Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKZ1_LEIMU

TriTrypDb:

LmxM.06.1120

Length:

273

Annotations

LeishMANIAdb annotations

A short well-folded TM protein, possibly with GPI anchor. Structurally weakly similar to PBN1, a GPI anchor biogenesis protein.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	4
GO:0016020	membrane	2	8
GO:0031090	organelle membrane	3	4
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AKZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKZ1

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	4
GO:0006505	GPI anchor metabolic process	6	4
GO:0006506	GPI anchor biosynthetic process	6	4
GO:0006629	lipid metabolic process	3	4
GO:0006643	membrane lipid metabolic process	4	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006661	phosphatidylinositol biosynthetic process	6	4
GO:0006664	glycolipid metabolic process	5	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0009247	glycolipid biosynthetic process	5	4
GO:0009987	cellular process	1	4
GO:0019538	protein metabolic process	3	4
GO:0019637	organophosphate metabolic process	3	4
GO:0036211	protein modification process	4	4
GO:0043170	macromolecule metabolic process	3	4
GO:0043412	macromolecule modification	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046467	membrane lipid biosynthetic process	4	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0046488	phosphatidylinositol metabolic process	6	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901135	carbohydrate derivative metabolic process	3	4
GO:1901137	carbohydrate derivative biosynthetic process	4	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901576	organic substance biosynthetic process	3	4
GO:1903509	liposaccharide metabolic process	4	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.432
CLV_NRD_NRD_1	200	202	PF00675	0.593
CLV_PCSK_KEX2_1	200	202	PF00082	0.593
CLV_PCSK_SKI1_1	133	137	PF00082	0.502
CLV_PCSK_SKI1_1	190	194	PF00082	0.677
CLV_PCSK_SKI1_1	201	205	PF00082	0.568
CLV_PCSK_SKI1_1	68	72	PF00082	0.520
DEG_APCC_DBOX_1	199	207	PF00400	0.455
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.428
DOC_MAPK_gen_1	166	173	PF00069	0.355
DOC_MAPK_gen_1	200	208	PF00069	0.363
DOC_MAPK_MEF2A_6	166	173	PF00069	0.317
DOC_MAPK_MEF2A_6	237	246	PF00069	0.389
DOC_MAPK_MEF2A_6	3	11	PF00069	0.546
DOC_MAPK_NFAT4_5	237	245	PF00069	0.318
DOC_PP1_RVXF_1	59	65	PF00149	0.363
DOC_PP2B_LxvP_1	169	172	PF13499	0.305
DOC_PP2B_LxvP_1	240	243	PF13499	0.424
DOC_PP4_FxxP_1	64	67	PF00568	0.357
DOC_USP7_MATH_1	172	176	PF00917	0.386
DOC_USP7_MATH_1	214	218	PF00917	0.460
DOC_USP7_MATH_1	23	27	PF00917	0.521
DOC_WW_Pin1_4	105	110	PF00397	0.334
DOC_WW_Pin1_4	181	186	PF00397	0.371
DOC_WW_Pin1_4	230	235	PF00397	0.453
DOC_WW_Pin1_4	31	36	PF00397	0.414
LIG_14-3-3_CanoR_1	115	124	PF00244	0.399
LIG_14-3-3_CanoR_1	215	221	PF00244	0.448
LIG_14-3-3_CanoR_1	61	65	PF00244	0.387
