BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKZ3_LEIMU

TriTrypDb:

LmxM.06.1140

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	536	540	PF00656	0.622
CLV_MEL_PAP_1	376	382	PF00089	0.624
CLV_NRD_NRD_1	140	142	PF00675	0.639
CLV_NRD_NRD_1	2	4	PF00675	0.567
CLV_NRD_NRD_1	319	321	PF00675	0.474
CLV_NRD_NRD_1	353	355	PF00675	0.746
CLV_NRD_NRD_1	514	516	PF00675	0.647
CLV_NRD_NRD_1	518	520	PF00675	0.633
CLV_NRD_NRD_1	650	652	PF00675	0.565
CLV_NRD_NRD_1	669	671	PF00675	0.319
CLV_NRD_NRD_1	713	715	PF00675	0.424
CLV_NRD_NRD_1	759	761	PF00675	0.513
CLV_NRD_NRD_1	781	783	PF00675	0.536
CLV_NRD_NRD_1	813	815	PF00675	0.736
CLV_NRD_NRD_1	818	820	PF00675	0.746
CLV_PCSK_FUR_1	515	519	PF00082	0.655
CLV_PCSK_KEX2_1	140	142	PF00082	0.637
CLV_PCSK_KEX2_1	2	4	PF00082	0.567
CLV_PCSK_KEX2_1	319	321	PF00082	0.474
CLV_PCSK_KEX2_1	353	355	PF00082	0.746
CLV_PCSK_KEX2_1	516	518	PF00082	0.690
CLV_PCSK_KEX2_1	650	652	PF00082	0.426
CLV_PCSK_KEX2_1	669	671	PF00082	0.401
CLV_PCSK_KEX2_1	713	715	PF00082	0.424
CLV_PCSK_KEX2_1	781	783	PF00082	0.536
CLV_PCSK_KEX2_1	812	814	PF00082	0.742
CLV_PCSK_KEX2_1	837	839	PF00082	0.821
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.746
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.744
CLV_PCSK_PC1ET2_1	837	839	PF00082	0.741
CLV_PCSK_PC7_1	349	355	PF00082	0.700
CLV_PCSK_PC7_1	665	671	PF00082	0.348
CLV_PCSK_SKI1_1	141	145	PF00082	0.546
CLV_PCSK_SKI1_1	194	198	PF00082	0.534
CLV_PCSK_SKI1_1	263	267	PF00082	0.490
CLV_PCSK_SKI1_1	609	613	PF00082	0.545
CLV_PCSK_SKI1_1	688	692	PF00082	0.669
CLV_PCSK_SKI1_1	713	717	PF00082	0.565
CLV_PCSK_SKI1_1	775	779	PF00082	0.463
CLV_PCSK_SKI1_1	792	796	PF00082	0.588
CLV_PCSK_SKI1_1	802	806	PF00082	0.527
DEG_APCC_DBOX_1	37	45	PF00400	0.511
DEG_Nend_UBRbox_1	1	4	PF02207	0.574
DEG_SCF_FBW7_1	202	209	PF00400	0.413
DOC_CYCLIN_RxL_1	789	797	PF00134	0.606
DOC_MAPK_gen_1	192	199	PF00069	0.333
DOC_MAPK_gen_1	593	602	PF00069	0.461
DOC_MAPK_gen_1	760	768	PF00069	0.504
DOC_MAPK_MEF2A_6	192	199	PF00069	0.333
DOC_PP2B_LxvP_1	187	190	PF13499	0.277
DOC_PP2B_LxvP_1	197	200	PF13499	0.384
DOC_PP2B_LxvP_1	638	641	PF13499	0.512
DOC_PP2B_LxvP_1	721	724	PF13499	0.458
DOC_PP2B_PxIxI_1	406	412	PF00149	0.753
