Mitochondrial fission process protein 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peripherally associated ATOM36

Species:

Leishmania mexicana

UniProt:

E9AKY9_LEIMU

TriTrypDb:

LmxM.06.1100

Length:

302

Annotations

LeishMANIAdb annotations

These proteins have some structural similarity to Mitochondrial fission process protein (MTFP) of animals.. Has a transit peptide-like sequence on its N-terminus.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AKY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKY9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070096	mitochondrial outer membrane translocase complex assembly	6	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.502
CLV_MEL_PAP_1	161	167	PF00089	0.302
CLV_NRD_NRD_1	176	178	PF00675	0.348
CLV_NRD_NRD_1	196	198	PF00675	0.181
CLV_NRD_NRD_1	258	260	PF00675	0.290
CLV_NRD_NRD_1	267	269	PF00675	0.428
CLV_NRD_NRD_1	30	32	PF00675	0.330
CLV_PCSK_FUR_1	265	269	PF00082	0.478
CLV_PCSK_KEX2_1	176	178	PF00082	0.256
CLV_PCSK_KEX2_1	196	198	PF00082	0.220
CLV_PCSK_KEX2_1	267	269	PF00082	0.451
CLV_PCSK_KEX2_1	32	34	PF00082	0.293
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.293
CLV_PCSK_PC7_1	192	198	PF00082	0.302
CLV_PCSK_SKI1_1	17	21	PF00082	0.302
DEG_Nend_Nbox_1	1	3	PF02207	0.727
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.502
DOC_MAPK_gen_1	176	182	PF00069	0.490
DOC_MAPK_MEF2A_6	208	216	PF00069	0.470
DOC_PP2B_LxvP_1	139	142	PF13499	0.465
DOC_PP4_FxxP_1	47	50	PF00568	0.490
DOC_USP7_MATH_1	163	167	PF00917	0.500
DOC_USP7_MATH_1	266	270	PF00917	0.638
DOC_USP7_MATH_1	272	276	PF00917	0.762
DOC_USP7_MATH_1	5	9	PF00917	0.502
DOC_USP7_UBL2_3	57	61	PF12436	0.530
LIG_14-3-3_CanoR_1	213	219	PF00244	0.338
LIG_14-3-3_CanoR_1	265	271	PF00244	0.670
LIG_APCC_ABBA_1	180	185	PF00400	0.530
LIG_FHA_1	153	159	PF00498	0.528
LIG_FHA_1	177	183	PF00498	0.499
LIG_FHA_1	188	194	PF00498	0.488
LIG_FHA_1	213	219	PF00498	0.295
LIG_FHA_1	291	297	PF00498	0.577
LIG_FHA_1	36	42	PF00498	0.447
LIG_FHA_2	152	158	PF00498	0.530
LIG_LIR_Apic_2	44	50	PF02991	0.490
LIG_LIR_Gen_1	137	145	PF02991	0.536
LIG_LIR_Nem_3	122	127	PF02991	0.530
LIG_LIR_Nem_3	137	141	PF02991	0.537
LIG_LIR_Nem_3	181	186	PF02991	0.544
LIG_LIR_Nem_3	236	241	PF02991	0.252
LIG_LYPXL_S_1	123	127	PF13949	0.265
LIG_LYPXL_SIV_4	112	120	PF13949	0.502
LIG_LYPXL_yS_3	124	127	PF13949	0.465
LIG_SH2_STAP1	89	93	PF00017	0.530
LIG_SH2_STAT5	113	116	PF00017	0.533
LIG_SH2_STAT5	119	122	PF00017	0.527
LIG_SH2_STAT5	131	134	PF00017	0.465
LIG_SH3_3	196	202	PF00018	0.478
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.360
LIG_UBA3_1	74	80	PF00899	0.312
MOD_CK1_1	25	31	PF00069	0.400
MOD_CK1_1	283	289	PF00069	0.663
MOD_CK2_1	278	284	PF00069	0.642
MOD_CK2_1	67	73	PF00069	0.384
MOD_GlcNHglycan	110	113	PF01048	0.435
MOD_GlcNHglycan	13	16	PF01048	0.341
MOD_GlcNHglycan	165	168	PF01048	0.420
MOD_GlcNHglycan	17	20	PF01048	0.324
MOD_GlcNHglycan	280	283	PF01048	0.767
MOD_GlcNHglycan	38	41	PF01048	0.400
MOD_GlcNHglycan	7	10	PF01048	0.294
MOD_GlcNHglycan	80	83	PF01048	0.344
MOD_GSK3_1	1	8	PF00069	0.348
MOD_GSK3_1	11	18	PF00069	0.477
MOD_N-GLC_1	36	41	PF02516	0.284
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	106	111	PF00069	0.319
MOD_NEK2_1	144	149	PF00069	0.430
MOD_NEK2_1	171	176	PF00069	0.353
MOD_NEK2_1	187	192	PF00069	0.408
MOD_NEK2_1	212	217	PF00069	0.337
MOD_NEK2_1	41	46	PF00069	0.303
MOD_NEK2_1	78	83	PF00069	0.400
MOD_PIKK_1	152	158	PF00454	0.400
MOD_PKA_1	176	182	PF00069	0.308
MOD_PKA_2	163	169	PF00069	0.475
MOD_PKA_2	176	182	PF00069	0.232
MOD_PKA_2	212	218	PF00069	0.330
MOD_PKA_2	266	272	PF00069	0.557
MOD_PKA_2	278	284	PF00069	0.722
MOD_PKB_1	33	41	PF00069	0.312
MOD_Plk_1	171	177	PF00069	0.425
MOD_Plk_1	36	42	PF00069	0.344
MOD_Plk_1	67	73	PF00069	0.360
MOD_Plk_4	134	140	PF00069	0.360
MOD_Plk_4	144	150	PF00069	0.374
MOD_Plk_4	214	220	PF00069	0.343
TRG_ENDOCYTIC_2	124	127	PF00928	0.342
TRG_ER_diArg_1	175	177	PF00400	0.427
TRG_ER_diArg_1	195	197	PF00400	0.298
TRG_ER_diArg_1	264	267	PF00400	0.553
TRG_ER_diArg_1	31	34	PF00400	0.346
TRG_NES_CRM1_1	178	189	PF08389	0.360
TRG_NLS_MonoExtC_3	30	35	PF00514	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z0	Leptomonas seymouri	63%	99%
A0A3S7WPK6	Leishmania donovani	95%	100%
A0A422NM25	Trypanosoma rangeli	41%	97%
A4HT02	Leishmania infantum	95%	100%
C9ZTN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	94%
E9AI25	Leishmania braziliensis	86%	100%
Q4QIW6	Leishmania major	93%	100%
V5B816	Trypanosoma cruzi	36%	97%