Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AL00_LEIMU

TriTrypDb:

LmxM.06.1210

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	552	556	PF00656	0.654
CLV_NRD_NRD_1	229	231	PF00675	0.531
CLV_NRD_NRD_1	377	379	PF00675	0.600
CLV_NRD_NRD_1	478	480	PF00675	0.580
CLV_PCSK_FUR_1	476	480	PF00082	0.580
CLV_PCSK_KEX2_1	229	231	PF00082	0.548
CLV_PCSK_KEX2_1	374	376	PF00082	0.590
CLV_PCSK_KEX2_1	454	456	PF00082	0.574
CLV_PCSK_KEX2_1	478	480	PF00082	0.580
CLV_PCSK_KEX2_1	572	574	PF00082	0.639
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.543
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.530
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.602
CLV_PCSK_SKI1_1	149	153	PF00082	0.518
CLV_PCSK_SKI1_1	389	393	PF00082	0.681
CLV_PCSK_SKI1_1	450	454	PF00082	0.529
CLV_PCSK_SKI1_1	569	573	PF00082	0.592
CLV_Separin_Metazoa	157	161	PF03568	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.698
DOC_CDC14_PxL_1	560	568	PF14671	0.590
DOC_CKS1_1	345	350	PF01111	0.622
DOC_MAPK_gen_1	236	245	PF00069	0.574
DOC_MAPK_gen_1	378	386	PF00069	0.487
DOC_MAPK_gen_1	499	506	PF00069	0.521
DOC_MAPK_MEF2A_6	189	196	PF00069	0.410
DOC_MAPK_MEF2A_6	236	245	PF00069	0.574
DOC_MAPK_MEF2A_6	79	87	PF00069	0.459
DOC_PP1_RVXF_1	52	58	PF00149	0.656
DOC_USP7_MATH_1	287	291	PF00917	0.603
DOC_USP7_MATH_1	341	345	PF00917	0.617
DOC_USP7_MATH_1	422	426	PF00917	0.616
DOC_USP7_MATH_1	492	496	PF00917	0.426
DOC_USP7_UBL2_3	242	246	PF12436	0.469
DOC_USP7_UBL2_3	450	454	PF12436	0.443
DOC_WW_Pin1_4	344	349	PF00397	0.571
DOC_WW_Pin1_4	35	40	PF00397	0.651
LIG_14-3-3_CanoR_1	160	166	PF00244	0.548
LIG_14-3-3_CanoR_1	403	413	PF00244	0.662
LIG_14-3-3_CanoR_1	426	436	PF00244	0.550
LIG_14-3-3_CanoR_1	465	471	PF00244	0.672
LIG_14-3-3_CanoR_1	54	62	PF00244	0.648
LIG_14-3-3_CanoR_1	573	579	PF00244	0.630
LIG_14-3-3_CanoR_1	79	83	PF00244	0.455
LIG_Actin_WH2_2	438	456	PF00022	0.436
LIG_APCC_ABBA_1	152	157	PF00400	0.512
LIG_APCC_ABBA_1	214	219	PF00400	0.486
LIG_APCC_ABBAyCdc20_2	322	328	PF00400	0.497
LIG_BIR_III_4	299	303	PF00653	0.612
LIG_BIR_III_4	316	320	PF00653	0.477
LIG_BRCT_BRCA1_1	360	364	PF00533	0.521
LIG_BRCT_BRCA1_1	533	537	PF00533	0.650
LIG_CaM_IQ_9	66	81	PF13499	0.438
LIG_CaM_NSCaTE_8	280	287	PF13499	0.473
LIG_Clathr_ClatBox_1	102	106	PF01394	0.655
LIG_FAT_LD_1	331	339	PF03623	0.466
LIG_FHA_1	25	31	PF00498	0.522
LIG_FHA_1	299	305	PF00498	0.637
LIG_FHA_1	368	374	PF00498	0.661
LIG_FHA_1	430	436	PF00498	0.564
LIG_FHA_1	549	555	PF00498	0.726
LIG_FHA_1	565	571	PF00498	0.497
LIG_FHA_1	573	579	PF00498	0.599
LIG_FHA_1	79	85	PF00498	0.642
LIG_FHA_2	127	133	PF00498	0.474
LIG_GBD_Chelix_1	570	578	PF00786	0.493
LIG_LIR_Apic_2	141	147	PF02991	0.611
LIG_LIR_Gen_1	248	258	PF02991	0.440
LIG_LIR_Gen_1	307	318	PF02991	0.422
LIG_LIR_Gen_1	534	545	PF02991	0.658
LIG_LIR_LC3C_4	271	276	PF02991	0.418
LIG_LIR_Nem_3	169	175	PF02991	0.563
LIG_LIR_Nem_3	215	220	PF02991	0.529
LIG_LIR_Nem_3	248	254	PF02991	0.447
LIG_LIR_Nem_3	307	313	PF02991	0.395
LIG_LIR_Nem_3	534	540	PF02991	0.654
LIG_LIR_Nem_3	557	563	PF02991	0.590
LIG_LYPXL_yS_3	563	566	PF13949	0.578
LIG_MLH1_MIPbox_1	360	364	PF16413	0.521
LIG_NRBOX	330	336	PF00104	0.467
LIG_PCNA_yPIPBox_3	189	200	PF02747	0.449
LIG_PCNA_yPIPBox_3	387	395	PF02747	0.633
LIG_Pex14_2	200	204	PF04695	0.536
LIG_SH2_CRK	144	148	PF00017	0.628
LIG_SH2_CRK	401	405	PF00017	0.592
