Separase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Separase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKZ5_LEIMU

TriTrypDb:

LmxM.06.1160

Length:

1098

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.653
CLV_C14_Caspase3-7	814	818	PF00656	0.725
CLV_NRD_NRD_1	123	125	PF00675	0.623
CLV_NRD_NRD_1	130	132	PF00675	0.555
CLV_NRD_NRD_1	320	322	PF00675	0.448
CLV_NRD_NRD_1	357	359	PF00675	0.559
CLV_NRD_NRD_1	504	506	PF00675	0.544
CLV_NRD_NRD_1	562	564	PF00675	0.403
CLV_NRD_NRD_1	807	809	PF00675	0.718
CLV_NRD_NRD_1	849	851	PF00675	0.486
CLV_NRD_NRD_1	975	977	PF00675	0.657
CLV_NRD_NRD_1	996	998	PF00675	0.335
CLV_PCSK_FUR_1	805	809	PF00082	0.509
CLV_PCSK_KEX2_1	1049	1051	PF00082	0.427
CLV_PCSK_KEX2_1	123	125	PF00082	0.623
CLV_PCSK_KEX2_1	130	132	PF00082	0.555
CLV_PCSK_KEX2_1	320	322	PF00082	0.497
CLV_PCSK_KEX2_1	357	359	PF00082	0.559
CLV_PCSK_KEX2_1	504	506	PF00082	0.536
CLV_PCSK_KEX2_1	562	564	PF00082	0.403
CLV_PCSK_KEX2_1	807	809	PF00082	0.636
CLV_PCSK_KEX2_1	848	850	PF00082	0.488
CLV_PCSK_KEX2_1	996	998	PF00082	0.335
CLV_PCSK_PC1ET2_1	1049	1051	PF00082	0.427
CLV_PCSK_SKI1_1	232	236	PF00082	0.381
CLV_PCSK_SKI1_1	27	31	PF00082	0.515
CLV_PCSK_SKI1_1	374	378	PF00082	0.627
CLV_PCSK_SKI1_1	451	455	PF00082	0.546
CLV_PCSK_SKI1_1	555	559	PF00082	0.484
CLV_PCSK_SKI1_1	611	615	PF00082	0.403
CLV_PCSK_SKI1_1	665	669	PF00082	0.580
CLV_PCSK_SKI1_1	688	692	PF00082	0.538
CLV_PCSK_SKI1_1	912	916	PF00082	0.409
CLV_Separin_Metazoa	693	697	PF03568	0.413
DEG_APCC_DBOX_1	373	381	PF00400	0.586
DEG_APCC_DBOX_1	639	647	PF00400	0.399
DEG_APCC_DBOX_1	664	672	PF00400	0.632
DEG_APCC_DBOX_1	687	695	PF00400	0.490
DEG_Nend_UBRbox_2	1	3	PF02207	0.647
DEG_ODPH_VHL_1	520	531	PF01847	0.362
DOC_ANK_TNKS_1	173	180	PF00023	0.470
DOC_ANK_TNKS_1	768	775	PF00023	0.388
DOC_CKS1_1	384	389	PF01111	0.610
DOC_CYCLIN_RxL_1	684	693	PF00134	0.510
DOC_MAPK_gen_1	848	857	PF00069	0.402
DOC_MAPK_MEF2A_6	13	21	PF00069	0.435
DOC_MAPK_MEF2A_6	374	382	PF00069	0.637
DOC_MAPK_MEF2A_6	447	456	PF00069	0.472
DOC_PP1_RVXF_1	116	123	PF00149	0.678
DOC_PP1_RVXF_1	48	54	PF00149	0.516
DOC_PP1_RVXF_1	686	693	PF00149	0.543
DOC_PP2B_LxvP_1	331	334	PF13499	0.482
DOC_PP2B_LxvP_1	344	347	PF13499	0.524
DOC_PP2B_LxvP_1	496	499	PF13499	0.440
DOC_PP2B_LxvP_1	622	625	PF13499	0.474
DOC_PP2B_PxIxI_1	257	263	PF00149	0.642
DOC_PP4_FxxP_1	834	837	PF00568	0.534
DOC_USP7_MATH_1	114	118	PF00917	0.641
DOC_USP7_MATH_1	162	166	PF00917	0.670
DOC_USP7_MATH_1	237	241	PF00917	0.516
