Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AL01_LEIMU

TriTrypDb:

LmxM.06.1220

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.592
CLV_NRD_NRD_1	308	310	PF00675	0.724
CLV_NRD_NRD_1	381	383	PF00675	0.750
CLV_NRD_NRD_1	443	445	PF00675	0.816
CLV_NRD_NRD_1	487	489	PF00675	0.573
CLV_NRD_NRD_1	557	559	PF00675	0.662
CLV_NRD_NRD_1	579	581	PF00675	0.731
CLV_NRD_NRD_1	643	645	PF00675	0.726
CLV_NRD_NRD_1	668	670	PF00675	0.650
CLV_NRD_NRD_1	694	696	PF00675	0.495
CLV_NRD_NRD_1	736	738	PF00675	0.656
CLV_NRD_NRD_1	749	751	PF00675	0.672
CLV_PCSK_FUR_1	485	489	PF00082	0.464
CLV_PCSK_KEX2_1	10	12	PF00082	0.592
CLV_PCSK_KEX2_1	389	391	PF00082	0.657
CLV_PCSK_KEX2_1	443	445	PF00082	0.816
CLV_PCSK_KEX2_1	487	489	PF00082	0.462
CLV_PCSK_KEX2_1	557	559	PF00082	0.662
CLV_PCSK_KEX2_1	579	581	PF00082	0.742
CLV_PCSK_KEX2_1	643	645	PF00082	0.728
CLV_PCSK_KEX2_1	668	670	PF00082	0.655
CLV_PCSK_KEX2_1	694	696	PF00082	0.495
CLV_PCSK_KEX2_1	749	751	PF00082	0.744
CLV_PCSK_KEX2_1	92	94	PF00082	0.618
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.648
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.618
CLV_PCSK_SKI1_1	166	170	PF00082	0.623
CLV_PCSK_SKI1_1	2	6	PF00082	0.612
CLV_PCSK_SKI1_1	366	370	PF00082	0.679
CLV_PCSK_SKI1_1	389	393	PF00082	0.597
CLV_PCSK_SKI1_1	476	480	PF00082	0.690
CLV_PCSK_SKI1_1	579	583	PF00082	0.586
CLV_PCSK_SKI1_1	601	605	PF00082	0.748
CLV_PCSK_SKI1_1	785	789	PF00082	0.647
DEG_APCC_DBOX_1	326	334	PF00400	0.731
DEG_APCC_DBOX_1	365	373	PF00400	0.677
DEG_Nend_UBRbox_1	1	4	PF02207	0.639
DEG_SPOP_SBC_1	403	407	PF00917	0.681
DOC_ANK_TNKS_1	496	503	PF00023	0.698
DOC_CKS1_1	115	120	PF01111	0.648
DOC_CKS1_1	198	203	PF01111	0.621
DOC_CKS1_1	603	608	PF01111	0.701
DOC_CYCLIN_RxL_1	363	370	PF00134	0.677
DOC_MAPK_DCC_7	777	786	PF00069	0.707
DOC_MAPK_gen_1	281	288	PF00069	0.739
DOC_MAPK_gen_1	579	585	PF00069	0.537
DOC_MAPK_gen_1	734	742	PF00069	0.674
DOC_MAPK_gen_1	749	756	PF00069	0.532
DOC_MAPK_JIP1_4	750	756	PF00069	0.511
DOC_MAPK_MEF2A_6	238	247	PF00069	0.534
DOC_MAPK_RevD_3	430	444	PF00069	0.645
DOC_PP1_RVXF_1	783	789	PF00149	0.683
DOC_PP2B_LxvP_1	535	538	PF13499	0.637
DOC_PP4_FxxP_1	561	564	PF00568	0.682
DOC_USP7_MATH_1	148	152	PF00917	0.723
DOC_USP7_MATH_1	193	197	PF00917	0.585
DOC_USP7_MATH_1	224	228	PF00917	0.519
DOC_USP7_MATH_1	478	482	PF00917	0.733
DOC_USP7_MATH_1	501	505	PF00917	0.745
