2	8	PF00069	0.686
MOD_CK2_1	2	8	PF00069	0.653
MOD_Cter_Amidation	165	168	PF01082	0.484
MOD_GSK3_1	45	52	PF00069	0.670
MOD_GSK3_1	63	70	PF00069	0.195
MOD_GSK3_1	94	101	PF00069	0.664
MOD_NEK2_1	158	163	PF00069	0.704
MOD_NEK2_1	63	68	PF00069	0.401
MOD_NEK2_1	91	96	PF00069	0.508
MOD_PK_1	170	176	PF00069	0.569
MOD_PKA_2	113	119	PF00069	0.523
MOD_PKA_2	158	164	PF00069	0.715
MOD_PKA_2	169	175	PF00069	0.645
MOD_PKA_2	45	51	PF00069	0.726
MOD_PKB_1	168	176	PF00069	0.719
MOD_Plk_4	229	235	PF00069	0.395
MOD_Plk_4	84	90	PF00069	0.389
MOD_Plk_4	98	104	PF00069	0.438
MOD_ProDKin_1	151	157	PF00069	0.648
MOD_ProDKin_1	47	53	PF00069	0.672
TRG_DiLeu_BaEn_1	198	203	PF01217	0.661
TRG_DiLeu_BaEn_4	195	201	PF01217	0.693
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.471
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.487
TRG_ENDOCYTIC_2	137	140	PF00928	0.389
TRG_ENDOCYTIC_2	184	187	PF00928	0.663
TRG_ENDOCYTIC_2	217	220	PF00928	0.412
TRG_ENDOCYTIC_2	34	37	PF00928	0.634
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBC2	Leptomonas seymouri	66%	100%
A0A0S4JA41	Bodo saltans	28%	100%
A0A1X0NGU0	Trypanosomatidae	36%	100%
A0A3S5H5V0	Leishmania donovani	94%	100%
A4H4T7	Leishmania braziliensis	85%	100%
A4HT17	Leishmania infantum	94%	100%
C9ZTQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QIV0	Leishmania major	92%	100%