Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AKZ9_LEIMU

TriTrypDb:

LmxM.06.1200

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.520
CLV_C14_Caspase3-7	281	285	PF00656	0.738
CLV_NRD_NRD_1	163	165	PF00675	0.695
CLV_NRD_NRD_1	249	251	PF00675	0.562
CLV_NRD_NRD_1	304	306	PF00675	0.630
CLV_NRD_NRD_1	325	327	PF00675	0.700
CLV_NRD_NRD_1	359	361	PF00675	0.692
CLV_NRD_NRD_1	386	388	PF00675	0.632
CLV_PCSK_KEX2_1	163	165	PF00082	0.791
CLV_PCSK_KEX2_1	249	251	PF00082	0.541
CLV_PCSK_KEX2_1	304	306	PF00082	0.667
CLV_PCSK_KEX2_1	308	310	PF00082	0.657
CLV_PCSK_KEX2_1	325	327	PF00082	0.700
CLV_PCSK_KEX2_1	359	361	PF00082	0.738
CLV_PCSK_KEX2_1	386	388	PF00082	0.632
CLV_PCSK_KEX2_1	63	65	PF00082	0.487
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.660
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.487
CLV_PCSK_PC7_1	304	310	PF00082	0.715
CLV_PCSK_PC7_1	59	65	PF00082	0.517
CLV_PCSK_SKI1_1	154	158	PF00082	0.741
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DOC_AGCK_PIF_3	391	394	PF00069	0.543
DOC_CKS1_1	348	353	PF01111	0.547
DOC_CYCLIN_RxL_1	330	341	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	363	366	PF00134	0.506
DOC_MAPK_FxFP_2	2	5	PF00069	0.582
DOC_PP1_RVXF_1	331	338	PF00149	0.630
DOC_PP1_RVXF_1	377	383	PF00149	0.555
DOC_PP2B_LxvP_1	363	366	PF13499	0.506
DOC_PP2B_LxvP_1	41	44	PF13499	0.638
DOC_PP4_FxxP_1	2	5	PF00568	0.646
DOC_USP7_MATH_1	175	179	PF00917	0.570
DOC_USP7_MATH_1	268	272	PF00917	0.539
DOC_USP7_MATH_1	78	82	PF00917	0.564
DOC_USP7_MATH_1	98	102	PF00917	0.394
DOC_WW_Pin1_4	140	145	PF00397	0.515
DOC_WW_Pin1_4	16	21	PF00397	0.677
DOC_WW_Pin1_4	162	167	PF00397	0.641
DOC_WW_Pin1_4	171	176	PF00397	0.599
DOC_WW_Pin1_4	178	183	PF00397	0.560
DOC_WW_Pin1_4	230	235	PF00397	0.739
DOC_WW_Pin1_4	286	291	PF00397	0.655
DOC_WW_Pin1_4	296	301	PF00397	0.622
DOC_WW_Pin1_4	347	352	PF00397	0.720
DOC_WW_Pin1_4	389	394	PF00397	0.452
DOC_WW_Pin1_4	47	52	PF00397	0.647
LIG_14-3-3_CanoR_1	260	267	PF00244	0.528
LIG_14-3-3_CanoR_1	342	351	PF00244	0.599
LIG_14-3-3_CanoR_1	386	391	PF00244	0.612
LIG_APCC_ABBA_1	276	281	PF00400	0.735
LIG_APCC_ABBAyCdc20_2	333	339	PF00400	0.601
LIG_BIR_III_2	77	81	PF00653	0.383
LIG_Clathr_ClatBox_1	219	223	PF01394	0.580
LIG_CtBP_PxDLS_1	365	369	PF00389	0.581
LIG_FHA_2	241	247	PF00498	0.766
LIG_FHA_2	348	354	PF00498	0.650
LIG_FHA_2	369	375	PF00498	0.591
LIG_Integrin_RGD_1	311	313	PF01839	0.633
LIG_IRF3_LxIS_1	41	46	PF10401	0.696
LIG_LIR_Nem_3	109	114	PF02991	0.499
LIG_LIR_Nem_3	389	394	PF02991	0.575
LIG_LYPXL_yS_3	4	7	PF13949	0.593
LIG_PDZ_Class_1	389	394	PF00595	0.552
LIG_SH2_CRK	99	103	PF00017	0.552
LIG_SH2_PTP2	6	9	PF00017	0.586
LIG_SH2_SRC	279	282	PF00017	0.500
LIG_SH2_SRC	6	9	PF00017	0.507
LIG_SH2_STAT5	6	9	PF00017	0.586
LIG_SH3_1	6	12	PF00018	0.480
