Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKZ0_LEIMU

TriTrypDb:

LmxM.06.1110

Length:

1092

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	727	731	PF00656	0.541
CLV_NRD_NRD_1	1085	1087	PF00675	0.692
CLV_NRD_NRD_1	31	33	PF00675	0.517
CLV_NRD_NRD_1	457	459	PF00675	0.590
CLV_NRD_NRD_1	524	526	PF00675	0.603
CLV_NRD_NRD_1	529	531	PF00675	0.607
CLV_NRD_NRD_1	535	537	PF00675	0.610
CLV_NRD_NRD_1	567	569	PF00675	0.734
CLV_NRD_NRD_1	600	602	PF00675	0.668
CLV_NRD_NRD_1	682	684	PF00675	0.725
CLV_NRD_NRD_1	833	835	PF00675	0.725
CLV_NRD_NRD_1	883	885	PF00675	0.646
CLV_PCSK_FUR_1	831	835	PF00082	0.546
CLV_PCSK_KEX2_1	31	33	PF00082	0.517
CLV_PCSK_KEX2_1	456	458	PF00082	0.597
CLV_PCSK_KEX2_1	524	526	PF00082	0.603
CLV_PCSK_KEX2_1	535	537	PF00082	0.610
CLV_PCSK_KEX2_1	567	569	PF00082	0.750
CLV_PCSK_KEX2_1	739	741	PF00082	0.630
CLV_PCSK_KEX2_1	833	835	PF00082	0.745
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.415
CLV_PCSK_PC1ET2_1	739	741	PF00082	0.481
CLV_PCSK_SKI1_1	182	186	PF00082	0.704
CLV_PCSK_SKI1_1	497	501	PF00082	0.620
CLV_PCSK_SKI1_1	524	528	PF00082	0.630
CLV_PCSK_SKI1_1	620	624	PF00082	0.611
CLV_PCSK_SKI1_1	672	676	PF00082	0.772
DEG_ODPH_VHL_1	266	277	PF01847	0.742
DEG_SPOP_SBC_1	491	495	PF00917	0.535
DOC_CYCLIN_yCln2_LP_2	144	147	PF00134	0.497
DOC_MAPK_gen_1	313	323	PF00069	0.772
DOC_MAPK_gen_1	442	451	PF00069	0.571
DOC_MAPK_gen_1	501	510	PF00069	0.691
DOC_MAPK_gen_1	884	894	PF00069	0.665
DOC_MAPK_MEF2A_6	45	53	PF00069	0.540
DOC_PP1_RVXF_1	65	72	PF00149	0.739
DOC_PP2B_LxvP_1	144	147	PF13499	0.497
DOC_PP2B_LxvP_1	275	278	PF13499	0.734
DOC_USP7_MATH_1	1022	1026	PF00917	0.545
DOC_USP7_MATH_1	110	114	PF00917	0.669
DOC_USP7_MATH_1	128	132	PF00917	0.737
DOC_USP7_MATH_1	256	260	PF00917	0.741
DOC_USP7_MATH_1	340	344	PF00917	0.760
DOC_USP7_MATH_1	347	351	PF00917	0.796
DOC_USP7_MATH_1	374	378	PF00917	0.755
DOC_USP7_MATH_1	398	402	PF00917	0.643
DOC_USP7_MATH_1	431	435	PF00917	0.749
DOC_USP7_MATH_1	49	53	PF00917	0.671
DOC_USP7_MATH_1	492	496	PF00917	0.595
DOC_USP7_MATH_1	63	67	PF00917	0.728
DOC_USP7_MATH_1	826	830	PF00917	0.770
DOC_USP7_MATH_1	997	1001	PF00917	0.711
DOC_USP7_UBL2_3	527	531	PF12436	0.418
DOC_WW_Pin1_4	1076	1081	PF00397	0.619
DOC_WW_Pin1_4	136	141	PF00397	0.557
DOC_WW_Pin1_4	209	214	PF00397	0.787
DOC_WW_Pin1_4	252	257	PF00397	0.680
DOC_WW_Pin1_4	260	265	PF00397	0.765
DOC_WW_Pin1_4	342	347	PF00397	0.791
DOC_WW_Pin1_4	362	367	PF00397	0.525
DOC_WW_Pin1_4	45	50	PF00397	0.692
DOC_WW_Pin1_4	566	571	PF00397	0.727
DOC_WW_Pin1_4	574	579	PF00397	0.535
DOC_WW_Pin1_4	692	697	PF00397	0.721
DOC_WW_Pin1_4	835	840	PF00397	0.632
DOC_WW_Pin1_4	856	861	PF00397	0.804
DOC_WW_Pin1_4	940	945	PF00397	0.805
DOC_WW_Pin1_4	986	991	PF00397	0.654