DOC_USP7_MATH_1	285	289	PF00917	0.575
DOC_USP7_MATH_1	298	302	PF00917	0.611
DOC_USP7_MATH_1	347	351	PF00917	0.676
DOC_USP7_MATH_1	486	490	PF00917	0.492
DOC_USP7_MATH_1	499	503	PF00917	0.648
DOC_USP7_MATH_1	513	517	PF00917	0.508
DOC_USP7_MATH_1	553	557	PF00917	0.535
DOC_USP7_MATH_1	595	599	PF00917	0.506
DOC_USP7_MATH_1	724	728	PF00917	0.512
DOC_USP7_MATH_1	746	750	PF00917	0.522
DOC_USP7_MATH_1	752	756	PF00917	0.452
DOC_USP7_MATH_1	816	820	PF00917	0.747
DOC_USP7_MATH_1	82	86	PF00917	0.797
DOC_USP7_MATH_1	93	97	PF00917	0.576
DOC_WW_Pin1_4	1063	1068	PF00397	0.525
DOC_WW_Pin1_4	172	177	PF00397	0.659
DOC_WW_Pin1_4	195	200	PF00397	0.579
DOC_WW_Pin1_4	254	259	PF00397	0.732
DOC_WW_Pin1_4	323	328	PF00397	0.705
DOC_WW_Pin1_4	383	388	PF00397	0.635
DOC_WW_Pin1_4	652	657	PF00397	0.566
DOC_WW_Pin1_4	676	681	PF00397	0.644
DOC_WW_Pin1_4	809	814	PF00397	0.657
LIG_14-3-3_CanoR_1	1013	1021	PF00244	0.534
LIG_14-3-3_CanoR_1	232	237	PF00244	0.421
LIG_14-3-3_CanoR_1	304	312	PF00244	0.644
LIG_14-3-3_CanoR_1	338	348	PF00244	0.694
LIG_14-3-3_CanoR_1	358	364	PF00244	0.506
LIG_14-3-3_CanoR_1	562	569	PF00244	0.495
LIG_14-3-3_CanoR_1	876	882	PF00244	0.364
LIG_14-3-3_CanoR_1	899	905	PF00244	0.497
LIG_14-3-3_CanoR_1	951	960	PF00244	0.528
LIG_Actin_WH2_2	12	29	PF00022	0.474
LIG_Actin_WH2_2	199	214	PF00022	0.366
LIG_BIR_III_2	73	77	PF00653	0.544
LIG_BIR_III_4	771	775	PF00653	0.340
LIG_BRCT_BRCA1_1	265	269	PF00533	0.616
LIG_BRCT_BRCA1_1	298	302	PF00533	0.600
LIG_BRCT_BRCA1_1	532	536	PF00533	0.465
LIG_BRCT_BRCA1_1	754	758	PF00533	0.328
LIG_BRCT_BRCA1_1	877	881	PF00533	0.315
LIG_CSL_BTD_1	834	837	PF09270	0.534
LIG_deltaCOP1_diTrp_1	296	302	PF00928	0.540
LIG_eIF4E_1	14	20	PF01652	0.467
LIG_eIF4E_1	685	691	PF01652	0.482
LIG_FHA_1	103	109	PF00498	0.597
LIG_FHA_1	1042	1048	PF00498	0.592
LIG_FHA_1	1064	1070	PF00498	0.663
LIG_FHA_1	162	168	PF00498	0.577
LIG_FHA_1	187	193	PF00498	0.521
LIG_FHA_1	257	263	PF00498	0.674
LIG_FHA_1	311	317	PF00498	0.454
LIG_FHA_1	384	390	PF00498	0.606
LIG_FHA_1	417	423	PF00498	0.547
LIG_FHA_1	470	476	PF00498	0.471
LIG_FHA_1	640	646	PF00498	0.466
LIG_FHA_1	659	665	PF00498	0.456
LIG_FHA_1	883	889	PF00498	0.449
LIG_FHA_1	979	985	PF00498	0.498
LIG_FHA_2	1003	1009	PF00498	0.580
LIG_FHA_2	150	156	PF00498	0.631
LIG_FHA_2	196	202	PF00498	0.616
LIG_FHA_2	810	816	PF00498	0.548
LIG_GBD_Chelix_1	606	614	PF00786	0.476
LIG_LIR_Gen_1	201	211	PF02991	0.428
LIG_LIR_Gen_1	689	699	PF02991	0.434
LIG_LIR_Gen_1	755	766	PF02991	0.312
LIG_LIR_Gen_1	781	790	PF02991	0.418
