Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKZ2_LEIMU

TriTrypDb:

LmxM.06.1130

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

E9AKZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.459
CLV_NRD_NRD_1	319	321	PF00675	0.202
CLV_PCSK_KEX2_1	159	161	PF00082	0.415
CLV_PCSK_KEX2_1	282	284	PF00082	0.292
CLV_PCSK_KEX2_1	319	321	PF00082	0.202
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.323
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.292
CLV_PCSK_SKI1_1	160	164	PF00082	0.405
DEG_Nend_UBRbox_3	1	3	PF02207	0.498
DEG_SCF_FBW7_2	5	10	PF00400	0.484
DOC_CKS1_1	150	155	PF01111	0.342
DOC_MAPK_gen_1	159	167	PF00069	0.323
DOC_MAPK_HePTP_8	231	243	PF00069	0.375
DOC_MAPK_MEF2A_6	119	126	PF00069	0.415
DOC_MAPK_MEF2A_6	234	243	PF00069	0.394
DOC_PP4_FxxP_1	321	324	PF00568	0.420
DOC_USP7_MATH_1	158	162	PF00917	0.565
DOC_USP7_MATH_1	36	40	PF00917	0.456
DOC_USP7_MATH_2	175	181	PF00917	0.239
DOC_WW_Pin1_4	13	18	PF00397	0.359
DOC_WW_Pin1_4	149	154	PF00397	0.499
DOC_WW_Pin1_4	171	176	PF00397	0.406
DOC_WW_Pin1_4	197	202	PF00397	0.381
DOC_WW_Pin1_4	3	8	PF00397	0.491
LIG_14-3-3_CanoR_1	137	141	PF00244	0.401
LIG_14-3-3_CanoR_1	160	167	PF00244	0.440
LIG_14-3-3_CanoR_1	212	217	PF00244	0.370
LIG_14-3-3_CanoR_1	45	53	PF00244	0.429
LIG_APCC_ABBA_1	5	10	PF00400	0.377
LIG_BIR_III_4	182	186	PF00653	0.353
LIG_CtBP_PxDLS_1	175	179	PF00389	0.249
LIG_FHA_1	149	155	PF00498	0.539
LIG_FHA_1	194	200	PF00498	0.507
LIG_FHA_1	203	209	PF00498	0.383
LIG_FHA_1	238	244	PF00498	0.398
LIG_FHA_1	290	296	PF00498	0.405
LIG_FHA_1	94	100	PF00498	0.434
LIG_FHA_2	161	167	PF00498	0.398
LIG_FHA_2	275	281	PF00498	0.431
LIG_FHA_2	288	294	PF00498	0.546
LIG_GBD_Chelix_1	78	86	PF00786	0.353
LIG_LIR_Gen_1	312	321	PF02991	0.289
LIG_LIR_Nem_3	31	35	PF02991	0.292
LIG_LIR_Nem_3	312	316	PF02991	0.338
LIG_NRP_CendR_1	326	328	PF00754	0.578
LIG_SH2_CRK	21	25	PF00017	0.332
LIG_SH2_CRK	313	317	PF00017	0.401
LIG_SH2_STAP1	255	259	PF00017	0.407
LIG_SH2_STAP1	42	46	PF00017	0.286
LIG_SH2_STAT5	138	141	PF00017	0.308
LIG_SH2_STAT5	32	35	PF00017	0.374
LIG_SH2_STAT5	42	45	PF00017	0.379
LIG_SH3_3	147	153	PF00018	0.569
LIG_SH3_3	8	14	PF00018	0.405
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.241
LIG_SUMO_SIM_par_1	195	200	PF11976	0.309
LIG_SUMO_SIM_par_1	77	83	PF11976	0.366
LIG_TYR_ITIM	19	24	PF00017	0.343
MOD_CK1_1	200	206	PF00069	0.394
MOD_CK1_1	3	9	PF00069	0.322
MOD_CK1_1	34	40	PF00069	0.390
MOD_CK2_1	171	177	PF00069	0.491
MOD_CK2_1	261	267	PF00069	0.439
MOD_GlcNHglycan	179	182	PF01048	0.381
MOD_GlcNHglycan	2	5	PF01048	0.305
MOD_GlcNHglycan	235	238	PF01048	0.426
MOD_GlcNHglycan	255	258	PF01048	0.219
MOD_GlcNHglycan	263	266	PF01048	0.222
MOD_GlcNHglycan	287	290	PF01048	0.512
MOD_GlcNHglycan	38	41	PF01048	0.395
MOD_GlcNHglycan	82	85	PF01048	0.454
MOD_GSK3_1	193	200	PF00069	0.407
MOD_GSK3_1	202	209	PF00069	0.417
MOD_GSK3_1	233	240	PF00069	0.398
MOD_GSK3_1	285	292	PF00069	0.528
MOD_GSK3_1	36	43	PF00069	0.396
MOD_NEK2_1	232	237	PF00069	0.256
MOD_NEK2_1	253	258	PF00069	0.512
MOD_NEK2_1	301	306	PF00069	0.332
MOD_NEK2_2	40	45	PF00069	0.445
MOD_PK_1	212	218	PF00069	0.372
MOD_PKA_2	136	142	PF00069	0.400
MOD_PKA_2	233	239	PF00069	0.386
MOD_PKA_2	44	50	PF00069	0.468
MOD_Plk_1	104	110	PF00069	0.305
MOD_Plk_1	274	280	PF00069	0.526
MOD_Plk_2-3	275	281	PF00069	0.411
MOD_Plk_4	237	243	PF00069	0.292
MOD_Plk_4	28	34	PF00069	0.280
MOD_ProDKin_1	13	19	PF00069	0.356
MOD_ProDKin_1	149	155	PF00069	0.488
MOD_ProDKin_1	171	177	PF00069	0.399
MOD_ProDKin_1	197	203	PF00069	0.385
MOD_ProDKin_1	3	9	PF00069	0.491
MOD_SUMO_rev_2	275	284	PF00179	0.279
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.207
TRG_ENDOCYTIC_2	21	24	PF00928	0.333
TRG_ENDOCYTIC_2	313	316	PF00928	0.310
TRG_ER_diArg_1	318	320	PF00400	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR4	Leptomonas seymouri	48%	100%
A0A1X0NGN1	Trypanosomatidae	28%	99%
A0A3S5H5U1	Leishmania donovani	89%	100%
A0A422NM50	Trypanosoma rangeli	25%	99%
A4H4S4	Leishmania braziliensis	74%	100%
A4HT05	Leishmania infantum	89%	100%
Q4QIW3	Leishmania major	87%	100%
Q9H977	Homo sapiens	26%	98%
Q9R0D8	Mus musculus	26%	98%
V5BT69	Trypanosoma cruzi	25%	99%