DOC_WW_Pin1_4	995	1000	PF00397	0.639
LIG_14-3-3_CanoR_1	1026	1034	PF00244	0.732
LIG_14-3-3_CanoR_1	196	201	PF00244	0.685
LIG_14-3-3_CanoR_1	368	375	PF00244	0.796
LIG_14-3-3_CanoR_1	379	385	PF00244	0.759
LIG_14-3-3_CanoR_1	400	406	PF00244	0.707
LIG_14-3-3_CanoR_1	535	541	PF00244	0.703
LIG_14-3-3_CanoR_1	553	561	PF00244	0.530
LIG_14-3-3_CanoR_1	67	72	PF00244	0.749
LIG_14-3-3_CanoR_1	712	718	PF00244	0.825
LIG_14-3-3_CanoR_1	937	945	PF00244	0.654
LIG_Actin_WH2_2	8	25	PF00022	0.531
LIG_APCC_ABBA_1	447	452	PF00400	0.548
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BIR_III_4	966	970	PF00653	0.595
LIG_BRCT_BRCA1_1	69	73	PF00533	0.735
LIG_BRCT_BRCA1_1	977	981	PF00533	0.598
LIG_FHA_1	1031	1037	PF00498	0.754
LIG_FHA_1	1086	1092	PF00498	0.522
LIG_FHA_1	535	541	PF00498	0.644
LIG_FHA_1	6	12	PF00498	0.660
LIG_FHA_1	786	792	PF00498	0.648
LIG_FHA_2	1014	1020	PF00498	0.529
LIG_FHA_2	210	216	PF00498	0.674
LIG_FHA_2	224	230	PF00498	0.631
LIG_FHA_2	725	731	PF00498	0.540
LIG_FHA_2	941	947	PF00498	0.595
LIG_GSK3_LRP6_1	835	840	PF00069	0.535
LIG_LIR_Gen_1	164	173	PF02991	0.733
LIG_LIR_Gen_1	594	603	PF02991	0.649
LIG_LIR_Gen_1	942	949	PF02991	0.616
LIG_LIR_Nem_3	1070	1074	PF02991	0.565
LIG_LIR_Nem_3	164	168	PF02991	0.739
LIG_LIR_Nem_3	594	599	PF02991	0.649
LIG_LIR_Nem_3	942	948	PF02991	0.732
LIG_LIR_Nem_3	980	985	PF02991	0.697
LIG_MYND_1	264	268	PF01753	0.744
LIG_PCNA_PIPBox_1	742	751	PF02747	0.702
LIG_PCNA_yPIPBox_3	122	133	PF02747	0.642
LIG_REV1ctd_RIR_1	979	987	PF16727	0.487
LIG_SH2_CRK	165	169	PF00017	0.738
LIG_SH2_CRK	994	998	PF00017	0.734
LIG_SH2_NCK_1	336	340	PF00017	0.546
LIG_SH2_STAP1	514	518	PF00017	0.722
LIG_SH2_STAT3	517	520	PF00017	0.515
LIG_SH2_STAT3	875	878	PF00017	0.570
LIG_SH2_STAT5	930	933	PF00017	0.691
LIG_SH2_STAT5	964	967	PF00017	0.700
LIG_SH3_1	833	839	PF00018	0.753
LIG_SH3_2	56	61	PF14604	0.738
LIG_SH3_3	1047	1053	PF00018	0.719
LIG_SH3_3	1077	1083	PF00018	0.559
LIG_SH3_3	210	216	PF00018	0.775
LIG_SH3_3	363	369	PF00018	0.558
LIG_SH3_3	43	49	PF00018	0.712
LIG_SH3_3	53	59	PF00018	0.788
LIG_SH3_3	780	786	PF00018	0.703
LIG_SH3_3	833	839	PF00018	0.753
LIG_SH3_3	993	999	PF00018	0.711
LIG_SH3_CIN85_PxpxPR_1	570	575	PF14604	0.538
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.642
LIG_SUMO_SIM_par_1	591	597	PF11976	0.655
LIG_TRAF2_1	1063	1066	PF00917	0.580
LIG_TRAF2_1	226	229	PF00917	0.758
LIG_TRAF2_1	322	325	PF00917	0.796
LIG_TRAF2_1	653	656	PF00917	0.543
LIG_TRAF2_1	771	774	PF00917	0.701
LIG_TRAF2_1	841	844	PF00917	0.793
LIG_TRAF2_1	897	900	PF00917	0.588
LIG_TRAF2_1	944	947	PF00917	0.618
LIG_TYR_ITIM	163	168	PF00017	0.525
LIG_WRC_WIRS_1	923	928	PF05994	0.655
MOD_CDC14_SPxK_1	217	220	PF00782	0.785