LIG_LIR_Gen_1	988	995	PF02991	0.463
LIG_LIR_Nem_3	180	185	PF02991	0.480
LIG_LIR_Nem_3	201	207	PF02991	0.427
LIG_LIR_Nem_3	439	443	PF02991	0.560
LIG_LIR_Nem_3	628	634	PF02991	0.563
LIG_LIR_Nem_3	679	685	PF02991	0.591
LIG_LIR_Nem_3	689	695	PF02991	0.382
LIG_LIR_Nem_3	738	744	PF02991	0.357
LIG_LIR_Nem_3	755	761	PF02991	0.295
LIG_LIR_Nem_3	781	786	PF02991	0.416
LIG_LIR_Nem_3	878	884	PF02991	0.297
LIG_LIR_Nem_3	988	994	PF02991	0.437
LIG_LYPXL_yS_3	919	922	PF13949	0.498
LIG_MLH1_MIPbox_1	754	758	PF16413	0.328
LIG_NRBOX	393	399	PF00104	0.618
LIG_NRBOX	969	975	PF00104	0.318
LIG_Rb_pABgroove_1	263	271	PF01858	0.619
LIG_RPA_C_Fungi	1038	1050	PF08784	0.382
LIG_RPA_C_Fungi	119	131	PF08784	0.577
LIG_RPA_C_Fungi	442	454	PF08784	0.527
LIG_RPA_C_Insects	1028	1043	PF08784	0.400
LIG_SH2_CRK	1030	1034	PF00017	0.472
LIG_SH2_CRK	126	130	PF00017	0.616
LIG_SH2_CRK	650	654	PF00017	0.564
LIG_SH2_CRK	843	847	PF00017	0.539
LIG_SH2_GRB2like	934	937	PF00017	0.334
LIG_SH2_NCK_1	843	847	PF00017	0.462
LIG_SH2_PTP2	14	17	PF00017	0.465
LIG_SH2_SRC	7	10	PF00017	0.510
LIG_SH2_SRC	934	937	PF00017	0.309
LIG_SH2_STAP1	433	437	PF00017	0.441
LIG_SH2_STAP1	44	48	PF00017	0.499
LIG_SH2_STAP1	471	475	PF00017	0.376
LIG_SH2_STAP1	7	11	PF00017	0.571
LIG_SH2_STAP1	877	881	PF00017	0.442
LIG_SH2_STAP1	966	970	PF00017	0.415
LIG_SH2_STAT5	14	17	PF00017	0.475
LIG_SH2_STAT5	437	440	PF00017	0.469
LIG_SH2_STAT5	471	474	PF00017	0.463
LIG_SH2_STAT5	764	767	PF00017	0.498
LIG_SH2_STAT5	775	778	PF00017	0.440
LIG_SH2_STAT5	843	846	PF00017	0.346
LIG_SH3_1	252	258	PF00018	0.602
LIG_SH3_3	170	176	PF00018	0.782
LIG_SH3_3	231	237	PF00018	0.545
LIG_SH3_3	252	258	PF00018	0.708
LIG_SH3_3	650	656	PF00018	0.567
LIG_SUMO_SIM_anti_2	641	647	PF11976	0.413
LIG_SUMO_SIM_anti_2	971	976	PF11976	0.312
LIG_SUMO_SIM_anti_2	990	996	PF11976	0.428
LIG_SUMO_SIM_par_1	654	661	PF11976	0.539
LIG_SUMO_SIM_par_1	868	875	PF11976	0.435
LIG_TRAF2_1	1074	1077	PF00917	0.593
LIG_TRAF2_1	704	707	PF00917	0.509
LIG_TYR_ITIM	841	846	PF00017	0.559
LIG_TYR_ITIM	917	922	PF00017	0.505
LIG_UBA3_1	972	977	PF00899	0.307
LIG_WRC_WIRS_1	437	442	PF05994	0.585
MOD_CK1_1	113	119	PF00069	0.780
MOD_CK1_1	256	262	PF00069	0.586
MOD_CK1_1	339	345	PF00069	0.795
MOD_CK1_1	412	418	PF00069	0.575
MOD_CK1_1	439	445	PF00069	0.482
MOD_CK1_1	516	522	PF00069	0.776
MOD_CK1_1	556	562	PF00069	0.552
MOD_CK1_1	676	682	PF00069	0.578
MOD_CK1_1	735	741	PF00069	0.525
MOD_CK1_1	793	799	PF00069	0.637
MOD_CK1_1	85	91	PF00069	0.777
MOD_CK1_1	875	881	PF00069	0.273