LIG_SH3_3	17	23	PF00018	0.535
LIG_SH3_3	174	180	PF00018	0.629
LIG_SH3_3	316	322	PF00018	0.581
LIG_SH3_3	6	12	PF00018	0.580
LIG_SUMO_SIM_anti_2	218	225	PF11976	0.462
LIG_TRAF2_1	351	354	PF00917	0.786
LIG_WRC_WIRS_1	235	240	PF05994	0.658
LIG_WRC_WIRS_1	58	63	PF05994	0.420
LIG_WW_3	19	23	PF00397	0.594
MOD_CDK_SPK_2	140	145	PF00069	0.502
MOD_CDK_SPK_2	347	352	PF00069	0.720
MOD_CDK_SPxK_1	16	22	PF00069	0.612
MOD_CDK_SPxxK_3	47	54	PF00069	0.515
MOD_CK1_1	178	184	PF00069	0.719
MOD_CK1_1	262	268	PF00069	0.621
MOD_CK1_1	341	347	PF00069	0.650
MOD_CK1_1	46	52	PF00069	0.611
MOD_CK2_1	207	213	PF00069	0.575
MOD_CK2_1	347	353	PF00069	0.756
MOD_CK2_1	368	374	PF00069	0.592
MOD_Cter_Amidation	323	326	PF01082	0.778
MOD_GlcNHglycan	269	273	PF01048	0.520
MOD_GlcNHglycan	300	303	PF01048	0.722
MOD_GlcNHglycan	368	371	PF01048	0.594
MOD_GlcNHglycan	45	48	PF01048	0.566
MOD_GlcNHglycan	51	54	PF01048	0.565
MOD_GSK3_1	162	169	PF00069	0.743
MOD_GSK3_1	171	178	PF00069	0.579
MOD_GSK3_1	230	237	PF00069	0.775
MOD_GSK3_1	241	248	PF00069	0.651
MOD_GSK3_1	282	289	PF00069	0.638
MOD_GSK3_1	338	345	PF00069	0.656
MOD_GSK3_1	364	371	PF00069	0.634
MOD_GSK3_1	43	50	PF00069	0.658
MOD_N-GLC_1	228	233	PF02516	0.667
MOD_N-GLC_2	191	193	PF02516	0.483
MOD_NEK2_1	189	194	PF00069	0.721
MOD_NEK2_1	253	258	PF00069	0.759
MOD_NEK2_1	267	272	PF00069	0.701
MOD_NEK2_1	340	345	PF00069	0.809
MOD_NEK2_1	368	373	PF00069	0.591
MOD_NEK2_2	282	287	PF00069	0.506
MOD_PIKK_1	343	349	PF00454	0.799
MOD_PKA_1	386	392	PF00069	0.627
MOD_PKA_2	122	128	PF00069	0.546
MOD_PKA_2	259	265	PF00069	0.520
MOD_PKA_2	341	347	PF00069	0.607
MOD_PKA_2	386	392	PF00069	0.673
MOD_PKB_1	309	317	PF00069	0.779
MOD_Plk_1	166	172	PF00069	0.605
MOD_Plk_1	37	43	PF00069	0.617
MOD_Plk_4	368	374	PF00069	0.746
MOD_Plk_4	386	392	PF00069	0.657
MOD_Plk_4	78	84	PF00069	0.455
MOD_ProDKin_1	140	146	PF00069	0.517
MOD_ProDKin_1	16	22	PF00069	0.675
MOD_ProDKin_1	162	168	PF00069	0.643
MOD_ProDKin_1	171	177	PF00069	0.595
MOD_ProDKin_1	178	184	PF00069	0.563
MOD_ProDKin_1	230	236	PF00069	0.740
MOD_ProDKin_1	286	292	PF00069	0.653
MOD_ProDKin_1	296	302	PF00069	0.625
MOD_ProDKin_1	347	353	PF00069	0.720
MOD_ProDKin_1	47	53	PF00069	0.648
TRG_ENDOCYTIC_2	114	117	PF00928	0.545
TRG_ENDOCYTIC_2	4	7	PF00928	0.593
TRG_ENDOCYTIC_2	99	102	PF00928	0.548
TRG_ER_diArg_1	249	251	PF00400	0.540
TRG_ER_diArg_1	304	307	PF00400	0.541
TRG_ER_diArg_1	385	387	PF00400	0.633
TRG_NLS_MonoExtC_3	306	311	PF00514	0.635
TRG_NLS_MonoExtN_4	304	311	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.746

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J6	Leptomonas seymouri	40%	100%
A0A3S5H5U8	Leishmania donovani	82%	100%
A4H4T2	Leishmania braziliensis	67%	100%
A4HT11	Leishmania infantum	83%	100%
Q4QIV6	Leishmania major	81%	100%