MOD_CDC14_SPxK_1	365	368	PF00782	0.558
MOD_CDK_SPK_2	252	257	PF00069	0.546
MOD_CDK_SPK_2	692	697	PF00069	0.744
MOD_CDK_SPK_2	835	840	PF00069	0.632
MOD_CDK_SPxK_1	214	220	PF00069	0.784
MOD_CDK_SPxK_1	362	368	PF00069	0.566
MOD_CDK_SPxxK_3	342	349	PF00069	0.544
MOD_CK1_1	10	16	PF00069	0.718
MOD_CK1_1	1000	1006	PF00069	0.661
MOD_CK1_1	102	108	PF00069	0.533
MOD_CK1_1	1051	1057	PF00069	0.504
MOD_CK1_1	131	137	PF00069	0.723
MOD_CK1_1	186	192	PF00069	0.654
MOD_CK1_1	2	8	PF00069	0.811
MOD_CK1_1	345	351	PF00069	0.783
MOD_CK1_1	408	414	PF00069	0.753
MOD_CK1_1	556	562	PF00069	0.697
MOD_CK1_1	613	619	PF00069	0.800
MOD_CK1_1	695	701	PF00069	0.818
MOD_CK1_1	710	716	PF00069	0.687
MOD_CK1_1	720	726	PF00069	0.536
MOD_CK1_1	902	908	PF00069	0.706
MOD_CK1_1	940	946	PF00069	0.766
MOD_CK1_1	986	992	PF00069	0.646
MOD_CK2_1	1024	1030	PF00069	0.779
MOD_CK2_1	1060	1066	PF00069	0.613
MOD_CK2_1	18	24	PF00069	0.518
MOD_CK2_1	209	215	PF00069	0.673
MOD_CK2_1	223	229	PF00069	0.632
MOD_CK2_1	347	353	PF00069	0.839
MOD_CK2_1	357	363	PF00069	0.795
MOD_CK2_1	591	597	PF00069	0.700
MOD_CK2_1	738	744	PF00069	0.615
MOD_CK2_1	77	83	PF00069	0.713
MOD_CK2_1	940	946	PF00069	0.689
MOD_CK2_1	995	1001	PF00069	0.802
MOD_DYRK1A_RPxSP_1	342	346	PF00069	0.656
MOD_DYRK1A_RPxSP_1	45	49	PF00069	0.689
MOD_GlcNHglycan	101	104	PF01048	0.733
MOD_GlcNHglycan	1053	1056	PF01048	0.745
MOD_GlcNHglycan	140	143	PF01048	0.556
MOD_GlcNHglycan	342	345	PF01048	0.714
MOD_GlcNHglycan	376	379	PF01048	0.784
MOD_GlcNHglycan	396	399	PF01048	0.482
MOD_GlcNHglycan	401	404	PF01048	0.702
MOD_GlcNHglycan	407	410	PF01048	0.752
MOD_GlcNHglycan	415	418	PF01048	0.723
MOD_GlcNHglycan	433	436	PF01048	0.841
MOD_GlcNHglycan	477	480	PF01048	0.743
MOD_GlcNHglycan	555	558	PF01048	0.767
MOD_GlcNHglycan	561	564	PF01048	0.770
MOD_GlcNHglycan	620	623	PF01048	0.641
MOD_GlcNHglycan	692	695	PF01048	0.822
MOD_GlcNHglycan	709	712	PF01048	0.632
MOD_GlcNHglycan	713	716	PF01048	0.723
MOD_GlcNHglycan	719	722	PF01048	0.649
MOD_GlcNHglycan	724	727	PF01048	0.613
MOD_GlcNHglycan	79	82	PF01048	0.644
MOD_GlcNHglycan	828	831	PF01048	0.740
MOD_GlcNHglycan	85	88	PF01048	0.668
MOD_GlcNHglycan	939	942	PF01048	0.685
MOD_GlcNHglycan	977	980	PF01048	0.765
MOD_GSK3_1	1022	1029	PF00069	0.749
MOD_GSK3_1	1044	1051	PF00069	0.610
MOD_GSK3_1	183	190	PF00069	0.673
MOD_GSK3_1	2	9	PF00069	0.758
MOD_GSK3_1	219	226	PF00069	0.697
MOD_GSK3_1	252	259	PF00069	0.775
MOD_GSK3_1	338	345	PF00069	0.749
MOD_GSK3_1	353	360	PF00069	0.729
MOD_GSK3_1	394	401	PF00069	0.701
MOD_GSK3_1	404	411	PF00069	0.729
MOD_GSK3_1	41	48	PF00069	0.668
MOD_GSK3_1	487	494	PF00069	0.799
MOD_GSK3_1	555	562	PF00069	0.817
MOD_GSK3_1	63	70	PF00069	0.692
MOD_GSK3_1	707	714	PF00069	0.727
MOD_GSK3_1	720	727	PF00069	0.742
