FAD_binding_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AL03_LEIMU

TriTrypDb:

LmxM.06.1240

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AL03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL03

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	9
GO:0004497	monooxygenase activity	3	9
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	9
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	5
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	5
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0071949	FAD binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.337
CLV_C14_Caspase3-7	50	54	PF00656	0.491
CLV_NRD_NRD_1	160	162	PF00675	0.527
CLV_NRD_NRD_1	3	5	PF00675	0.670
CLV_NRD_NRD_1	325	327	PF00675	0.335
CLV_PCSK_KEX2_1	3	5	PF00082	0.670
CLV_PCSK_KEX2_1	325	327	PF00082	0.276
CLV_PCSK_KEX2_1	74	76	PF00082	0.497
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.477
CLV_PCSK_SKI1_1	243	247	PF00082	0.276
CLV_PCSK_SKI1_1	309	313	PF00082	0.388
CLV_PCSK_SKI1_1	372	376	PF00082	0.257
CLV_PCSK_SKI1_1	444	448	PF00082	0.524
CLV_PCSK_SKI1_1	66	70	PF00082	0.326
DEG_APCC_DBOX_1	2	10	PF00400	0.630
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SCF_FBW7_1	90	97	PF00400	0.312
DEG_SPOP_SBC_1	300	304	PF00917	0.346
DEG_SPOP_SBC_1	342	346	PF00917	0.337
DOC_CKS1_1	246	251	PF01111	0.388
DOC_CYCLIN_RxL_1	306	315	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.341
DOC_MAPK_gen_1	161	169	PF00069	0.395
DOC_MAPK_HePTP_8	145	157	PF00069	0.470
DOC_MAPK_MEF2A_6	148	157	PF00069	0.452
DOC_PP1_RVXF_1	160	167	PF00149	0.352
DOC_PP2B_LxvP_1	339	342	PF13499	0.217
DOC_USP7_MATH_1	342	346	PF00917	0.316
DOC_USP7_MATH_1	354	358	PF00917	0.332
DOC_USP7_MATH_1	400	404	PF00917	0.307
DOC_USP7_MATH_1	408	412	PF00917	0.242
DOC_USP7_MATH_1	460	464	PF00917	0.475
DOC_USP7_MATH_1	465	469	PF00917	0.456
DOC_USP7_MATH_1	94	98	PF00917	0.354
DOC_WW_Pin1_4	124	129	PF00397	0.446
DOC_WW_Pin1_4	245	250	PF00397	0.412
DOC_WW_Pin1_4	301	306	PF00397	0.301
DOC_WW_Pin1_4	343	348	PF00397	0.287
DOC_WW_Pin1_4	364	369	PF00397	0.206
DOC_WW_Pin1_4	447	452	PF00397	0.552
DOC_WW_Pin1_4	9	14	PF00397	0.626
DOC_WW_Pin1_4	90	95	PF00397	0.347
LIG_14-3-3_CanoR_1	135	140	PF00244	0.523
LIG_14-3-3_CanoR_1	148	155	PF00244	0.452
LIG_14-3-3_CanoR_1	186	194	PF00244	0.252
LIG_14-3-3_CanoR_1	238	243	PF00244	0.447
LIG_14-3-3_CanoR_1	3	13	PF00244	0.587
LIG_14-3-3_CanoR_1	325	331	PF00244	0.287
LIG_BRCT_BRCA1_1	135	139	PF00533	0.526
LIG_Clathr_ClatBox_1	67	71	PF01394	0.355
LIG_FHA_1	140	146	PF00498	0.636
LIG_FHA_1	246	252	PF00498	0.298
LIG_FHA_1	256	262	PF00498	0.230
LIG_FHA_1	294	300	PF00498	0.253
LIG_FHA_1	400	406	PF00498	0.335
LIG_FHA_1	431	437	PF00498	0.529
LIG_FHA_1	448	454	PF00498	0.407
LIG_FHA_1	54	60	PF00498	0.365
LIG_FHA_1	87	93	PF00498	0.348
LIG_FHA_2	147	153	PF00498	0.564
LIG_FHA_2	206	212	PF00498	0.518
LIG_FHA_2	221	227	PF00498	0.303
LIG_FHA_2	290	296	PF00498	0.308
LIG_FHA_2	313	319	PF00498	0.364
LIG_FHA_2	436	442	PF00498	0.376
LIG_GBD_Chelix_1	60	68	PF00786	0.381
LIG_LIR_Gen_1	156	164	PF02991	0.368
LIG_LIR_Gen_1	276	281	PF02991	0.317
LIG_LIR_Nem_3	156	160	PF02991	0.399
LIG_LIR_Nem_3	226	232	PF02991	0.337
LIG_LIR_Nem_3	276	280	PF02991	0.317
LIG_MLH1_MIPbox_1	136	140	PF16413	0.633
LIG_Pex14_2	277	281	PF04695	0.257
LIG_REV1ctd_RIR_1	278	286	PF16727	0.388
LIG_SH2_NCK_1	78	82	PF00017	0.518
LIG_SH2_STAP1	255	259	PF00017	0.276
LIG_SH2_STAP1	396	400	PF00017	0.257
LIG_SH3_3	198	204	PF00018	0.390
LIG_SH3_3	365	371	PF00018	0.265
LIG_SUMO_SIM_par_1	88	93	PF11976	0.307