LIG_Actin_WH2_2	96	113	PF00022	0.457
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BRCT_BRCA1_1	27	31	PF00533	0.462
LIG_BRCT_BRCA1_1	36	40	PF00533	0.307
LIG_eIF4E_1	252	258	PF01652	0.441
LIG_FHA_1	129	135	PF00498	0.362
LIG_FHA_1	93	99	PF00498	0.382
LIG_FHA_2	202	208	PF00498	0.413
LIG_FHA_2	227	233	PF00498	0.463
LIG_LIR_Apic_2	52	56	PF02991	0.384
LIG_LIR_Apic_2	63	67	PF02991	0.317
LIG_LIR_Gen_1	175	185	PF02991	0.438
LIG_LIR_Gen_1	37	45	PF02991	0.443
LIG_LIR_Nem_3	104	110	PF02991	0.338
LIG_LIR_Nem_3	175	180	PF02991	0.417
LIG_LIR_Nem_3	183	189	PF02991	0.463
LIG_LIR_Nem_3	37	41	PF02991	0.384
LIG_NRBOX	256	262	PF00104	0.441
LIG_SH2_CRK	107	111	PF00017	0.337
LIG_SH2_CRK	254	258	PF00017	0.346
LIG_SH2_CRK	38	42	PF00017	0.388
LIG_SH2_SRC	252	255	PF00017	0.441
LIG_SH2_STAP1	116	120	PF00017	0.409
LIG_SH2_STAP1	221	225	PF00017	0.413
LIG_SH2_STAT5	107	110	PF00017	0.271
LIG_SH2_STAT5	129	132	PF00017	0.431
LIG_SH2_STAT5	153	156	PF00017	0.445
LIG_SH2_STAT5	198	201	PF00017	0.428
LIG_SH2_STAT5	252	255	PF00017	0.307
LIG_SH2_STAT5	38	41	PF00017	0.377
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.571
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.246
LIG_TRAF2_1	229	232	PF00917	0.471
LIG_WW_1	35	38	PF00397	0.396
MOD_CDK_SPxK_1	105	111	PF00069	0.400
MOD_CDK_SPxxK_3	230	237	PF00069	0.357
MOD_CK1_1	217	223	PF00069	0.461
MOD_CK1_1	230	236	PF00069	0.349
MOD_CK1_1	34	40	PF00069	0.397
MOD_CK2_1	115	121	PF00069	0.287
MOD_CK2_1	172	178	PF00069	0.380
MOD_CK2_1	226	232	PF00069	0.462
MOD_DYRK1A_RPxSP_1	105	109	PF00069	0.318
MOD_GlcNHglycan	147	150	PF01048	0.638
MOD_GlcNHglycan	221	224	PF01048	0.603
MOD_GlcNHglycan	25	28	PF01048	0.655
MOD_GlcNHglycan	86	89	PF01048	0.637
MOD_GSK3_1	101	108	PF00069	0.379
MOD_GSK3_1	111	118	PF00069	0.372
MOD_GSK3_1	180	187	PF00069	0.382
MOD_GSK3_1	19	26	PF00069	0.569
MOD_GSK3_1	215	222	PF00069	0.432
MOD_GSK3_1	226	233	PF00069	0.390
MOD_GSK3_1	30	37	PF00069	0.401
MOD_N-GLC_1	127	132	PF02516	0.637
MOD_NEK2_1	180	185	PF00069	0.411
MOD_PIKK_1	89	95	PF00454	0.463
MOD_PKA_2	214	220	PF00069	0.468
MOD_PKA_2	60	66	PF00069	0.384
MOD_Plk_4	253	259	PF00069	0.284
MOD_Plk_4	36	42	PF00069	0.388
MOD_Plk_4	66	72	PF00069	0.335
MOD_ProDKin_1	105	111	PF00069	0.338
MOD_ProDKin_1	181	187	PF00069	0.368
MOD_ProDKin_1	230	236	PF00069	0.444
MOD_ProDKin_1	31	37	PF00069	0.411
TRG_ENDOCYTIC_2	107	110	PF00928	0.330
TRG_ENDOCYTIC_2	177	180	PF00928	0.377
TRG_ENDOCYTIC_2	254	257	PF00928	0.326
TRG_ENDOCYTIC_2	38	41	PF00928	0.376
TRG_ER_diArg_1	165	168	PF00400	0.408
TRG_ER_diArg_1	199	201	PF00400	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4M9	Leptomonas seymouri	56%	98%
A0A1X0NHE9	Trypanosomatidae	37%	98%
A0A422NM30	Trypanosoma rangeli	35%	100%
A4H4S3	Leishmania braziliensis	77%	100%
A4HT04	Leishmania infantum	87%	100%
C9ZTN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	92%
Q4QIW4	Leishmania major	87%	100%