FAD_binding_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AL03_LEIMU

TriTrypDb:

LmxM.06.1240

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AL03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL03

Function

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Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	9
GO:0004497	monooxygenase activity	3	9
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	9
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	5
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	5
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.337
CLV_C14_Caspase3-7	50	54	PF00656	0.491
CLV_NRD_NRD_1	160	162	PF00675	0.527
CLV_NRD_NRD_1	3	5	PF00675	0.670
CLV_NRD_NRD_1	325	327	PF00675	0.335
CLV_PCSK_KEX2_1	3	5	PF00082	0.670
CLV_PCSK_KEX2_1	325	327	PF00082	0.276
CLV_PCSK_KEX2_1	74	76	PF00082	0.497
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.477
CLV_PCSK_SKI1_1	243	247	PF00082	0.276

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4M2	Leptomonas seymouri	75%	97%
A0A1X0NI75	Trypanosomatidae	57%	96%
A0A3R7KEW4	Trypanosoma rangeli	55%	99%
A0A3S7WPP5	Leishmania donovani	89%	100%
A1KVW0	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	25%	100%
A4H4T6	Leishmania braziliensis	83%	100%
A4HT15	Leishmania infantum	89%	100%
C9ZTQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	96%
F1RAX8	Danio rerio	27%	100%
O01884	Caenorhabditis elegans	26%	100%

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