MOD_CK2_1	1071	1077	PF00069	0.589
MOD_CK2_1	113	119	PF00069	0.643
MOD_CK2_1	172	178	PF00069	0.629
MOD_CK2_1	918	924	PF00069	0.450
MOD_Cter_Amidation	502	505	PF01082	0.482
MOD_Cter_Amidation	560	563	PF01082	0.377
MOD_GlcNHglycan	1021	1024	PF01048	0.576
MOD_GlcNHglycan	1058	1061	PF01048	0.625
MOD_GlcNHglycan	1084	1087	PF01048	0.544
MOD_GlcNHglycan	112	115	PF01048	0.729
MOD_GlcNHglycan	195	198	PF01048	0.764
MOD_GlcNHglycan	275	281	PF01048	0.662
MOD_GlcNHglycan	338	341	PF01048	0.690
MOD_GlcNHglycan	349	352	PF01048	0.612
MOD_GlcNHglycan	427	430	PF01048	0.429
MOD_GlcNHglycan	499	502	PF01048	0.614
MOD_GlcNHglycan	505	508	PF01048	0.702
MOD_GlcNHglycan	524	527	PF01048	0.429
MOD_GlcNHglycan	597	600	PF01048	0.666
MOD_GlcNHglycan	734	737	PF01048	0.483
MOD_GlcNHglycan	746	749	PF01048	0.456
MOD_GlcNHglycan	776	779	PF01048	0.359
MOD_GlcNHglycan	792	795	PF01048	0.649
MOD_GlcNHglycan	822	825	PF01048	0.519
MOD_GlcNHglycan	900	903	PF01048	0.409
MOD_GlcNHglycan	91	94	PF01048	0.795
MOD_GlcNHglycan	936	939	PF01048	0.480
MOD_GSK3_1	1015	1022	PF00069	0.323
MOD_GSK3_1	1078	1085	PF00069	0.567
MOD_GSK3_1	110	117	PF00069	0.708
MOD_GSK3_1	193	200	PF00069	0.772
MOD_GSK3_1	254	261	PF00069	0.629
MOD_GSK3_1	336	343	PF00069	0.637
MOD_GSK3_1	383	390	PF00069	0.573
MOD_GSK3_1	412	419	PF00069	0.690
MOD_GSK3_1	499	506	PF00069	0.638
MOD_GSK3_1	516	523	PF00069	0.479
MOD_GSK3_1	553	560	PF00069	0.443
MOD_GSK3_1	584	591	PF00069	0.623
MOD_GSK3_1	595	602	PF00069	0.606
MOD_GSK3_1	672	679	PF00069	0.525
MOD_GSK3_1	680	687	PF00069	0.513
MOD_GSK3_1	752	759	PF00069	0.363
MOD_GSK3_1	816	823	PF00069	0.634
MOD_GSK3_1	85	92	PF00069	0.713
MOD_GSK3_1	871	878	PF00069	0.326
MOD_GSK3_1	898	905	PF00069	0.507
MOD_N-GLC_1	283	288	PF02516	0.617
MOD_N-GLC_1	752	757	PF02516	0.332
MOD_N-GLC_1	820	825	PF02516	0.613
MOD_NEK2_1	1019	1024	PF00069	0.613
MOD_NEK2_1	1029	1034	PF00069	0.387
MOD_NEK2_1	210	215	PF00069	0.530
MOD_NEK2_1	378	383	PF00069	0.539
MOD_NEK2_1	424	429	PF00069	0.439
MOD_NEK2_1	494	499	PF00069	0.551
MOD_NEK2_1	657	662	PF00069	0.678
MOD_NEK2_1	757	762	PF00069	0.433
MOD_NEK2_1	841	846	PF00069	0.428
MOD_NEK2_1	871	876	PF00069	0.436
MOD_NEK2_1	900	905	PF00069	0.502
MOD_NEK2_1	929	934	PF00069	0.377
MOD_NEK2_1	987	992	PF00069	0.461
MOD_NEK2_2	285	290	PF00069	0.612
MOD_NEK2_2	436	441	PF00069	0.585
MOD_NEK2_2	752	757	PF00069	0.332
MOD_OFUCOSY	1070	1075	PF10250	0.666
MOD_PIKK_1	162	168	PF00454	0.696
MOD_PIKK_1	186	192	PF00454	0.574
MOD_PIKK_1	232	238	PF00454	0.466
MOD_PIKK_1	303	309	PF00454	0.588