DOC_USP7_MATH_1	681	685	PF00917	0.754
DOC_WW_Pin1_4	101	106	PF00397	0.792
DOC_WW_Pin1_4	114	119	PF00397	0.623
DOC_WW_Pin1_4	134	139	PF00397	0.735
DOC_WW_Pin1_4	197	202	PF00397	0.614
DOC_WW_Pin1_4	409	414	PF00397	0.778
DOC_WW_Pin1_4	426	431	PF00397	0.739
DOC_WW_Pin1_4	560	565	PF00397	0.791
DOC_WW_Pin1_4	569	574	PF00397	0.849
DOC_WW_Pin1_4	586	591	PF00397	0.669
DOC_WW_Pin1_4	594	599	PF00397	0.734
DOC_WW_Pin1_4	602	607	PF00397	0.489
DOC_WW_Pin1_4	611	616	PF00397	0.723
DOC_WW_Pin1_4	626	631	PF00397	0.585
DOC_WW_Pin1_4	655	660	PF00397	0.725
DOC_WW_Pin1_4	689	694	PF00397	0.710
LIG_14-3-3_CanoR_1	15	21	PF00244	0.615
LIG_14-3-3_CanoR_1	210	220	PF00244	0.499
LIG_14-3-3_CanoR_1	258	264	PF00244	0.478
LIG_14-3-3_CanoR_1	309	317	PF00244	0.545
LIG_14-3-3_CanoR_1	327	331	PF00244	0.697
LIG_14-3-3_CanoR_1	35	44	PF00244	0.659
LIG_14-3-3_CanoR_1	390	398	PF00244	0.714
LIG_14-3-3_CanoR_1	457	465	PF00244	0.643
LIG_14-3-3_CanoR_1	511	519	PF00244	0.506
LIG_14-3-3_CanoR_1	557	562	PF00244	0.711
LIG_14-3-3_CanoR_1	579	584	PF00244	0.771
LIG_14-3-3_CanoR_1	601	606	PF00244	0.716
LIG_14-3-3_CanoR_1	623	628	PF00244	0.768
LIG_14-3-3_CanoR_1	647	653	PF00244	0.648
LIG_14-3-3_CanoR_1	668	677	PF00244	0.639
LIG_14-3-3_CanoR_1	680	689	PF00244	0.660
LIG_14-3-3_CanoR_1	737	743	PF00244	0.681
LIG_14-3-3_CanoR_1	775	784	PF00244	0.579
LIG_AP2alpha_2	343	345	PF02296	0.689
LIG_AP2alpha_2	355	357	PF02296	0.610
LIG_APCC_ABBA_1	784	789	PF00400	0.494
LIG_BIR_III_2	18	22	PF00653	0.628
LIG_BRCT_BRCA1_1	124	128	PF00533	0.600
LIG_BRCT_BRCA1_1	232	236	PF00533	0.372
LIG_BRCT_BRCA1_1	86	90	PF00533	0.562
LIG_BRCT_BRCA1_2	86	92	PF00533	0.563
LIG_eIF4E_1	56	62	PF01652	0.402
LIG_FHA_1	177	183	PF00498	0.491
LIG_FHA_1	20	26	PF00498	0.704
LIG_FHA_1	511	517	PF00498	0.510
LIG_FHA_1	580	586	PF00498	0.612
LIG_FHA_1	598	604	PF00498	0.683
LIG_FHA_1	673	679	PF00498	0.632
LIG_FHA_1	737	743	PF00498	0.564
LIG_FHA_2	153	159	PF00498	0.641
LIG_FHA_2	186	192	PF00498	0.569
LIG_FHA_2	212	218	PF00498	0.632
LIG_FHA_2	260	266	PF00498	0.471
LIG_FHA_2	635	641	PF00498	0.580
LIG_GBD_Chelix_1	161	169	PF00786	0.592
LIG_Integrin_RGD_1	695	697	PF01839	0.482
LIG_LIR_Apic_2	559	564	PF02991	0.677
LIG_LIR_Gen_1	125	134	PF02991	0.517
LIG_LIR_Gen_1	155	165	PF02991	0.503
LIG_LIR_Gen_1	262	271	PF02991	0.552
LIG_LIR_Gen_1	313	320	PF02991	0.684
LIG_LIR_Nem_3	125	131	PF02991	0.513
