Cysteine dioxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1637), putative

Species:

Leishmania mexicana

UniProt:

E9AL02_LEIMU

TriTrypDb:

LmxM.06.1230

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL02

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	12
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	12
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051213	dioxygenase activity	3	12
GO:0047800	cysteamine dioxygenase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.431
CLV_C14_Caspase3-7	56	60	PF00656	0.539
CLV_NRD_NRD_1	6	8	PF00675	0.522
CLV_NRD_NRD_1	85	87	PF00675	0.162
CLV_PCSK_FUR_1	21	25	PF00082	0.388
CLV_PCSK_KEX2_1	23	25	PF00082	0.412
CLV_PCSK_KEX2_1	6	8	PF00082	0.540
CLV_PCSK_KEX2_1	85	87	PF00082	0.227
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.438
CLV_PCSK_PC7_1	19	25	PF00082	0.404
CLV_PCSK_SKI1_1	24	28	PF00082	0.416
DEG_APCC_DBOX_1	148	156	PF00400	0.457
DEG_Nend_UBRbox_3	1	3	PF02207	0.474
DOC_CYCLIN_RxL_1	126	135	PF00134	0.491
DOC_PP4_FxxP_1	123	126	PF00568	0.448
DOC_USP7_MATH_1	165	169	PF00917	0.472
DOC_USP7_MATH_1	98	102	PF00917	0.551
DOC_USP7_UBL2_3	23	27	PF12436	0.542
DOC_USP7_UBL2_3	268	272	PF12436	0.491
DOC_WW_Pin1_4	10	15	PF00397	0.579
DOC_WW_Pin1_4	195	200	PF00397	0.561
DOC_WW_Pin1_4	224	229	PF00397	0.461
DOC_WW_Pin1_4	92	97	PF00397	0.545
LIG_14-3-3_CanoR_1	24	30	PF00244	0.517
LIG_14-3-3_CanoR_1	6	15	PF00244	0.554
LIG_14-3-3_CanoR_1	85	94	PF00244	0.573
LIG_BIR_III_2	187	191	PF00653	0.457
LIG_FHA_1	167	173	PF00498	0.457
LIG_FHA_1	248	254	PF00498	0.500
LIG_FHA_1	89	95	PF00498	0.491
LIG_FHA_2	196	202	PF00498	0.537
LIG_FHA_2	33	39	PF00498	0.528
LIG_FHA_2	45	51	PF00498	0.406
LIG_LIR_Apic_2	279	284	PF02991	0.451
LIG_LIR_Gen_1	287	293	PF02991	0.260
LIG_LIR_Gen_1	41	51	PF02991	0.417
LIG_LIR_Nem_3	119	125	PF02991	0.523
LIG_LIR_Nem_3	287	292	PF02991	0.410
LIG_LIR_Nem_3	50	54	PF02991	0.529
LIG_MAD2	129	137	PF02301	0.405
LIG_PTB_Apo_2	63	70	PF02174	0.362
LIG_PTB_Phospho_1	63	69	PF10480	0.362
LIG_SH2_CRK	281	285	PF00017	0.480
LIG_SH2_NCK_1	230	234	PF00017	0.480
LIG_SH2_STAT5	242	245	PF00017	0.499
LIG_SH2_STAT5	54	57	PF00017	0.467
LIG_SH3_3	121	127	PF00018	0.480
LIG_SH3_3	90	96	PF00018	0.546
LIG_TRFH_1	123	127	PF08558	0.400
MOD_CK1_1	10	16	PF00069	0.508
MOD_CK1_1	33	39	PF00069	0.515
MOD_CK1_1	44	50	PF00069	0.299
MOD_CK1_1	88	94	PF00069	0.420
MOD_CK2_1	32	38	PF00069	0.476
MOD_GlcNHglycan	2	5	PF01048	0.544
MOD_GlcNHglycan	281	284	PF01048	0.350
MOD_GlcNHglycan	87	90	PF01048	0.429
MOD_GlcNHglycan	9	12	PF01048	0.745
MOD_GSK3_1	10	17	PF00069	0.577
MOD_GSK3_1	30	37	PF00069	0.430
MOD_GSK3_1	88	95	PF00069	0.395
MOD_LATS_1	83	89	PF00433	0.205
MOD_N-GLC_1	172	177	PF02516	0.350
MOD_N-GLC_1	279	284	PF02516	0.490
MOD_NEK2_1	107	112	PF00069	0.337
MOD_NEK2_1	247	252	PF00069	0.362
MOD_NEK2_1	25	30	PF00069	0.501
MOD_NEK2_1	32	37	PF00069	0.498
MOD_NEK2_2	108	113	PF00069	0.289
MOD_NEK2_2	14	19	PF00069	0.504
MOD_PIKK_1	158	164	PF00454	0.356
MOD_PIKK_1	214	220	PF00454	0.302
MOD_PKA_1	85	91	PF00069	0.169
MOD_PKA_2	85	91	PF00069	0.465
MOD_Plk_1	247	253	PF00069	0.303
MOD_Plk_4	108	114	PF00069	0.323
MOD_Plk_4	137	143	PF00069	0.285
MOD_Plk_4	172	178	PF00069	0.389
MOD_ProDKin_1	10	16	PF00069	0.575
MOD_ProDKin_1	195	201	PF00069	0.447
MOD_ProDKin_1	224	230	PF00069	0.307
MOD_ProDKin_1	92	98	PF00069	0.425
TRG_ER_diArg_1	19	22	PF00400	0.390
TRG_ER_diArg_1	6	9	PF00400	0.549
TRG_ER_diArg_1	85	87	PF00400	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C5	Leptomonas seymouri	57%	100%
A0A0S4IQ52	Bodo saltans	30%	100%
A0A1X0NH28	Trypanosomatidae	40%	100%
A0A3S5H5U9	Leishmania donovani	89%	100%
A0A422NM88	Trypanosoma rangeli	32%	100%
A4H4T5	Leishmania braziliensis	81%	100%
A4HT14	Leishmania infantum	90%	100%
C9ZTQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QIV3	Leishmania major	89%	100%
V5BT74	Trypanosoma cruzi	39%	100%