LIG_SH2_NCK_1	326	330	PF00017	0.488
LIG_SH2_SRC	326	329	PF00017	0.493
LIG_SH2_STAP1	326	330	PF00017	0.488
LIG_SH2_STAT3	104	107	PF00017	0.591
LIG_SH2_STAT5	104	107	PF00017	0.652
LIG_SH2_STAT5	220	223	PF00017	0.569
LIG_SH2_STAT5	257	260	PF00017	0.485
LIG_SH2_STAT5	56	59	PF00017	0.584
LIG_SH2_STAT5	72	75	PF00017	0.620
LIG_SH3_3	196	202	PF00018	0.453
LIG_SH3_3	465	471	PF00018	0.696
LIG_SH3_3	89	95	PF00018	0.583
LIG_TRAF2_1	203	206	PF00917	0.466
LIG_WRC_WIRS_1	201	206	PF05994	0.567
LIG_WW_3	470	474	PF00397	0.564
MOD_CDK_SPxK_1	344	350	PF00069	0.563
MOD_CK1_1	111	117	PF00069	0.621
MOD_CK1_1	282	288	PF00069	0.591
MOD_CK1_1	290	296	PF00069	0.568
MOD_CK1_1	34	40	PF00069	0.683
MOD_CK1_1	344	350	PF00069	0.702
MOD_CK2_1	126	132	PF00069	0.491
MOD_CK2_1	200	206	PF00069	0.422
MOD_CK2_1	427	433	PF00069	0.501
MOD_GlcNHglycan	110	113	PF01048	0.539
MOD_GlcNHglycan	284	287	PF01048	0.606
MOD_GlcNHglycan	33	36	PF01048	0.724
MOD_GlcNHglycan	360	363	PF01048	0.531
MOD_GlcNHglycan	420	423	PF01048	0.502
MOD_GlcNHglycan	429	432	PF01048	0.525
MOD_GlcNHglycan	468	471	PF01048	0.681
MOD_GlcNHglycan	483	486	PF01048	0.493
MOD_GlcNHglycan	494	497	PF01048	0.510
MOD_GlcNHglycan	533	536	PF01048	0.566
MOD_GlcNHglycan	62	65	PF01048	0.520
MOD_GSK3_1	128	135	PF00069	0.690
MOD_GSK3_1	161	168	PF00069	0.661
MOD_GSK3_1	25	32	PF00069	0.619
MOD_GSK3_1	278	285	PF00069	0.506
MOD_GSK3_1	33	40	PF00069	0.662
MOD_GSK3_1	418	425	PF00069	0.475
MOD_GSK3_1	518	525	PF00069	0.619
MOD_GSK3_1	544	551	PF00069	0.629
MOD_GSK3_1	572	579	PF00069	0.542
MOD_GSK3_1	60	67	PF00069	0.535
MOD_N-GLC_1	404	409	PF02516	0.465
MOD_N-GLC_1	504	509	PF02516	0.445
MOD_N-GLC_1	548	553	PF02516	0.590
MOD_N-GLC_1	64	69	PF02516	0.433
MOD_NEK2_1	175	180	PF00069	0.482
MOD_NEK2_1	269	274	PF00069	0.474
MOD_NEK2_1	369	374	PF00069	0.563
MOD_NEK2_1	404	409	PF00069	0.647
MOD_NEK2_1	416	421	PF00069	0.524
MOD_NEK2_1	441	446	PF00069	0.612
MOD_NEK2_1	453	458	PF00069	0.518
MOD_NEK2_1	50	55	PF00069	0.489
MOD_NEK2_1	522	527	PF00069	0.616
MOD_NEK2_1	531	536	PF00069	0.563
MOD_NEK2_1	548	553	PF00069	0.519
MOD_NEK2_1	574	579	PF00069	0.625
MOD_PIKK_1	106	112	PF00454	0.555
MOD_PIKK_1	132	138	PF00454	0.537
MOD_PIKK_1	257	263	PF00454	0.439
MOD_PIKK_1	290	296	PF00454	0.612
MOD_PIKK_1	504	510	PF00454	0.459
MOD_PIKK_1	522	528	PF00454	0.593
MOD_PIKK_1	572	578	PF00454	0.561
MOD_PKA_1	572	578	PF00069	0.496
MOD_PKA_2	282	288	PF00069	0.551
MOD_PKA_2	416	422	PF00069	0.507
MOD_PKA_2	461	467	PF00069	0.632
MOD_PKA_2	572	578	PF00069	0.589
MOD_PKA_2	78	84	PF00069	0.546
MOD_Plk_1	25	31	PF00069	0.631
MOD_Plk_1	336	342	PF00069	0.475
MOD_Plk_1	504	510	PF00069	0.476
MOD_Plk_1	548	554	PF00069	0.576
MOD_Plk_1	64	70	PF00069	0.434
MOD_Plk_4	175	181	PF00069	0.426
MOD_Plk_4	549	555	PF00069	0.594
MOD_ProDKin_1	344	350	PF00069	0.573
MOD_ProDKin_1	35	41	PF00069	0.647
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.458
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.643
TRG_ENDOCYTIC_2	401	404	PF00928	0.589
TRG_ENDOCYTIC_2	563	566	PF00928	0.578
TRG_ENDOCYTIC_2	72	75	PF00928	0.662
TRG_ER_diArg_1	386	389	PF00400	0.750
TRG_ER_diArg_1	475	478	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF5	Leptomonas seymouri	32%	100%
A0A3S7WPN2	Leishmania donovani	87%	99%
A4H4T3	Leishmania braziliensis	67%	99%
A4HT12	Leishmania infantum	87%	99%
Q4QIV5	Leishmania major	86%	100%