Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania mexicana

UniProt:

E9AKZ8_LEIMU

TriTrypDb:

LmxM.06.1190

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 3
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005783	endoplasmic reticulum	5	1

Expansion

Sequence features

E9AKZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKZ8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	7
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016860	intramolecular oxidoreductase activity	3	7
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.426
CLV_PCSK_KEX2_1	107	109	PF00082	0.311
CLV_PCSK_KEX2_1	2	4	PF00082	0.480
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.260
CLV_PCSK_SKI1_1	89	93	PF00082	0.317
DEG_Nend_UBRbox_1	1	4	PF02207	0.520
DOC_CKS1_1	119	124	PF01111	0.375
DOC_MAPK_gen_1	67	75	PF00069	0.354
DOC_PP4_FxxP_1	119	122	PF00568	0.375
DOC_USP7_MATH_1	133	137	PF00917	0.383
DOC_USP7_MATH_1	33	37	PF00917	0.429
DOC_WW_Pin1_4	118	123	PF00397	0.334
LIG_14-3-3_CanoR_1	2	9	PF00244	0.497
LIG_14-3-3_CanoR_1	67	73	PF00244	0.284
LIG_14-3-3_CanoR_1	78	88	PF00244	0.355
LIG_BRCT_BRCA1_1	140	144	PF00533	0.260
LIG_FHA_1	55	61	PF00498	0.326
LIG_GBD_Chelix_1	15	23	PF00786	0.480
LIG_LIR_Apic_2	116	122	PF02991	0.392
LIG_LIR_Apic_2	129	133	PF02991	0.440
LIG_LIR_Gen_1	54	63	PF02991	0.306
LIG_LIR_Nem_3	100	105	PF02991	0.344
LIG_LIR_Nem_3	44	49	PF02991	0.212
LIG_LIR_Nem_3	54	59	PF02991	0.235
LIG_LYPXL_yS_3	102	105	PF13949	0.264
LIG_NRBOX	18	24	PF00104	0.526
LIG_PCNA_yPIPBox_3	78	92	PF02747	0.219
LIG_Pex14_2	142	146	PF04695	0.429
LIG_SH2_CRK	120	124	PF00017	0.313
LIG_SH2_CRK	130	134	PF00017	0.236
LIG_SH2_CRK	56	60	PF00017	0.250
LIG_SH2_SRC	96	99	PF00017	0.375
LIG_SH2_STAP1	56	60	PF00017	0.250
LIG_SH2_STAT5	120	123	PF00017	0.311
LIG_SH2_STAT5	137	140	PF00017	0.353
LIG_SH2_STAT5	49	52	PF00017	0.239
LIG_SH2_STAT5	56	59	PF00017	0.327
LIG_SH2_STAT5	61	64	PF00017	0.159
LIG_SH2_STAT5	96	99	PF00017	0.375
LIG_SH3_3	47	53	PF00018	0.273
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.372
LIG_SUMO_SIM_par_1	36	42	PF11976	0.315
LIG_TYR_ITIM	118	123	PF00017	0.347
LIG_WRC_WIRS_1	139	144	PF05994	0.242
MOD_CK2_1	28	34	PF00069	0.519
MOD_CK2_1	81	87	PF00069	0.392
MOD_GlcNHglycan	30	33	PF01048	0.494
MOD_GSK3_1	77	84	PF00069	0.335
MOD_NEK2_1	1	6	PF00069	0.467
MOD_NEK2_1	138	143	PF00069	0.275
MOD_NEK2_1	23	28	PF00069	0.408
MOD_NEK2_1	79	84	PF00069	0.262
MOD_PIKK_1	1	7	PF00454	0.341
MOD_PIKK_1	79	85	PF00454	0.237
MOD_PKA_2	1	7	PF00069	0.545
MOD_PKA_2	133	139	PF00069	0.219
MOD_PKA_2	42	48	PF00069	0.344
MOD_PKA_2	77	83	PF00069	0.324
MOD_Plk_1	33	39	PF00069	0.419
MOD_Plk_4	10	16	PF00069	0.372
MOD_Plk_4	113	119	PF00069	0.287
MOD_Plk_4	133	139	PF00069	0.287
MOD_Plk_4	54	60	PF00069	0.279
MOD_Plk_4	68	74	PF00069	0.407
MOD_ProDKin_1	118	124	PF00069	0.334
TRG_ENDOCYTIC_2	102	105	PF00928	0.342
TRG_ENDOCYTIC_2	120	123	PF00928	0.309
TRG_ENDOCYTIC_2	56	59	PF00928	0.301
TRG_ER_diArg_1	1	3	PF00400	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I216	Leptomonas seymouri	63%	100%
A0A0N1I5T9	Leptomonas seymouri	31%	100%
A0A0N1IJS7	Leptomonas seymouri	27%	90%
A0A0S4JA26	Bodo saltans	29%	89%
A0A1X0NGQ4	Trypanosomatidae	53%	99%
A0A3R7NHA8	Trypanosoma rangeli	35%	80%
A0A3S5H5U6	Leishmania donovani	92%	70%
A0A422NM49	Trypanosoma rangeli	46%	99%
A4H4R8	Leishmania braziliensis	29%	100%
A4H4T0	Leishmania braziliensis	83%	100%
A4HSZ7	Leishmania infantum	32%	100%
A4HT10	Leishmania infantum	92%	100%
C9ZTP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	97%
C9ZTP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AKY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q10N04	Oryza sativa subsp. japonica	30%	100%
Q4QIV7	Leishmania major	85%	100%
Q4QIX1	Leishmania major	32%	100%
Q8I7Z7	Leishmania donovani	32%	100%