DOC_PP4_FxxP_1	767	770	PF00568	0.549
DOC_SPAK_OSR1_1	683	687	PF12202	0.462
DOC_USP7_MATH_1	170	174	PF00917	0.699
DOC_USP7_MATH_1	253	257	PF00917	0.497
DOC_USP7_MATH_1	275	279	PF00917	0.732
DOC_USP7_MATH_1	397	401	PF00917	0.741
DOC_USP7_MATH_1	438	442	PF00917	0.724
DOC_USP7_MATH_1	46	50	PF00917	0.495
DOC_USP7_MATH_1	504	508	PF00917	0.829
DOC_USP7_MATH_1	551	555	PF00917	0.800
DOC_USP7_MATH_1	746	750	PF00917	0.793
DOC_USP7_MATH_1	822	826	PF00917	0.711
DOC_USP7_MATH_1	88	92	PF00917	0.558
DOC_WW_Pin1_4	202	207	PF00397	0.639
DOC_WW_Pin1_4	271	276	PF00397	0.434
DOC_WW_Pin1_4	309	314	PF00397	0.727
DOC_WW_Pin1_4	331	336	PF00397	0.629
DOC_WW_Pin1_4	4	9	PF00397	0.545
DOC_WW_Pin1_4	427	432	PF00397	0.754
DOC_WW_Pin1_4	557	562	PF00397	0.672
DOC_WW_Pin1_4	65	70	PF00397	0.468
DOC_WW_Pin1_4	688	693	PF00397	0.530
DOC_WW_Pin1_4	751	756	PF00397	0.601
DOC_WW_Pin1_4	818	823	PF00397	0.717
DOC_WW_Pin1_4	827	832	PF00397	0.707
LIG_14-3-3_CanoR_1	194	200	PF00244	0.509
LIG_14-3-3_CanoR_1	22	28	PF00244	0.573
LIG_14-3-3_CanoR_1	298	304	PF00244	0.590
LIG_14-3-3_CanoR_1	38	42	PF00244	0.494
LIG_14-3-3_CanoR_1	423	433	PF00244	0.840
LIG_14-3-3_CanoR_1	435	443	PF00244	0.697
LIG_14-3-3_CanoR_1	456	463	PF00244	0.662
LIG_14-3-3_CanoR_1	634	639	PF00244	0.496
LIG_14-3-3_CanoR_1	745	755	PF00244	0.562
LIG_14-3-3_CanoR_1	781	790	PF00244	0.621
LIG_14-3-3_CanoR_1	812	817	PF00244	0.749
LIG_14-3-3_CanoR_1	87	93	PF00244	0.601
LIG_Actin_WH2_2	577	595	PF00022	0.510
LIG_Actin_WH2_2	649	667	PF00022	0.630
LIG_BIR_III_4	371	375	PF00653	0.696
LIG_CaM_NSCaTE_8	159	166	PF13499	0.446
LIG_CSL_BTD_1	211	214	PF09270	0.490
LIG_FHA_1	208	214	PF00498	0.610
LIG_FHA_1	300	306	PF00498	0.591
LIG_FHA_1	319	325	PF00498	0.668
LIG_FHA_1	334	340	PF00498	0.494
LIG_FHA_1	37	43	PF00498	0.512
LIG_FHA_1	375	381	PF00498	0.540
LIG_FHA_1	457	463	PF00498	0.756
LIG_FHA_1	466	472	PF00498	0.793
LIG_FHA_1	633	639	PF00498	0.499
LIG_FHA_1	710	716	PF00498	0.501
LIG_FHA_1	752	758	PF00498	0.496
LIG_FHA_1	77	83	PF00498	0.650
LIG_FHA_1	799	805	PF00498	0.620
LIG_FHA_1	98	104	PF00498	0.741
LIG_FHA_2	120	126	PF00498	0.809
LIG_FHA_2	362	368	PF00498	0.704
LIG_FHA_2	471	477	PF00498	0.818
LIG_FHA_2	558	564	PF00498	0.623
LIG_FHA_2	578	584	PF00498	0.413