LIG_LIR_Nem_3	155	160	PF02991	0.516
LIG_LIR_Nem_3	262	266	PF02991	0.515
LIG_LIR_Nem_3	313	319	PF02991	0.661
LIG_LIR_Nem_3	699	705	PF02991	0.656
LIG_LYPXL_S_1	701	705	PF13949	0.649
LIG_LYPXL_yS_3	702	705	PF13949	0.646
LIG_NRBOX	164	170	PF00104	0.610
LIG_SH2_CRK	157	161	PF00017	0.585
LIG_SH2_SRC	277	280	PF00017	0.483
LIG_SH2_STAP1	157	161	PF00017	0.483
LIG_SH2_STAT5	335	338	PF00017	0.733
LIG_SH2_STAT5	434	437	PF00017	0.779
LIG_SH2_STAT5	50	53	PF00017	0.546
LIG_SH3_1	76	82	PF00018	0.701
LIG_SH3_2	410	415	PF14604	0.761
LIG_SH3_3	102	108	PF00018	0.601
LIG_SH3_3	112	118	PF00018	0.705
LIG_SH3_3	195	201	PF00018	0.717
LIG_SH3_3	234	240	PF00018	0.591
LIG_SH3_3	373	379	PF00018	0.656
LIG_SH3_3	392	398	PF00018	0.800
LIG_SH3_3	407	413	PF00018	0.605
LIG_SH3_3	427	433	PF00018	0.690
LIG_SH3_3	516	522	PF00018	0.808
LIG_SH3_3	526	532	PF00018	0.687
LIG_SH3_3	570	576	PF00018	0.623
LIG_SH3_3	609	615	PF00018	0.558
LIG_SH3_3	624	630	PF00018	0.534
LIG_SH3_3	76	82	PF00018	0.575
LIG_SH3_3	765	771	PF00018	0.564
LIG_SH3_CIN85_PxpxPR_1	302	307	PF14604	0.547
LIG_SUMO_SIM_anti_2	582	589	PF11976	0.519
LIG_SUMO_SIM_par_1	200	206	PF11976	0.453
LIG_SUMO_SIM_par_1	581	589	PF11976	0.522
LIG_UBA3_1	61	66	PF00899	0.407
LIG_WRC_WIRS_1	85	90	PF05994	0.575
LIG_WW_3	440	444	PF00397	0.740
LIG_WW_3	530	534	PF00397	0.771
MOD_CDC14_SPxK_1	412	415	PF00782	0.763
MOD_CDC14_SPxK_1	563	566	PF00782	0.690
MOD_CDC14_SPxK_1	692	695	PF00782	0.543
MOD_CDK_SPK_2	134	139	PF00069	0.649
MOD_CDK_SPK_2	426	431	PF00069	0.653
MOD_CDK_SPK_2	655	660	PF00069	0.562
MOD_CDK_SPK_2	689	694	PF00069	0.643
MOD_CDK_SPxK_1	409	415	PF00069	0.814
MOD_CDK_SPxK_1	560	566	PF00069	0.684
MOD_CDK_SPxK_1	689	695	PF00069	0.550
MOD_CDK_SPxxK_3	594	601	PF00069	0.600
MOD_CK1_1	124	130	PF00069	0.714
MOD_CK1_1	13	19	PF00069	0.713
MOD_CK1_1	132	138	PF00069	0.712
MOD_CK1_1	203	209	PF00069	0.424
MOD_CK1_1	259	265	PF00069	0.565
MOD_CK1_1	326	332	PF00069	0.730
MOD_CK1_1	401	407	PF00069	0.688
MOD_CK1_1	549	555	PF00069	0.741
MOD_CK1_1	559	565	PF00069	0.695
MOD_CK1_1	584	590	PF00069	0.684
MOD_CK1_1	597	603	PF00069	0.504
MOD_CK1_1	626	632	PF00069	0.858
MOD_CK1_1	648	654	PF00069	0.715
MOD_CK1_1	684	690	PF00069	0.690
MOD_CK1_1	94	100	PF00069	0.566
MOD_CK2_1	150	156	PF00069	0.653
MOD_CK2_1	191	197	PF00069	0.425
MOD_CK2_1	229	235	PF00069	0.651
MOD_CK2_1	345	351	PF00069	0.714
MOD_CK2_1	477	483	PF00069	0.780
