DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania mexicana

UniProt:

E9AKZ4_LEIMU

TriTrypDb:

LmxM.06.1150

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.690
CLV_NRD_NRD_1	14	16	PF00675	0.657
CLV_NRD_NRD_1	309	311	PF00675	0.554
CLV_NRD_NRD_1	324	326	PF00675	0.508
CLV_NRD_NRD_1	361	363	PF00675	0.247
CLV_NRD_NRD_1	486	488	PF00675	0.503
CLV_PCSK_FUR_1	359	363	PF00082	0.169
CLV_PCSK_FUR_1	483	487	PF00082	0.519
CLV_PCSK_KEX2_1	14	16	PF00082	0.657
CLV_PCSK_KEX2_1	309	311	PF00082	0.537
CLV_PCSK_KEX2_1	324	326	PF00082	0.426
CLV_PCSK_KEX2_1	361	363	PF00082	0.247
CLV_PCSK_KEX2_1	485	487	PF00082	0.519
CLV_PCSK_SKI1_1	266	270	PF00082	0.169
CLV_PCSK_SKI1_1	416	420	PF00082	0.362
CLV_PCSK_SKI1_1	456	460	PF00082	0.405
DEG_APCC_DBOX_1	411	419	PF00400	0.423
DEG_ODPH_VHL_1	8	21	PF01847	0.507
DEG_SPOP_SBC_1	312	316	PF00917	0.422
DOC_CKS1_1	179	184	PF01111	0.807
DOC_MAPK_gen_1	14	21	PF00069	0.487
DOC_MAPK_gen_1	387	396	PF00069	0.445
DOC_MAPK_gen_1	412	420	PF00069	0.416
DOC_MAPK_MEF2A_6	14	21	PF00069	0.535
DOC_PP1_RVXF_1	242	248	PF00149	0.388
DOC_USP7_MATH_1	149	153	PF00917	0.340
DOC_USP7_MATH_1	191	195	PF00917	0.767
DOC_USP7_MATH_1	240	244	PF00917	0.209
DOC_USP7_MATH_1	250	254	PF00917	0.398
DOC_USP7_MATH_1	275	279	PF00917	0.699
DOC_USP7_MATH_1	312	316	PF00917	0.631
DOC_USP7_MATH_1	382	386	PF00917	0.390
DOC_USP7_MATH_1	452	456	PF00917	0.429
DOC_USP7_MATH_1	66	70	PF00917	0.718
DOC_WW_Pin1_4	119	124	PF00397	0.520
DOC_WW_Pin1_4	126	131	PF00397	0.367
DOC_WW_Pin1_4	175	180	PF00397	0.644
DOC_WW_Pin1_4	251	256	PF00397	0.407
DOC_WW_Pin1_4	278	283	PF00397	0.749
DOC_WW_Pin1_4	285	290	PF00397	0.774
DOC_WW_Pin1_4	292	297	PF00397	0.676
DOC_WW_Pin1_4	73	78	PF00397	0.571
LIG_14-3-3_CanoR_1	139	147	PF00244	0.391
LIG_14-3-3_CanoR_1	14	20	PF00244	0.641
LIG_14-3-3_CanoR_1	196	204	PF00244	0.701
LIG_14-3-3_CanoR_1	309	318	PF00244	0.568
LIG_14-3-3_CanoR_1	347	356	PF00244	0.411
LIG_14-3-3_CanoR_1	504	510	PF00244	0.587
LIG_Actin_RPEL_3	8	27	PF02755	0.429
LIG_Actin_WH2_2	403	418	PF00022	0.515
LIG_APCC_ABBA_1	339	344	PF00400	0.488
LIG_APCC_ABBA_1	418	423	PF00400	0.358
LIG_BIR_III_2	209	213	PF00653	0.465
LIG_BRCT_BRCA1_1	454	458	PF00533	0.477
LIG_BRCT_BRCA1_1	75	79	PF00533	0.416
LIG_FHA_1	21	27	PF00498	0.636
LIG_FHA_1	28	34	PF00498	0.641
LIG_FHA_2	112	118	PF00498	0.660
LIG_FHA_2	417	423	PF00498	0.343
LIG_FHA_2	506	512	PF00498	0.553
LIG_LIR_Nem_3	209	214	PF02991	0.396
LIG_LIR_Nem_3	432	437	PF02991	0.450
LIG_LYPXL_yS_3	211	214	PF13949	0.368
LIG_MYND_1	6	10	PF01753	0.454
LIG_PCNA_PIPBox_1	100	109	PF02747	0.450
LIG_PCNA_yPIPBox_3	100	111	PF02747	0.567
LIG_RPA_C_Fungi	320	332	PF08784	0.297
LIG_SH2_PTP2	417	420	PF00017	0.473
LIG_SH2_STAP1	267	271	PF00017	0.490
LIG_SH2_STAP1	367	371	PF00017	0.390
LIG_SH2_STAT3	169	172	PF00017	0.502
LIG_SH2_STAT3	470	473	PF00017	0.322
LIG_SH2_STAT5	375	378	PF00017	0.227
LIG_SH2_STAT5	417	420	PF00017	0.473
LIG_SH3_1	4	10	PF00018	0.484
LIG_SH3_3	176	182	PF00018	0.718
LIG_SH3_3	277	283	PF00018	0.724
LIG_SH3_3	290	296	PF00018	0.564
LIG_SH3_3	394	400	PF00018	0.525
LIG_SH3_3	4	10	PF00018	0.532
LIG_SH3_3	421	427	PF00018	0.414
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.417
LIG_TYR_ITIM	415	420	PF00017	0.485