MOD_GSK3_1	747	754	PF00069	0.514
MOD_GSK3_1	79	86	PF00069	0.689
MOD_GSK3_1	973	980	PF00069	0.773
MOD_LATS_1	1024	1030	PF00433	0.521
MOD_LATS_1	39	45	PF00433	0.726
MOD_LATS_1	551	557	PF00433	0.529
MOD_N-GLC_1	186	191	PF02516	0.635
MOD_N-GLC_1	541	546	PF02516	0.634
MOD_N-GLC_1	67	72	PF02516	0.816
MOD_NEK2_1	618	623	PF00069	0.529
MOD_NEK2_1	973	978	PF00069	0.756
MOD_OFUCOSY	1010	1015	PF10250	0.507
MOD_PIKK_1	2	8	PF00454	0.751
MOD_PIKK_1	295	301	PF00454	0.560
MOD_PIKK_1	353	359	PF00454	0.665
MOD_PIKK_1	738	744	PF00454	0.661
MOD_PK_1	954	960	PF00069	0.697
MOD_PKA_2	1005	1011	PF00069	0.660
MOD_PKA_2	1085	1091	PF00069	0.516
MOD_PKA_2	219	225	PF00069	0.804
MOD_PKA_2	236	242	PF00069	0.502
MOD_PKA_2	256	262	PF00069	0.796
MOD_PKA_2	399	405	PF00069	0.647
MOD_PKA_2	534	540	PF00069	0.716
MOD_PKA_2	597	603	PF00069	0.643
MOD_PKA_2	711	717	PF00069	0.827
MOD_PKA_2	77	83	PF00069	0.784
MOD_Plk_1	1029	1035	PF00069	0.789
MOD_Plk_1	1044	1050	PF00069	0.633
MOD_Plk_1	186	192	PF00069	0.632
MOD_Plk_1	228	234	PF00069	0.739
MOD_Plk_1	67	73	PF00069	0.776
MOD_Plk_1	902	908	PF00069	0.604
MOD_Plk_2-3	18	24	PF00069	0.518
MOD_Plk_2-3	534	540	PF00069	0.600
MOD_Plk_4	128	134	PF00069	0.635
MOD_Plk_4	196	202	PF00069	0.692
MOD_Plk_4	49	55	PF00069	0.549
MOD_Plk_4	591	597	PF00069	0.652
MOD_Plk_4	968	974	PF00069	0.692
MOD_Plk_4	977	983	PF00069	0.622
MOD_ProDKin_1	1076	1082	PF00069	0.626
MOD_ProDKin_1	136	142	PF00069	0.555
MOD_ProDKin_1	209	215	PF00069	0.790
MOD_ProDKin_1	252	258	PF00069	0.682
MOD_ProDKin_1	260	266	PF00069	0.763
MOD_ProDKin_1	342	348	PF00069	0.794
MOD_ProDKin_1	362	368	PF00069	0.527
MOD_ProDKin_1	45	51	PF00069	0.695
MOD_ProDKin_1	566	572	PF00069	0.723
MOD_ProDKin_1	574	580	PF00069	0.536
MOD_ProDKin_1	692	698	PF00069	0.721
MOD_ProDKin_1	835	841	PF00069	0.633
MOD_ProDKin_1	856	862	PF00069	0.802
MOD_ProDKin_1	940	946	PF00069	0.806
MOD_ProDKin_1	986	992	PF00069	0.657
MOD_ProDKin_1	995	1001	PF00069	0.641
MOD_SUMO_for_1	761	764	PF00179	0.614
MOD_SUMO_rev_2	1065	1074	PF00179	0.559
MOD_SUMO_rev_2	305	315	PF00179	0.665
TRG_ENDOCYTIC_2	165	168	PF00928	0.739
TRG_ER_diArg_1	1004	1007	PF00400	0.725
TRG_ER_diArg_1	176	179	PF00400	0.727
TRG_ER_diArg_1	501	504	PF00400	0.697
TRG_ER_diArg_1	566	568	PF00400	0.668
TRG_ER_diArg_1	796	799	PF00400	0.647
TRG_ER_diArg_1	831	834	PF00400	0.713
TRG_ER_diArg_1	906	909	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	1062	1066	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	887	891	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J9	Leptomonas seymouri	32%	100%
A0A3S7WPM1	Leishmania donovani	78%	99%
A4H4S2	Leishmania braziliensis	49%	100%
A4HT03	Leishmania infantum	78%	99%
Q4QIW5	Leishmania major	76%	100%