MOD_CK2_1	634	640	PF00069	0.661
MOD_CK2_1	668	674	PF00069	0.656
MOD_CK2_1	724	730	PF00069	0.652
MOD_Cter_Amidation	8	11	PF01082	0.471
MOD_GlcNHglycan	124	127	PF01048	0.768
MOD_GlcNHglycan	150	153	PF01048	0.652
MOD_GlcNHglycan	169	172	PF01048	0.650
MOD_GlcNHglycan	205	208	PF01048	0.549
MOD_GlcNHglycan	232	235	PF01048	0.572
MOD_GlcNHglycan	258	261	PF01048	0.488
MOD_GlcNHglycan	272	275	PF01048	0.715
MOD_GlcNHglycan	46	49	PF01048	0.639
MOD_GlcNHglycan	460	463	PF01048	0.747
MOD_GlcNHglycan	480	483	PF01048	0.634
MOD_GlcNHglycan	569	572	PF01048	0.634
MOD_GlcNHglycan	647	650	PF01048	0.798
MOD_GlcNHglycan	665	668	PF01048	0.646
MOD_GlcNHglycan	670	673	PF01048	0.704
MOD_GlcNHglycan	746	749	PF01048	0.651
MOD_GlcNHglycan	777	780	PF01048	0.742
MOD_GSK3_1	10	17	PF00069	0.707
MOD_GSK3_1	116	123	PF00069	0.777
MOD_GSK3_1	129	136	PF00069	0.559
MOD_GSK3_1	148	155	PF00069	0.612
MOD_GSK3_1	172	179	PF00069	0.523
MOD_GSK3_1	193	200	PF00069	0.493
MOD_GSK3_1	225	232	PF00069	0.532
MOD_GSK3_1	252	259	PF00069	0.561
MOD_GSK3_1	305	312	PF00069	0.768
MOD_GSK3_1	315	322	PF00069	0.673
MOD_GSK3_1	397	404	PF00069	0.700
MOD_GSK3_1	546	553	PF00069	0.804
MOD_GSK3_1	556	563	PF00069	0.675
MOD_GSK3_1	581	588	PF00069	0.756
MOD_GSK3_1	597	604	PF00069	0.575
MOD_GSK3_1	607	614	PF00069	0.754
MOD_GSK3_1	668	675	PF00069	0.746
MOD_GSK3_1	680	687	PF00069	0.605
MOD_GSK3_1	738	745	PF00069	0.581
MOD_GSK3_1	754	761	PF00069	0.731
MOD_LATS_1	303	309	PF00433	0.636
MOD_LATS_1	380	386	PF00433	0.530
MOD_N-GLC_1	11	16	PF02516	0.730
MOD_N-GLC_1	44	49	PF02516	0.716
MOD_N-GLC_2	352	354	PF02516	0.670
MOD_NEK2_1	121	126	PF00069	0.716
MOD_NEK2_1	133	138	PF00069	0.628
MOD_NEK2_1	169	174	PF00069	0.495
MOD_NEK2_1	3	8	PF00069	0.579
MOD_NEK2_1	319	324	PF00069	0.606
MOD_NEK2_1	345	350	PF00069	0.714
MOD_NEK2_1	724	729	PF00069	0.756
MOD_NEK2_1	756	761	PF00069	0.607
MOD_NEK2_2	225	230	PF00069	0.603
MOD_PIKK_1	681	687	PF00454	0.676
MOD_PIKK_1	758	764	PF00454	0.744
MOD_PK_1	623	629	PF00069	0.681
MOD_PK_1	738	744	PF00069	0.648
MOD_PK_1	749	755	PF00069	0.615
MOD_PKA_1	10	16	PF00069	0.501
MOD_PKA_1	309	315	PF00069	0.489
MOD_PKA_1	382	388	PF00069	0.739
MOD_PKA_1	389	395	PF00069	0.665
MOD_PKA_1	557	563	PF00069	0.660
MOD_PKA_1	579	585	PF00069	0.537
MOD_PKA_1	668	674	PF00069	0.634
MOD_PKA_1	749	755	PF00069	0.719
MOD_PKA_2	10	16	PF00069	0.528
MOD_PKA_2	143	149	PF00069	0.780