LIG_TRAF2_1	314	317	PF00917	0.306
LIG_UBA3_1	436	445	PF00899	0.480
LIG_WRC_WIRS_1	274	279	PF05994	0.369
LIG_WRC_WIRS_1	327	332	PF05994	0.287
MOD_CDK_SPxxK_3	343	350	PF00069	0.287
MOD_CK1_1	188	194	PF00069	0.333
MOD_CK1_1	205	211	PF00069	0.560
MOD_CK1_1	212	218	PF00069	0.357
MOD_CK1_1	220	226	PF00069	0.276
MOD_CK1_1	247	253	PF00069	0.317
MOD_CK1_1	293	299	PF00069	0.236
MOD_CK1_1	5	11	PF00069	0.462
MOD_CK1_1	55	61	PF00069	0.469
MOD_CK2_1	146	152	PF00069	0.602
MOD_CK2_1	205	211	PF00069	0.470
MOD_CK2_1	220	226	PF00069	0.136
MOD_CK2_1	311	317	PF00069	0.361
MOD_CK2_1	4	10	PF00069	0.439
MOD_CK2_1	400	406	PF00069	0.388
MOD_CK2_1	435	441	PF00069	0.372
MOD_Cter_Amidation	72	75	PF01082	0.453
MOD_GlcNHglycan	214	217	PF01048	0.333
MOD_GlcNHglycan	219	222	PF01048	0.281
MOD_GlcNHglycan	23	26	PF01048	0.343
MOD_GlcNHglycan	410	413	PF01048	0.412
MOD_GlcNHglycan	47	50	PF01048	0.633
MOD_GlcNHglycan	479	482	PF01048	0.306
MOD_GlcNHglycan	71	74	PF01048	0.442
MOD_GSK3_1	135	142	PF00069	0.541
MOD_GSK3_1	205	212	PF00069	0.523
MOD_GSK3_1	289	296	PF00069	0.273
MOD_GSK3_1	5	12	PF00069	0.445
MOD_GSK3_1	51	58	PF00069	0.493
MOD_GSK3_1	86	93	PF00069	0.376
MOD_N-GLC_1	146	151	PF02516	0.607
MOD_N-GLC_2	273	275	PF02516	0.257
MOD_NEK2_1	139	144	PF00069	0.597
MOD_NEK2_1	2	7	PF00069	0.616
MOD_NEK2_1	209	214	PF00069	0.514
MOD_NEK2_1	260	265	PF00069	0.351
MOD_NEK2_1	28	33	PF00069	0.371
MOD_NEK2_1	311	316	PF00069	0.268
MOD_NEK2_1	430	435	PF00069	0.330
MOD_NEK2_1	44	49	PF00069	0.457
MOD_NEK2_1	466	471	PF00069	0.485
MOD_NEK2_1	476	481	PF00069	0.362
MOD_NEK2_1	59	64	PF00069	0.514
MOD_NEK2_1	69	74	PF00069	0.383
MOD_NEK2_1	83	88	PF00069	0.437
MOD_PIKK_1	185	191	PF00454	0.268
MOD_PIKK_1	312	318	PF00454	0.270
MOD_PIKK_1	59	65	PF00454	0.375
MOD_PK_1	88	94	PF00069	0.443
MOD_PKA_1	444	450	PF00069	0.540
MOD_PKA_2	134	140	PF00069	0.635
MOD_PKA_2	147	153	PF00069	0.590
MOD_PKA_2	185	191	PF00069	0.516
MOD_PKA_2	2	8	PF00069	0.607
MOD_PKA_2	237	243	PF00069	0.447
MOD_Plk_4	135	141	PF00069	0.523
MOD_Plk_4	205	211	PF00069	0.464
MOD_Plk_4	400	406	PF00069	0.370
MOD_Plk_4	55	61	PF00069	0.402
MOD_ProDKin_1	124	130	PF00069	0.459
MOD_ProDKin_1	245	251	PF00069	0.412
MOD_ProDKin_1	301	307	PF00069	0.301
MOD_ProDKin_1	343	349	PF00069	0.287
MOD_ProDKin_1	364	370	PF00069	0.206
MOD_ProDKin_1	447	453	PF00069	0.558
MOD_ProDKin_1	9	15	PF00069	0.617
MOD_ProDKin_1	90	96	PF00069	0.343
MOD_SUMO_rev_2	345	351	PF00179	0.197
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.437
TRG_ENDOCYTIC_2	115	118	PF00928	0.343
TRG_ER_diArg_1	2	4	PF00400	0.623
TRG_ER_diArg_1	325	327	PF00400	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4M2	Leptomonas seymouri	75%	97%
A0A1X0NI75	Trypanosomatidae	57%	96%
A0A3R7KEW4	Trypanosoma rangeli	55%	99%
A0A3S7WPP5	Leishmania donovani	89%	100%
A1KVW0	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	25%	100%
A4H4T6	Leishmania braziliensis	83%	100%
A4HT15	Leishmania infantum	89%	100%
C9ZTQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	96%
F1RAX8	Danio rerio	27%	100%
O01884	Caenorhabditis elegans	26%	100%
P25535	Escherichia coli (strain K12)	26%	100%
P53318	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P75728	Escherichia coli (strain K12)	25%	100%
Q2KIL4	Bos taurus	25%	100%
Q2RMZ4	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	26%	100%
Q4QIV2	Leishmania major	89%	99%
Q68FU7	Rattus norvegicus	26%	100%
Q6DF46	Xenopus tropicalis	29%	100%
Q8R1S0	Mus musculus	27%	100%
Q9Y2Z9	Homo sapiens	25%	100%
V5B825	Trypanosoma cruzi	54%	99%