LIG_WW_3	281	285	PF00397	0.482
MOD_CDC14_SPxK_1	281	284	PF00782	0.479
MOD_CDK_SPxK_1	278	284	PF00069	0.457
MOD_CK1_1	145	151	PF00069	0.406
MOD_CK1_1	152	158	PF00069	0.390
MOD_CK1_1	178	184	PF00069	0.693
MOD_CK1_1	195	201	PF00069	0.554
MOD_CK1_1	259	265	PF00069	0.355
MOD_CK1_1	278	284	PF00069	0.772
MOD_CK1_1	313	319	PF00069	0.456
MOD_CK1_1	349	355	PF00069	0.432
MOD_CK1_1	385	391	PF00069	0.450
MOD_CK1_1	67	73	PF00069	0.626
MOD_CK2_1	230	236	PF00069	0.414
MOD_CK2_1	505	511	PF00069	0.552
MOD_GlcNHglycan	117	120	PF01048	0.686
MOD_GlcNHglycan	147	150	PF01048	0.304
MOD_GlcNHglycan	175	178	PF01048	0.647
MOD_GlcNHglycan	240	243	PF01048	0.372
MOD_GlcNHglycan	384	387	PF01048	0.438
MOD_GlcNHglycan	480	483	PF01048	0.533
MOD_GlcNHglycan	49	52	PF01048	0.724
MOD_GlcNHglycan	516	519	PF01048	0.361
MOD_GlcNHglycan	66	69	PF01048	0.631
MOD_GSK3_1	107	114	PF00069	0.582
MOD_GSK3_1	115	122	PF00069	0.613
MOD_GSK3_1	124	131	PF00069	0.395
MOD_GSK3_1	138	145	PF00069	0.404
MOD_GSK3_1	191	198	PF00069	0.747
MOD_GSK3_1	232	239	PF00069	0.390
MOD_GSK3_1	278	285	PF00069	0.762
MOD_GSK3_1	348	355	PF00069	0.298
MOD_GSK3_1	404	411	PF00069	0.449
MOD_GSK3_1	459	466	PF00069	0.536
MOD_GSK3_1	47	54	PF00069	0.676
MOD_GSK3_1	510	517	PF00069	0.448
MOD_GSK3_1	64	71	PF00069	0.643
MOD_N-GLC_1	124	129	PF02516	0.284
MOD_NEK2_1	124	129	PF00069	0.329
MOD_NEK2_1	21	26	PF00069	0.690
MOD_NEK2_1	27	32	PF00069	0.651
MOD_NEK2_1	458	463	PF00069	0.475
MOD_NEK2_1	49	54	PF00069	0.544
MOD_NEK2_1	495	500	PF00069	0.587
MOD_NEK2_1	505	510	PF00069	0.569
MOD_NEK2_2	29	34	PF00069	0.686
MOD_PIKK_1	138	144	PF00454	0.323
MOD_PIKK_1	459	465	PF00454	0.411
MOD_PK_1	15	21	PF00069	0.484
MOD_PKA_2	107	113	PF00069	0.530
MOD_PKA_2	138	144	PF00069	0.351
MOD_PKA_2	149	155	PF00069	0.304
MOD_PKA_2	195	201	PF00069	0.743
MOD_PKA_2	346	352	PF00069	0.466
MOD_PKA_2	437	443	PF00069	0.405
MOD_PKB_1	414	422	PF00069	0.418
MOD_PKB_1	491	499	PF00069	0.315
MOD_Plk_1	124	130	PF00069	0.217
MOD_Plk_1	352	358	PF00069	0.217
MOD_Plk_4	21	27	PF00069	0.525
MOD_Plk_4	313	319	PF00069	0.379
MOD_ProDKin_1	119	125	PF00069	0.511
MOD_ProDKin_1	126	132	PF00069	0.367
MOD_ProDKin_1	175	181	PF00069	0.649
MOD_ProDKin_1	251	257	PF00069	0.407
MOD_ProDKin_1	278	284	PF00069	0.756
MOD_ProDKin_1	285	291	PF00069	0.773
MOD_ProDKin_1	292	298	PF00069	0.668
MOD_ProDKin_1	73	79	PF00069	0.554
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.461
TRG_ENDOCYTIC_2	211	214	PF00928	0.368
TRG_ENDOCYTIC_2	417	420	PF00928	0.473
TRG_ER_diArg_1	13	15	PF00400	0.721
TRG_ER_diArg_1	324	326	PF00400	0.528
TRG_ER_diArg_1	358	361	PF00400	0.286
TRG_ER_diArg_1	412	415	PF00400	0.538
TRG_ER_diArg_1	483	486	PF00400	0.561
TRG_ER_diArg_1	488	491	PF00400	0.557
TRG_NES_CRM1_1	84	97	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	374	379	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ62	Leptomonas seymouri	61%	100%
A0A0S4KFW8	Bodo saltans	29%	100%
A0A1X0NIH3	Trypanosomatidae	37%	100%
A0A3R7NRE8	Trypanosoma rangeli	37%	100%
A0A3S5H5U3	Leishmania donovani	89%	100%
A4H4S6	Leishmania braziliensis	75%	100%
A4HT07	Leishmania infantum	89%	100%
C9ZTN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	92%
Q4QIW1	Leishmania major	91%	100%
V5BNK9	Trypanosoma cruzi	38%	100%