LIG_FHA_2	689	695	PF00498	0.557
LIG_FHA_2	91	97	PF00498	0.720
LIG_LIR_Apic_2	413	417	PF02991	0.546
LIG_LIR_Gen_1	327	335	PF02991	0.634
LIG_LIR_Gen_1	627	633	PF02991	0.279
LIG_LIR_Nem_3	209	215	PF02991	0.599
LIG_LIR_Nem_3	327	331	PF02991	0.513
LIG_LIR_Nem_3	627	631	PF02991	0.426
LIG_LIR_Nem_3	771	777	PF02991	0.459
LIG_MYND_1	151	155	PF01753	0.608
LIG_SH2_CRK	215	219	PF00017	0.581
LIG_SH2_CRK	414	418	PF00017	0.549
LIG_SH2_CRK	597	601	PF00017	0.582
LIG_SH2_STAP1	19	23	PF00017	0.562
LIG_SH2_STAP1	597	601	PF00017	0.582
LIG_SH2_STAT5	43	46	PF00017	0.512
LIG_SH2_STAT5	619	622	PF00017	0.575
LIG_SH3_3	208	214	PF00018	0.490
LIG_SH3_3	254	260	PF00018	0.523
LIG_SH3_3	310	316	PF00018	0.738
LIG_SH3_3	391	397	PF00018	0.722
LIG_SH3_3	689	695	PF00018	0.593
LIG_SH3_3	78	84	PF00018	0.507
LIG_SUMO_SIM_anti_2	627	633	PF11976	0.341
LIG_SUMO_SIM_anti_2	719	724	PF11976	0.566
LIG_SUMO_SIM_anti_2	99	108	PF11976	0.722
LIG_SUMO_SIM_par_1	99	108	PF11976	0.722
LIG_TRAF2_1	134	137	PF00917	0.744
LIG_TRAF2_1	691	694	PF00917	0.706
MOD_CDK_SPK_2	827	832	PF00069	0.717
MOD_CDK_SPxxK_3	827	834	PF00069	0.752
MOD_CK1_1	105	111	PF00069	0.766
MOD_CK1_1	113	119	PF00069	0.707
MOD_CK1_1	171	177	PF00069	0.646
MOD_CK1_1	225	231	PF00069	0.428
MOD_CK1_1	235	241	PF00069	0.695
MOD_CK1_1	247	253	PF00069	0.640
MOD_CK1_1	318	324	PF00069	0.576
MOD_CK1_1	334	340	PF00069	0.476
MOD_CK1_1	361	367	PF00069	0.798
MOD_CK1_1	402	408	PF00069	0.806
MOD_CK1_1	424	430	PF00069	0.845
MOD_CK1_1	458	464	PF00069	0.655
MOD_CK1_1	475	481	PF00069	0.684
MOD_CK1_1	484	490	PF00069	0.735
MOD_CK1_1	49	55	PF00069	0.495
MOD_CK1_1	556	562	PF00069	0.705
MOD_CK1_1	65	71	PF00069	0.441
MOD_CK1_1	655	661	PF00069	0.611
MOD_CK1_1	747	753	PF00069	0.680
MOD_CK1_1	784	790	PF00069	0.625
MOD_CK1_1	815	821	PF00069	0.794
MOD_CK2_1	557	563	PF00069	0.721
MOD_CK2_1	571	577	PF00069	0.467
MOD_CK2_1	688	694	PF00069	0.567
MOD_CK2_1	90	96	PF00069	0.723
MOD_Cter_Amidation	810	813	PF01082	0.738
MOD_GlcNHglycan	112	115	PF01048	0.736
MOD_GlcNHglycan	170	173	PF01048	0.667
MOD_GlcNHglycan	242	245	PF01048	0.726
MOD_GlcNHglycan	247	250	PF01048	0.679
MOD_GlcNHglycan	277	280	PF01048	0.692
MOD_GlcNHglycan	281	284	PF01048	0.732
MOD_GlcNHglycan	34	37	PF01048	0.582