MOD_PIKK_1	380	386	PF00454	0.609
MOD_PIKK_1	416	422	PF00454	0.532
MOD_PIKK_1	953	959	PF00454	0.361
MOD_PKA_2	193	199	PF00069	0.713
MOD_PKA_2	303	309	PF00069	0.530
MOD_PKA_2	416	422	PF00069	0.530
MOD_PKA_2	503	509	PF00069	0.631
MOD_PKA_2	561	567	PF00069	0.578
MOD_PKA_2	639	645	PF00069	0.384
MOD_PKA_2	85	91	PF00069	0.581
MOD_PKA_2	875	881	PF00069	0.276
MOD_PKA_2	898	904	PF00069	0.512
MOD_PKA_2	950	956	PF00069	0.558
MOD_PKB_1	949	957	PF00069	0.425
MOD_Plk_1	101	107	PF00069	0.697
MOD_Plk_1	118	124	PF00069	0.592
MOD_Plk_1	378	384	PF00069	0.643
MOD_Plk_1	513	519	PF00069	0.611
MOD_Plk_1	752	758	PF00069	0.323
MOD_Plk_2-3	584	590	PF00069	0.573
MOD_Plk_2-3	811	817	PF00069	0.495
MOD_Plk_4	134	140	PF00069	0.739
MOD_Plk_4	639	645	PF00069	0.437
MOD_Plk_4	752	758	PF00069	0.459
MOD_Plk_4	841	847	PF00069	0.255
MOD_ProDKin_1	1063	1069	PF00069	0.527
MOD_ProDKin_1	172	178	PF00069	0.659
MOD_ProDKin_1	195	201	PF00069	0.560
MOD_ProDKin_1	254	260	PF00069	0.727
MOD_ProDKin_1	323	329	PF00069	0.713
MOD_ProDKin_1	383	389	PF00069	0.634
MOD_ProDKin_1	652	658	PF00069	0.566
MOD_ProDKin_1	676	682	PF00069	0.641
MOD_ProDKin_1	809	815	PF00069	0.656
MOD_SUMO_for_1	29	32	PF00179	0.498
MOD_SUMO_for_1	671	674	PF00179	0.596
TRG_DiLeu_BaEn_1	24	29	PF01217	0.435
TRG_DiLeu_BaEn_1	589	594	PF01217	0.617
TRG_DiLeu_BaEn_1	641	646	PF01217	0.505
TRG_DiLeu_LyEn_5	24	29	PF01217	0.435
TRG_ENDOCYTIC_2	1030	1033	PF00928	0.416
TRG_ENDOCYTIC_2	126	129	PF00928	0.614
TRG_ENDOCYTIC_2	14	17	PF00928	0.448
TRG_ENDOCYTIC_2	437	440	PF00928	0.483
TRG_ENDOCYTIC_2	650	653	PF00928	0.555
TRG_ENDOCYTIC_2	843	846	PF00928	0.544
TRG_ENDOCYTIC_2	919	922	PF00928	0.498
TRG_ER_diArg_1	122	124	PF00400	0.638
TRG_ER_diArg_1	129	131	PF00400	0.554
TRG_ER_diArg_1	319	321	PF00400	0.393
TRG_ER_diArg_1	356	358	PF00400	0.547
TRG_ER_diArg_1	805	808	PF00400	0.643
TRG_ER_diArg_1	83	86	PF00400	0.534
TRG_ER_diArg_1	848	850	PF00400	0.492
TRG_ER_diArg_1	949	952	PF00400	0.414
TRG_ER_diArg_1	995	997	PF00400	0.316
TRG_NLS_Bipartite_1	320	339	PF00514	0.430
TRG_NLS_MonoExtN_4	332	339	PF00514	0.487
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	688	693	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV03	Leptomonas seymouri	47%	100%
A0A3R7L2Z7	Trypanosoma rangeli	29%	100%
A0A3S5H5U4	Leishmania donovani	88%	100%
A4H4S7	Leishmania braziliensis	76%	100%
C9ZTP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AG70	Leishmania infantum	88%	100%
Q4QIW0	Leishmania major	87%	100%
V5B820	Trypanosoma cruzi	29%	100%