MOD_PKA_2	326	332	PF00069	0.730
MOD_PKA_2	389	395	PF00069	0.715
MOD_PKA_2	416	422	PF00069	0.798
MOD_PKA_2	436	442	PF00069	0.738
MOD_PKA_2	510	516	PF00069	0.571
MOD_PKA_2	517	523	PF00069	0.634
MOD_PKA_2	556	562	PF00069	0.683
MOD_PKA_2	579	585	PF00069	0.704
MOD_PKA_2	668	674	PF00069	0.634
MOD_PKA_2	681	687	PF00069	0.677
MOD_PKA_2	736	742	PF00069	0.680
MOD_PKA_2	749	755	PF00069	0.555
MOD_PKA_2	94	100	PF00069	0.707
MOD_PKB_1	307	315	PF00069	0.499
MOD_Plk_1	225	231	PF00069	0.613
MOD_Plk_1	446	452	PF00069	0.736
MOD_Plk_4	156	162	PF00069	0.487
MOD_Plk_4	259	265	PF00069	0.524
MOD_Plk_4	3	9	PF00069	0.594
MOD_Plk_4	315	321	PF00069	0.714
MOD_Plk_4	326	332	PF00069	0.591
MOD_Plk_4	46	52	PF00069	0.555
MOD_Plk_4	581	587	PF00069	0.738
MOD_Plk_4	749	755	PF00069	0.719
MOD_Plk_4	84	90	PF00069	0.598
MOD_ProDKin_1	101	107	PF00069	0.791
MOD_ProDKin_1	114	120	PF00069	0.617
MOD_ProDKin_1	134	140	PF00069	0.735
MOD_ProDKin_1	197	203	PF00069	0.615
MOD_ProDKin_1	409	415	PF00069	0.783
MOD_ProDKin_1	426	432	PF00069	0.740
MOD_ProDKin_1	560	566	PF00069	0.793
MOD_ProDKin_1	569	575	PF00069	0.848
MOD_ProDKin_1	586	592	PF00069	0.669
MOD_ProDKin_1	594	600	PF00069	0.733
MOD_ProDKin_1	602	608	PF00069	0.492
MOD_ProDKin_1	611	617	PF00069	0.723
MOD_ProDKin_1	626	632	PF00069	0.583
MOD_ProDKin_1	655	661	PF00069	0.724
MOD_ProDKin_1	689	695	PF00069	0.709
TRG_DiLeu_BaEn_1	156	161	PF01217	0.515
TRG_DiLeu_BaEn_1	714	719	PF01217	0.738
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.787
TRG_ENDOCYTIC_2	157	160	PF00928	0.485
TRG_ENDOCYTIC_2	277	280	PF00928	0.536
TRG_ENDOCYTIC_2	702	705	PF00928	0.646
TRG_ER_diArg_1	280	283	PF00400	0.738
TRG_ER_diArg_1	306	309	PF00400	0.529
TRG_ER_diArg_1	363	366	PF00400	0.631
TRG_ER_diArg_1	442	444	PF00400	0.822
TRG_ER_diArg_1	485	488	PF00400	0.466
TRG_ER_diArg_1	579	581	PF00400	0.815
TRG_ER_diArg_1	668	670	PF00400	0.660
TRG_ER_diArg_1	693	695	PF00400	0.541
TRG_ER_diArg_1	725	728	PF00400	0.680
TRG_ER_diArg_1	749	751	PF00400	0.750
TRG_ER_diArg_1	93	96	PF00400	0.658
TRG_ER_FFAT_2	559	567	PF00635	0.683
TRG_NES_CRM1_1	699	714	PF08389	0.743
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.782
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWN9	Leptomonas seymouri	32%	100%
A0A3S7WPP9	Leishmania donovani	82%	100%
A4H4T4	Leishmania braziliensis	57%	95%
A4HT13	Leishmania infantum	81%	100%
Q4QIV4	Leishmania major	78%	100%