MOD_GlcNHglycan	399	402	PF01048	0.742
MOD_GlcNHglycan	423	426	PF01048	0.856
MOD_GlcNHglycan	436	439	PF01048	0.613
MOD_GlcNHglycan	440	443	PF01048	0.542
MOD_GlcNHglycan	555	558	PF01048	0.670
MOD_GlcNHglycan	58	61	PF01048	0.587
MOD_GlcNHglycan	688	691	PF01048	0.666
MOD_GlcNHglycan	706	709	PF01048	0.466
MOD_GlcNHglycan	746	749	PF01048	0.676
MOD_GlcNHglycan	751	754	PF01048	0.674
MOD_GlcNHglycan	783	786	PF01048	0.577
MOD_GlcNHglycan	808	811	PF01048	0.713
MOD_GlcNHglycan	822	825	PF01048	0.567
MOD_GSK3_1	108	115	PF00069	0.697
MOD_GSK3_1	119	126	PF00069	0.734
MOD_GSK3_1	2	9	PF00069	0.474
MOD_GSK3_1	202	209	PF00069	0.618
MOD_GSK3_1	232	239	PF00069	0.674
MOD_GSK3_1	240	247	PF00069	0.756
MOD_GSK3_1	271	278	PF00069	0.481
MOD_GSK3_1	314	321	PF00069	0.700
MOD_GSK3_1	32	39	PF00069	0.508
MOD_GSK3_1	331	338	PF00069	0.438
MOD_GSK3_1	355	362	PF00069	0.701
MOD_GSK3_1	42	49	PF00069	0.483
MOD_GSK3_1	434	441	PF00069	0.787
MOD_GSK3_1	457	464	PF00069	0.678
MOD_GSK3_1	470	477	PF00069	0.665
MOD_GSK3_1	549	556	PF00069	0.735
MOD_GSK3_1	740	747	PF00069	0.719
MOD_GSK3_1	749	756	PF00069	0.629
MOD_GSK3_1	798	805	PF00069	0.677
MOD_GSK3_1	818	825	PF00069	0.842
MOD_GSK3_1	86	93	PF00069	0.571
MOD_NEK2_1	112	117	PF00069	0.637
MOD_NEK2_1	237	242	PF00069	0.659
MOD_NEK2_1	261	266	PF00069	0.598
MOD_NEK2_1	494	499	PF00069	0.636
MOD_NEK2_1	566	571	PF00069	0.517
MOD_NEK2_1	607	612	PF00069	0.483
MOD_NEK2_1	62	67	PF00069	0.588
MOD_NEK2_1	664	669	PF00069	0.483
MOD_NEK2_1	740	745	PF00069	0.703
MOD_NEK2_1	783	788	PF00069	0.510
MOD_NEK2_2	299	304	PF00069	0.609
MOD_NEK2_2	374	379	PF00069	0.622
MOD_PIKK_1	113	119	PF00454	0.740
MOD_PIKK_1	424	430	PF00454	0.845
MOD_PIKK_1	46	52	PF00454	0.493
MOD_PIKK_1	496	502	PF00454	0.756
MOD_PIKK_1	504	510	PF00454	0.648
MOD_PIKK_1	812	818	PF00454	0.732
MOD_PIKK_1	824	830	PF00454	0.736
MOD_PKA_1	2	8	PF00069	0.554
MOD_PKA_1	517	523	PF00069	0.622
MOD_PKA_1	781	787	PF00069	0.546
MOD_PKA_1	812	818	PF00069	0.732
MOD_PKA_2	2	8	PF00069	0.554
MOD_PKA_2	225	231	PF00069	0.538
MOD_PKA_2	318	324	PF00069	0.526
MOD_PKA_2	37	43	PF00069	0.512
MOD_PKA_2	405	411	PF00069	0.656
MOD_PKA_2	434	440	PF00069	0.787
MOD_PKA_2	455	461	PF00069	0.702
MOD_PKA_2	46	52	PF00069	0.475
MOD_PKA_2	517	523	PF00069	0.694
MOD_PKA_2	571	577	PF00069	0.530
MOD_PKA_2	664	670	PF00069	0.634
MOD_PKA_2	744	750	PF00069	0.766
MOD_PKA_2	781	787	PF00069	0.546
MOD_PKA_2	812	818	PF00069	0.619
MOD_PKA_2	86	92	PF00069	0.631
MOD_PKB_1	515	523	PF00069	0.625
MOD_Plk_1	465	471	PF00069	0.710
MOD_Plk_1	577	583	PF00069	0.627
MOD_Plk_1	658	664	PF00069	0.544
MOD_Plk_2-3	577	583	PF00069	0.627
MOD_Plk_2-3	97	103	PF00069	0.804
MOD_Plk_4	123	129	PF00069	0.518
MOD_Plk_4	335	341	PF00069	0.440
MOD_Plk_4	37	43	PF00069	0.512
MOD_Plk_4	458	464	PF00069	0.706
MOD_Plk_4	49	55	PF00069	0.487
MOD_Plk_4	612	618	PF00069	0.396
MOD_Plk_4	624	630	PF00069	0.386
MOD_Plk_4	699	705	PF00069	0.524
MOD_Plk_4	726	732	PF00069	0.334
MOD_ProDKin_1	202	208	PF00069	0.627
MOD_ProDKin_1	271	277	PF00069	0.445
MOD_ProDKin_1	309	315	PF00069	0.732
MOD_ProDKin_1	331	337	PF00069	0.620
MOD_ProDKin_1	4	10	PF00069	0.546
MOD_ProDKin_1	427	433	PF00069	0.753
MOD_ProDKin_1	557	563	PF00069	0.660
MOD_ProDKin_1	65	71	PF00069	0.472
MOD_ProDKin_1	688	694	PF00069	0.546
MOD_ProDKin_1	751	757	PF00069	0.584
MOD_ProDKin_1	818	824	PF00069	0.717
MOD_ProDKin_1	827	833	PF00069	0.705
MOD_SUMO_rev_2	694	703	PF00179	0.595
TRG_DiLeu_BaEn_1	583	588	PF01217	0.612
TRG_DiLeu_BaEn_1	99	104	PF01217	0.727
TRG_ENDOCYTIC_2	597	600	PF00928	0.591
TRG_ER_diArg_1	1	3	PF00400	0.580
TRG_ER_diArg_1	139	141	PF00400	0.641
TRG_ER_diArg_1	319	322	PF00400	0.675
TRG_ER_diArg_1	515	518	PF00400	0.709
TRG_ER_diArg_1	633	636	PF00400	0.550
TRG_ER_diArg_1	650	652	PF00400	0.451
TRG_ER_diArg_1	668	670	PF00400	0.506
TRG_ER_diArg_1	675	678	PF00400	0.487
TRG_ER_diArg_1	713	715	PF00400	0.424
TRG_ER_diArg_1	781	783	PF00400	0.536
TRG_ER_diArg_1	812	814	PF00400	0.742
TRG_NES_CRM1_1	563	577	PF08389	0.426
TRG_NLS_MonoCore_2	514	519	PF00514	0.703
TRG_NLS_MonoExtC_3	514	519	PF00514	0.722
TRG_NLS_MonoExtN_4	515	520	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	734	738	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	792	797	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD2	Leptomonas seymouri	39%	100%
A0A3S5H5U2	Leishmania donovani	85%	100%
A4H4S5	Leishmania braziliensis	70%	98%
A4HT06	Leishmania infantum	86%	100%
Q4QIW2	Leishmania major	79%	99%